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1. 发明申请

WO1998020120A1 MUTANT PENICILLIN G ACYLASES 审中-公开
公开(公告)号：WO1998020120A1
公开(公告)日：1998-05-14
申请号：PCT/US1997020298
申请日：1997-10-31
申请人： BRISTOL-MYERS SQUIBB COMPANY
发明人： BRISTOL-MYERS SQUIBB COMPANY , YOU, Li , USHER, John, J. , WHITE, Brenda, J. , NOVOTNY, Jiri
IPC分类号： C12N09/84
CPC分类号： C12N9/84 , C12N11/14 , C12P35/00
摘要： New mutant penicillin G acylases preferably from E. coli are provided, exhibiting altered enzymatic activity. These penicillin G acylases are obtained by expression of a gene encoding said penicillin G acylase having an amino acid sequence which differs at least in one amino acid from the wild-type penicillin G acylase.
摘要翻译：提供优选来自大肠杆菌的新突变体青霉素G酰基转移酶，显示出改变的酶活性。这些青霉素G酰基转移酶是通过表达编码所述青霉素G酰基转移酶的基因获得的，该氨基酸序列至少在一个氨基酸中与野生型青霉素G酰基转移酶不同。

2. 发明申请

WO1997015665A1 HETEROTETRAMERIC COILED COIL STRUCTURES 审中-公开
标题翻译：超高频线圈线圈结构
公开(公告)号：WO1997015665A1
公开(公告)日：1997-05-01
申请号：PCT/US1996016902
申请日：1996-10-21
申请人： BRISTOL-MYERS SQUIBB COMPANY
发明人： BRISTOL-MYERS SQUIBB COMPANY , NOVOTNY, Jiri , FAIRMAN, Robert , LAVOIE, Thomas, B. , CHAO, Hann-Guang , MATSUEDA, Gary, R.
IPC分类号： C12N15/12
CPC分类号： C07K14/4703 , C07K14/001 , C07K2319/00
摘要： A composition of matter as shown in the figure wherein: (a) I, II, III and IV are each alpha-helical polypeptides of about 21 to 35 residues; (b) moieties in positions a and d of helices I and IV are each independently amino acid residues; (c) moieties in positions b and c of helices I and III are each independently positively charged amino acid residues; (d) moieties in positions b and c of helices II and IV are each independently negatively charged amino acid residues; (e) moieties in positions e and g of helices I, II, III, and IV are each independently amino acid residues; and (f) moieties in positions f of helices I, II, III, and IV are each independently amino acid residues; and (g) each of I, II, III, and IV is optionally substituted at either or both of its termini with an effector domain or a specific ligand binding domain. Such a composition of matter is useful, among other things, for ligand-targeted drug delivery.
摘要翻译：如图所示的物质组合物，其中：（a）I，II，III和IV各自为约21至35个残基的α-螺旋多肽; （b）螺旋I和IV位置a和d的部分各自独立地为氨基酸残基; （c）螺旋I和III位置b和c的部分各自独立地带正电荷的氨基酸残基; （d）螺旋II和IV位置b和c的部分各自独立地带负电荷的氨基酸残基; （e）螺旋I，II，III和IV位置e和g的部分各自独立地为氨基酸残基; 和（f）螺旋I，II，III和IV位置f的部分各自独立地是氨基酸残基; 和（g）I，II，III和IV中的每一个任选地在其末端的一个或两个末端与效应结构域或特异性配体结合结构域取代。这样的物质组合物除其他之外对于配体靶向药物递送是有用的。

3. 发明申请

WO1997016550A1 POLYPEPTIDE FRAGMENTS DERIVED FROM THE OBESE GENE PRODUCT 审中-公开
标题翻译：从OBESE基因产品衍生的多肽片段
公开(公告)号：WO1997016550A1
公开(公告)日：1997-05-09
申请号：PCT/US1996017365
申请日：1996-10-28
申请人： BRISTOL-MYERS SQUIBB COMPANY
发明人： BRISTOL-MYERS SQUIBB COMPANY , MAPELLI, Claudio , MEYERS, Chester, A. , KRYSTEK, Stanley, R., Jr. , NOVOTNY, Jiri
IPC分类号： C12N15/16
CPC分类号： C07K14/5759 , A61K38/00
摘要： Novel C-terminal fragments of the obese gene product. The fragments retain anti-obesity and/or anti-diabetic activities. The fragments contain less than 68 amino acids, two of which are capable of forming cross-linkages, preferably cysteines.
摘要翻译：肥胖基因产物的新C-末端片段。片段保留抗肥胖和/或抗糖尿病活动。片段含有少于68个氨基酸，其中两个能够形成交联，优选半胱氨酸。

4. 发明公开

EP0941345A2 CHIMERIC, HUMANIZED AND SINGLE CHAIN ANTIBODIES TO ALPHA-2-ANTIPLASMIN 失效
标题翻译：嵌合，人性化，单链抗体反对的α-2-抗纤溶酶
公开(公告)号：EP0941345A2
公开(公告)日：1999-09-15
申请号：EP97942436.0
申请日：1997-09-19
申请人： THE GENERAL HOSPITAL CORPORATION , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BRISTOL-MYERS SQUIBB COMPANY
发明人： REED, Guy L. , HARRIS, Linda , BAJORATH, Jurgen , MATSUEDA, Gary R. , HSU, Mei-Yin , NOVOTNY, Jiri
IPC分类号： G01N33 , A61K39 , A61K45 , A61P7 , A61P9 , A61P11 , C07K16 , C12N5 , C12N15 , C12P21 , A61K38 , C12R1
CPC分类号： G01N33/86 , A61K38/00 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K16/38 , C07K2317/24 , C07K2319/00 , A61K2300/00
摘要： An immunologic molecule, wherein said immunologic molecule does not compete with monoclonal antibody RWR and is capable of binding to and inhibit both (1) human and nonhuman circulating alpha-2-antiplasmins and (2) human and nonhuman fibrin cross-linked alpha-2-antiplasmins selected from the group consisting of a chimeric antibody, a humanized antibody, and a single chain antibody. The invention further relates to nucleic acid molecules encoding said immunologic molecules.

5. 发明授权

EP0961825B1 MUTANT PENICILLIN G ACYLASES 失效
标题翻译：突变体青霉素G酰化酶
公开(公告)号：EP0961825B1
公开(公告)日：2008-07-30
申请号：EP97947397.2
申请日：1997-10-31
申请人： Bristol-Myers Squibb Company
发明人： YOU, Li , USHER, John, J. , WHITE, Brenda, J. , NOVOTNY, Jiri
IPC分类号： C12N9/84 , C12N15/00 , C12N1/20 , C07H21/04 , C12P35/00 , C12P37/00
CPC分类号： C12N9/84 , C12N11/14 , C12P35/00
摘要： New mutant penicillin G acylases preferably from E. coli are provided, exhibiting altered enzymatic activity. These penicillin G acylases are obtained by expression of a gene encoding said penicillin G acylase having an amino acid sequence which differs at least in one amino acid from the wild-type penicillin G acylase.

6. 发明公开

EP0961825A1 MUTANT PENICILLIN G ACYLASES 失效
标题翻译：突变青霉素G酰基转移酶
公开(公告)号：EP0961825A1
公开(公告)日：1999-12-08
申请号：EP97947397.0
申请日：1997-10-31
申请人： BRISTOL-MYERS SQUIBB COMPANY
发明人： YOU, Li , USHER, John, J. , WHITE, Brenda, J. , NOVOTNY, Jiri
IPC分类号： C12N15 , C12N1 , C12N5 , C12N9 , C12N11 , C12P35
CPC分类号： C12N9/84 , C12N11/14 , C12P35/00
摘要： New mutant penicillin G acylases preferably from E. coli are provided, exhibiting altered enzymatic activity. These penicillin G acylases are obtained by expression of a gene encoding said penicillin G acylase having an amino acid sequence which differs at least in one amino acid from the wild-type penicillin G acylase.

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