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1. 发明申请

WO2010151644A3 ANTINEOPLASTIC HYDROGELS, AND ENZYME-INSTRUCTED PREPARATIONS THEREOF 审中-公开
公开(公告)号：WO2010151644A3
公开(公告)日：2010-12-29
申请号：PCT/US2010/039789
申请日：2010-06-24
申请人： BRANDEIS UNIVERSITY , GAO, Yuan , KUANG, Yi , XU, Bing
发明人： GAO, Yuan , KUANG, Yi , XU, Bing
IPC分类号： C07D309/12 , C07D305/14 , C07D239/04 , C07D231/54
摘要： Disclosed is a general methodology to create nano fibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself. It is shown that with proper molecular design, the integration of enzymatic reaction and self-assembly provides a powerful method to create molecular hydrogels of clinically-used therapeutics without compromising their bioactivities. In addition, the results disclosed herein demonstrate enzyme-instructed self-assembly as a facile strategy for generating the supramolecular hydrogels of molecules that inherently have poor solubility in water. For example, by covalently connecting paclitaxel with a motif that is prone to self-assemble, a hydrogel of paclitaxel can be formed without compromising the activity of the paclitaxel.

2. 发明申请

WO2012166705A2 SUPRAMOLECULAR NANOFIBERS AND HYDROGELS BASED ON AMINO ACID-NUCLEOBASE-GLYCOSIDE CONJUGATES 审中-公开
标题翻译：基于氨基酸 - 核苷酸 - 甘氨酸结合子的分子纳米粒子和羟基
公开(公告)号：WO2012166705A2
公开(公告)日：2012-12-06
申请号：PCT/US2012/039821
申请日：2012-05-29
申请人： BRANDEIS UNIVERSITY , XU, Bing
发明人： XU, Bing
IPC分类号： C07H17/02 , C07H19/00 , A61K38/14 , A61K31/706 , A61P35/00
CPC分类号： C07H13/04 , A61K9/06 , A61K9/70 , A61K47/183 , A61K47/22 , A61K47/26 , A61L31/129
摘要： Described herein are hydrogelators that include a nucleobase, an amino acid, and a glycoside. The hydrogelators have increased resistance to proteases and can self-assemble into supramolecular nanofibers or hydrogels. The supramolecular structures may be used to help grow cells or deliver a substance to a cell.
摘要翻译：本文描述的是包含核碱基，氨基酸和糖苷的水凝胶。水凝胶具有增加的抗蛋白酶的能力，可以自组装成超分子纳米纤维或水凝胶。超分子结构可用于帮助生长细胞或将物质递送至细胞。

3. 发明申请

WO2012166706A3 SUPRAMOLECULAR NANOFIBERS AND HYDROGELS BASED ON OLIGOPEPTIDES FUNCTIONALIZED WITH NUCLEOBASES 审中-公开
公开(公告)号：WO2012166706A3
公开(公告)日：2012-12-06
申请号：PCT/US2012/039822
申请日：2012-05-29
申请人： BRANDEIS UNIVERSITY , XU, Bing
发明人： XU, Bing
IPC分类号： C07D239/46 , C07D473/04 , A61K31/513 , A61K31/52
摘要： Described herein are nucleopeptide compounds that include a nucleobase and an oligopeptide. The compounds may self-assemble to form supramolecular hydrogels. Also, the compounds may be used as a platform to examine specific biological functions (e.g., binding to DNA and RNA) of a dynamic supramolecular system that is able to interact with both proteins and nucleic acids. Other uses include: methods of growing cells and methods of delivering a substance to a cell.

4. 发明申请

WO2015030734A1 THERMOFORMED ELECTRODE ARRAYS 审中-公开
标题翻译：热电极阵列
公开(公告)号：WO2015030734A1
公开(公告)日：2015-03-05
申请号：PCT/US2013/056875
申请日：2013-08-27
申请人： ADVANCED BIONICS AG , XU, Bing , KOESTER, Kurt J. , DOWNING, Mark B.
发明人： XU, Bing , KOESTER, Kurt J. , DOWNING, Mark B.
IPC分类号： A61N1/05
CPC分类号： A61N1/0541 , B29C51/02
摘要： A cochlear lead includes a thermoformed circuit with a substrate with electrodes formed on the substrate and shaped to curve around a longitudinal axis of the cochlear lead. Traces are also formed on the substrate and connected to the electrodes. Intermediate sections between the electrodes may be curved about an axis that is orthogonal to the longitudinal axis.
摘要翻译：耳蜗引线包括具有基底的热成型电路，其具有形成在基底上的电极并成形为围绕耳蜗导线的纵向轴线弯曲。迹线也形成在基板上并连接到电极。电极之间的中间部分可以围绕与纵向轴线正交的轴线弯曲。

5. 发明申请

WO2003015290A1 TURBO DECODER WITH REDUCED-SIZE BRANCH METRIC CACHE 审中-公开
标题翻译： TURBO解码器与减小尺寸分配量度高速缓存
公开(公告)号：WO2003015290A1
公开(公告)日：2003-02-20
申请号：PCT/US2002/024537
申请日：2002-08-02
申请人： LUCENT TECHNOLOGIES INC. , GARRETT, David , XU, Bing
发明人： GARRETT, David , XU, Bing
IPC分类号： H03M13/45
CPC分类号： H03M13/3905 , H03M13/3961
摘要： A method and an apparatus for producing branch metrics in a LogMAP turbo decoding operation. During a forward recursion of a trellis, a set of primary branch metrics is generated. The primary branch metrics are stored in receiver form in a relatively small memory cache module (370) and corresponding secondary branch metrics are produced by negating the primary branch metrics. The primary branch metrics and said secondary branch metrics constitute all possible branch metrics for a given state in the trellis. During a backwards recursion of the trellis, the stored primary branch metrics are retrieved from the memory cache module (370) and the secondary branch metrics are regenerated by negating the retrieved primary branch metrics.
摘要翻译：一种用于在LogMAP turbo解码操作中产生分支度量的方法和装置。在网格的向前递归期间，生成一组主分支度量。主分支度量以接收器形式存储在相对小的存储器高速缓存模块（370）中，并且通过否定主分支度量来产生相应的次分支度量。主分支指标和所述辅助分支指标构成网格中给定状态的所有可能的分支指标。在网格的向后递归期间，从存储器高速缓存模块（370）检索存储的主分支度量，并且通过否定检索到的主分支度量来重新生成次分支度量。

6. 发明申请

WO2003015289A1 CLAMPING AND NON LINEAR QUANTIZATION OF EXTRINSIC INFORMATION IN AN ITERATIVE DECODER 审中-公开
标题翻译：在迭代解码器中的极限信息的钳位和非线性定量
公开(公告)号：WO2003015289A1
公开(公告)日：2003-02-20
申请号：PCT/US2002/024538
申请日：2002-08-02
申请人： LUCENT TECHNOLOGIES INC. , GARRETT, David , XU, Bing
发明人： GARRETT, David , XU, Bing
IPC分类号： H03M13/29
CPC分类号： H03M13/3905 , H03M13/2957 , H03M13/6502 , H03M13/6591 , H03M13/6594
摘要： A method of iterative soft input-soft output decoding in which loglikelihood ratio and output extrinsic determination is performed upon a time slice of a trellis. A priori data input to the determination that are greater than or equal to a predetermined value are identified, and where such data is identified for any one time slice, that one time slice is removed from the determination. A quantizing function may be applied to the output extrinsic for each time slice. The quantizing function advantageously consists of a companding and flooring function. The quantized value is substituted for the output extrinsic value for that time slice.
摘要翻译：一种迭代软输入 - 软输出解码的方法，其中在网格的时间片上执行对数似然比和输出外在确定。识别对于大于或等于预定值的确定的先验数据输入，并且其中对于任何一个时间片标识了这样的数据，则从该确定中移除该一个时间片。量化功能可以应用于每个时间片的外在输出。量化功能有利地包括压扩和地板功能。量化值代替该时间片的输出外在值。

7. 发明申请

WO2008085691A2 MULTIFUNCTIONAL SUPRAMOLECULAR HYDROGELS AS BIOMATERIALS 审中-公开
标题翻译：多功能超分子水凝胶作为生物材料
公开(公告)号：WO2008085691A2
公开(公告)日：2008-07-17
申请号：PCT/US2007/088317
申请日：2007-12-20
申请人： THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY , XU, Bing , YANG, Zhimou , LIANG, Gaolin , WANG, Qigang
发明人： XU, Bing , YANG, Zhimou , LIANG, Gaolin , WANG, Qigang
IPC分类号： A61K9/26 , B01J13/00 , C12N1/04 , C12N9/00 , C12Q1/25
CPC分类号： B01J13/0052 , A61K9/0014 , A61K38/05 , A61K47/183 , A61K47/6903 , C12N11/08 , C12Q1/34 , G01N2500/00
摘要： The present invention provides supramolecular hydrogels having a three-dimensional, self- assembling, elastic, network structure comprising non-polymeric, functional molecules and a liquid medium, whereby the functional molecules are noncovalently crosslinked. The present invention also provides methods of making supramolecular hydrogels that show biostability. The functional molecules may be antibiotics, carbohydrates, aminosugars, small peptides, α- amino acids, β-amino acids, unnatural amino acids, halogenated amino acids, or a combination thereof. Applications of the present invention include use of the supramolecular hydrogel as a biomaterial for wound healing, drug delivery, enzymatic reactions, enzyme detection and identification of enzyme inhibitors.
摘要翻译：本发明提供具有包含非聚合物功能分子和液体介质的三维自组装，弹性网络结构的超分子水凝胶，由此功能分子是非共价交联的。本发明还提供制备显示生物稳定性的超分子水凝胶的方法。功能分子可以是抗生素，碳水化合物，氨基糖，小肽，α-氨基酸，β-氨基酸，非天然氨基酸，卤代氨基酸或其组合。本发明的应用包括使用超分子水凝胶作为用于伤口愈合，药物递送，酶促反应，酶检测和酶抑制剂鉴定的生物材料。

8. 发明申请

WO2006037113A3 MULTIFUNCTIONAL SUPRAMOLECULAR HYDROGELS AS BIOMATERIALS 审中-公开
公开(公告)号：WO2006037113A3
公开(公告)日：2006-04-06
申请号：PCT/US2005/035112
申请日：2005-09-27
申请人： THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY , XU, Bing , YANG, Zhimou , XU, Keming
发明人： XU, Bing , YANG, Zhimou , XU, Keming
IPC分类号： A61K47/30
摘要： The present invention pertains to the design and application of a supramolecular hydrogel having a three-dimensional, selfassembling, elastic, network structure comprising non-polymeric, functional molecules and a liquid medium, whereby the functional molecules are noncovalently crosslinked. The functional molecules may be, for instance, anti-inflammatory molecules, antibiotics, metal chelators, anticancer agents, small peptides, surface-modified nanoparticles, or a combination thereof. The design of the hydrogel includes: 1) modifying functional molecules to convert them into hydrogelators while enhancing or maintaining their therapeutic properties and 2) triggering -the hydrogelation process by physical, chemical, or enzymatic processes, thereby resulting in the creation of a supramolecular hydrogel via formation of non-covalent crosslinks by the functional molecules. Applications of the present invention include use of the supramolecular hydrogel, for instance, as a biomaterial for wound healing, tissue engineering, drug delivery, and drug/inhibitor screening.

9. 发明申请

WO2018152733A1 PRIORITIZED LIST OF WORK TASKS 审中-公开
公开(公告)号：WO2018152733A1
公开(公告)日：2018-08-30
申请号：PCT/CN2017/074553
申请日：2017-02-23
申请人： HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP , XU, Bing
发明人： XU, Bing
IPC分类号： G06F17/30
摘要： A computing device includes a processor and a machine-readable storage medium storing instructions. The instructions are executable by the processor to: determine a first plurality of priority scores for a plurality of work tasks； determine a first prioritized list of work tasks based on the first plurality of priority scores； detect a plurality of user selections from the first prioritized list of work tasks； determine a second plurality of priority scores using a regression analysis of the plurality of user selections from the first prioritized list of work tasks； and determine a second prioritized list of work tasks based on the second plurality of priority scores.

10. 发明申请

WO2015030739A1 IMPLANTABLE LEADS WITH FLAG EXTENSIONS 审中-公开
标题翻译：可扩展的领导与标志扩展
公开(公告)号：WO2015030739A1
公开(公告)日：2015-03-05
申请号：PCT/US2013/056910
申请日：2013-08-27
申请人： ADVANCED BIONICS AG , XU, Bing , KOESTER, Kurt J. , DOWNING, Mark B.
发明人： XU, Bing , KOESTER, Kurt J. , DOWNING, Mark B.
IPC分类号： A61N1/36
CPC分类号： A61N1/0541 , A61N1/36036
摘要： In one example, an implantable lead includes a substrate and an electrically conductive material disposed on the substrate to form a flexible circuit. The flexible circuit includes a proximal end adapted to electrically connect to an implantable processor, a distal portion adapted to stimulate a cochlear nerve, and a lead body extending from the proximal end to the distal portion, the lead body having a longitudinal axis and comprising a plurality of electrical traces adapted to carry electrical signals from the proximal end to the distal portion. A flag extension is formed in the substrate and extends laterally outward from the lead body longitudinal axis. A method for forming a cochlear lead with a flag extension is also provided.
摘要翻译：在一个示例中，可植入引线包括基板和设置在基板上以形成柔性电路的导电材料。柔性电路包括适于电连接到可植入处理器的近端，适于刺激耳蜗神经的远端部分和从近端延伸到远端部分的引线主体，所述引线主体具有纵向轴线并且包括多个电迹线适于将电信号从近端传送到远端部分。在基板上形成标志延伸部，并且从引线主体纵向轴线横向向外延伸。还提供了一种用于形成具有标志延伸的耳蜗导线的方法。

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