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    • 1. 发明专利
    • Responsive paramagnetic mri contrast agent
    • 反应性PARAMAGNETIC MRI对比剂
    • JP2011235125A
    • 2011-11-24
    • JP2011151981
    • 2011-07-08
    • Bracco Imaging Spaブラッコ イメージング エッセ ピ アBRACCO IMAGING S.p.A.
    • AIME SILVIODELLI CASTELLI DANIELAFEDELI FRANCOTERRENO ENZO
    • A61B5/055A61K49/00A61K49/06A61K49/10C07D257/02C07D487/08
    • A61K49/0002A61K49/106
    • PROBLEM TO BE SOLVED: To provide a method based on the CEST procedure for the in vivo, in vitro or ex vivo determination of a physical or chemical parameter of diagnostic interest which includes the administration of a responsive paramagnetic CEST contrast agent.SOLUTION: The paramagnetic contrast agent is a responsive agent, i.e. an agent which combines the characterizing features of a CEST agent with the fact that the saturation transfer effect that it enables is sensitive to the physical or chemical parameter of diagnostic interest. Accordingly, the contrast agent is a paramagnetic compound which comprises at least one mobile proton in chemical exchange with the water medium protons and which is able, when a proper radiofrequency irradiating field is applied at the resonance frequency of the exchangeable proton, to generate a saturation transfer (ST) effect between the mobile proton and the water medium protons that only correlates to the physico-chemical parameter of diagnostic interest.
    • 要解决的问题:提供基于CEST程序的方法,用于体内,体外或离体测定诊断感兴趣的物理或化学参数,其包括施用响应性顺磁性CEST造影剂。 解决方案:顺磁造影剂是响应剂,即将CEST试剂的特征特征与其使能的饱和转移效应相结合的诊断感兴趣的物理或化学参数这一事实的试剂。 因此,造影剂是顺磁性化合物,其包含与水介质质子化学交换的至少一个可移动质子,并且当以可交换质子的共振频率施加适当的射频照射场时,能够产生饱和度 在移动质子和水介质质子之间的转移(ST)效应仅与诊断感兴趣的物理化学参数相关。 版权所有(C)2012,JPO&INPIT
    • 2. 发明专利
    • Responsive paramagnetic mri contrast agent
    • 反应性PARAMAGNETIC MRI对比剂
    • JP2010088901A
    • 2010-04-22
    • JP2009264106
    • 2009-11-19
    • Bracco Imaging Spaブラッコ イメージング エッセ ピ アBRACCO IMAGING S.p.A.
    • AIME SILVIODELLI CASTELLI DANIELAFEDELI FRANCOTERRENO ENZO
    • A61B5/055A61K49/00A61K49/06A61K49/10C07D257/02G01R33/28
    • A61K49/0002A61K49/106
    • PROBLEM TO BE SOLVED: To provide a method based on a CEST procedure for the in vivo or in vitro determination of physical or chemical parameters using a responsive paramagnetic CEST contrast agent. SOLUTION: The responsive paramagnetic CEST contrast agent including at least one exchangeable proton whose saturation capability is correlated to an important physical or chemical parameter is used to display a CEST MR image which is responsive for the parameter in the organ or tissue under examination. The paramagnetic contrast agent for use is a responsive agent, i.e., an agent which combines the characteristic features of a CEST agent with the fact of sensitivity to the physical or chemical parameter which is diagnostically important. The contrast agent thereby includes at least one mobile proton in chemical exchange with water medium protons and is capable of generating a saturation transfer (ST) effect between the mobile proton and the water medium protons when a proper high frequency impression magnetic field is applied at the resonance frequency of the exchangeable proton. COPYRIGHT: (C)2010,JPO&INPIT
    • 要解决的问题:提供基于CEST程序的方法,用于使用响应顺磁性CEST造影剂体内或体外测定物理或化学参数。 解决方案:响应顺磁性CEST造影剂包括至少一种可重复质子,其饱和能力与重要的物理或化学参数相关,用于显示对所检查的器官或组织中参数的响应的CEST MR图像 。 用于使用的顺磁造影剂是一种响应剂,即将CEST试剂的特征与对于诊断上重要的物理或化学参数敏感的事实相结合的试剂。 因此,造影剂包括与水介质质子化学交换的至少一个可移动质子,并且当在该介质质子上施加适当的高频压印磁场时能够在移动质子和水介质质子之间产生饱和转移(ST)效应 可交换质子的共振频率。 版权所有(C)2010,JPO&INPIT