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1. 发明申请

WO2004065577A2 POLYNUCLEOTIDES AND POLYPEPTIDES ASSOCIATED WITH THE NF-KB PATHWAY 审中-公开
标题翻译：与NF-KB途径相关的多核苷酸和多肽
公开(公告)号：WO2004065577A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/000798
申请日：2004-01-13
申请人： BRISTOL-MYERS SQUIBB COMPANY , NADLER, Steven, G. , NEUBAUER, Michael, G. , FEDER, John, N. , CARMAN, Julie
发明人： NADLER, Steven, G. , NEUBAUER, Michael, G. , FEDER, John, N. , CARMAN, Julie
IPC分类号： C12N
CPC分类号： C07K14/47
摘要： The present invention relates to polynucleotide and polypeptide sequences newly identified as associated with the NF-kB pathway. The identification of such polynucleotides and polypeptides is an important advancement toward discovering and identifying new drug targets for the treatment of NF-kB pathway-related diseases, disorders, and conditions. The invention further relates to compositions and methods for the treatment of diseases or disorders associated with the NF-kB signaling pathway using the sequences of the invention.
摘要翻译：本发明涉及新鉴定为与NF-kB途径相关的多核苷酸和多肽序列。这种多核苷酸和多肽的鉴定是发现和鉴定用于治疗NF-kB途径相关疾病，病症和病症的新药物靶标的重要进展。本发明还涉及使用本发明的序列治疗与NF-kB信号传导途径相关的疾病或病症的组合物和方法。

2. 发明申请

WO2004100886A2 POLYNUCLEOTIDES AND POLYPEPTIDES ASSOCIATED WITH THE NF-kB PATHWAY 审中-公开
标题翻译：与NF-kB途径相关的多核苷酸和多肽
公开(公告)号：WO2004100886A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/014279
申请日：2004-05-06
申请人： BRISTOL-MYERS SQUIBB COMPANY , CARMAN, Julie , FEDER, John, N. , NADLER, Steven, G.
发明人： CARMAN, Julie , FEDER, John, N. , NADLER, Steven, G.
IPC分类号： A61K
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides polynucleotides encoding NF-kB-associated polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these NF-kB-associated polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码NF-kB相关多肽，其片段和同源物的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些NF-kB相关多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

3. 发明申请

WO2003048323A3 POLYNUCLEOTIDES AND POLYPEPTIDES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS 审中-公开
公开(公告)号：WO2003048323A3
公开(公告)日：2003-06-12
申请号：PCT/US2002/038461
申请日：2002-12-03
申请人： BRISTOL-MYERS SQUIBB COMPANY , CARMAN, Julie , NADLER, Steven, G , BOWEN, Michael , NEUBAUER, Michael , LU, Pin
发明人： CARMAN, Julie , NADLER, Steven, G , BOWEN, Michael , NEUBAUER, Michael , LU, Pin
IPC分类号： G01N33/566 , G01N33/567
摘要： The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.

4. 发明申请

WO2003048323A2 POLYNUCLEOTIDES AND POLYPEPTIDES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS 审中-公开
标题翻译：与发病风湿性关节炎相关的多核苷酸和多肽
公开(公告)号：WO2003048323A2
公开(公告)日：2003-06-12
申请号：PCT/US2002/038461
申请日：2002-12-03
申请人： BRISTOL-MYERS SQUIBB COMPANY , CARMAN, Julie , NADLER, Steven, G , BOWEN, Michael , NEUBAUER, Michael , LU, Pin
发明人： CARMAN, Julie , NADLER, Steven, G , BOWEN, Michael , NEUBAUER, Michael , LU, Pin
IPC分类号： C12N
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.
摘要翻译：本发明涉及编码与类风湿性关节炎及其同系物相关的多肽的多核苷酸。本发明还涉及在诊断，治疗和/或预防类风湿性关节炎和相关疾病状态中利用这些多核苷酸和多肽的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法，以及鉴定的化合物。

5. 发明申请

WO2003048394A1 POLYNUCLEOTIDES AND POLYPEPTIDES ASSOCIATED WITH THE DEVELOPMENT OF OSTEOARTHRITIS 审中-公开
标题翻译：与OSTEOARTHRITIS发展相关的多核苷酸和多肽
公开(公告)号：WO2003048394A1
公开(公告)日：2003-06-12
申请号：PCT/US2002/038407
申请日：2002-12-03
申请人： BRISTOL-MYERS SQUIBB COMPANY , CARMAN, Julie , NADLER, Steven, G , BOWEN, Michael , NEUBAUER, Michael , LU, Pin
发明人： CARMAN, Julie , NADLER, Steven, G , BOWEN, Michael , NEUBAUER, Michael , LU, Pin
IPC分类号： C12Q1/68
CPC分类号： A61K49/0004 , A61K38/00 , A61K47/6901 , C07K14/4713 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The present invention is directed to polynucleotides encoding polypeptides associated with the development of osteoarthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of osteoarthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.
摘要翻译：本发明涉及编码与骨关节炎发展相关的多肽的多核苷酸及其同源物。本发明还涉及在诊断，治疗和/或预防骨关节炎和相关疾病状态中利用这些多核苷酸和多肽的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法，以及鉴定的化合物。

6. 发明申请

WO2005003299A2 POLYNUCLEOTIDES ENCODING NOVEL GUANYLATE BINDING PROTEINS (GBP'S) 审中-公开
标题翻译：编码新型结合蛋白的多核苷酸（GBP'S）
公开(公告)号：WO2005003299A2
公开(公告)日：2005-01-13
申请号：PCT/US2004/017397
申请日：2004-06-02
申请人： BRISTOL-MYERS SQUIBB COMPANY , CARMAN, Julie , WARNER, Stephen, J.
发明人： CARMAN, Julie , WARNER, Stephen, J.
IPC分类号： C12N
CPC分类号： C07K14/47
摘要： The present invention provides polynucleotides encoding human and murine guanylate binding protein polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The present invention further relates to diagnostic and therapeutic methods for applying the guanylate binding protein polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as rheumatoid arthritis and/or conditions related to aberrant NF- κB activity. The present invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码人和鼠鸟苷酸结合蛋白多肽的多核苷酸，其片段和同系物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及用于将鸟苷酸结合蛋白多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法，所述疾病和/或病症例如类风湿性关节炎和/或与异常相关的病症 NF-κB活性。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

7. 发明申请

WO2002086076A2 POLYNUCLEOTIDES AND POLYPEPTIDES ASSOCIATED WITH THE NF-KB PATHWAY 审中-公开
标题翻译：与NF-KB途径相关的多核苷酸和多肽
公开(公告)号：WO2002086076A2
公开(公告)日：2002-10-31
申请号：PCT/US2002/012636
申请日：2002-04-19
申请人： BRISTOL-MYERS SQUIBB COMPANY , CARMAN, Julie , FEDER, John , NADLER, Steven
发明人： CARMAN, Julie , FEDER, John , NADLER, Steven
IPC分类号： C12N
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides polynucleotides encoding NF-kB-associated polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these NF-kB-associated polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码NF-kB相关多肽，其片段和同源物的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些NF-kB相关多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

8. 发明申请

WO2019046233A1 A METHOD TO MONITOR PHARMACODYNAMIC RESPONSES MEDIATED BY IN VIVO ADMINISTRATION OF GLUCOCORTICOIDS 审中-公开
公开(公告)号：WO2019046233A1
公开(公告)日：2019-03-07
申请号：PCT/US2018/048240
申请日：2018-08-28
申请人： BRISTOL-MYERS SQUIBB COMPANY
发明人： CARMAN, Julie , HU, Yanhua
IPC分类号： C12Q1/6883
摘要： The present invention relates generally to a method of monitoring pharmacodynamic responses mediated by in vivo administration of glucocorticoids. More specifically, the present invention relates to a method of using a change in gene signature as a pharmacodynamic marker of glucocorticoid exposure.

9. 发明公开

EP1379540A2 POLYNUCLEOTIDES AND POLYPEPTIDES ASSOCIATED WITH THE NF-KB PATHWAY 审中-公开
标题翻译： BY NF-路径相关联的多肽和多核苷酸
公开(公告)号：EP1379540A2
公开(公告)日：2004-01-14
申请号：EP02721795.9
申请日：2002-04-19
申请人： Bristol-Myers Squibb Company
发明人： CARMAN, Julie , FEDER, John , NADLER, Steven
IPC分类号： C07H21/04
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides polynucleotides encoding NF-kB-associated polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these NF-kB-associated polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

10. 发明公开

EP1629086A2 POLYNUCLEOTIDES ENCODING NOVEL GUANYLATE BINDING PROTEINS (GBP'S) 审中-公开
标题翻译：新鸟苷酸结合蛋白（GBP'S）编码多核苷酸
公开(公告)号：EP1629086A2
公开(公告)日：2006-03-01
申请号：EP04776233.1
申请日：2004-06-02
申请人： Bristol-Myers Squibb Company
发明人： CARMAN, Julie , WARNER, Stephen, J.
IPC分类号： C12N1/00
CPC分类号： C07K14/47
摘要： The present invention provides polynucleotides encoding human and murine guanylate binding protein polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The present invention further relates to diagnostic and therapeutic methods for applying the guanylate binding protein polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as rheumatoid arthritis and/or conditions related to aberrant NF- κB activity. The present invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

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