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1. 发明申请

WO2010124050A1 METHOD FOR MAKING ENDOPROSTHESES 审中-公开
标题翻译：制造内源性方法
公开(公告)号：WO2010124050A1
公开(公告)日：2010-10-28
申请号：PCT/US2010/031992
申请日：2010-04-22
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RADHAKRISHNAN, Rajesh , SCHEWE, Scott, R. , SCHOENLE, Victor
发明人： RADHAKRISHNAN, Rajesh , SCHEWE, Scott, R. , SCHOENLE, Victor
IPC分类号： C23C14/04 , C23C14/22 , A61F2/82
CPC分类号： A61L33/00 , A61F2/82 , C23C14/046 , C23C14/22
摘要： A coating (62) having a smooth orange peel morphology is formed on an adluminal surface (44) of a stent (42), concurrently with the formation of a coating (60) having a rough rice grain morphology on an abluminal surface (46) of the stent. During the formation of the two coatings, a mandrel (50) is placed adjacent to the adluminal surface of the stent but does not generally contact the adluminal surface.
摘要翻译：在支架（42）的近端表面（44）上形成具有光滑橙皮形态的涂层（62），同时在外侧表面（46）上形成具有粗糙米粒形态的涂层（60）的支架。在形成两个涂层期间，心轴（50）放置在支架的近端面附近，但通常不接触椎间孔表面。

2. 发明申请

WO2010014612A2 BIOERODIBLE ENDOPROSTHESIS 审中-公开
标题翻译：生物学上的内生性
公开(公告)号：WO2010014612A2
公开(公告)日：2010-02-04
申请号：PCT/US2009/051965
申请日：2009-07-28
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RADHAKRISHNAN, Rajesh , CHANDRASEKARAN, Chandru , SCHEWE, Scott, R. , MERDAN, Ken
发明人： RADHAKRISHNAN, Rajesh , CHANDRASEKARAN, Chandru , SCHEWE, Scott, R. , MERDAN, Ken
IPC分类号： A61L31/02 , A61L31/04 , A61L31/14
CPC分类号： A61L31/08
摘要： An endoprosthesis includes a plurality of struts defining a flow passage. At least one strut includes (a) a body comprising a bioerodible material and having a thickness and (b) a coating overlying the body. The coating includes a plurality of regions that allow physiological fluids to contact a plurality of corresponding areas of the underlying body when the endoprosthesis is implanted in a physiological environment. The plurality of regions are sized and arranged so that the contacted areas of the body erode substantially through the body in the thickness direction while the coating remains on the body when the endoprosthesis is implanted in the physiological environment.
摘要翻译：内假体包括限定流动通道的多个支柱。至少一个支柱包括（a）包含生物腐蚀性材料并且具有厚度的主体和（b）覆盖在身体上的涂层。涂层包括多个区域，当内生假体植入生理环境时，允许生理流体接触下面身体的多个对应区域。多个区域的尺寸和布置使得当内部假体植入生理环境时，身体的接触区域在厚度方向上基本上穿过身体侵蚀，同时涂层保留在身体上。

3. 发明申请

WO2009059098A2 ENDOPROSTHESIS COATING 审中-公开
标题翻译：内部涂层
公开(公告)号：WO2009059098A2
公开(公告)日：2009-05-07
申请号：PCT/US2008/081945
申请日：2008-10-31
申请人： BOSTON SCIENTIFIC LIMITED , SCHOENLE, Victor , SCHEWE, Scott R. , RADHAKRISHNAN, Rajesh
发明人： SCHOENLE, Victor , SCHEWE, Scott R. , RADHAKRISHNAN, Rajesh
IPC分类号： A61L31/08
CPC分类号： A61L33/00 , A61L31/082 , A61L31/088 , A61L31/14 , C23C14/025 , C23C14/046 , C23C14/08 , C23C14/3464 , C23C14/352
摘要： A method includes: providing a tubular substrate in a chamber, the tubular substrate having a lumen, an abluminal surface and a luminal surface; providing a target in the lumen; depositing a first coating onto the abluminal surface and a second coating onto the luminal surface while keeping the tubular substrate in the chamber. An endoprosthesis, such as a stent, including a first coating on at least one portion of its abluminal surface and a second coating on at least one portion of its luminal surface is also disclosed.
摘要翻译：一种方法包括：在腔室中提供管状基底，所述管状基底具有内腔，腔内表面和腔表面; 在管腔中提供目标; 将第一涂层沉积到腔内表面上，并将第二涂层沉积到腔表面上，同时将管状基底保持在腔室中。还公开了内置假体，例如支架，其包括其外侧表面的至少一部分上的第一涂层和其管腔表面的至少一部分上的第二涂层。

4. 发明申请

WO2007092158A1 ULTRASOUND ACTIVATED MEDICAL DEVICE 审中-公开
标题翻译：超声波激活医疗器械
公开(公告)号：WO2007092158A1
公开(公告)日：2007-08-16
申请号：PCT/US2007/001900
申请日：2007-01-25
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RADHAKRISHNAN, Rajesh , CHANDRASEKARAN, Chandru
发明人： RADHAKRISHNAN, Rajesh , CHANDRASEKARAN, Chandru
IPC分类号： A61F2/82 , A61K9/00
CPC分类号： A61L27/54 , A61F2250/0068 , A61K9/0009 , A61K9/1075 , A61L27/34 , A61L27/50 , A61L2300/236 , A61L2300/256 , A61L2300/414 , A61L2300/432 , A61L2300/45 , A61L2300/604
摘要： A medical device (40) comprising a medical device body having drug-loaded vesicles (10) thereon. The vesicles are ultrasound sensitive and release the drug upon ultrasound stimulation. Also provided is a method for controlling drug release from a medical device using drug-loaded vesicles that are ultrasound sensitive.
摘要翻译：一种医疗装置（40），包括其上装有药物的囊泡（10）的医疗装置主体。囊泡是超声敏感的，并在超声刺激下释放药物。还提供了一种使用超声敏感的药物负载囊泡从医疗装置控制药物释放的方法。

5. 发明申请

WO2011081958A1 ENDOPROSTHESIS 审中-公开
标题翻译：内置假体
公开(公告)号：WO2011081958A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/060412
申请日：2010-12-15
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , ATANASOSKA, Liliana , RADHAKRISHNAN, Rajesh
发明人： WEBER, Jan , ATANASOSKA, Liliana , RADHAKRISHNAN, Rajesh
IPC分类号： A61F2/90
CPC分类号： A61F2/91 , A61F2210/0004 , A61F2210/0076 , A61F2230/0054 , A61F2250/0067
摘要： An endoprosthesis, e.g., a bioerodable stent, that is treated by plasma immersion ion implantation on the surface and optionally in the bulk. Releasable therapeutic agent, drug, or pharmaceutically active compound may be incorporated into the treated surface of the endoprosthesis to provide desired medical benefits.
摘要翻译：内表假体，例如生物可蚀塑的支架，其通过等离子体浸没离子注入在表面上和任选地在本体中进行处理。可释放的治疗剂，药物或药物活性化合物可以并入内用假体的经处理的表面以提供所需的医疗益处。

6. 发明申请

WO2009137786A1 ENDOPROSTHESES 审中-公开
标题翻译：用假体
公开(公告)号：WO2009137786A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/043326
申请日：2009-05-08
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , RADHAKRISHNAN, Rajesh , ARCAND, Ben , WARNER, Robert, W.
发明人： ATANASOSKA, Liliana , RADHAKRISHNAN, Rajesh , ARCAND, Ben , WARNER, Robert, W.
IPC分类号： A61F2/90 , A61L31/02
CPC分类号： A61F2/91 , A61F2230/0013 , A61F2240/001 , A61F2250/0031 , A61L31/022 , A61L31/10 , A61L31/148 , A61L2400/12 , A61L2400/18 , C08L67/04
摘要： An endoprosthesis includes a body defining a flow passage therethrough. The body is capable of maintaining patency in a blood vessel and includes iron or an alloy thereof. The body has a nano-structured surface comprising iron oxide in which the individual nano-structures have a height to thickness aspect ratio of at least 5:1.
摘要翻译：内假体包括限定穿过其中的流动通道的主体。身体能够在血管中保持通畅并且包括铁或其合金。主体具有包含氧化铁的纳米结构化表面，其中各个纳米结构的高度与厚度纵横比至少为5:1。

7. 发明申请

WO2011119430A1 ENDOPROSTHESIS 审中-公开
标题翻译：内置假体
公开(公告)号：WO2011119430A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/029005
申请日：2011-03-18
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , KOSTREWA, Angela , CAMBRONNE, Matthew , FENG, James Q. , RADHAKRISHNAN, Rajesh
发明人： ATANASOSKA, Liliana , KOSTREWA, Angela , CAMBRONNE, Matthew , FENG, James Q. , RADHAKRISHNAN, Rajesh
IPC分类号： A61L31/08 , A61L31/14
CPC分类号： A61L31/022 , A61L31/06 , A61L31/088 , A61L31/10 , A61L31/148 , A61L31/16 , Y10T29/49982 , C08L67/04
摘要： Endoprostheses and methods of making endoprostheses are disclosed. For example, endoprostheses are described that include an endoprosthesis body, a biodegradable metallic tie layer, and a polymer coating about the endoprosthesis body. The biodegradable tie layer and the polymer coating can have a high peel strength from the body.
摘要翻译：公开内裤假体和内用假体的方法。例如，描述了内括约肌体，其包括内置假体，可生物降解的金属粘结层和围绕内假体的聚合物涂层。可生物降解的粘结层和聚合物涂层可以具有来自身体的高剥离强度。

8. 发明申请

WO2010144266A2 ELECTROCHEMICAL THERAPEUTIC AGENT DELIVERY DEVICE 审中-公开
标题翻译：电化学治疗剂递送装置
公开(公告)号：WO2010144266A2
公开(公告)日：2010-12-16
申请号：PCT/US2010/036403
申请日：2010-05-27
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , RADHAKRISHNAN, Rajesh , WARNER, Robert, W.
发明人： ATANASOSKA, Liliana , RADHAKRISHNAN, Rajesh , WARNER, Robert, W.
IPC分类号： A61L29/14
CPC分类号： A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/416 , A61N1/30
摘要： A therapeutic agent delivery device and method for eluting a therapeutic agent to a target location are disclosed. The device may comprise a first conductive element, a second conductive element, an electrochemical composition including an electrolyte and a therapeutic agent, and a permeable membrane covering the electrochemical composition. The first conductive element and the second conductive element are adapted to be connected to a voltage source. When the voltage source is connected to the first conductive element and the second conductive element, an electrochemical reaction occurs causing the therapeutic agent to pass through the permeable membrane and thereby to elute to a target location.
摘要翻译：公开了用于将治疗剂洗脱到目标位置的治疗剂递送装置和方法。该装置可以包括第一导电元件，第二导电元件，包括电解质和治疗剂的电化学组合物，以及覆盖电化学组合物的可渗透膜。第一导电元件和第二导电元件适于连接到电压源。当电压源连接到第一导电元件和第二导电元件时，发生电化学反应，导致治疗剂通过可渗透膜，从而洗脱到目标位置。

9. 发明申请

WO2007058841A1 COATED AND IMPRINTED MEDICAL DEVICES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：涂覆和改进的医疗装置及其制造方法
公开(公告)号：WO2007058841A1
公开(公告)日：2007-05-24
申请号：PCT/US2006/043450
申请日：2006-11-07
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RADHAKRISHNAN, Rajesh , CHANDRASEKARAN, Chandru
发明人： RADHAKRISHNAN, Rajesh , CHANDRASEKARAN, Chandru
IPC分类号： A61F2/06
CPC分类号： B05D1/42 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D5/02 , B41M3/006
摘要： The present invention relates generally to coated medical devices, preferably a stent, that has a drug-eluting surface completely or partially coated with a coating that is imprinted with an impression. In particular, the invention is directed to a coated medical device having a coating that comprises biologically active materials, polymers, or a combination thereof. The coating is imprinted with an impression by printing, molding, lithography, or embossing techniques. Preferably, the patterning imprinted on the coating is capable of releasing biologically active materials in different amounts, at different rates, and/or at different time periods. The invention also relates to methods of making and methods of using the coated medical device.
摘要翻译：本发明一般涉及具有药物洗脱表面的涂覆的医疗装置，优选支架，其完全或部分涂覆有印有印模的涂层。特别地，本发明涉及具有包含生物活性材料，聚合物或其组合的涂层的涂覆医疗装置。通过印刷，模塑，光刻或压花技术印刷印模。优选地，印刷在涂层上的图案能够以不同的速率和/或在不同的时间段以不同的量释放生物活性材料。本发明还涉及制造方法和使用涂覆的医疗装置的方法。

10. 发明申请

WO2012118526A1 LOW STRAIN HIGH STRENGTH STENT 审中-公开
标题翻译：低应变高强度STENT
公开(公告)号：WO2012118526A1
公开(公告)日：2012-09-07
申请号：PCT/US2011/052804
申请日：2011-09-22
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： BOISMIER, Dennis, A. , AGRAWAL, Sumit , MEYER, Michael, P. , RADHAKRISHNAN, Rajesh
IPC分类号： A61F2/90
CPC分类号： A61F2/915 , A61F2002/91508 , A61F2002/91525 , A61F2002/91541 , A61F2002/91575 , A61F2250/0036
摘要： In at least one embodiment, a stent comprises an expandable framework comprising a plurality of serpentine bands and a plurality of connector struts. Each serpentine band comprises a plurality of alternating struts and turns. A plurality of the serpentine bands each have their proximal turns aligned on a common stent circumference and comprise first distal turns and second distal turns. The first distal turns are aligned with one another on a common stent circumference. The second distal turns aligned with one another on another common stent circumference. Each band in the plurality comprises first struts and second struts. Each first strut is attached between a proximal turn and a first distal turn, and each second strut is attached between a proximal turn and a second distal turn. The second struts are wider than said first struts.
摘要翻译：在至少一个实施例中，支架包括包括多个蛇形带和多个连接器支柱的可扩展框架。每个蛇形带包括多个交替的支柱和匝。多个蛇形带各自具有在共同的支架圆周上对齐的近端匝，并且包括第一远端匝和第二远端匝。第一远端匝在共同的支架圆周上彼此对准。第二个远端匝在另一个共同的支架圆周上彼此对准。多个中的每个带包括第一支柱和第二支柱。每个第一支柱连接在近端匝和第一远端匝之间，并且每个第二支柱附接在近匝和第二远端匝之间。第二支柱比所述第一支柱宽。

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