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1. 发明专利

IL240555A Hydantoins that modulate bace-mediated app processing 未知
公开(公告)号：IL240555A
公开(公告)日：2019-02-28
申请号：IL24055515
申请日：2015-08-12
申请人： BUCK INST RES AGING , VARGHESE JOHN , DALE E BREDESEN
发明人： VARGHESE JOHN , DALE E BREDESEN
IPC分类号： A61K31/4166 , A61K31/4168 , A61K31/4439 , A61K31/46 , A61K31/506 , A61K45/06 , A61P25/00
摘要： In certain embodiments hydantoin compounds are provided herein that are effective to inhibit BACE activity against APP. Without being bound to a particular theory, it is believed the activity of the hydantoins identified herein appears to be associated with binding to BACE and/or to APP particularly when these moieties form a BACE/APP complex. Accordingly, it is believed the compounds described herein represent a new class of compounds designated herein as APP-Binding-BACE Inhibitors (ABBIs) and provide a new mechanism to modulate APP processing. The hydantoins described herein appear to show improved brain permeability and functional BACE inhibition.

2. 发明专利

IL262957D0 Compounds to promote normal processing of app 未知
公开(公告)号：IL262957D0
公开(公告)日：2018-12-31
申请号：IL26295718
申请日：2018-11-12
申请人： BUCK INST RES AGING , VARGHESE JOHN , DALE E BREDESEN , PATRICIA R SPILMAN , BARBARA JAGODZINSKA
发明人： VARGHESE JOHN , DALE E BREDESEN , PATRICIA R SPILMAN , BARBARA JAGODZINSKA
IPC分类号： A61K20060101
摘要： In various embodiments, compositions and methods are provided for treatment and/or prevention of amyloidogenic diseases. In certain embodiments, the methods entail administering an effective amount of compound C41 to a subject in need thereof for prophylactic or therapeutic effect. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In certain embodiments, methods of reducing the risk, lessening the severity, or delaying the progression or onset of a disease characterized by beta-amyloid deposits in the brain of a mammal are also provided. In certain embodiments, methods of directly or indirectly enhances sAPPα, lowers Aβ, p-Tau, inhibits the C-terminal cleavage of APP resulting in the formation of APP-C31 peptide and APPneo (APP664) and improves memory in a mammal are provided.

3. 发明专利

IL240555D0 Hydantoins that modulate bace-mediated app processing 未知
公开(公告)号：IL240555D0
公开(公告)日：2015-10-29
申请号：IL24055515
申请日：2015-08-12
申请人： BUCK INST FOR RES ON AGING , VARGHESE JOHN , DALE E BREDESEN
发明人： VARGHESE JOHN , DALE E BREDESEN
IPC分类号： C07D20060101
摘要： In certain embodiments hydantoin compounds are provided herein that are effective to inhibit BACE activity against APP. Without being bound to a particular theory, it is believed the activity of the hydantoins identified herein appears to be associated with binding to BACE and/or to APP particularly when these moieties form a BACE/APP complex. Accordingly, it is believed the compounds described herein represent a new class of compounds designated herein as APP-Binding-BACE Inhibitors (ABBIs) and provide a new mechanism to modulate APP processing. The hydantoins described herein appear to show improved brain permeability and functional BACE inhibition.

4. 发明专利

BR112015023215A2 suplementos cognitivos aprimorados 未知
公开(公告)号：BR112015023215A2
公开(公告)日：2017-07-18
申请号：BR112015023215
申请日：2014-03-13
申请人： BUCK INST RES AGING
发明人： DALE E BREDESEN , VARGHESE JOHN
IPC分类号： A01N65/00
摘要： resumo “suplementos cognitivos aprimorados” trata-se de suplementos e métodos de uso dos mesmos para aprimorar funções cognitivas, tais como aprendizado, memória, concentração, foco, atenção e humor.

5. 发明专利

BR112015002309A2 formulação de múltiplos componentes para aprimorar a função neurológica 未知
公开(公告)号：BR112015002309A2
公开(公告)日：2017-07-04
申请号：BR112015002309
申请日：2013-08-07
申请人： BUCK INST RES AGING
发明人： DALE E BREDESEN , STELIOS TZANNIS
IPC分类号： A23L33/15 , A61K31/195 , A61K31/122 , A61K31/20 , A61K31/355 , A61K31/375 , A61K31/4415 , A61K31/51 , A61K31/593 , A61K31/714 , A61K33/04 , A61K33/06 , A61P25/28
摘要： abstract of the disclosure in certain embodiments multi-component formulations are provided where the formulations comprise a first component comprising one or more vitamins selected from the group consisting of one or more b vitamins, vitamin c, vitamin d, vitamin e, co-enzyme q10, vitamin k, and folate; a second component comprising one or more elements selected from the group consisting of selenium, lithium, magnesium, and molybdenum; a third component comprising one or more omega-3 fatty acids; and a fourth component comprising one or more amino acids selected from the group consisting of trimethylglycine, n-acetyl cysteine, s-adenosyl methionine, l-tryptophan, and glutathione. tradução do resumo resumo patente de invenção: "formulação de múltiplos componentes para aprimorar a função neurológica". a presente invenção refere-se, em certas modalidades, a formulações de múltiplos componentes fornecidas, em que as formulações compreendem um primeiro componente que compreende uma ou mais vitaminas selecionadas a partir do grupo que consiste em uma ou mais vitaminas b, vitamina c, vitamina d, vitamina e, coenzima q10, vitamina k e folato; um segundo componente que compreende um ou mais elementos selecionados a partir do grupo que consiste em selênio, lítio, magnésio e molibdênio; um terceiro componente que compreende um ou mais ácidos graxos ômega-3; e um quarto componente que compreende um ou mais aminoácidos selecionados a partir do grupo que consiste em trimetilglicina, n-acetil cisteína, s-adenosil metionina, l-triptofano e glutationa. 1/1

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