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1. 发明申请

WO1995016469A1 MULTILAYER LYOPHILE FOR PREPARING RADIOPHARMACEUTICALS 审中-公开
标题翻译：用于制备放射线显微镜的多层LYOPHILE
公开(公告)号：WO1995016469A1
公开(公告)日：1995-06-22
申请号：PCT/IB1994000390
申请日：1994-12-05
申请人： BRACCO INTERNATIONAL B.V.
发明人： BRACCO INTERNATIONAL B.V. , NOWOTNIK, David, P.
IPC分类号： A61K51/12
CPC分类号： A61K51/0497 , A61K51/1258
摘要： The present invention is directed to a stable multilayer lyophile having a radioligand in a first layer and at least one other layer having at least one component which is chemically incompatible with the radioligand in the first layer. The invention also comprises an optional interface layer. The multilayer lyophile provides a number of advantages. First, it allows incompatible ingredients to be contained in separate layers in a single vial. Secondly, it is easier to use because less manipulation is required as compared to a multicontainer kit. Thirdly, less raw materials are required for manufacture because only one package, one label, etc., is needed. Finally, there is increased manufacturing efficiency because only one freeze drying run is needed to prepare the product.
摘要翻译：本发明涉及在第一层中具有放射性配体的稳定的多层冻干制品和至少一种具有至少一种在第一层中与放射性配体化学不相容的组分的其它层。本发明还包括可选接口层。多层冻干提供了许多优点。首先，它允许不相容的成分包含在单个小瓶中的单独层中。其次，使用更容易，因为与多容器套件相比，需要较少的操作。第三，制造需要较少的原材料，因为只需要一个包装，一个标签等。最后，提高制造效率，因为只需要一次冷冻干燥来制备产品。

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