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    • 3. 发明申请
    • MEDICAL DEVICES HAVING A BIORESORBABLE COATING LAYER WITH A PRE-DETERMINED PATTERN FOR FRAGMENTATION
    • 具有预先确定的图案的可生物降解涂层的医疗装置
    • WO2009137384A2
    • 2009-11-12
    • PCT/US2009/042666
    • 2009-05-04
    • BOSTON SCIENTIFIC SCIMED, INC.EDELMAN, PeterALI, Afsar
    • EDELMAN, PeterALI, Afsar
    • A61L31/10A61L31/14A61L31/16
    • A61L31/148A61L31/10A61L31/16A61L2300/00
    • Intravascular medical devices comprising a coating layer disposed on a substrate associated with the medical device, wherein the coating layer has a pre-determined fragmentation pattern. At least a portion of the coating layer comprises a plurality of discontinuous bioresorbable members, wherein the discontinuous bioresorbable members have a size less than the luminal diameter of an arteriole. The coating layer may be formed by excavating portions of a coating layer (e.g., by laser ablation) to create gaps which define the discontinuous bioresorbable members. In certain embodiments, the coating layer is formed of a heat-bondable material. In such embodiments, the discontinuous bioresorbable members may be adhered to the substrate via heat bonds. Also disclosed are methods of forming a coating layer on medical devices and methods of treating intravascular sites.
    • 包括设置在与医疗装置相关联的衬底上的涂层的血管内医疗装置,其中所述涂层具有预定的碎裂模式。 所述涂层的至少一部分包括多个不连续的生物可再吸收构件,其中所述不连续的生物可再吸收构件的尺寸小于小动脉的管腔直径。 可以通过挖掘涂层的部分(例如通过激光烧蚀)来形成涂层以产生限定不连续生物可再吸收构件的间隙。 在某些实施方案中,涂层由可热粘合的材料形成。 在这样的实施例中,不连续的生物可再吸收构件可以通过热键粘附到基底上。 还公开了在医疗装置上形成涂层的方法和治疗血管内部位的方法。