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1. 发明专利

CA2219490A1 MAGNETOFLUID-ASSISTED ELECTROMAGNETIC DRIVE FOR A BLOOD PUMP USED TO SUPPORT THE HEART OR FOR PARTIAL OR COMPLETE REPLACEMENT OF THE HEART 未知
公开(公告)号：CA2219490A1
公开(公告)日：1997-09-04
申请号：CA2219490
申请日：1997-02-27
申请人： MUELLER JOHANNES , REHFELD ARMIN , NETHE ARNIM , HNDEL THOMAS H , BUSKE NORBERT , STAHLMANN HANNS DIETRICH
发明人： MUELLER JOHANNES , REHFELD ARMIN , NETHE ARNIM , H HNDEL THOMAS , BUSKE NORBERT , STAHLMANN HANNS-DIETRICH
IPC分类号： F04B43/08 , A61M1/10 , H01F1/44
摘要： The invention relates to an magnetic fluid-assisted electromagnetic drive for a blood pump used to support the heart or for partial or complete replacement of the heart. The blood pump is of a weight and energy density corresponding closely to those of the natural heart and especially suitable for implantation, the aim being to reduce the size of the total system in relation to known systems while improving its efficiency. This is achieved as follows: a blood pump is provided with a magnetic fluid-assisted electromagnetic drive comprising one or more electromagnets and force-converting devices, the intermediate chamber of at least one electromagnetic circuit is completely or partially filled with magnetic fluid and the poles have permanent magnetic properties. A magnetic fluid with a saturation magnetisation of between 150 and 450 mT and initial permeability of between 5 and 25 is used.

2. 发明专利

CA2219503A1 MAGNETOFLUID WITH HIGH SATURATION MAGNETISATION 未知
公开(公告)号：CA2219503A1
公开(公告)日：1997-09-04
申请号：CA2219503
申请日：1997-02-27
申请人： BUSKE NORBERT , MUELLER JOHANNES , REHFELD ARMIN , NETHE ARNIM , STAHLMANN HANNS DIETRICH , HNDEL THOMAS H
发明人： BUSKE NORBERT , MUELLER JOHANNES , REHFELD ARMIN , NETHE ARNIM , H HNDEL THOMAS
IPC分类号： A61M1/10 , H01F1/44 , H02K1/02 , H02K33/02
摘要： It has been the task of the invention to form a magnetofluid with a hig h saturation magnetisation which has a saturation concentration that lies above 100 mT in order to be able to transmit higher forces. According to the invention, this is attained by stably dispersing cobalt a nd nanometer particles modified with mono-molecular adsorption layers in carrier liquids, whereby the volume concentration of the ferromagnetic component comes to 5 to 35 per cent, preferably to 15 to 30 %, and the volume concentration of the modified particles (naked particles with adsorption shell) comes up to 50 per cent by volume.

3. 发明专利

HU9901479A2 MAGNETIC FLUID-ASSISTED ELECTROMAGNETIC DRIVE FOR A BLOOD PUMP USED TO SUPPORT THE HEART OR FOR PARTIAL OR COMPLETE REPLACEMENT OF THE HEART 未知
公开(公告)号：HU9901479A2
公开(公告)日：1999-08-30
申请号：HU9901479
申请日：1997-02-27
申请人： BUSKE NORBERT , HAEHNDEL THOMAS , MUELLER JOHANNES , NETHE ARNIM , REHFELD ARMIN , STAHLMANN HANNS DIETRICH
发明人： BUSKE NORBERT , HAEHNDEL THOMAS , MUELLER JOHANNES , NETHE ARNIM , REHFELD ARMIN , STAHLMANN HANNS-DIETRICH
IPC分类号： A61M1/10 , H01F1/44 , F04B43/08 , A61M1/12 , F04B43/09
摘要： PCT No. PCT/DE97/00441 Sec. 371 Date Jan. 26, 1998 Sec. 102(e) Date Jan. 26, 1998 PCT Filed Feb. 27, 1997 PCT Pub. No. WO97/31662 PCT Pub. Date Sep. 4, 1997The invention relates to a magnetofluid-supported electromagnetic drive for a blood pump for supporting or partially to totally replacing the heart whereby the blood pump in its weight as well as its energy density nearly corresponds to the natural heart and is especially suitable for an implantation whereby a reduction of the total system in comparison with known systems is to be made possible and the efficiency is improved at the same time. This task is solved by the blood pump having a magnetofluid-supported electromagnetic drive consisting of one or several electromagnets and force-transforming facilities and with the space of at least one electromagnetic circuit being completely or partially filled with magnetofluid, whereby the poles show permanent-magnetic properties. Thereby, a magnetofluid with a saturation magnetization of 150 to 450 mT has been used with an initial permeability of 5 to 25.

4. 发明专利

CA2219503C MAGNETOFLUID WITH HIGH SATURATION MAGNETISATION 未知
公开(公告)号：CA2219503C
公开(公告)日：2001-04-24
申请号：CA2219503
申请日：1997-02-27
申请人： NETHE ARNIM , HAEHNDEL THOMAS , MUELLER JOHANNES , BUSKE NORBERT , REHFELD ARMIN , STAHLMANN HANNS-DIETRICH
发明人： NETHE ARNIM , HAEHNDEL THOMAS , MUELLER JOHANNES , BUSKE NORBERT , REHFELD ARMIN , STAHLMANN HANNS-DIETRICH
IPC分类号： A61M1/10 , H01F1/44 , H02K1/02 , H02K33/02
摘要： It has been the task of the invention to form a magnetofluid with a hig h saturation magnetisation which has a saturation concentration that lies above 100 mT in order to be able to transmit higher forces. According to the invention, this is attained by stably dispersing cobalt a nd nanometer particles modified with mono-molecular adsorption layers in carrier liquids, whereby the volume concentration of the ferromagnetic component comes to 5 to 35 per cent, preferably to 15 to 30 %, and the volume concentration of the modified particles (naked particles with adsorption shell) comes up to 50 per cent by volume.

5. 发明申请

WO0063595A3 DEVICE FOR SEALING AN ANNULAR GAP 审中-公开
标题翻译：装置用于密封的环形间隙的
公开(公告)号：WO0063595A3
公开(公告)日：2001-04-26
申请号：PCT/EP0003559
申请日：2000-04-19
申请人： MEDIPORT KARDIOTECHNIK GMBH , NUESSER PETER , MUELLER JOHANNES , BUSKE NORBERT , NEUMANN WERNER
发明人： NUESSER PETER , MUELLER JOHANNES , BUSKE NORBERT , NEUMANN WERNER
IPC分类号： F16J15/43 , F16L25/00
CPC分类号： F16J15/43
摘要： The invention relates to a device for sealing an annular gap. The aim of the invention is to provide a device for sealing an annular gap(1) by means of a magnetic liquid (11). The inventive device can seal two contactless, axially adjacent pipe ends (9, 10) in such a way that no exchange takes place between the fluid medium in the pipes and the proximity and that the magnetic liquid does not mix with the fluid medium and that the pipes can be moved and rotated against each other involving little friction. To this end, the pipe ends forming an annular gap are connected to the poles of a magnetic arrangement (8) in a magnetically conducting manner. Said magnetic arrangement is fixed around the annular gap area. A magnetic liquid is arranged in the annular gap.
摘要翻译：本发明涉及一种设备，用于密封的环形间隙。本发明具有在管中提供了一种用于通过磁性液体（11），以使可用的，其允许两个接触，轴向相邻的管端（9，10）的密封，使得的装置密封的环形间隙（1），流体介质之间的对象并且没有发生交换的环境中，磁性流体不与针对彼此能够在管道的流体介质和一种低摩擦的移动性和可旋转混合。该目的的实现在于该环间隙形成管端部到的固定围绕周围的磁铁装置（8）的环形间隙区域的磁极是磁性导电连接和磁性流体设置在所述环形间隙中。

6. 发明申请

WO0111039A3 NEW SEQUENCE VARIANTS OF THE HUMAN 1-ADRENORECEPTOR GENE AND USE THEREOF 审中-公开
标题翻译：人1-ADRENOZEPTORGENS及其使用序列变异
公开(公告)号：WO0111039A3
公开(公告)日：2001-08-30
申请号：PCT/DE0002648
申请日：2000-08-04
申请人： MAX DELBRUECK CENTRUM , WALLUKAT GERD , PODLOWSKI SVENJA , WENZEL KATRIN , MUELLER JOHANNES
发明人： WALLUKAT GERD , PODLOWSKI SVENJA , WENZEL KATRIN , MUELLER JOHANNES
IPC分类号： C07K14/72 , C12N15/12 , C12Q1/68 , C07K14/705
CPC分类号： C12Q1/6883 , C07K14/723 , C12Q2600/156
摘要： The invention relates to new sequence variants of the human beta 1-adrenoreceptor gene and to the use of polymorphisms in the human beta 1-adrenoreceptor gene for diagnosing cardiomyopathies.
摘要翻译：本发明涉及的人β1-Adrenozeptorgens和在人β1-Adrenozeptorgen使用多态性对于心肌病的诊断的新型序列变体。

7. 发明申请

WO9962933A3 RATIONALLY DESIGNED PEPTIDES, PRODUCTION AND USE THEREOF 审中-公开
标题翻译：合理设计的肽，其生产和使用
公开(公告)号：WO9962933A3
公开(公告)日：2000-04-06
申请号：PCT/DE9901575
申请日：1999-05-28
申请人： AFFINA IMMUNTECHNIK GMBH , WALLUKAT GERD , SCHNEIDER GISBERT , SCHROEDL WIELAND , MUELLER JOHANNES , ROENSPECK WOLFGANG , WREDE PAUL , KUNZE RUDOLF
发明人： WALLUKAT GERD , SCHNEIDER GISBERT , SCHROEDL WIELAND , MUELLER JOHANNES , ROENSPECK WOLFGANG , WREDE PAUL , KUNZE RUDOLF
IPC分类号： C07K1/04 , C07K7/06 , C07K1/00 , A61K38/04 , C07B61/00 , C07K14/705 , C12N15/10
CPC分类号： C07K7/06 , C07K1/047
摘要： The invention relates to rationally designed peptides and to the production and use thereof for biotechnological, medical, diagnostic and therapeutic purposes. The method for generating peptides that are suitable for bonding auto-antibodies is characterized by the following: identification of a seed peptide with the suitable activity, production of a small number of peptide variants from the physico-chemical area around the seed peptide using a computer-assisted calculation method; synthesis and testing of the activity of said peptide variants; modelling of a quantitative sequence/activity ratio by means of an artificial neuronal network; and the production of peptides by simulated evolution in the sequence area using the trained neuronal network. The invention specifically relates to the peptide DRFGDKIAF.
摘要翻译：本发明涉及合理地设计肽，它们的制备方法和它们用于生物技术，医学，诊断和治疗目的的用途。适合于自身抗体结合对肽的产生的方法，其特征在于识别Saatpeptids与适当的活性; 生成从围绕Saatpeptid的物理化学空间计算机辅助计算方法的辅助下围绕肽变体的一小部分; 合成和这些肽变体的活性的测试; 建模通过人工神经网络的方法的定量序列/活性关系; 并通过训练神经网络的方法产生由序列空间模拟进化肽。特别地，该肽DRFGDKDIAF。

8. 发明申请

WO02088547A3 METHOD FOR CONTROLLING AN ASSIST PUMP FOR FLUID DELIVERY SYSTEMS WITH PULSATILE PRESSURE 审中-公开
标题翻译：一种用于控制支持水泵上的流体处理系统的脉动压力
公开(公告)号：WO02088547A3
公开(公告)日：2003-03-13
申请号：PCT/EP0204688
申请日：2002-04-26
申请人： BERLIN HEART AG , NUESSER PETER , MUELLER JOHANNES , DEUS FRANK , GOETTEL PETER , HOFFMANN JAN , GRAICHEN KURT , ARNDT ANDREAS , MERKEL TOBIAS
发明人： NUESSER PETER , MUELLER JOHANNES , DEUS FRANK , GOETTEL PETER , HOFFMANN JAN , GRAICHEN KURT , ARNDT ANDREAS , MERKEL TOBIAS
IPC分类号： A61M1/10 , F04D3/00 , F04D13/06 , F04D15/00
CPC分类号： F04D13/0606 , F04D3/00 , F04D15/0066
摘要： The invention relates to a method for controlling an assist pump for fluid delivery systems with pulsatile pressure. If, for example, a heart-assist pump is operated with a constant rotational speed, the blood is continually delivered through the assist pump even when the cardiac chamber is in the decontraction phase. The inventive method ensures that an assist pump functions in an assisting manner only during the pressure phase of the main pump by constantly determining the pressure difference between the inlet and delivery side of the assist pump and by constantly determining the rate of flow through the assist pump. The rotational speed of the assist pump is controlled as to prevent the determined pressure difference from falling below a predeterminable value and to prevent the rate of flow from falling below zero.
摘要翻译：一种用于控制与脉动压力流体输送系统的辅助泵方法。例如，以恒定速度操作的心室辅助泵，它发生血液进一步通过辅助泵推动，即使心室处于Dekontraktionsphase。用本发明的方法，实现了一个辅助泵支持行为仅在由所述辅助泵的输入和输出端与流量之间的压力差的主泵的压力相被连续地由辅助泵和辅助泵的旋转速度来确定被控制，使得所述压力差确定不低于预先给定的值，且流速不低于零。

9. 发明申请

WO9828543A3 DEVICE FOR FEEDING SINGLE-PHASE AND POLYPHASE FLUIDS 审中-公开
标题翻译：用于输送单相和多相流体的装置
公开(公告)号：WO9828543A3
公开(公告)日：1998-10-08
申请号：PCT/DE9703034
申请日：1997-12-23
申请人： NUESSER PETER , MUELLER JOHANNES , PETERS HANS ERHARD
发明人： NUESSER PETER , MUELLER JOHANNES , PETERS HANS-ERHARD
IPC分类号： A61M1/10 , F04D13/06 , F04D
CPC分类号： F04D13/0646 , A61M1/1008 , A61M1/101 , A61M1/122
摘要： The invention relates to a device for non-alterative propelling of single-phase and polyphase fluids, specially a blood pump, having a rotating member, which feeds energy to the fluid to be propelled, and at least one regulating device, which is placed in front of and/or behind the rotating member. According to the invention, the rotating member is configured as a tube (2), in whose inner side the blading (32) is fixed or forms a single piece, wherein the tube (2) is placed from the outside in the housing (7) of the device (1). The invention provides a device for non-alterative propelling of single-phase polyphase fluids, which does not alter or insignificantly changes the properties of the medium to be propelled and which considerably reduces hemolysis and the formation of thrombus during the propelling of blood.

10. 发明专利

CH686824A5 Entgleisungsdetektor zur Schnellbremsausloesung. 未知
公开(公告)号：CH686824A5
公开(公告)日：1996-07-15
申请号：CH268394
申请日：1994-09-02
申请人： MUELLER JOHANNES
发明人： MUELLER JOHANNES
IPC分类号： B60T7/12 , B60T17/18 , G01P15/03

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