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1. 发明申请

WO2003057226A1 USE OF PHOSPHOLIPIDS IN PERITONEAL DIALYSIS 审中-公开
标题翻译：磷脂在腹膜透析中的应用
公开(公告)号：WO2003057226A1
公开(公告)日：2003-07-17
申请号：PCT/GB2003/000086
申请日：2003-01-14
申请人： BRITANNIA PHARMACEUTICALS LIMITED , HILLS, Brian, Andrew , WOODCOCK, Derek , THOMPSON, Jim
发明人： HILLS, Brian, Andrew , WOODCOCK, Derek , THOMPSON, Jim
IPC分类号： A61K31/685
CPC分类号： A61K9/0019 , A61K31/661 , A61K31/685 , A61K47/10 , A61K2300/00
摘要： The efficiency of ultrafiltration in continuous ambulatory peritoneal dialysis (CAPD) is improved by administering a composition comprising at least one surface active phospholipid (SAPL) in powder form, especially as a mixture of phosphatidyl choline and phosphatidyl glycerol, into the peritoneal cavity before commencing CAPD or between CAPD sessions. The SAPL composition may be introduced during surgery to prepare a patient for CAPD and/or subsequently through the incision for the CAPD catheter, or through the catheter itself, between CAPD sessions when one batch of dialysis fluid has been removed and before a fresh batch is supplied.
摘要翻译：连续不卧床腹膜透析（CAPD）中的超滤效率通过在开始CAPD之前将包含至少一种粉末形式的表面活性磷脂（SAPL），特别是作为磷脂酰胆碱和磷脂酰甘油的混合物的组合物施用到腹膜腔中来改善或在CAPD会话之间。 SAPL组合物可以在外科手术期间引入，以便在一批透析液已经被去除之后并且在新鲜批次之前在CAPD期间之前准备CAPD患者和/或随后通过CAPD导管的切口或通过导管本身提供。

2. 发明申请

WO2003000344A1 USE OF PHOSPHOLIPIDS FOR THE PREVENTION 0F SURGICAL ADHESIONS 审中-公开
标题翻译：使用磷脂预防0F手术粘连
公开(公告)号：WO2003000344A1
公开(公告)日：2003-01-03
申请号：PCT/GB2002/002915
申请日：2002-06-25
申请人： BRITANNIA PHARMACEUTICALS LIMITED , HILLS, Brian, Andrew , WOODCOCK, Derek
发明人： HILLS, Brian, Andrew , WOODCOCK, Derek
IPC分类号： A61P41/00
CPC分类号： A61K31/685 , A61K31/683 , A61K2300/00
摘要： A surface active phospholipid (SAPL) composiiton in the form of a solution, dispersed or especially a paste comprising DPPC (dipalmitoyl-phospatidyl-choline) is used to reduce the risk of adhesions after surgery, especially open surgery on the spine, tendons or peripheral nerves.
摘要翻译：使用分散或特别是包含DPPC（二棕榈酰 - 磷脂酰胆碱）的糊剂形式的表面活性磷脂（SAPL）组合物来降低术后粘连的风险，特别是在脊柱，腱或外周的开放手术神经。

3. 发明申请

WO2002094283A3 USE OF PHOSPHOLIPIDS IN THE TREATMENT OF DEGENERATIVE LUNG DISEASE SUCH AS COPD OR CYSTIC FIBROSIS AND TO ENHANCE DELIVERY OF DRUGS 审中-公开
公开(公告)号：WO2002094283A3
公开(公告)日：2002-11-28
申请号：PCT/GB2002/002196
申请日：2002-05-21
申请人： BRITANNIA PHARMACEUTICALS LIMITED , HILLS, Brian, Andrew , WOODCOCK, Derek , STANIFORTH, John , CONWAY, Joy , THOMPSON, Jim
发明人： HILLS, Brian, Andrew , WOODCOCK, Derek , STANIFORTH, John , CONWAY, Joy , THOMPSON, Jim
IPC分类号： A61K31/00
摘要： Surface active phospholipid (SAPL) is administered as a dry powder for the treatment of neutrophil-induced or irreversible degenerative lung disease, especially chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). The SAPL powder is also used in combination therapy to enhance the delivery of biologically active substances to airways to treat COPD and CF, and to enhance the delivery of other actives via mucosal membranes.

4. 发明申请

WO2002094283A2 USE OF PHOSPHOLIPIDS IN THE TREATMENT OF DEGENERATIVE LUNG DISEASE AND TO ENHANCE DELIVERY OF DRUGS 审中-公开
标题翻译：使用磷脂治疗退行性肺疾病并加强药物输送
公开(公告)号：WO2002094283A2
公开(公告)日：2002-11-28
申请号：PCT/GB2002/002196
申请日：2002-05-21
申请人： BRITANNIA PHARMACEUTICALS LIMITED , HILLS, Brian, Andrew
发明人： HILLS, Brian, Andrew
IPC分类号： A61K31/575
CPC分类号： A61K9/0075 , A61K31/685
摘要： Surface active phospholipid (SAPL) is administered as a dry powder for the treatment of neutrophil-induced or irreversible degenerative lung disease, especially chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). The SAPL powder is also used in combination therapy to enhance the delivery of biologically active substances to airways to treat COPD and CF, and to enhance the delivery of other actives via mucosal membranes.
摘要翻译：表面活性磷脂（SAPL）作为干粉末施用，用于治疗中性粒细胞诱导或不可逆性退行性肺病，特别是慢性阻塞性肺疾病（COPD）和囊性纤维化（CF）。 SAPL粉末也用于联合治疗以增强生物活性物质向气道的递送以治疗COPD和CF，并且通过粘膜增强其它活性物质的递送。

5. 发明申请

WO2005027933A1 UNSATURATED PHOSPHATIDYLCHOLINES AND USES THEREOF 审中-公开
标题翻译：不饱和磷脂酰胆碱及其用途
公开(公告)号：WO2005027933A1
公开(公告)日：2005-03-31
申请号：PCT/AU2004/001290
申请日：2004-09-21
申请人： THE CORPORATION OF THE TRUSTEES OF THE ORDER OF THE SISTERS OF MERCY IN QUEENSLAND , CHEN, Yi , HILLS, Brian, Andrew
发明人： CHEN, Yi , HILLS, Brian, Andrew
IPC分类号： A61K31/6615
CPC分类号： A61K31/685 , A61K31/6615 , A61K2300/00
摘要： The present invention relates generally to a method for providing formation, ultrafiltration and/or lubrication between two or more opposing or in contact surfaces. More particularly, the present invention effects one or more of surface tension reduction anti-stick, barrier formation, ultrafiltration, lubrication and/or effector of cellular therapeutic, and regeneration between two or more surfaces by the application or absorption of an unsaturated phosphatidylcholine alone or in combination with a saturated phosphatidylcholine. The present invention further provides compositions comprising unsaturated phosphatidylcholine species alone or in combination with a saturated phosphatidylcholine and their use in the treatment and/or prophylaxis of particular medical conditions such as osteoarthritis, surgical adhesion, burns injuries, ocular disorders, ultra-filtration failure in peritoneal dialysis, barrier disorders of the skin and mucosa, middle ear disorders, as a facilitation of cellular therapeutics and regenerative medicine and for lubricating interactive surfaces in artificial joints.
摘要翻译：本发明一般涉及在两个或更多个相对或接触表面之间提供地层，超滤和/或润滑的方法。更具体地，本发明通过单独施用或吸收不饱和磷脂酰胆碱来实现表面张力降低抗粘，阻挡层形成，超滤，细胞治疗的润滑和/或效应器中的一个或多个，以及两个或更多个表面之间的再生与饱和磷脂酰胆碱组合。本发明还提供了单独或与饱和磷脂酰胆碱组合的不饱和磷脂酰胆碱物质的组合物及其用于治疗和/或预防特定医学病症如骨关节炎，手术粘连，烧伤，眼部疾病，超滤失败腹膜透析，皮肤和粘膜的屏障障碍，中耳障碍，促进细胞治疗剂和再生药物以及润滑人造关节中的相互作用表面。

6. 发明公开

EP1133301A1 ANTI-ASTHMATIC COMBINATIONS COMPRISING SURFACE ACTIVE PHOSPHOLIPIDS 审中-公开
标题翻译：平喘组合含有表面活性剂磷脂
公开(公告)号：EP1133301A1
公开(公告)日：2001-09-19
申请号：EP99956235.8
申请日：1999-11-26
申请人： BRITANNIA PHARMACEUTICALS LIMITED
发明人： HILLS, Brian, Andrew , WOODCOCK, Derek, Alan , STANIFORTH, John, Nicholas
IPC分类号： A61K31/66 , A61P11/06 , A61K45/06
CPC分类号： A61K9/0078 , A61K9/008 , A61K31/66 , A61K45/06 , A61M15/009 , A61M2202/064 , A61K2300/00
摘要： A combination product for use in treating asthma and other respiratory conditions comprising a medicament comprising a surface active phospholipid composition in the form of a fine powder and an antiasthma drug. The product is arranged to be administered to the lungs by inhalation, for example, by a device 1.

7. 发明公开

EP1082108A2 IMPROVEMENTS IN MEDICAMENTS FOR ASTHMA TREATMENT 有权
标题翻译：磷脂用于制备药物用于治疗哮喘的治疗
公开(公告)号：EP1082108A2
公开(公告)日：2001-03-14
申请号：EP98955794.7
申请日：1998-11-26
申请人： BRITANNIA PHARMACEUTICALS LIMITED
发明人： HILLS, Brian, Andrew , WOODCOCK, Derek, Alan
IPC分类号： A61K31/00
CPC分类号： A61M11/02 , A61M11/001 , A61M11/002 , A61M15/00 , A61M2205/8225 , Y10S514/826 , Y10S514/958 , Y10S514/959
摘要： A method and apparatus is disclosed for treating asthma and other respiratory conditions. A medicament comprising a surface active phospholipid (SAPL) is prepared in the form of a fine powder and administered to the lungs in a gas stream. A preferred SAPL is a solid blend of dipalmitoyl phosphatidyl choline (DPPC) and phosphatidyl glycerol (PG).

8. 发明授权

EP1054679B1 USE OF SURFACE ACTIVE AGENT FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF DISORDERS OF THE MIDDLE EAR 有权
标题翻译：表面活性剂的使用单元，准备药物中耳疾病治疗
公开(公告)号：EP1054679B1
公开(公告)日：2003-02-12
申请号：EP98955783.0
申请日：1998-11-26
申请人： BRITANNIA PHARMACEUTICALS LIMITED
发明人： HILLS, Brian, Andrew , WOODCOCK, Derek, Alan
IPC分类号： A61K31/66 , A61P27/16
CPC分类号： A61K31/685 , A61K31/683
摘要： The invention relates to the treatment of serous otitis media (glue ear). A medicament is disclosed which comprises a surface active phospholipid (SAPL) which is instilled as a powder into the middle ear. The SAPL has an affinity for the surface of the Eustachian tube and forms a film over its surface which prevents or deters reblockage of the tube.

9. 发明授权

EP1082108B1 IMPROVEMENTS IN MEDICAMENTS FOR ASTHMA TREATMENT 有权
标题翻译：磷脂用于制备药物用于治疗哮喘的治疗
公开(公告)号：EP1082108B1
公开(公告)日：2002-12-18
申请号：EP98955794.7
申请日：1998-11-26
申请人： BRITANNIA PHARMACEUTICALS LIMITED
发明人： HILLS, Brian, Andrew , WOODCOCK, Derek, Alan
IPC分类号： A61K31/00 , A61K31/685 , A61K31/683 , A61M15/00 , A61P11/06
CPC分类号： A61M11/02 , A61M11/001 , A61M11/002 , A61M15/00 , A61M2205/8225 , Y10S514/826 , Y10S514/958 , Y10S514/959
摘要： A method and apparatus is disclosed for treating asthma and other respiratory conditions. A medicament comprising a surface active phospholipid (SAPL) is prepared in the form of a fine powder and administered to the lungs in a gas stream. A preferred SAPL is a solid blend of dipalmitoyl phosphatidyl choline (DPPC) and phosphatidyl glycerol (PG).

10. 发明公开

EP1069902A1 USE OF PHOSPHOLIPIDS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE PREVENTION OF ADHESIONS 有权
标题翻译：磷脂用于制备药物预防粘连USE
公开(公告)号：EP1069902A1
公开(公告)日：2001-01-24
申请号：EP98955792.1
申请日：1998-11-26
申请人： BRITANNIA PHARMACEUTICALS LIMITED
发明人： HILLS, Brian, Andrew , WOODCOCK, Derek, Alan
IPC分类号： A61K31/66
CPC分类号： A61K31/685 , Y10S514/951
摘要： A medicament is disclosed for reducing the probability of surgical adhesions. The medicament comprises a surface active phospholipid which is capable of binding to mesothical membranes and is applied as a dry powder or dispersion in saline to the wound site.

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