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1. 发明申请

WO2008042466A2 APPARATUSES AND METHODS TO TREAT ATHEROSCLEROTIC PLAQUES 审中-公开
标题翻译：用于治疗动脉粥样硬化斑块的装置和方法
公开(公告)号：WO2008042466A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/068354
申请日：2007-05-07
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FREYMAN, Toby , HERRMANN, Robert , NAIMARK, Wendy , PALASIS, Maria
发明人： FREYMAN, Toby , HERRMANN, Robert , NAIMARK, Wendy , PALASIS, Maria
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61L31/148 , A61L2300/604
摘要： This invention comprises an apparatus for treating an atherosclerotic plaque in a coronary artery of a mammal by placing at or proximate to an entrance to the coronary artery and upstream of the vulnerable plaque, and an effective amount of a therapeutic agent for the treatment of the plaque. This invention comprises delivering a deposition of a therapeutic drug high in the coronary arterial tree for treatment of downstream vulnerable plaques. The invention also comprises slow release formulation and delivery of an apparatus that is totally degradable or removed and/or replaced.
摘要翻译：本发明包括一种用于通过放置在冠状动脉的入口处或在冠状动脉的入口附近和易损斑块的上游来治疗哺乳动物冠状动脉中的动脉粥样硬化斑块的设备，以及有效量的用于治疗斑块的治疗剂。本发明包括递送在冠状动脉树中高度治疗药物的沉积以治疗下游易损斑块。本发明还包括缓释制剂和递送完全可降解或移除和/或替换的装置。

2. 发明申请

WO2006107408A1 ROTATABLE MULTI-PORT THERAPEUTIC DELIVERY DEVICE 审中-公开
标题翻译：可旋转的多端口治疗设备
公开(公告)号：WO2006107408A1
公开(公告)日：2006-10-12
申请号：PCT/US2006/005009
申请日：2006-02-14
申请人： BOSTON SCIENTIFIC SCIMED, INC. , NAIMARK, Wendy , PALASIS, Maria , FREYMAN, Toby , SHAW, William, J.
发明人： NAIMARK, Wendy , PALASIS, Maria , FREYMAN, Toby , SHAW, William, J.
IPC分类号： A61M25/00
CPC分类号： A61M25/0069
摘要： The present invention relates to the delivery of therapeutic to a target area. More particularly, the present invention relates to therapeutic delivery devices, with, one or more therapeutic delivery bodies that have new and unique degrees of freedom of motion. A therapeutic delivery device (100, 300, 700, 900, 1200, 1300, 1800) according to the invention comprises a steerable elongated member (310, 710, 910, 1210, 1310, 1810) sized for insertion into a body of a patient; and a rotatable therapeutic delivery body (320, 720, 920, 1220, 1320, 1815) rotatably supported by the elongated member; the delivery body free to rotate about at least one axis of rotation, the delivery body having one or more therapeutic delivery ports, the rotatable therapeutic delivery body sized for insertion into a body of a patient.
摘要翻译：本发明涉及将治疗剂递送至目标区域。更具体地，本发明涉及具有一种或多种具有新的和独特的运动自由度的治疗递送体的治疗递送装置。根据本发明的治疗性输送装置（100,300,700,900,1200,1300,1800）包括尺寸适于插入患者体内的可操纵细长构件（310,710,910,1210,1310,1810） ; 以及由所述细长构件可旋转地支撑的可旋转治疗递送体（320,720,920,1220,1320,1815）所述递送体自由地围绕至少一个旋转轴线旋转，所述递送体具有一个或多个治疗递送口，所述可转动的治疗递送体的尺寸设置成插入到患者体内。

3. 发明申请

WO2007089976A2 LOCAL CONTROL OF INFLAMMATION 审中-公开
标题翻译：炎症的局部控制
公开(公告)号：WO2007089976A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/060581
申请日：2007-01-16
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FREYMAN, Toby , NAIMARK, Wendy , PALASIS, Maria
发明人： FREYMAN, Toby , NAIMARK, Wendy , PALASIS, Maria
IPC分类号： A61F2/06
CPC分类号： A61F2/02 , A61F2/0077 , A61F2/07 , A61F2230/008 , A61F2250/0039 , A61F2250/0067
摘要： A medical device includes a carrier and an agent. The agent is formulated to control inflammation of biological tissue, such as heart tissue, and is releasably coupled to the carrier. The carrier is configured to be disposed in operative proximity to the biological tissue to be treated by the agent. In one embodiment, the carrier is configured to release the agent or otherwise deliver the agent to the biological tissue, thus controlling inflammation of the tissue. Also, a method to improve healing of biological tissue includes placing a medical device proximate to the heart of a patient, where the medical device has a carrier and an agent configured to control inflammation, the agent is releasably coupled to the carrier. In one embodiment, the method includes causing the agent to be released from the carrier.
摘要翻译：医疗器械包括载体和药剂。制剂用于控制诸如心脏组织的生物组织的炎症，并且可释放地联接到载体上。载体被配置为设置在操作中接近要由药剂处理的生物组织。在一个实施方案中，载体被配置为释放试剂或以其它方式将试剂递送到生物组织，从而控制组织的炎症。而且，改善生物组织愈合的方法包括将医疗装置放置在患者的心脏附近，其中医疗装置具有载体和构造成控制炎症的药剂，药剂可释放地联接到载体上。在一个实施例中，该方法包括使得试剂从载体释放。

4. 发明申请

WO2007037850A2 ENHANCED DELIVERY OF CELLS 审中-公开
标题翻译：增强细胞的传递
公开(公告)号：WO2007037850A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/032767
申请日：2006-08-23
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FREYMAN, Toby , PALASIS, Maria , NAIMARK, Wendy
发明人： FREYMAN, Toby , PALASIS, Maria , NAIMARK, Wendy
IPC分类号： A61K35/28
CPC分类号： A61M25/10 , A61K31/28 , A61K31/7076 , A61K35/28 , A61K45/00 , A61K45/06 , A61K2300/00 , A61M5/1407 , A61M2025/1052 , A61M2210/125
摘要： The present invention provides a method comprising administering cells by infusion through a blood vessel and administering a vasodilator, a vascular enhancer, or both. In accordance with one embodiment, the delivery of stem cells to the myocardium by intracoronary infusion is improved by administration of one or more vasodilators and/or vascular permeability enhancers prior to or at the time of cell therapy.
摘要翻译：本发明提供了一种方法，其包括通过血管输注施用细胞并施用血管扩张剂，血管增强剂或两者。根据一个实施方案，通过在细胞治疗之前或期间通过施用一种或多种血管扩张剂和/或血管通透性增强剂来改善通过冠状动脉内输注将干细胞递送至心肌。

5. 发明申请

WO2007030534A3 STENT WITH POCKETS CONTAINING A THERAPEUTIC AGENT 审中-公开
公开(公告)号：WO2007030534A3
公开(公告)日：2007-03-15
申请号：PCT/US2006/034707
申请日：2006-09-06
申请人： BOSTON SCIENTIFIC SCIMED, INC. , NAIMARK, Wendy , SHANK, Peter , PALASIS, Maria , FREYMAN, Toby , PANOS, Anastasia , EPSTEIN, Samuel, J. , ROUSSEAU, Alexandra
发明人： NAIMARK, Wendy , SHANK, Peter , PALASIS, Maria , FREYMAN, Toby , PANOS, Anastasia , EPSTEIN, Samuel, J. , ROUSSEAU, Alexandra
IPC分类号： A61L31/16
摘要： A medical device for delivering a therapeutic agent to a body lumen is described. The device may generally be a stent with an inner sidewall surface and an outer sidewall surface, with a plurality of struts having a plurality of openings therein. An inner and outer layer may be applied to the stent, forming pockets within at least a portion of the openings. The pockets may be filled with at least one therapeutic agent. The pockets may take a variety of shapes and sizes, and may be designed for release or rupture in variety of ways.

6. 发明申请

WO2006096286A1 CATHETER HAVING A DISTAL DRUG DELIVERY UNIT AND METHOD OF USING SAME 审中-公开
标题翻译：具有远程药物输送单元的导管及其使用方法
公开(公告)号：WO2006096286A1
公开(公告)日：2006-09-14
申请号：PCT/US2006/004993
申请日：2006-02-14
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FREYMAN, Toby , MICKLEY, Timothy, J. , NAIMARK, Wendy , PALASIS, Maria
发明人： FREYMAN, Toby , MICKLEY, Timothy, J. , NAIMARK, Wendy , PALASIS, Maria
IPC分类号： A61M25/00
CPC分类号： A61M25/0082 , A61M5/14526 , A61M5/14593 , A61M5/148 , A61M5/1483 , A61M25/0074 , A61M25/0084 , A61M2025/0091
摘要： A catheter having a drug delivery unit at the distal end thereof. The drug delivery unit includes an actuator capable of assuming an activated and an inactivated configuration. The drag delivery unit also includes a receptacle capable of accepting a therapeutic agent. The actuator and receptacle are in communication with each other such that the actuator transmits force to the receptacle and the receptacle accepts force from the actuator in an activated configuration of the actuator. Also provided is a method of delivering a therapeutic agent to a target site using the catheter of the present invention.
摘要翻译：一种在其远端具有药物输送单元的导管。药物递送单元包括能够承受激活和非活化构型的致动器。牵引输送单元还包括能够接受治疗剂的容器。致动器和容器彼此连通，使得致动器将力传递到插座，并且插座在致动器的激活配置中接受来自致动器的力。还提供了使用本发明的导管将治疗剂递送到靶位点的方法。

7. 发明申请

WO2009089110A2 METHODS FOR REPAIR AND REGENERATION OF BONE MARROW 审中-公开
标题翻译：骨质疏松修复和再生方法
公开(公告)号：WO2009089110A2
公开(公告)日：2009-07-16
申请号：PCT/US2009/030046
申请日：2009-01-02
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FREYMAN, Toby , NAIMARK, Wendy , PALASIS, Maria
发明人： FREYMAN, Toby , NAIMARK, Wendy , PALASIS, Maria
IPC分类号： A61K49/00 , A61K35/12
CPC分类号： A61L27/3847 , A61L27/3633 , A61L27/3834
摘要： The invention is directed to a method for treating a tissue or organ in a subject by directly administering an effective amount of an exogenous, decellularized extracellular matrix or a mixture of extracellular matrix and mesenchymal stem cells into the intended site of activity, such as bone marrow cavity. In one embodiment, the invention provides methods of treating bone marrow to increase the number of circulating progenitor and stem cells. In some other embodiments of the invention, the decellularized extracellular matrix to be directly administered is configured to be a time released therapeutic.
摘要翻译：本发明涉及一种通过将有效量的外源性脱细胞细胞外基质或细胞外基质和间充质干细胞的混合物直接施用于预期的活性位点（例如骨髓）来治疗受试者的组织或器官的方法腔。在一个实施方案中，本发明提供了治疗骨髓以增加循环祖细胞和干细胞数量的方法。在本发明的一些其它实施方案中，待直接施用的脱细胞细胞外基质配置为时间释放治疗剂。

8. 发明申请

WO2006023104A1 METHOD AND APPARATUS FOR INJECTION COATING A MEDICAL DEVICE 审中-公开
标题翻译：用于注射涂敷医疗装置的方法和装置
公开(公告)号：WO2006023104A1
公开(公告)日：2006-03-02
申请号：PCT/US2005/023622
申请日：2005-07-01
申请人： BOSTON SCIENTIFIC SCIMED, INC. , PANOS, Anastasia , NAIMARK, Wendy , PALASIS, Maria , FREYMAN, Toby , EPSTEIN, Samuel, J.
发明人： PANOS, Anastasia , NAIMARK, Wendy , PALASIS, Maria , FREYMAN, Toby , EPSTEIN, Samuel, J.
IPC分类号： A61F2/06
CPC分类号： B05C5/0208 , A61F2/86 , A61F2002/072 , A61L31/08 , A61L31/10 , A61L2420/02 , B05C13/025 , B05D1/002 , B05D1/26 , B05D1/30
摘要： Methods and apparatus for coating at least a portion of the surface of medical devices (40, 131) using an injection coating device (20) are disclosed. In one embodiment, the invention includes a coating method wherein an orifice (23) of the injection coating device (20) is placed adjacent a vertically positioned medical device (40), coating material is ejected from the orifice (23) onto the medical device (40), and the coating material gravitationally flows downward coating the medical device (40). In another embodiment, an orifice (23) of an injection coating device is positioned adjacent a horizontally positioned medical device (40) to gravitationally flow and deposit coating material onto the medical device (40). These methods may be used to apply one or more coating materials, simultaneously or in sequence. In another embodiment, multiple injection coating devices (134) may be utilized. In certain embodiments of the invention, the coating materials include therapeutic or biologically active agents.
摘要翻译：公开了使用注射涂覆装置（20）涂覆医疗装置（40,131）表面的至少一部分表面的方法和装置。在一个实施方案中，本发明包括一种涂覆方法，其中喷射涂覆装置（20）的孔口（23）邻近于垂直定位的医疗装置（40）放置，涂层材料从孔口（23）喷射到医疗装置（40），并且所述涂覆材料重力地向下流动涂覆所述医疗装置（40）。在另一个实施例中，注射涂覆装置的孔口（23）邻近水平定位的医疗装置（40）定位，以将涂层材料重力流动并沉积到医疗装置（40）上。这些方法可以同时或按顺序施用一种或多种涂料。在另一个实施例中，可以使用多个注射涂覆装置（134）。在本发明的某些实施方案中，涂层材料包括治疗或生物活性剂。

9. 发明申请

WO2008094548A3 LOCAL DELIVERY OF THERAPEUTIC AGENT TO HEART VALVES 审中-公开
公开(公告)号：WO2008094548A3
公开(公告)日：2008-08-07
申请号：PCT/US2008/001160
申请日：2008-01-30
申请人： BOSTON SCIENTIFIC SCIMED, INC. , PALASIS, Maria , MICKLEY, Timothy, J. , FREYMAN, Toby , NAIMARK, Wendy
发明人： PALASIS, Maria , MICKLEY, Timothy, J. , FREYMAN, Toby , NAIMARK, Wendy
IPC分类号： A61M31/00 , A61F2/24
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device (502) is provided comprising a body. The body may have a portion (518) thereof including therapeutic agent (516) and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.

10. 发明申请

WO2006078444A1 DELIVERY OF THERAPEUTIC THROUGH MULTIPLE DELIVERY MEMBERS 审中-公开
标题翻译：通过多个交付成员交付治疗
公开(公告)号：WO2006078444A1
公开(公告)日：2006-07-27
申请号：PCT/US2006/000062
申请日：2006-01-03
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FREYMAN, Toby , PALASIS, Maria , NAIMARK, Wendy , SHAW, William, J.
发明人： FREYMAN, Toby , PALASIS, Maria , NAIMARK, Wendy , SHAW, William, J.
IPC分类号： A61M25/00 , A61M25/10 , A61M5/32
CPC分类号： A61M25/0068 , A61B2017/00247 , A61B2018/00392 , A61M25/0071 , A61M25/0074 , A61M25/0084 , A61M25/10 , A61M2025/0058 , A61M2025/0076 , A61M2025/0079 , A61M2025/0085 , A61M2025/0681
摘要： Embodiments of the present application regard the delivery of therapeutic. One such apparatus may comprise multiple, independently-activated, injection devices (140) for the delivery of therapeutic or other substances. This apparatus may include a first catheter (120) ; a second catheter (130) in the first catheter and a multiple delivery member injection device (140) . This multiple delivery member may include an expandable member and a plurality of injection elements (220-224). A third catheter may be positioned in the second catheter. This third catheter may have a distal end connected to a wall of the expandable member and a plurality of filling tubes (230-234) connected to an distal end of the third catheter. In some of the embodiments each of the injection elements may hold a pressurized therapeutic prior to release of the therapeutic .
摘要翻译：本申请的实施方案涉及治疗的递送。一种这样的装置可以包括用于递送治疗剂或其它物质的多个独立激活的注射装置（140）。该装置可包括第一导管（120）; 第一导管中的第二导管（130）和多个递送部件注射装置（140）。该多个传送构件可以包括可扩张构件和多个注射元件（220-224）。第三导管可以定位在第二导管中。该第三导管可以具有连接到可扩张构件的壁的远端和连接到第三导管的远端的多个填充管（230-234）。在一些实施方案中，每个注射元件可以在释放治疗剂之前保持加压治疗。

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