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1. 发明申请

WO2008051339A1 FILM COATING MEDICAL DEVICES 审中-公开
标题翻译：电影涂装医疗器械
公开(公告)号：WO2008051339A1
公开(公告)日：2008-05-02
申请号：PCT/US2007/020326
申请日：2007-09-20
申请人： BOSTON SCIENTIFIC SCIMED, INC. , O'CONNOR, Tim , MCMORROW, Dave , SOBRINO, Gabriel , WARD, Liam , HYNES, Noel
发明人： O'CONNOR, Tim , MCMORROW, Dave , SOBRINO, Gabriel , WARD, Liam , HYNES, Noel
IPC分类号： B05C3/00 , B05C9/02 , B05C1/02
CPC分类号： B05C1/022 , A61L2420/02
摘要： The present invention relates to a coating assembly (102) and methods that employ the coating assembly (102) to control the thickness of therapeutic or other coatings delivered to a medical device during a coating process. In one embodiment the coating assembly may include a coating plate having a coating transfer surface and a shoulder having a first height, a mandrel (104) moveable over the coating transfer surface, and a coating dispenser (118) positioned in fluid communication with the coating transfer surface. The invention also includes a method of coating a medical device. This method may include placing a medical device on a mandrel (104), dispensing coating onto a coating transfer surface of a coating plate, moving the mandrel (104) and the medical device (106) over the coating transfer surface of the coating plate (110) so that coating resident on the coating transfer surface transfers to an exposed surface of the medical device, and removing the medical device from the mandrel.
摘要翻译：本发明涉及一种涂覆组件（102）和使用该涂层组件（102）来控制在涂覆过程期间递送至医疗装置的治疗剂或其它涂层的厚度的方法。在一个实施例中，涂层组件可以包括具有涂层转移表面和具有第一高度的肩部的涂层板，可移动到涂层转移表面上的心轴（104）以及与涂层流体连通的涂布分配器（118）转移面。本发明还包括涂覆医疗装置的方法。该方法可以包括将医疗装置放置在心轴（104）上，将涂层分配到涂覆板的涂层转移表面上，将心轴（104）和医疗装置（106）移动到涂覆板的涂层转移表面 110），使得驻留在涂层转移表面上的涂层转移到医疗装置的暴露表面，并从心轴移除医疗装置。

2. 发明申请

WO2005089951A1 METHOD FOR SPRAY COATING OF MEDICAL DEVICES BY ATOMIZATION OF A LIQUID FILM 审中-公开
标题翻译：通过液体膜的喷雾喷雾涂覆医疗装置的方法
公开(公告)号：WO2005089951A1
公开(公告)日：2005-09-29
申请号：PCT/US2005/007706
申请日：2005-03-09
申请人： BOSTON SCIENTIFIC SCIMED, INC. , O'CONNOR, Tim , SOBRINO, Gabriel
发明人： O'CONNOR, Tim , SOBRINO, Gabriel
IPC分类号： B05B7/06
CPC分类号： B05B7/066
摘要： An method for spray deposition of small targets, such as medical devices like stents, is disclosed in which a finer atomized spray droplet size is achieved by pre-filming the coating material (A) onto a flat face (26) before entraining the coating material (A) within the atomizing fluid (C), which improves manufacturing repeatability, reduces coating variances, and increases therapeutic dosage predictability. In certain embodiments of the invention, the coating materials include therapeutic agents and biologically active materials.
摘要翻译：公开了一种用于喷射沉积小靶的方法，例如诸如支架的医疗装置，其中通过在将涂层材料（A）夹带在涂覆材料（A）之前将涂层材料（A）预成膜，从而实现更精细的雾化喷雾液滴尺寸（A）在雾化流体（C）内，这提高了制造重复性，降低了涂层变化，并提高了治疗剂量的可预测性。在本发明的某些实施方案中，涂层材料包括治疗剂和生物活性材料。

3. 发明申请

WO2008066656A2 STENTS WITH DRUG ELUTING COATINGS 审中-公开
标题翻译：带药液涂层的手套
公开(公告)号：WO2008066656A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/023221
申请日：2007-11-01
申请人： BOSTON SCIENTIFIC SCIMED, INC. , MALONE, Anthony , O'CONNOR, Tim , MCMORROW, Dave , FLANAGAN, Aiden
发明人： MALONE, Anthony , O'CONNOR, Tim , MCMORROW, Dave , FLANAGAN, Aiden
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/622
摘要： Provided is a coated medical device ( e.g. , a stent) comprising one or more surfaces having dispersed thereon a plurality of microparticles comprising an active pharmaceutical ingredient (API) and a polymer. Specifically, the microparticles are disposed on a device surface in a microparticulate phase coating, i.e. , as discrete microparticles in the absence of a continuous phase coating. The medical device effectively adheres one or more APIs to its surface, and allows controlled release of the APIs from the device surface to a desired treatment area by using a minimal amount of polymer. The medical device is suitable for insertion or implantation into a subject, preferably a human. Also provided are methods for preparing and using the coated medical device.
摘要翻译：提供了包含一个或多个在其上分散有多个包含活性药物成分（API）和聚合物的微粒的表面的涂覆医疗装置（例如支架）。具体地，微粒在微粒相涂层中的器件表面上，即在不存在连续相涂覆的情况下作为离散微粒布置。医疗设备有效地将一个或多个API粘附到其表面，并且允许通过使用最少量的聚合物将API从设备表面控制释放到期望的治疗区域。医疗装置适于插入或植入受试者，优选人。还提供了制备和使用涂覆的医疗装置的方法。

4. 发明申请

WO2008054655A2 SYSTEM AND METHOD FOR COATING A MEDICAL DEVICE 审中-公开
标题翻译：用于涂敷医疗装置的系统和方法
公开(公告)号：WO2008054655A2
公开(公告)日：2008-05-08
申请号：PCT/US2007/022405
申请日：2007-10-22
申请人： BOSTON SCIENTIFIC SCIMED, INC. , O'CONNOR, Tim , HE, Lijuan , FLANAGAN, Aiden , MALONE, Anthony , HEANEY, Barry , MCMORROW, Dave
发明人： O'CONNOR, Tim , HE, Lijuan , FLANAGAN, Aiden , MALONE, Anthony , HEANEY, Barry , MCMORROW, Dave
CPC分类号： B05D1/28 , B05D1/002 , B05D1/32 , Y10T29/49927
摘要： A method and device for coating a medical device, such as a stent, including rolling the stent against a ribbon or gravure roll impregnated with coating material. The ribbon and gravure roll may include a recessed pattern matching a strut pattern of the stent. The stent may also be rolled against a plate or cylinder while coating material is forced onto the stent through a pattern of holes or openings in the plate or cylinder matching a strut pattern of the stent.
摘要翻译：一种用于涂覆诸如支架的医疗装置的方法和装置，包括将支架滚压到浸渍有涂层材料的带或凹版辊上。带和凹版辊可以包括与支架的支柱图案相匹配的凹陷图案。支架也可以滚动抵靠板或圆柱体，同时通过与支架的支柱图案匹配的板或圆筒中的孔或开口的图案将涂层材料压在支架上。

5. 发明申请

WO2008051342A2 REDUCTION OF BURST RELEASE FROM THERAPEUTICALLY TREATED MEDICAL DEVICES 审中-公开
标题翻译：从治疗医疗器械减少爆发
公开(公告)号：WO2008051342A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/020346
申请日：2007-09-19
申请人： BOSTON SCIENTIFIC SCIMED, INC. , O'CONNOR, Tim , FLANAGAN, Aiden , MCMORROW, Dave , MALONE, Anthony
发明人： O'CONNOR, Tim , FLANAGAN, Aiden , MCMORROW, Dave , MALONE, Anthony
IPC分类号： A61L31/16
CPC分类号： A61L31/16 , A61F2250/0067 , A61L31/08 , A61L2300/602
摘要： The present invention generally relates to the conditioning of coated medical devices such as stents. More specifically, the present invention relates to methods for positioning a medical device within an elution media for a predetermined time period to eliminate a burst release from the coating. Under methods and processes of the invention, a medical device target surface may be identified and coated with therapeutic. The coated surface of the medical device may then be positioned within an elution media for a predetermined period of time to release a predetermined amount of coating.
摘要翻译：本发明一般涉及诸如支架之类的涂覆的医疗装置的调理。更具体地，本发明涉及用于将洗涤介质中的医疗装置定位在预定时间段内以消除从涂层中爆发释放的方法。在本发明的方法和方法下，可以鉴定医疗器械靶表面并用治疗剂涂覆。然后可以将医疗装置的涂覆表面定位在洗脱介质中预定的时间段以释放预定量的涂层。

6. 发明申请

WO2008034047A2 ENDOPROSTHESIS WITH ADJUSTABLE SURFACE FEATURES 审中-公开
标题翻译：具有可调节表面特征的内窥镜
公开(公告)号：WO2008034047A2
公开(公告)日：2008-03-20
申请号：PCT/US2007/078475
申请日：2007-09-14
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FLANAGAN, Aiden , MCMORROW, Dave , MALONE, Anthony , O'CONNOR, Tim , HEANEY, Barry
发明人： FLANAGAN, Aiden , MCMORROW, Dave , MALONE, Anthony , O'CONNOR, Tim , HEANEY, Barry
IPC分类号： A61L27/14 , A61L31/10 , A61L31/04
CPC分类号： A61L31/146 , A61F2/82 , A61F2/91 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/626
摘要： Endoprostheses (e.g., stents) containing adjustable surfaces are disclosed.
摘要翻译：公开了包含可调表面的内假体（例如，支架）。

7. 发明申请

WO2008036380A1 STENT WITH SUPPORT ELEMENT 审中-公开
标题翻译：支持元素
公开(公告)号：WO2008036380A1
公开(公告)日：2008-03-27
申请号：PCT/US2007/020428
申请日：2007-09-20
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HEANEY, Barry , MCMORROW, Dave , MALONE, Anthony , FLANAGAN, Aiden , O'CONNOR, Tim
发明人： HEANEY, Barry , MCMORROW, Dave , MALONE, Anthony , FLANAGAN, Aiden , O'CONNOR, Tim
IPC分类号： A61F2/90
CPC分类号： A61F2/91 , A61F2/852 , A61F2/86 , A61F2220/0033 , A61F2220/005 , A61F2220/0058 , A61F2250/0063 , A61F2250/0068
摘要： An implantable stent comprising a first strut having an abluminal surface, and subluminal surface, and at least one side surface; a first depression formed in the abluminal surface; and a first support element at least partially disposed in the first depression; wherein at least a portion of the first support element extends beyond the abluminal surface of the first strut.
摘要翻译：一种可植入支架，其包括具有近端表面的第一支柱和亚锥形表面，以及至少一个侧表面; 形成在外侧表面的第一凹陷; 以及至少部分地设置在所述第一凹部中的第一支撑元件; 其中所述第一支撑元件的至少一部分延伸超过所述第一支柱的所述外侧表面。

8. 发明申请

WO2013016203A1 NERVE MODULATION SYSTEM WITH A NERVE MODULATION ELEMENT POSITIONABLE IN A HELICAL GUIDE 审中-公开
标题翻译：神经调节系统，神经调节元件可以在医疗指南中定位
公开(公告)号：WO2013016203A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/047632
申请日：2012-07-20
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , FLANAGAN, Aiden , O'CONNOR, Tim
发明人： WEBER, Jan , FLANAGAN, Aiden , O'CONNOR, Tim
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61B2018/00511 , A61B2018/00577 , F04C2270/0421
摘要： A system for nerve modulation includes a first elongate element (14) having a distal end and a proximal end and having a helical guide (26) having a proximal end and a distal end. The system also includes a second elongate element (12) having a distal end and a proximal end and having a nerve modulation element (22) proximate the distal end. A sheath (16) is disposed about both the first and second elongate elements.
摘要翻译：用于神经调节的系统包括具有远端和近端的具有近端和远端的螺旋引导件（26）的第一细长元件（14）。该系统还包括具有远端和近端并具有靠近远端的神经调制元件（22）的第二细长元件（12）。围绕第一和第二细长元件设置护套（16）。

9. 发明申请

WO2009042673A1 MEDICAL DEVICES HAVING A FILTER INSERT FOR CONTROLLED DIFFUSION 审中-公开
标题翻译：具有用于控制扩散的过滤器插件的医疗装置
公开(公告)号：WO2009042673A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/077505
申请日：2008-09-24
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CLARKE, John , O'CONNOR, Tim , XU, Yixin , O'BRIEN, Barry, J.
发明人： CLARKE, John , O'CONNOR, Tim , XU, Yixin , O'BRIEN, Barry, J.
IPC分类号： A61F2/00 , A61F2/82 , A61K9/00 , A61F2/01 , A61F2/04 , A61N1/36 , A61N1/39
CPC分类号： A61F2/82 , A61F2/00 , A61F2/01 , A61F2/04 , A61F2/91 , A61F2220/0058 , A61F2250/0068
摘要： An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material (115) that comprises a first therapeutic agent, and (b) a pre-formed filter insert (120) disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device in vivo.
摘要翻译：提供了一种植入式或可插入的医疗装置，其包括作为部件：（a）底物组分，其包含至少部分地填充有包含第一治疗剂的含治疗剂的材料（115）的凹陷，和（b）预先形成的过滤器插入物（120），其设置在凹陷中，使得其在体内植入或插入装置时调节化学物质在装置的凹陷和外部之间的运输。

10. 发明申请

WO2009032665A2 POROUS MEDICAL ARTICLES FOR THERAPEUTIC AGENT DELIVERY 审中-公开
标题翻译：用于治疗药物递送的多种医学文章
公开(公告)号：WO2009032665A2
公开(公告)日：2009-03-12
申请号：PCT/US2008/074387
申请日：2008-08-27
申请人： BOSTON SCIENTIFIC SCIMED, INC. , MCMORROW, David , MALONE, Anthony , O'CONNOR, Tim , O'BRIEN, Barry, J
发明人： MCMORROW, David , MALONE, Anthony , O'CONNOR, Tim , O'BRIEN, Barry, J
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/416
摘要： According to an aspect of the present invention a method is provided which a porous medical article is contacted with a solution that contains a therapeutic agent and a solvent in order to load the pores of the medical article, after which the solvent is sublimated.
摘要翻译：根据本发明的一个方面，提供了一种方法，使多孔医疗制品与含有治疗剂和溶剂的溶液接触，以便加载医疗用品的孔，之后溶剂升华。

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