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1. 发明申请

US20110300555A1 ASSAY DEVICE COMPRISING BUBBLE-FORMING MEANS 有权
标题翻译：包含泡沫成型装置的测定装置
公开(公告)号：US20110300555A1
公开(公告)日：2011-12-08
申请号：US12937465
申请日：2009-04-09
申请人： Balbir Raj , David Tolley
发明人： Balbir Raj , David Tolley
IPC分类号： G01N33/76 , C12M1/40 , G01N30/96 , G01N33/53
CPC分类号： G01N33/54366 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/025 , B01L2300/0816 , B01L2400/0406 , B01L2400/046 , B01L2400/0622 , G01N33/581 , G01N2333/59 , G01N2333/908
摘要： Disclosed is a method for determining the presence and/or amount Oran analyte of interest in a liquid sample comprising the steps of: contacting the liquid sample suspected of containing analyte with a gas generating means (eg. catalase and peracid or peroxygen compound), which gas generating means forms a gas dependent upon the presence, absence or amount of analyte, which gas creates one or more bubbles in the liquid sample which act to alter the flow of liquid along a flow path; and determining an alteration of flow in the liquid wherein the alteration of flow of liquid along the flow path is indicative of the presence and/or amount of analyte in the liquid sample.
摘要翻译：公开了一种用于确定液体样品中目标的存在和/或量Oran分析物的方法，包括以下步骤：将怀疑含有分析物的液体样品与气体产生装置（例如过氧化氢酶和过酸或过氧化合物）接触，气体发生装置根据分析物的存在，不存在或数量形成气体，该气体在液体样品中产生一个或多个气泡，其用于改变液体沿着流动路径的流动; 以及确定液体中的流动的改变，其中沿着流动路径的液体流动的改变指示液体样品中分析物的存在和/或量。

2. 发明授权

US07901949B2 Assay 有权
标题翻译：测定
公开(公告)号：US07901949B2
公开(公告)日：2011-03-08
申请号：US11423581
申请日：2006-06-12
申请人： Balbir Raj
发明人： Balbir Raj
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , G01N33/54306 , G01N33/54386 , G01N33/54393 , Y10S435/81
摘要： The present invention provides an assay kit for detecting an analyte of interest in a sample. The kit comprises a) a reporter species; b) a labelled species having first and second binding regions, wherein the first binding region is capable of binding to the analyte of interest and the second binding region is capable of binding to the reporter species; c) an immobilised species capable of binding to the first binding region of the labelled species; and d) immobilised capture reagent capable of binding to the reporter species. The arrangement is such that the sample is contacted with the labelled species, is then contacted with the immobilised species and is subsequently contacted with the immobilised capture reagent, the reporter species being added prior to exposure of the sample to the immobilised capture reagent. If no analyte is present in the sample, the labelled species becomes bound to the immobilised species and is therefore unable to bind to the immobilised capture reagent. If analyte is present in the sample, the analyte binds to the labelled species such that the labelled species is unable to bind to the immobilised species but can bind to the immobilised capture reagent via the reporter species, the presence of the analyte thus being determined by the presence of labelled species bound to the immobilised capture reagent via the reporter species.
摘要翻译：本发明提供了用于检测样品中感兴趣的分析物的测定试剂盒。该套件包括a）报道物种; b）具有第一和第二结合区域的标记物质，其中所述第一结合区域能够结合目标分析物，并且所述第二结合区域能够结合所述报告物种; c）能够结合标记物种的第一结合区域的固定化物质; 和d）能够结合报告物种的固定捕获试剂。该装置使得样品与标记物质接触，然后与固定化物质接触，随后与固定的捕获试剂接触，报道物种在将样品暴露于固定的捕获试剂之前加入。如果样品中没有分析物，则标记物质与固定化物质结合，因此不能与固定的捕获试剂结合。如果分析物存在于样品中，则分析物结合到标记的物质，使得标记的物质不能结合固定的物质，但是可以通过报道物质与固定的捕获试剂结合，因此分析物的存在由标记物质通过报道物种与固定的捕获试剂结合的存在。

3. 发明申请

US20070015290A1 Assay 有权
标题翻译：测定
公开(公告)号：US20070015290A1
公开(公告)日：2007-01-18
申请号：US11423581
申请日：2006-06-12
申请人： Balbir Raj
发明人： Balbir Raj
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , G01N33/54306 , G01N33/54386 , G01N33/54393 , Y10S435/81
摘要： The present invention provides an assay kit for detecting an analyte of interest in a sample. The kit comprises a) a reporter species; b) a labelled species having first and second binding regions, wherein the first binding region is capable of binding to the analyte of interest and the second binding region is capable of binding to the reporter species; c) an immobilised species capable of binding to the first binding region of the labelled species; and d) immobilised capture reagent capable of binding to the reporter species. The arrangement is such that the sample is contacted with the labelled species, is then contacted with the immobilised species and is subsequently contacted with the immobilised capture reagent, the reporter species being added prior to exposure of the sample to the immobilised capture reagent. If no analyte is present in the sample, the labelled species becomes bound to the immobilised species and is therefore unable to bind to the immobilised capture reagent. If analyte is present in the sample, the analyte binds to the labelled species such that the labelled species is unable to bind to the immobilised species but can bind to the immobilised capture reagent via the reporter species, the presence of the analyte thus being determined by the presence of labelled species bound to the immobilised capture reagent via the reporter species.
摘要翻译：本发明提供了用于检测样品中感兴趣的分析物的测定试剂盒。该套件包括a）报道物种; b）具有第一和第二结合区域的标记物质，其中所述第一结合区域能够结合目标分析物，并且所述第二结合区域能够结合所述报告物种; c）能够结合标记物种的第一结合区域的固定化物质; 和d）能够结合报告物种的固定捕获试剂。该装置使得样品与标记物质接触，然后与固定化物质接触，随后与固定的捕获试剂接触，报道物种在将样品暴露于固定的捕获试剂之前加入。如果样品中没有分析物，则标记物质与固定化物质结合，因此不能与固定的捕获试剂结合。如果分析物存在于样品中，则分析物结合到标记的物质，使得标记的物质不能结合固定的物质，但可以通过报道物质与固定的捕获试剂结合，因此分析物的存在由通过报道物种结合到固定的捕获试剂上的标记物质的存在。

4. 发明授权

US09151749B2 Assay device comprising bubble-forming means 有权
标题翻译：包含气泡形成装置的测定装置
公开(公告)号：US09151749B2
公开(公告)日：2015-10-06
申请号：US12937465
申请日：2009-04-09
申请人： Balbir Raj
发明人： Balbir Raj , David Tolley
IPC分类号： C12Q1/00 , G01N33/543 , B01L3/00 , G01N33/58
CPC分类号： G01N33/54366 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/025 , B01L2300/0816 , B01L2400/0406 , B01L2400/046 , B01L2400/0622 , G01N33/581 , G01N2333/59 , G01N2333/908
摘要： Disclosed is a method for determining the presence and/or amount Oran analyte of interest in a liquid sample comprising the steps of: contacting the liquid sample suspected of containing analyte with a gas generating means (eg. catalase and peracid or peroxygen compound), which gas generating means forms a gas dependent upon the presence, absence or amount of analyte, which gas creates one or more bubbles in the liquid sample which act to alter the flow of liquid along a flow path; and determining an alteration of flow in the liquid wherein the alteration of flow of liquid along the flow path is indicative of the presence and/or amount of analyte in the liquid sample.
摘要翻译：公开了一种用于确定液体样品中目标的存在和/或量Oran分析物的方法，包括以下步骤：将怀疑含有分析物的液体样品与气体产生装置（例如过氧化氢酶和过酸或过氧化合物）接触，气体发生装置根据分析物的存在，不存在或数量形成气体，该气体在液体样品中产生一个或多个气泡，其用于改变液体沿着流动路径的流动; 以及确定液体中的流动的改变，其中沿着流动路径的液体流动的改变指示液体样品中分析物的存在和/或量。

5. 发明申请

US20110223690A1 ASSAY 审中-公开
标题翻译：测定
公开(公告)号：US20110223690A1
公开(公告)日：2011-09-15
申请号：US13018828
申请日：2011-02-01
申请人： Balbir Raj
发明人： Balbir Raj
IPC分类号： G01N33/543
CPC分类号： G01N33/558 , G01N33/54306 , G01N33/54386 , G01N33/54393 , Y10S435/81
摘要： The present invention provides an assay kit for detecting an analyte of interest in a sample. The kit comprises a) a reporter species; b) a labelled species having first and second binding regions, wherein the first binding region is capable of binding to the analyte of interest and the second binding region is capable of binding to the reporter species; c) an immobilised species capable of binding to the first binding region of the labelled species; and d) immobilised capture reagent capable of binding to the reporter species. The arrangement is such that the sample is contacted with the labelled species, is then contacted with the immobilised species and is subsequently contacted with the immobilised capture reagent, the reporter species being added prior to exposure of the sample to the immobilised capture reagent. If no analyte is present in the sample, the labelled species becomes bound to the immobilised species and is therefore unable to bind to the immobilised capture reagent. If analyte is present in the sample, the analyte binds to the labelled species such that the labelled species is unable to bind to the immobilised species but can bind to the immobilised capture reagent via the reporter species, the presence of the analyte thus being determined by the presence of labelled species bound to the immobilised capture reagent via the reporter species.
摘要翻译：本发明提供了用于检测样品中感兴趣的分析物的测定试剂盒。该套件包括a）报道物种; b）具有第一和第二结合区域的标记物质，其中所述第一结合区域能够结合目标分析物，并且所述第二结合区域能够结合所述报道物质; c）能够结合标记物种的第一结合区域的固定化物质; 和d）能够结合报告物种的固定捕获试剂。该装置使得样品与标记物质接触，然后与固定化物质接触，随后与固定的捕获试剂接触，报道物种在将样品暴露于固定的捕获试剂之前加入。如果样品中没有分析物，则标记物质与固定化物质结合，因此不能与固定的捕获试剂结合。如果分析物存在于样品中，则分析物结合到标记的物质，使得标记的物质不能结合固定的物质，但是可以通过报道物质与固定的捕获试剂结合，因此分析物的存在由标记物质通过报道物种与固定的捕获试剂结合的存在。

6. 发明申请

US20100209297A1 Assay Device 有权
标题翻译：测定装置
公开(公告)号：US20100209297A1
公开(公告)日：2010-08-19
申请号：US12595741
申请日：2008-04-09
申请人： Balbir Raj , Saji Eapen , Ezra Linley
发明人： Balbir Raj , Saji Eapen , Ezra Linley
IPC分类号： G01N33/53
CPC分类号： G01N33/76 , B01L2300/0825 , B01L2300/087 , B01L2400/0406 , C12Q2537/125 , G01N33/558 , G01N33/689 , Y10T29/494
摘要： Disclosed is an assay device for the determination of the presence and/or extent if an analyte in a liquid sample over an extended concentration range comprising a first assay and a second assay, wherein the first assay for an analyte comprises a first flow-path having a sole detection zone capable of immobilising a labelled binding reagent and the second assay for said analyte comprises a second flow-path having a sole detection zone capable of immobilising a labelled binding reagent, wherein the presence of labelled binding reagent at the detection zones provides an indication of the presence and/or extent of analyte in said liquid sample.
摘要翻译：公开了一种用于确定在包括第一测定和第二测定的扩展浓度范围内的液体样品中的分析物的存在和/或程度的测定装置，其中用于分析物的第一测定包括第一流动路径，其具有能够固定标记的结合试剂的唯一检测区域和用于所述分析物的第二测定物包括具有能够固定标记的结合试剂的唯一检测区域的第二流动路径，其中在检测区域处标记的结合试剂的存在提供了指示所述液体样品中分析物的存在和/或程度。

7. 发明授权

US08721990B2 Assay device 有权
标题翻译：测定装置
公开(公告)号：US08721990B2
公开(公告)日：2014-05-13
申请号：US12595741
申请日：2008-04-09
申请人： Balbir Raj , Saji Eapen , Ezra Linley
发明人： Balbir Raj , Saji Eapen , Ezra Linley
IPC分类号： G01N21/75 , G01N33/76 , G01N33/68 , G01N33/558
CPC分类号： G01N33/76 , B01L2300/0825 , B01L2300/087 , B01L2400/0406 , C12Q2537/125 , G01N33/558 , G01N33/689 , Y10T29/494
摘要： Disclosed is an assay device for the determination of the presence and/or extent if an analyte in a liquid sample over an extended concentration range comprising a first assay and a second assay, wherein the first assay for an analyte comprises a first flow-path having a sole detection zone capable of immobilizing a labelled binding reagent and the second assay for said analyte comprises a second flow-path having a sole detection zone capable of immobilizing a labelled binding reagent, wherein the presence of labelled binding reagent at the detection zones provides an indication of the presence and/or extent of analyte in said liquid sample.
摘要翻译：公开了一种用于确定在包括第一测定和第二测定的扩展浓度范围内的液体样品中的分析物的存在和/或程度的测定装置，其中用于分析物的第一测定包括第一流动路径，其具有能够固定标记的结合试剂的唯一检测区域和用于所述分析物的第二测定物包括具有能够固定标记的结合试剂的唯一检测区域的第二流动路径，其中在检测区域处标记的结合试剂的存在提供了指示所述液体样品中分析物的存在和/或程度。

8. 发明申请

US20130309760A1 Assay Device 有权
标题翻译：测定装置
公开(公告)号：US20130309760A1
公开(公告)日：2013-11-21
申请号：US13988953
申请日：2011-11-24
申请人： Balbir Raj , Saji Eapen , Ian Scrimgeour
发明人： Balbir Raj , Saji Eapen , Ian Scrimgeour
IPC分类号： G01N33/76
CPC分类号： G01N33/76 , G01N33/54366 , G01N33/558
摘要： The present invention relates generally to an assay device with improved tolerance to mishandling and/or use by the user. More particularly, the invention relates to an assay device with reduced susceptibility to flooding.
摘要翻译：本发明一般涉及具有改进的误操作和/或使用者容忍度的测定装置。更具体地，本发明涉及具有降低的淹水敏感性的测定装置。

9. 发明申请

US20100320237A1 FLUID DISPENSING APPARATUS WITH LOCKABLE ACTUATOR 审中-公开
标题翻译：具有可锁定执行器的流体分配装置
公开(公告)号：US20100320237A1
公开(公告)日：2010-12-23
申请号：US12486618
申请日：2009-06-17
申请人： Balbir Raj , Matthew Rose
发明人： Balbir Raj , Matthew Rose
IPC分类号： B67D5/40 , B67D5/33
CPC分类号： B05B11/306
摘要： One embodiment is a dispensing apparatus including a dispensing head for a fluid, wherein the dispensing head comprises an actuator, a pump mechanism and a locking member. The actuator is movable relative to the pump mechanism from a lock position to a first pump position and moveable relative to the pump mechanism between a first pump position and a second pump position for actuating said pump mechanism. The dispensing apparatus is configurable into a locked configuration, in which the actuator is in the lock position and in which the locking member is braced between the actuator and the pump mechanism to prevent movement of the actuator from the lock position, and an unlocked configuration in which the locking member allows movement of the actuator from the lock position, and wherein the dispensing head is adapted to revert from the unlocked configuration when the actuator is returned to the lock position. A biasing means in the form of a spring, elastic, gravitational or magnetic means may also be included as may a hinged locking member or a guide slot arrangement.
摘要翻译：一个实施例是包括用于流体的分配头的分配装置，其中分配头包括致动器，泵机构和锁定构件。致动器可相对于泵机构从锁定位置移动到第一泵位置，并且可相对于泵机构在第一泵位置和第二泵位置之间移动，用于致动所述泵机构。分配装置可配置成锁定构造，其中致动器处于锁定位置，并且锁定构件支撑在致动器和泵机构之间，以防止致动器从锁定位置移动，并且解锁构造锁定构件允许致动器从锁定位置移动，并且其中当致动器返回到锁定位置时，分配头适于从解锁构造恢复。可以包括弹簧，弹性，重力或磁性装置形式的偏置装置，如铰链锁定构件或引导狭槽装置。

10. 发明申请

US20090196792A1 Multiple Assay Device 审中-公开
标题翻译：多重测定装置
公开(公告)号：US20090196792A1
公开(公告)日：2009-08-06
申请号：US12202639
申请日：2008-09-02
申请人： Balbir Raj , Ezra Linley , Saji Eapen
发明人： Balbir Raj , Ezra Linley , Saji Eapen
IPC分类号： G01N31/22
CPC分类号： G01N33/76 , B01L2300/0825 , B01L2300/087 , B01L2400/0406 , C12Q2537/125 , G01N33/558 , G01N33/689 , Y10T29/494
摘要： Disclosed is an assay device for the determination of analyte in a liquid sample over an extended concentration range comprising a first assay and a second assay, wherein the first assay for an analyte comprises a first flow-path having a sole detection zone capable of immobilising a labelled binding reagent and the second assay for said analyte comprises a second flow-path having a sole detection zone capable of immobilising a labelled binding reagent, wherein the presence of labelled binding reagent at the detection zones provides an indication of the presence and/or extent of analyte in said liquid sample.
摘要翻译：公开了一种用于在包括第一测定和第二测定的扩展浓度范围内测定液体样品中的分析物的测定装置，其中分析物的第一测定物包括具有能够固定标记的结合试剂和用于所述分析物的第二测定物包含具有能够固定标记的结合试剂的唯一检测区的第二流动路径，其中在检测区域处标记的结合试剂的存在提供了存在和/或程度的指示的所述液体样品中的分析物。

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