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1. 发明申请

WO2011082171A1 SYSTEMS AND METHODS FOR MULTI-FREQUENCY IMAGING OF PATIENT TISSUE USING INTRAVASCULAR ULTRASOUND IMAGING SYSTEMS 审中-公开
标题翻译：使用静脉超声成像系统对患者组织进行多次成像的系统和方法
公开(公告)号：WO2011082171A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/062238
申请日：2010-12-28
申请人： BOSTON SCIENTIFIC SCIMED, INC. , LI, Wenguang , TEO, Tat-Jin , SATHYANARAYANA, Shashidhar
发明人： LI, Wenguang , TEO, Tat-Jin , SATHYANARAYANA, Shashidhar
IPC分类号： A61B8/12 , G01S15/89
CPC分类号： A61B8/4461 , A61B5/02007 , A61B8/12 , A61B8/445 , G01S15/8952
摘要： A method for imaging patient tissue using an intravascular ultrasound image includes inserting a catheter (102) into a patient blood vessel. The catheter includes at least one transducer (312) configured and arranged for insertion into a lumen of the catheter. Acoustic signals are transmitted from the at least one transducer along a series of scan lines towards patient tissue between incremental rotations of the at least one transducer. The transmitted acoustic signals include first acoustic signals having first frequency bandwidths centered at a first center frequency and second acoustic signals having second frequency bandwidths centered at a second center frequency. Corresponding echo signals reflected from patient tissue are received, transformed, processed, and displayed.
摘要翻译：使用血管内超声图像对患者组织进行成像的方法包括将导管（102）插入患者血管。该导管包括至少一个构造和布置成用于插入导管内腔的换能器（312）。在至少一个换能器的增量旋转之间，声信号沿着一系列扫描线从至少一个换能器传送到患者组织。所发送的声信号包括具有以第一中心频率为中心的第一频率带宽的第一声信号和具有以第二中心频率为中心的第二频带宽度的第二声信号。从患者组织反射的相应的回波信号被接收，变换，处理和显示。

2. 发明申请

WO2013013156A2 PERCUTANEOUS DEVICES AND METHODS TO VISUALIZE, TARGET AND ABLATE NERVES 审中-公开
标题翻译： PERCUTANEOUS DEVICES AND METHODS to VISUALIZE，TARGET AND ABLATE NERVES
公开(公告)号：WO2013013156A2
公开(公告)日：2013-01-24
申请号：PCT/US2012/047614
申请日：2012-07-20
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SCHEUERMANN, Torsten , TEO, Tat-Jin , HASTINGS, Roger N.
发明人： SCHEUERMANN, Torsten , TEO, Tat-Jin , HASTINGS, Roger N.
IPC分类号： A61M25/10 , A61B5/00 , A61B18/24 , A61B5/20
CPC分类号： A61N7/02 , A61B5/0071 , A61B5/0095 , A61B5/01 , A61B5/04001 , A61B5/201 , A61B5/4029 , A61B8/4461 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B18/26 , A61B2018/00023 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00386 , A61B2018/00404 , A61B2018/00494 , A61B2018/00511 , A61B2018/00577 , A61B2018/00791 , A61B2090/3966 , A61N1/403 , A61N7/00 , A61N2007/003 , A61N2007/0082 , A61N2007/0091
摘要： Apparatuses for identifying nerve tissue and methods for making and using the same are disclosed. An example apparatus may include an elongate shaft having a distal region configured to be percutaneously deployed within a patient. An active imaging structure may be disposed on the distal region. The active imaging structure may be configured to remotely image nerve tissue by exciting a signal in nerve tissue from a percutaneous location and receiving the signal from a percutaneous location. The active imaging structure may include one or more probes.
摘要翻译：公开了用于鉴定神经组织的装置及其制造和使用方法。示例性装置可以包括细长轴，其具有构造成经皮部署在患者体内的远侧区域。主动成像结构可以设置在远侧区域上。活动成像结构可以被配置为通过从经皮位置激发神经组织中的信号并从经皮位置接收信号来远程地图像神经组织。主动成像结构可以包括一个或多个探针。

3. 发明申请

WO2012091903A1 IMAGING ASSEMBLY COMBINING INTRAVASCULAR ULTRASOUND AND OPTICAL COHERENCE TOMOGRAPHY 审中-公开
标题翻译：成像组件结合血管内超声和光学相干计算
公开(公告)号：WO2012091903A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/064358
申请日：2011-12-12
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： TEO, Tat-Jin , HASTINGS, Roger
IPC分类号： A61B8/12 , A61B3/10 , A61B5/00
CPC分类号： A61B8/12 , A61B5/0066 , A61B5/0084 , A61B5/6852 , A61B5/6876 , A61B5/7425 , A61B8/445 , A61B8/4461
摘要： Techniques are described that combine intravascular ultrasound ("IVUS") and optical coherence tomography into a single catheter that utilizes a micro-motor driven imaging core for imaging of patient tissue, e.g., a blood vessel wall. In one example, an imaging assembly includes a catheter (100), an imaging core (200) with a micro-motor, one or more transducer conductors, an optical coherence tomography apparatus (136), and one or more optical fibers (138) in communication with the optical coherence tomography apparatus.
摘要翻译：描述了将血管内超声（“IVUS”）和光学相干断层摄影结合到单个导管中的技术，该导管利用微电机驱动的成像核心来成像患者组织，例如血管壁。在一个示例中，成像组件包括导管（100），具有微电机的成像芯（200），一个或多个换能器导体，光学相干断层摄影装置（136）和一个或多个光纤（138）与光学相干断层摄影装置通信。

4. 发明申请

WO2010138448A1 SYSTEMS AND METHODS FOR MAKING AND USING IMAGE-GUIDED INTRAVASCULAR AND ENDOCARDIAL THERAPY SYSTEMS 审中-公开
标题翻译：制造和使用图像引导的血管内和外科治疗系统的系统和方法
公开(公告)号：WO2010138448A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/035944
申请日：2010-05-24
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KIM, Grace , TEO, Tat-Jin , HUIBREGTSE, Barbara
发明人： KIM, Grace , TEO, Tat-Jin , HUIBREGTSE, Barbara
IPC分类号： A61B8/12
CPC分类号： A61B5/4839 , A61B8/12 , A61B8/445
摘要： A catheter assembly includes a catheter and a delivery element The catheter has a distal end with a distal tip, a proximal end, and a longitudinal length, the catheter includes a body that defines a central lumen extending along the catheter to the distal end. The catheter also includes a forward-facing transducer array disposed at the distal tip of the catheter. The transducer array is configured and arranged for transforming applied electrical signals to acoustic signals and also for transforming received echo signals to electrical signals. At least one catheter conductor is electrically coupled to the transducer array and extends along the catheter. The delivery element is disposed in the lumen of the catheter. The delivery element includes a distal tip that is configured and arranged for contacting patient tissue, The distal tip of the delivery element is configured and arranged to extend beyond the distal tip of the catheter.
摘要翻译：导管组件包括导管和输送元件。导管具有远端，其具有远侧末端，近端和纵向长度，导管包括限定沿着导管延伸到远端的中心腔的主体。导管还包括设置在导管的远端的前向换能器阵列。换能器阵列被配置和布置用于将施加的电信号转换成声信号，并且还用于将接收到的回波信号变换为电信号。至少一个导管导体电耦合到换能器阵列并且沿导管延伸。输送元件设置在导管的内腔中。递送元件包括构造和布置成用于接触患者组织的远侧末端。输送元件的远侧末端被构造和布置成延伸超过导管的远侧末端。

5. 发明申请

WO2010117634A2 SYSTEMS AND METHODS FOR MAKING AND USING A IMAGING CORE OF AN INTRAVASCULAR ULTRASOUND IMAGING SYSTEM 审中-公开
标题翻译：用于制造和使用静脉超声成像系统的成像核心的系统和方法
公开(公告)号：WO2010117634A2
公开(公告)日：2010-10-14
申请号：PCT/US2010/028454
申请日：2010-03-24
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HASTINGS, Roger, N. , PIKUS, Michael, J. , EDMUNDS, Kevin, D. , TEO, Tat-Jin
发明人： HASTINGS, Roger, N. , PIKUS, Michael, J. , EDMUNDS, Kevin, D. , TEO, Tat-Jin
IPC分类号： A61B8/14
CPC分类号： A61B8/4461 , A61B5/02007 , A61B8/12 , A61B8/4281 , A61B8/445
摘要： An imaging assembly for an intravascular ultrasound system includes a catheter, an imaging core, and at least one transducer conductor. The imaging core is insertable into the catheter and extendable from a distal end of the catheter. The imaging core includes a rotatable magnet, a tilted reflective surface, and at least one fixed transducer all disposed in a body. The rotatable magnet is configured and arranged to rotate by a magnetic field generated external to the catheter. The tilted reflective surface rotates with the magnet. The at least one transducer is configured and arranged for transforming applied electrical signals to acoustic signals and also for transforming received echo signals to electrical signals. The at least one transducer conductor is electrically coupled to the at least one transducer and is configured and arranged to extend into the catheter when the imaging core is extended from the catheter.
摘要翻译：用于血管内超声系统的成像组件包括导管，成像芯和至少一个换能器导体。成像芯可插入导管中并且可从导管的远端延伸。成像芯包括可旋转的磁体，倾斜的反射表面以及全部设置在主体中的至少一个固定换能器。可旋转磁体被构造和布置成通过导管外部产生的磁场旋转。倾斜的反射表面与磁体一起旋转。所述至少一个换能器被配置和布置成用于将所施加的电信号变换成声信号，并且还用于将接收的回波信号变换为电信号。所述至少一个换能器导体电耦合到所述至少一个换能器并且被配置和布置成当所述成像芯从所述导管延伸时延伸到所述导管中。

6. 发明申请

WO2010117630A1 SYSTEMS AND METHODS FOR MAKING AND USING A MOTOR DISTALLY-POSITIONED WITHIN A CATHETER OF AN INTRAVASCULAR ULTRASOUND IMAGING SYSTEM 审中-公开
标题翻译：用于制造和使用在静脉超声成像系统的导管内进行远程定位的电机的系统和方法
公开(公告)号：WO2010117630A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/028439
申请日：2010-03-24
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HASTINGS, Roger, N. , PIKUS, Michael, J. , TEO, Tat-Jin , RICHARDSON, Leonard, B. , EDMUNDS, Kevin, D.
发明人： HASTINGS, Roger, N. , PIKUS, Michael, J. , TEO, Tat-Jin , RICHARDSON, Leonard, B. , EDMUNDS, Kevin, D.
IPC分类号： A61B8/12
CPC分类号： A61B8/12 , A61B8/445
摘要： An imaging core, that is configured and arranged for insertion into a catheter, includes a mirror disposed at a distal end of a rotatable driveshaft; a motor coupled to the driveshaft and including a rotatable magnet and at least two magnetic field windings disposed around at least a portion of the magnet on a rigid slotted material; and at least one fixed transducer positioned between the motor and the rotatable mirror. The driveshaft extends through an aperture in the magnet to allow passage of the driveshaft through the at least one transducer to the rotatable mirror. At least one transducer conductor is electrically coupled to the at least one transducer and in electrical communication with the proximal end of the catheter. At least one motor conductor is electrically coupled to the magnetic field windings and in electrical communication with the proximal end of the catheter.
摘要翻译：被构造和布置成用于插入导管中的成像芯包括布置在可旋转驱动轴的远端处的反射镜; 耦合到所述驱动轴并且包括可旋转磁体的电动机和至少两个设置在所述磁体的至少一部分上的刚性开槽材料上的磁场绕组; 以及位于电动机和可旋转镜之间的至少一个固定换能器。驱动轴延伸通过磁体中的孔，以允许驱动轴通过至少一个换能器到达可旋转镜。至少一个换能器导体电耦合到至少一个换能器并且与导管的近端电连通。至少一个电动机导体电耦合到磁场绕组并且与导管的近端电连通。

7. 发明申请

WO2013074661A2 INTEGRATED ULTRASOUND ABLATION AND IMAGING DEVICE AND RELATED METHODS 审中-公开
标题翻译：一体化超声波吸收和成像装置及相关方法
公开(公告)号：WO2013074661A2
公开(公告)日：2013-05-23
申请号：PCT/US2012/065064
申请日：2012-11-14
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： HASTINGS, Roger N. , PIKUS, Michael J. , EDMUNDS, Kevin D. , SMITH, Scott R. , RICHARDSON, Leonard B. , TEO, Tat-Jin
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/12 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00636 , A61B2090/3784 , A61N7/022 , A61N2007/003 , A61N2007/0052 , A61N2007/0078 , A61N2007/0091 , A61N2007/0095 , A61N2007/027
摘要： Intravascular nerve modulation systems and methods for making and using the same are disclosed. An example system may include an elongate shaft having a proximal end region and a distal end region and a central longitudinal axis. An ablation transducer may be disposed at the distal end region. The system may also include a rotational drive configured to rotate the ablation transducer about the central longitudinal axis. A control and power system may be operably connected to the ablation transducer and the rotational drive. In some instances, the ablation transducer may be a combined ablation and imaging transducer.
摘要翻译：公开了血管内神经调节系统及其制造和使用方法。示例性系统可以包括具有近端区域和远端区域以及中心纵向轴线的细长轴。消融换能器可以设置在远端区域。该系统还可以包括旋转驱动器，其构造成围绕中心纵向轴线旋转消融换能器。控制和动力系统可以可操作地连接到消融换能器和旋转驱动器。在一些情况下，消融换能器可以是组合消融和成像换能器。

8. 发明申请

WO2011037842A2 SYSTEMS AND METHODS FOR MAKING AND USING A STEPPER MOTOR FOR AN INTRAVASCULAR ULTRASOUND IMAGING SYSTEM 审中-公开
标题翻译：用于制造和使用步进电机进行静脉超声成像系统的系统和方法
公开(公告)号：WO2011037842A2
公开(公告)日：2011-03-31
申请号：PCT/US2010/049384
申请日：2010-09-17
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HASTINGS, Roger, N. , EDMUNDS, Kevin, D. , TEO, Tat-Jin
发明人： HASTINGS, Roger, N. , EDMUNDS, Kevin, D. , TEO, Tat-Jin
IPC分类号： A61B8/12
CPC分类号： A61B8/4461 , A61B8/12 , A61B8/445
摘要： A catheter assembly for an intravascular ultrasound system includes an imaging core disposed in a lumen of a catheter. The imaging core includes a stepper motor that rotates a mirror coupled to a driveshaft. The stepper motor provides step-wise rotation of the driveshaft using a rotatabSe magnet and at least two magnetic field windings disposed around at least a portion of the magnet. At least one fixed transducer is positioned between the stepper motor and the mirror. The stepper motor permits stepwise rotation of the driveshaft with steps of 3 degrees or less. At least one transducer conductor is electrically coupled to the at least one transducer and in electrical communication with a proximal end of the catheter. At least one motor conductor is electrically coupled to the magnetic field windings and in electrical communication with the proximal end of the catheter.
摘要翻译：用于血管内超声系统的导管组件包括设置在导管内腔中的成像芯。成像芯包括使耦合到驱动轴的反射镜旋转的步进电机。步进电机使用旋转磁体和至少两个设置在磁体的至少一部分周围的磁场绕组来提供驱动轴的逐步旋转。至少有一个固定传感器位于步进电机和镜子之间。步进电机允许驱动轴逐步旋转3度或更小的步长。至少一个换能器导体电耦合到所述至少一个换能器并且与导管的近端电连通。至少一个电动机导体电耦合到磁场绕组并且与导管的近端电连通。

9. 发明申请

WO2009117217A1 ULTRASOUND IMAGING WITH SPECKLE SUPPRESSION 审中-公开
标题翻译：超声波成像与带状抑制
公开(公告)号：WO2009117217A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/034953
申请日：2009-02-24
申请人： BOSTON SCIENTIFIC SCIMED, INC , TEO, Tat-Jin
发明人： TEO, Tat-Jin
IPC分类号： G01S7/52 , G10K11/34 , A61B8/14
CPC分类号： A61B8/14 , G01S7/52077 , G01S15/8927
摘要： Described herein are systems and methods for suppressing speckle noise in ultrasound imaging. In an embodiment, speckle noise suppression is provided by incoherently summing echo waves that impinge the active aperture of the transducers. This incoherent summation prevents echo waves from destructively interfering and therefore prevents the signal 'nulls' that characterize speckle noise. In an exemplary embodiment, the incoherent summation is performed by sub-dividing a transducer into a plurality of smaller transducers (210a, 210b, 210c) and incoherently summing the electrical signals from the smaller transducers. In one exemplary embodiment, each of the smaller transducers is coupled to a separate rectifier (230a, 230b, 230c), which rectifies the electrical signal from the respective transducer into a rectified signal. The rectified signals from the rectifiers are then summed (250) to provide the incoherent summation.
摘要翻译：这里描述了用于抑制超声成像中的斑点噪声的系统和方法。在一个实施例中，散斑噪声抑制是通过对入射到换能器的有效孔径的回波进行非相干求和来提供的。这种非相干求和可以防止回波产生破坏性的干扰，从而防止表征斑点噪声的信号“零”。在示例性实施例中，通过将换能器分割成多个较小的换能器（210a，210b，210c）并对来自较小换能器的电信号进行非相干求和来执行非相干相加。在一个示例性实施例中，每个更小的换能器耦合到单独的整流器（230a，230b，230c），其将来自相应换能器的电信号整流为整流信号。然后将来自整流器的整流信号求和（250）以提供非相干求和。

10. 发明申请

WO2009114278A1 IMAGING CATHETER WITH INTEGRATED CONTRAST AGENT INJECTOR 审中-公开
标题翻译：成像导管与集成对比剂注射器
公开(公告)号：WO2009114278A1
公开(公告)日：2009-09-17
申请号：PCT/US2009/035254
申请日：2009-02-26
申请人： BOSTON SCIENTIFIC SCIMED, INC , KNIGHT, Jon, M. , TEO, Tat-Jin , ROMLEY, Richard , LI, Wenguang
发明人： KNIGHT, Jon, M. , TEO, Tat-Jin , ROMLEY, Richard , LI, Wenguang
IPC分类号： A61B8/00 , A61B8/12 , A61M37/00 , A61B8/06 , A61M5/00
CPC分类号： A61B8/06 , A61B8/12 , A61B8/481 , A61B8/543 , A61M5/007 , A61M5/172 , A61M37/0092 , A61M2025/0037 , A61M2025/0039
摘要： Described herein are systems and methods that integrate the injection of contrast agents with imaging catheters. In an embodiment, an imaging catheter (105) comprises a catheter sheath (110) and an imager (125), e.g., ultrasound transducer. The imaging catheter further comprises a contrast lumen (115) having one or more exit ports (135) for injecting contrast agent into the patient. The contrast lumen extends along the catheter sheath and may be external to or integrated into the catheter sheath. Preferably, the exit port of the contrast lumen is positioned along the catheter sheath at a relatively short known distance from the imager. The catheter may include multiple contrast lumens for injecting different types of contrast agents. In an embodiment, a synchronizing controller is provided to automatically synchronize the injection of contrast agent with imaging. In another embodiment, drug-filled microbubbles in combination with ultrasound imaging are used to deliver a controlled drug dose to a specific treatment site.
摘要翻译：本文描述的是将造影剂注射成像导管整合的系统和方法。在一个实施例中，成像导管（105）包括导管护套（110）和成像器（125），例如超声换能器。成像导管还包括具有用于将造影剂注射到患者体内的一个或多个出口（135）的造影腔（115）。造影腔沿着导管鞘延伸并且可以在导管鞘外部或整合到导管鞘中。优选地，造影管腔的出口以距离成像器相对短的已知距离沿着导管护套定位。导管可以包括用于注射不同类型的造影剂的多个对比腔。在一个实施例中，提供同步控制器以自动同步造影剂的注入与成像。在另一个实施方案中，将药物填充的微泡与超声成像组合用于将受控药物剂量递送至特定治疗部位。

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