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1. 发明专利

AU2786992A HEXAHYDROFURO(2,3-B)FURANS AS PAF ANTAGONISTS 未知
公开(公告)号：AU2786992A
公开(公告)日：1993-05-21
申请号：AU2786992
申请日：1992-10-21
申请人： BRITISH BIO-TECHNOLOGY LIMITED
发明人： MARK WHITTAKER
IPC分类号： C07D493/04 , C07D519/00
摘要： PCT No. PCT/GB92/01931 Sec. 371 Date Apr. 18, 1994 Sec. 102(e) Date Apr. 18, 1994 PCT Filed Oct. 21, 1992 PCT Pub. No. WO93/08194 PCT Pub. Date Apr. 29, 1993.The invention concerns compounds of the formula I: I wherein the variables are described in the specification which are antagonists of platelet activity factor.

2. 发明专利

AU1412192A 1-OXA-2,9-DIPHENYL-SPIRO(4,4)NONANE DERIVATIVES AS PAF ANTAGONISTS 未知
公开(公告)号：AU1412192A
公开(公告)日：1992-10-06
申请号：AU1412192
申请日：1992-03-04
申请人： BRITISH BIO-TECHNOLOGY LIMITED
发明人： ALAN HORNSBY DAVIDSON , MARK WHITTAKER , ZOE MARIE SPAVOLD
IPC分类号： C07D307/94 , C07D405/06
摘要： Compounds of general formula I; wherein: each of R , R , and R independently represents hydrogen, -C1-C6 alkyl, -C2-C6 alkenyl, -C1-C6 alkyl, -SC1-C6 alkyl, halo, -CN, -NO2, -SOC1-C6 alkyl, -SO2C1-C6 alkyl, -SO2NH2, -COC1-C6 alkyl, -CHO, -COOC1-C6 alkyl, -CH2OH, benzyl, benzoyl, -CF3, -CONH2, -NHCOC1-C6 alkyl; each of R and R independently represents hydrogen, -C1-C6 alkyl, -C2-C6 alkenyl, -OC1-C6 alkyl, -SC1-C6 alkyl, halo, -CN, -NO2, -SOC1-C6 alkyl, -SO2C1-C6 alkyl, -SO2NH2, -COOH, -COC1-C6 alkyl, -CHO, -COOC1-C6 alkyl, -CH2OH, -OH, benzyl, benzoyl, -CF3, -CONH2, -NHCOC1-C6 alkyl or a -OC(=O)R group wherein R represents -C1-C6 alkyl, -C2-C6 alkenyl, -OC1-C6 alkyl, -SC1-C6 alkyl, -COC1-C6 alkyl, -COOC1-C6 alkyl, benzyl, benzoyl, -CF3, -CN or a V group wherein V represents a) a group wherein t is an integer from 0 to 3 and each of R , R and R is independently hydrogen, -C1-C6 alkyl, -C2-C6 alkenyl, -OC1-C6 alkyl, -SC1-C6 alkyl, halo, -CN, -NO2, -SOC1-C6 alkyl, -SO2C1-C6 alkyl, -SO2NH2, -COOH, -COC1-C6 alkyl, -CHO, -COOC1-C6 alkyl, -CH2OH, -OH, benzyl, benzoyl, -CF3, -CONH2, -NHCOC1-C6 alkyl; b) a group -(CH2)s-Y wherein s is an integer from 0 to 5 and Y represents a 5- or 6-membered aromatic heterocyclic ring containing one or more sp2 nitrogen atoms in its ring, which heterocyclic ring may be optionally fused to a benzene ring or to a further 5- or 6-membered aromatic heterocyclic ring containing one or more nitrogen atoms, wherein at least one of the said heterocyclic rings may also contain an oxygen or sulphur atom, and wherein any of the rings may be optionally substituted with one or more substituents selected from -C1-C6 alkyl, -OC1-C6 alkyl, halo, -CF3 and -CN; or R together with R forms a =O, =N-OH, =NHR or =CHR group, wherein R is as defined above; each of R and R independently represents hydrogen, -C1-C6 alkyl, -COC1-C6 alkyl, benzyl, a group V as defined above or a -COV group wherein V is as defined above; or R together with R form a =CR R group wherein each of R and R independently represent a hydrogen atom, a C1-C18 alkyl, a -C2-C6 alkenyl, pyrrole or a group V as defined above; and their pharmaceutically and veterinarily acceptable acid addition salts and hydrates are antagonists of platelet activating factor (PAF) and as such are useful in the treatment or amelioration of various diseases or conditions mediated by PAF.

3. 发明专利

AU637356B2 NOVEL BENZIMIDAZOLE DERIVATIVES 未知
公开(公告)号：AU637356B2
公开(公告)日：1993-05-27
申请号：AU5162690
申请日：1990-02-23
申请人： BRITISH BIO-TECHNOLOGY LIMITED
发明人： MARK WHITTAKER , CHRISTOPHER DAVID FLOYD , JONATHAN PHILLIP DICKENS , ALAN HORNSBY DAVIDSON
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61K31/675 , A61P7/02 , A61P9/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P27/02 , A61P29/00 , A61P37/00 , C07C211/52 , C07C309/65 , C07C309/66 , C07C309/72 , C07D235/02 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/18 , C07D235/26 , C07D235/28 , C07D401/04 , C07D401/12 , C07D403/04 , C07D417/04 , C07F9/6506
摘要： Compounds of general formula I: I wherein: each of R1-R8, k, and V represent disclosed functional groups that have been chosen such that all disclosed variations of compound I and their pharmaceutically and veterinarily acceptable acid addition salts and hydrates are antagonists of platelet activating factor (PAF) and as such are useful in the treatment or amelioration of various diseases or disorders mediated by PAF.

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