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1. 发明申请

WO2011002760A1 BIODEGRADABLE IMPLANT FOR TREATING OR PREVENTING REPERFUSION INJURY 审中-公开
标题翻译：用于治疗或预防再灌注损伤的生物可降解植入物
公开(公告)号：WO2011002760A1
公开(公告)日：2011-01-06
申请号：PCT/US2010/040371
申请日：2010-06-29
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , FLANAGAN, Aiden , HARRISON, Kent , DAVIS, Liza J. , SOGARD, David J.
发明人： ATANASOSKA, Liliana , FLANAGAN, Aiden , HARRISON, Kent , DAVIS, Liza J. , SOGARD, David J.
IPC分类号： A61N1/30 , A61L31/14 , H01M6/06
CPC分类号： A61K9/0009 , A61K9/0024 , A61L31/148 , A61N1/306
摘要： A biodegradable implant for iontophoretic therapeutic agent delivery is provided. The implant comprises a biodegradable battery and at least one biodegradable iontophoresis electrode assembly. The biodegradable battery comprises first and second biodegradable electrodes and a biodegradable polymer electrolyte layer between the first and second biodegradable electrodes. The biodegradable iontophoresis electrode assembly comprises a biodegradable iontophoresis electrode and a charged therapeutic agent. When the biodegradable battery is electrically connected to generate an electric current through the biodegradable iontophoresis electrode assembly, the charged therapeutic agent is delivered by iontophoresis to a target location. The charged therapeutic agent may be a scavenger for reactive oxygen species. The electrical connection of the biodegradable battery may be controlled remotely.
摘要翻译：提供了用于离子电渗治疗剂递送的生物可降解植入物。植入物包括可生物降解的电池和至少一个可生物降解的离子电渗电极组件。生物可降解电池包括第一和第二生物可降解电极和第一和第二生物可降解电极之间的可生物降解的聚合物电解质层。可生物降解的离子电渗电极组件包括可生物降解的离子电渗电极和带电的治疗剂。当可生物降解的电池电连接以产生通过可生物降解的离子电渗电极组件的电流时，带电的治疗剂通过离子电渗法递送到目标位置。带电的治疗剂可以是活性氧的清除剂。可生物降解的电池的电气连接可以远程控制。

2. 发明申请

WO2010129184A2 MAGNETIC PARTICLES FOR DELIVERING THERAPEUTIC AGENT TO A TARGET LOCATION 审中-公开
标题翻译：用于将治疗药物递送至目标位置的磁性颗粒
公开(公告)号：WO2010129184A2
公开(公告)日：2010-11-11
申请号：PCT/US2010/032035
申请日：2010-04-22
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FLANAGAN, Aiden , HARRISON, Kent , ATANASOSKA, Liliana , SOGARD, David J. , DAVIS, Liza J.
发明人： FLANAGAN, Aiden , HARRISON, Kent , ATANASOSKA, Liliana , SOGARD, David J. , DAVIS, Liza J.
IPC分类号： A61K9/00
CPC分类号： A61K9/0009 , A61K9/1676 , A61K9/501 , A61K9/5094 , A61K9/5115
摘要： A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel.
摘要翻译：提供了根据一个实施例的用于将治疗剂递送到身体中的目标位置的系统，其包括多个磁性颗粒，每个携带治疗剂的磁性颗粒和用于将磁性颗粒吸引到目标位置的磁性装置。磁性颗粒可以通过导管输送到目标位置上游的血管中，使得它们朝向目标位置行进。根据另一实施例的用于将治疗剂递送到身体中的目标位置的方法包括提供多个磁性颗粒，每个磁性颗粒携带治疗剂，将磁性装置放置在将磁性颗粒吸引到目标位置的位置，并且允许磁性颗粒通过磁性颗粒吸引到磁性装置来注入目标位置。治疗剂可以包括用于预防或治疗再灌注损伤的治疗剂，并且提供多个磁性颗粒的步骤可以包括通过血管递送多个磁性颗粒。

3. 发明申请

WO2011008534A1 IMPLANTABLE SELF-POWERED BIODEGRADABLE MEDICAL DEVICE TO TREAT OR PREVENT REPERFUSION INJURY 审中-公开
标题翻译：可植入式自动生物可降解医疗设备治疗或预防再灌注损伤
公开(公告)号：WO2011008534A1
公开(公告)日：2011-01-20
申请号：PCT/US2010/040362
申请日：2010-06-29
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , FLANAGAN, Aiden , DAVIS, Liza J. , HARRISON, Kent , SOGARD, David J.
发明人： ATANASOSKA, Liliana , FLANAGAN, Aiden , DAVIS, Liza J. , HARRISON, Kent , SOGARD, David J.
IPC分类号： A61M31/00 , A61N1/30
CPC分类号： A61M5/14276
摘要： In one embodiment, the present disclosure provides a biodegradable, self-powered medical device for preventing or reducing reperfusion injury, comprising a galvanic cell, the galvanic cell comprising: a first biodegradable electrode member; and a second biodegradable electrode member comprising a biodegradable conductive polymer and an electrode-releasable therapeutic agent, wherein the galvanic cell generates an electric force sufficient to cause the electrode-releasable therapeutic agent to be released from the biodegradable conductive polymer and elute to a target location. The device may further include a reservoir material containing a burst-release therapeutic agent.
摘要翻译：在一个实施方案中，本公开提供了一种用于预防或减少再灌注损伤的可生物降解的自供电医疗装置，包括原电池，所述原电池包括：第一可生物降解的电极构件; 以及包含可生物降解的导电聚合物和电极可释放的治疗剂的第二可生物降解的电极构件，其中所述原电池产生足以使所述电极可释放的治疗剂从所述可生物降解的导电聚合物释放并洗脱至目标位置的电力。该装置还可以包括含有爆发释放治疗剂的贮存器材料。

4. 发明申请

WO2008121933A1 USING MAGNETISM TO PREPARE A MEDICAL DEVICE 审中-公开
标题翻译：使用MAGNETISM制定医疗器械
公开(公告)号：WO2008121933A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/058848
申请日：2008-03-31
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , FLANAGAN, Aiden , O'CONNOR, Timothy , MCMORROW, David , NOLAN, Robert , MALONE, Anthony , WEBER, Jan
发明人： ATANASOSKA, Liliana , FLANAGAN, Aiden , O'CONNOR, Timothy , MCMORROW, David , NOLAN, Robert , MALONE, Anthony , WEBER, Jan
IPC分类号： A61F2/82 , B05D1/00 , B05B5/00 , B05C3/09 , A61L31/10
CPC分类号： B05B5/00 , A61F2/91 , A61F2210/009 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/60 , A61L2300/62 , B05C3/09 , B05D1/18 , B05D1/32 , B05D3/207 , B05D2401/32
摘要： The present invention is directed to methods, processes, and systems for delivering therapeutic agent to a medical device (114). Under some methods, processes, and systems of the invention, particles including a magnetic material (122) and a therapeutic agent may be directed towards a medical device via magnetic attraction (132). In another embodiment particles including a magnetic material may force a therapeutic agent/solvent solution into porous matrix by using a magnetic attraction. In still another embodiment, a medical device having at least a portion thereof including a magnetic material is used to attract and adhere particles comprising magnetic material and therapeutic agent to a target surface of the medical device, wherein the particles are fused to the target surface.
摘要翻译：本发明涉及将治疗剂递送到医疗装置（114）的方法，过程和系统。在一些方法下，本发明的方法和系统可以通过磁吸引（132）将包括磁性材料（122）和治疗剂的颗粒引向医疗装置。在另一个实施方案中，包括磁性材料的颗粒可以通过使用磁吸引剂将治疗剂/溶剂溶液强制成多孔基质。在另一个实施例中，使用包括磁性材料的至少其一部分的医疗装置将包含磁性材料和治疗剂的颗粒吸附并附着到医疗装置的靶表面上，其中所述颗粒与目标表面融合。

5. 发明申请

WO2010101901A2 SELF-BUFFERING MEDICAL IMPLANTS 审中-公开
标题翻译：自助医疗植入物
公开(公告)号：WO2010101901A2
公开(公告)日：2010-09-10
申请号：PCT/US2010/025896
申请日：2010-03-02
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , SHIPPY, James, Lee, III , HOLMAN, Tom , ARNEY, Michael, S. , SCHOENLE, Victor , GENOVESE, Frank , FENG, James Q. , FLANAGAN, Aiden , WEBER, Jan
发明人： ATANASOSKA, Liliana , SHIPPY, James, Lee, III , HOLMAN, Tom , ARNEY, Michael, S. , SCHOENLE, Victor , GENOVESE, Frank , FENG, James Q. , FLANAGAN, Aiden , WEBER, Jan
IPC分类号： A61L27/04
CPC分类号： A61L31/148 , A61L27/34 , A61L27/446 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2400/12 , A61L2420/04 , C08L67/04
摘要： A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.
摘要翻译：医疗植入物包括生物腐蚀性部分，其包括生物可蚀解聚合物和生物腐蚀性金属。生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。生物腐蚀金属在生理条件下降解形成碱性降解产物。酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。在一个方面，生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。在另一方面，医疗植入物可以包括主体，身体上的生物可蚀解聚合物的多个离散沉积物，以及身体上的生物可腐蚀金属的多个离散沉积物。

6. 发明申请

WO2011126708A1 ENDOPROSTHESIS 审中-公开
标题翻译：内置假体
公开(公告)号：WO2011126708A1
公开(公告)日：2011-10-13
申请号：PCT/US2011/029002
申请日：2011-03-18
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , ATANASOSKA, Liliana , SHIPPY III, James Lee , SCHEUERMANN, Torsten , GREGORICH, Daniel J. , MEYER, Michael P.
发明人： WEBER, Jan , ATANASOSKA, Liliana , SHIPPY III, James Lee , SCHEUERMANN, Torsten , GREGORICH, Daniel J. , MEYER, Michael P.
IPC分类号： A61L31/08 , A61L31/14
CPC分类号： A61L31/088 , A61L31/044 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/16 , Y10T29/49826 , C08L67/04
摘要： Among other things, a bio-erodible implantable endoprosthesis comprises a member that includes (a) a core having a surface, and (b) a bio-erodible metal on a least a portion of the surface of the core, wherein the bio-erodible metal erodes more slowly than the core and includes openings through which physiological fluids can access the core upon implantation.
摘要翻译：除其他之外，生物可蚀刻的可植入内用假体包括一种构件，其包括（a）具有表面的芯，和（b）芯的表面的至少一部分上的生物可侵蚀金属，其中生物可蚀刻金属腐蚀比核心更慢，并且包括生理流体在植入时可通过其进入核心的开口。

7. 发明申请

WO2011011531A2 BIOERODIBLE MEDICAL IMPLANTS 审中-公开
标题翻译：生物医学植入物
公开(公告)号：WO2011011531A2
公开(公告)日：2011-01-27
申请号：PCT/US2010/042772
申请日：2010-07-21
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , STINSON, Jonathan, S. , DENG, Charles , BOISMIER, Dennis, A. , WEBER, Jan , SCHEUERMANN, Torsten
发明人： ATANASOSKA, Liliana , STINSON, Jonathan, S. , DENG, Charles , BOISMIER, Dennis, A. , WEBER, Jan , SCHEUERMANN, Torsten
IPC分类号： A61L31/02
CPC分类号： A61L31/022 , A61L31/124 , A61L31/127 , A61L31/148
摘要： A medical implant includes a bioerodible portion adapted to degrade under physiological conditions. The bioerodible portion includes a bioerodible metal matrix and a salt or clay within the bioerodible metal matrix.
摘要翻译：医疗植入物包括适于在生理条件下降解的生物可蚀解部分。生物可蚀解部分包括生物蚀解性金属基质和生物蚀解性金属基质内的盐或粘土。

8. 发明申请

WO2010019645A2 MEDICAL DEVICES HAVING ELECTRODEPOSITED CONDUCTIVE POLYMER COATINGS 审中-公开
标题翻译：具有电沉积导电聚合物涂层的医疗装置
公开(公告)号：WO2010019645A2
公开(公告)日：2010-02-18
申请号：PCT/US2009/053521
申请日：2009-08-12
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , CHANDRASEKARAN, Chandru , WARNER, Robert, W. , WEBER, Jan
发明人： ATANASOSKA, Liliana , CHANDRASEKARAN, Chandru , WARNER, Robert, W. , WEBER, Jan
IPC分类号： A61L31/10
CPC分类号： A61L31/10 , A61L31/14 , C08L101/12
摘要： According to one aspect, the present invention provides implantable or insertable medical devices that comprise a substrate and a coating over the substrate that comprises at least one type of conductive polymer and at least one type of additional polymer.
摘要翻译：根据一个方面，本发明提供了可植入或可插入的医疗装置，其包括衬底和衬底上的涂层，其包括至少一种类型的导电聚合物和至少一种类型的另外的聚合物。

9. 发明申请

WO2009154961A3 MEDICAL DEVICES HAVING ELECTRODEPOSITED COATINGS 审中-公开
公开(公告)号：WO2009154961A3
公开(公告)日：2009-12-23
申请号：PCT/US2009/045223
申请日：2009-05-27
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , FALK, Wayne , ZOROMSKI, Michele , WARNER, Robert, W.
发明人： ATANASOSKA, Liliana , FALK, Wayne , ZOROMSKI, Michele , WARNER, Robert, W.
IPC分类号： A61L31/02 , A61L31/08 , A61L31/12 , A61L31/16
摘要： According to one aspect, the present invention provides implantable or insertable medical devices that comprise a conductive substrate and an electrodeposited coating over the substrate. The electrodeposited coating includes (a) one or more types of inorganic materials, (b) one or more types of polymeric materials and (c) optionally, one or more types of therapeutic agents. Still other aspects of the invention concern methods of making and using such devices.

10. 发明申请

WO2008083069A2 BIOERODIBLE NANO-FIBROUS AND NANO-POROUS CONDUCTIVE COMPOSITES 审中-公开
标题翻译：可生物降解的纳米纤维和纳米多孔导电复合材料
公开(公告)号：WO2008083069A2
公开(公告)日：2008-07-10
申请号：PCT/US2007/088533
申请日：2007-12-21
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , FENG, James Q. , WEBER, Jan , SHIPPY III, James Lee
发明人： ATANASOSKA, Liliana , FENG, James Q. , WEBER, Jan , SHIPPY III, James Lee
IPC分类号： A61L27/44 , A61L27/50 , A61L27/54 , A61L27/58 , A61L29/12 , A61L29/14 , A61L29/16 , A61L31/12 , A61L31/14 , A61L31/16
CPC分类号： A61L27/40 , A61L27/14 , A61L27/50 , A61L27/58 , A61L2400/12
摘要： A bioerodible conductive tissue scaffold that can provide, e.g., improved tissue growth.
摘要翻译：可以提供例如改善的组织生长的生物蚀蚀性导电组织支架。

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