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1. 发明申请

WO2010096516A2 BIOERODIBLE ENDOPROSTHESIS 审中-公开
标题翻译：生物不良内分泌
公开(公告)号：WO2010096516A2
公开(公告)日：2010-08-26
申请号：PCT/US2010024520
申请日：2010-02-18
申请人： BOSTON SCIENT SCIMED INC , SCHEUERMANN TORSTEN , WEBER JAN , ALBRECHT PETER
发明人： SCHEUERMANN TORSTEN , WEBER JAN , ALBRECHT PETER
IPC分类号： A61L29/02
CPC分类号： A61L31/022 , A61L29/02 , A61L29/148 , A61L31/148
摘要： A bioerodible stent, having a composition comprising Fe, Mn, Si and C has desirable mechanical, erosion, and physiological characteristics.
摘要翻译：具有包含Fe，Mn，Si和C的组成的生物可蚀解支架具有期望的机械，侵蚀和生理特性。

2. 发明申请

WO2009131911A2 MEDICAL DEVICES HAVING A COATING OF INORGANIC MATERIAL 审中-公开
标题翻译：具有无机材料涂层的医疗装置
公开(公告)号：WO2009131911A2
公开(公告)日：2009-10-29
申请号：PCT/US2009040964
申请日：2009-04-17
申请人： BOSTON SCIENT SCIMED INC , FLANAGAN AIDEN , KILCOOLEY JOHN , O'CONNOR TIM , O'BRIEN BARRY , SEIDEL DOMINIQUE , KUEHLING MICHAEL , SCHEUERMANN TORSTEN , WEBER JAN
发明人： FLANAGAN AIDEN , KILCOOLEY JOHN , O'CONNOR TIM , O'BRIEN BARRY , SEIDEL DOMINIQUE , KUEHLING MICHAEL , SCHEUERMANN TORSTEN , WEBER JAN
IPC分类号： A61L31/08 , A61L31/16
CPC分类号： A61L29/10 , A61L29/16 , A61L31/082 , A61L31/16 , A61L2300/602 , A61L2300/61
摘要： In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating. In yet another aspect, a medical device has a polymer layer comprising a block co-polymer, wherein the polymer layer contains a therapeutic agent, and a barrier layer disposed over the polymer layer, wherein the barrier layer comprises an inorganic material, and wherein the barrier layer has a plurality of discontinuities. Methods of forming coatings on medical devices and methods of delivering therapeutic agents to body sites are also disclosed.
摘要翻译：在一个方面，医疗装置具有第一构造和第二构造，包含治疗剂的贮存器和设置在贮存器上方的阻挡层，其中阻挡层包括无机材料。在另一方面，医疗装置具有容纳治疗剂的储存器，设置在贮存器上方的阻挡层，其中所述阻挡层包括无机材料，以及设置在所述阻挡层和所述医疗装置的表面之间的可溶胀材料，其中可膨胀材料是暴露于含水环境时膨胀的材料。在另一方面，医疗装置具有多层涂层，其具有交替的储层和阻挡层，以及穿透多层涂层的至少部分厚度的多个挖掘区域。在另一方面，医疗装置具有包含嵌段共聚物的聚合物层，其中所述聚合物层含有治疗剂，以及设置在所述聚合物层上的阻挡层，其中所述阻挡层包含无机材料，并且其中阻挡层具有多个不连续性。还公开了在医疗装置上形成涂层的方法和将治疗剂递送到身体部位的方法。

3. 发明申请

WO2010011515A3 MEDICAL DEVICES HAVING INORGANIC BARRIER COATINGS 审中-公开
标题翻译：具有无机屏障涂层的医疗设备
公开(公告)号：WO2010011515A3
公开(公告)日：2010-11-25
申请号：PCT/US2009050365
申请日：2009-07-13
申请人： BOSTON SCIENT SCIMED INC , SCHEUERMANN TORSTEN , KUEHLING MICHAEL , WEBER JAN , SEIDEL DOMINIQUE
发明人： SCHEUERMANN TORSTEN , KUEHLING MICHAEL , WEBER JAN , SEIDEL DOMINIQUE
IPC分类号： A61L31/14 , A61L31/08 , A61L31/16
CPC分类号： A61L31/16 , A61L31/082 , A61L31/146 , A61L2300/608 , A61L2420/08
摘要： Medical devices having a barrier layer comprising an inorganic material. The medical device has a reservoir containing a therapeutic agent and the barrier layer is disposed over the reservoir. In one aspect, the barrier layer has one permeability to the therapeutic agent at one portion of the medical device and a different permeability at another portion of the medical device. In another aspect, the dosage amount of the therapeutic agent in the reservoir at one portion of the medical device is different from the dosage amount of the therapeutic agent in the reservoir at another portion of the medical device. In another aspect, a bioresorbable layer is disposed over the barrier layer at one or more portions of the medical device, wherein the bioresorbable layer comprises a bioresorbable material. Also, methods of coating a medical device are disclosed, in which a barrier layer over a medical device is formed using a lithographic etching process where a plurality of particles serve as an etch mask.
摘要翻译：具有包含无机材料的阻挡层的医疗装置。医疗装置具有容纳治疗剂的储存器，并且阻挡层设置在储存器上方。在一个方面，阻隔层在医疗装置的一部分具有对治疗剂的一种渗透性，并且在医疗装置的另一部分具有不同的渗透性。在另一方面，医疗装置的一部分处的储器中的治疗剂的剂量与医疗装置的另一部分处的储器中的治疗剂的剂量不同。另一方面，生物可再吸收层在医疗装置的一个或多个部分处设置在阻隔层上，其中生物可吸收层包含生物可吸收材料。而且，公开了涂覆医疗装置的方法，其中使用平版印刷蚀刻工艺形成医疗装置上的阻挡层，其中多个颗粒用作蚀刻掩模。

4. 发明申请

WO2011011531A3 BIOERODIBLE MEDICAL IMPLANTS 审中-公开
标题翻译：生物医用植物
公开(公告)号：WO2011011531A3
公开(公告)日：2011-03-24
申请号：PCT/US2010042772
申请日：2010-07-21
申请人： BOSTON SCIENT SCIMED INC , ATANASOSKA LILIANA , STINSON JONATHAN S , DENG CHARLES , BOISMIER DENNIS A , WEBER JAN , SCHEUERMANN TORSTEN
发明人： ATANASOSKA LILIANA , STINSON JONATHAN S , DENG CHARLES , BOISMIER DENNIS A , WEBER JAN , SCHEUERMANN TORSTEN
IPC分类号： A61L31/02 , A61L31/12 , A61L31/14
CPC分类号： A61L31/022 , A61L31/124 , A61L31/127 , A61L31/148
摘要： A medical implant includes a bioerodible portion adapted to degrade under physiological conditions. The bioerodible portion includes a bioerodible metal matrix and a salt or clay within the bioerodible metal matrix.
摘要翻译：医疗植入物包括适于在生理条件下降解的生物可蚀解部分。生物可蚀解部分包括生物腐蚀性金属基质和生物可腐蚀金属基质内的盐或粘土。

5. 发明申请

WO2010132244A3 BIOERODIBLE ENDOPROSTHESIS 审中-公开
标题翻译：生物学上的内生性
公开(公告)号：WO2010132244A3
公开(公告)日：2011-01-06
申请号：PCT/US2010033648
申请日：2010-05-05
申请人： BOSTON SCIENT SCIMED INC , WEBER JAN , SCHEUERMANN TORSTEN
发明人： WEBER JAN , SCHEUERMANN TORSTEN
IPC分类号： A61F2/90
CPC分类号： A61F2/91 , A61F2/852 , A61F2210/0004 , A61F2220/0033 , A61F2220/005 , A61F2250/003 , A61F2250/0063
摘要： A stent includes a first tubular element formed of a first bioerodible metal composition and second tubular element formed of a second biodegradable metal composition. The first and second tubular elements are concentrically arranged; and the first and second bioerodible metal compositions are different.
摘要翻译：支架包括由第一生物腐蚀性金属组合物形成的第一管状元件和由第二生物可降解金属组合物形成的第二管状元件。第一和第二管状元件同心地布置; 并且第一和第二生物腐蚀性金属组合物是不同的。

6. 发明申请

WO2010042471A2 MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENTS TO BODY LUMENS 审中-公开
标题翻译：用于向身体照明递送治疗剂的医疗设备
公开(公告)号：WO2010042471A2
公开(公告)日：2010-04-15
申请号：PCT/US2009059630
申请日：2009-10-06
申请人： BOSTON SCIENT SCIMED INC , WEBER JAN , SCHEUERMANN TORSTEN
发明人： WEBER JAN , SCHEUERMANN TORSTEN
IPC分类号： A61F2/958 , A61L29/08 , A61L29/16
CPC分类号： A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L2300/232 , A61L2300/416 , A61L2300/62 , A61M2025/105 , C08L5/08
摘要： In accordance with one aspect, the invention provides a drug delivery device for delivery of a drug to the body. The device is provided with at least one layer that comprises drug- containing particles.
摘要翻译：根据一个方面，本发明提供了一种用于将药物输送至身体的药物输送装置。该装置具有至少一个包含含药颗粒的层。

7. 发明申请

WO2010124049A3 ENDOPROSTHESIS WITH SELECTIVE DRUG COATINGS 审中-公开
标题翻译：与选择性药物涂层结合
公开(公告)号：WO2010124049A3
公开(公告)日：2011-02-24
申请号：PCT/US2010031990
申请日：2010-04-22
申请人： BOSTON SCIENT SCIMED INC , KUEHLING MICHAEL , SCHEUERMANN TORSTEN , WEBER JAN , XU YIXIN
发明人： KUEHLING MICHAEL , SCHEUERMANN TORSTEN , WEBER JAN , XU YIXIN
IPC分类号： A61L31/08 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/10 , A61L31/088 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/45 , A61L2300/61
摘要： An endoprosthesis such as a coronary stent includes a luminal surface, at least a portion of which is covered with a first coating including a first drug, and an ab luminal surface, at least a portion of which is covered with a second coating including a second drug. The first drug has a first eluting profile based on the first coating, and the second drug has a second eluting profile based on the second coating, the first eluting profile being different from the second eluting profile. Methods of making the same are also provided.
摘要翻译：诸如冠状动脉支架的内假体包括腔表面，其至少一部分被第一涂层覆盖，第一涂层包括第一药物和至少一部分覆盖有第二涂层的第二涂层，所述第二涂层包括第二涂层药物。第一种药物基于第一种涂层具有第一洗脱分布，第二种药物基于第二种涂层具有第二种洗脱分布，第一种洗脱分布与第二种洗脱分布不同。还提供了制备其的方法。

8. 发明申请

WO2010101988A3 ENDOPROSTHESIS COMPRISING A POROUS HYDROPHILIC CERAMIC COATING 审中-公开
标题翻译：包含多孔水泥陶瓷涂层的内含物
公开(公告)号：WO2010101988A3
公开(公告)日：2010-12-23
申请号：PCT/US2010026026
申请日：2010-03-03
申请人： BOSTON SCIENT SCIMED INC , WEBER JAN , SCHEUERMANN TORSTEN
发明人： WEBER JAN , SCHEUERMANN TORSTEN
IPC分类号： A61L31/08 , A61L31/14 , A61L31/16
CPC分类号： A61L33/00 , A61L31/088 , A61L31/14 , A61L31/146
摘要： A hydrophilic ceramic coating is formed on an endoprosthesis preform. The hydrophilic ceramic coating is porous and can store nano-sized drug particles.
摘要翻译：在内置假体预成型件上形成亲水性陶瓷涂层。亲水陶瓷涂层是多孔的，可以存储纳米尺寸的药物颗粒。

9. 发明申请

WO2010027678A3 MEDICAL DEVICES HAVING INORGANIC COATINGS FOR THERAPEUTIC AGENT DELIVERY 审中-公开
标题翻译：具有无机涂层用于治疗药物递送的医疗装置
公开(公告)号：WO2010027678A3
公开(公告)日：2010-09-23
申请号：PCT/US2009054394
申请日：2009-08-20
申请人： BOSTON SCIENT SCIMED INC , WEBER JAN , SCHEUERMANN TORSTEN , O'BRIEN BARRY J , XU YIXIN , FORSYTH BRUCE
发明人： WEBER JAN , SCHEUERMANN TORSTEN , O'BRIEN BARRY J , XU YIXIN , FORSYTH BRUCE
IPC分类号： A61L27/30 , A61L27/54 , A61L27/56 , A61L31/08 , A61L31/14 , A61L31/16
CPC分类号： A61L27/30 , A61L27/54 , A61L27/56 , A61L31/082 , A61L31/146 , A61L31/16 , A61L2300/608
摘要： According to an aspect of the invention, medical devices are provided that comprise a substrate, at least one therapeutic agent disposed over or in the substrate, and at least one inorganic layer disposed over the therapeutic agent and the substrate, wherein the inorganic layer is either a porous inorganic layer or is a non-porous layer that becomes a porous inorganic layer in vivo. Other aspects of the invention comprise methods for forming medical devices.
摘要翻译：根据本发明的一个方面，提供了医疗装置，其包括衬底，设置在衬底上或衬底中的至少一种治疗剂，以及设置在治疗剂和衬底上的至少一个无机层，其中无机层是多孔无机层，或者是在体内成为多孔无机层的无孔层。本发明的其它方面包括用于形成医疗装置的方法。

10. 发明申请

WO2009132176A3 MEDICAL DEVICES HAVING INORGANIC PARTICLE LAYERS 审中-公开
标题翻译：具有无机颗粒层的医疗器械
公开(公告)号：WO2009132176A3
公开(公告)日：2010-09-02
申请号：PCT/US2009041520
申请日：2009-04-23
申请人： BOSTON SCIENT SCIMED INC , KUEHLING MICHAEL , SEIDEL DOMINIQUE , SCHEUERMANN TORSTEN , WEBER JAN
发明人： KUEHLING MICHAEL , SEIDEL DOMINIQUE , SCHEUERMANN TORSTEN , WEBER JAN
IPC分类号： A61L31/08 , A61L31/16
CPC分类号： A61L31/16 , A61L31/08 , A61L2300/61 , A61L2300/62 , A61L2420/02
摘要： An expandable medical device having a particle layer disposed over a reservoir containing a therapeutic agent. The particle layer has a first porosity when the medical device is in the unexpanded configuration and a second porosity when the medical device is in the expanded configuration. The particle layer comprises a plurality of micron-sized or nano-sized particles. In certain embodiments, the particles are not connected to each other, and as such, the different porosities are provided by changes in the spacing between the particles as the medical device is expanded/unexpanded. Also disclosed are medical devices having a particle layer, wherein the particle layer comprises a plurality of encapsulated particles, and methods of coating medical devices with particles.
摘要翻译：一种可膨胀医疗装置，其具有设置在含有治疗剂的贮器上的颗粒层。当医疗装置处于未膨胀构型时，颗粒层具有第一孔隙度，并且当医疗装置处于膨胀构型时具有第二孔隙率。颗粒层包含多个微米级或纳米尺寸的颗粒。在某些实施方案中，颗粒彼此不连接，因此，当医疗装置膨胀/未膨胀时，由颗粒之间的间隔的变化提供不同的孔隙度。还公开了具有颗粒层的医疗装置，其中所述颗粒层包含多个包封的颗粒，以及用颗粒涂覆医疗装置的方法。

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