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1. 发明申请

WO2008094548A2 LOCAL DELIVERY OF THERAPEUTIC AGENT TO HEART VALVES 审中-公开
标题翻译：局部将治疗药物送至心脏瓣膜
公开(公告)号：WO2008094548A2
公开(公告)日：2008-08-07
申请号：PCT/US2008001160
申请日：2008-01-30
申请人： BOSTON SCIENT SCIMED INC , PALASIS MARIA , MICKLEY TIMOTHY J , FREYMAN TOBY , NAIMARK WENDY
发明人： PALASIS MARIA , MICKLEY TIMOTHY J , FREYMAN TOBY , NAIMARK WENDY
CPC分类号： A61M31/002 , A61F2/24 , A61F2250/0067
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.
摘要翻译：本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。在一个实施例中，提供了包括身体的医疗装置。身体可以具有包括治疗剂的部分，并且可以构造成在靠近心脏瓣膜的位置支撑装置。根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。然后释放的治疗剂可以被递送到心脏瓣膜。

2. 发明申请

WO2009089110A3 METHODS FOR REPAIR AND REGENERATION OF BONE MARROW 审中-公开
标题翻译：骨质疏松修复和再生方法
公开(公告)号：WO2009089110A3
公开(公告)日：2010-03-18
申请号：PCT/US2009030046
申请日：2009-01-02
申请人： BOSTON SCIENT SCIMED INC , FREYMAN TOBY , NAIMARK WENDY , PALASIS MARIA
发明人： FREYMAN TOBY , NAIMARK WENDY , PALASIS MARIA
IPC分类号： A61L27/36 , A61L27/38
CPC分类号： A61L27/3847 , A61L27/3633 , A61L27/3834
摘要： The invention is directed to a method for treating a tissue or organ in a subject by directly administering an effective amount of an exogenous, decellularized extracellular matrix or a mixture of extracellular matrix and mesenchymal stem cells into the intended site of activity, such as bone marrow cavity. In one embodiment, the invention provides methods of treating bone marrow to increase the number of circulating progenitor and stem cells. In some other embodiments of the invention, the decellularized extracellular matrix to be directly administered is configured to be a time released therapeutic.
摘要翻译：本发明涉及一种通过将有效量的外源性脱细胞细胞外基质或细胞外基质和间充质干细胞的混合物直接施用于预期的活性位点（例如骨髓）来治疗受试者的组织或器官的方法腔。在一个实施方案中，本发明提供了治疗骨髓以增加循环祖细胞和干细胞数量的方法。在本发明的一些其它实施方案中，待直接施用的脱细胞细胞外基质配置为时间释放治疗剂。

3. 发明申请

WO2008042466A3 APPARATUSES AND METHODS TO TREAT ATHEROSCLEROTIC PLAQUES 审中-公开
标题翻译：装置和方法来治疗甲状腺功能障碍
公开(公告)号：WO2008042466A3
公开(公告)日：2008-10-23
申请号：PCT/US2007068354
申请日：2007-05-07
申请人： BOSTON SCIENT SCIMED INC , FREYMAN TOBY , HERRMANN ROBERT , NAIMARK WENDY , PALASIS MARIA
发明人： FREYMAN TOBY , HERRMANN ROBERT , NAIMARK WENDY , PALASIS MARIA
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61L31/148 , A61L2300/604
摘要： This invention comprises an apparatus for treating an atherosclerotic plaque in a coronary artery of a mammal by placing at or proximate to an entrance to the coronary artery and upstream of the vulnerable plaque, and an effective amount of a therapeutic agent for the treatment of the plaque. This invention comprises delivering a deposition of a therapeutic drug high in the coronary arterial tree for treatment of downstream vulnerable plaques. The invention also comprises slow release formulation and delivery of an apparatus that is totally degradable or removed and/or replaced.
摘要翻译：本发明包括一种用于通过放置在冠状动脉入口处或接近于冠状动脉入口处和易损斑块上游来治疗哺乳动物冠状动脉中的动脉粥样硬化斑块的装置，以及有效量的用于治疗斑块的治疗剂。本发明包括在冠状动脉树中输送高度治疗药物的沉积物以治疗下游脆弱斑块。本发明还包括缓释制剂和递送完全可降解或除去和/或更换的装置。

4. 发明申请

WO2007089976A3 LOCAL CONTROL OF INFLAMMATION 审中-公开
标题翻译：炎症的局部控制
公开(公告)号：WO2007089976A3
公开(公告)日：2007-10-04
申请号：PCT/US2007060581
申请日：2007-01-16
申请人： BOSTON SCIENT SCIMED INC , FREYMAN TOBY , NAIMARK WENDY , PALASIS MARIA
发明人： FREYMAN TOBY , NAIMARK WENDY , PALASIS MARIA
IPC分类号： A61F2/06
CPC分类号： A61F2/02 , A61F2/0077 , A61F2/07 , A61F2230/008 , A61F2250/0039 , A61F2250/0067
摘要： A medical device includes a carrier and an agent. The agent is formulated to control inflammation of biological tissue, such as heart tissue, and is releasably coupled to the carrier. The carrier (130) is configured to be disposed in operative proximity to the biological tissue to be treated by the agent (120). In one embodiment, the carrier is configured to release the agent or otherwise deliver the agent to the biological tissue, thus controlling inflammation of the tissue. Also, a method to improve healing of biological tissue includes placing a medical device proximate to the heart of a patient, where the medical device has a carrier and an agent configured to control inflammation, the agent is releasably coupled to the carrier. In one embodiment, the method includes causing the agent to be released from the carrier.
摘要翻译：医疗器械包括载体和药剂。制剂用于控制诸如心脏组织的生物组织的炎症，并且可释放地联接到载体上。载体（130）构造成被布置成可操作地接近要由药剂（120）处理的生物组织。在一个实施方案中，载体被配置为释放试剂或以其它方式将试剂递送到生物组织，从而控制组织的炎症。而且，改善生物组织愈合的方法包括将医疗装置放置在患者的心脏附近，其中医疗装置具有载体和构造成控制炎症的药剂，药剂可释放地联接到载体上。在一个实施例中，该方法包括使得试剂从载体释放。

5. 发明申请

WO2007037850A3 ENHANCED DELIVERY OF CELLS 审中-公开
标题翻译：增强了细胞的递送
公开(公告)号：WO2007037850A3
公开(公告)日：2007-07-26
申请号：PCT/US2006032767
申请日：2006-08-23
申请人： BOSTON SCIENT SCIMED INC , FREYMAN TOBY , PALASIS MARIA , NAIMARK WENDY
发明人： FREYMAN TOBY , PALASIS MARIA , NAIMARK WENDY
IPC分类号： A61K35/28 , A61K31/7076 , A61K45/00 , A61P9/10
CPC分类号： A61M25/10 , A61K31/28 , A61K31/7076 , A61K35/28 , A61K45/00 , A61K45/06 , A61K2300/00 , A61M5/1407 , A61M2025/1052 , A61M2210/125
摘要： The present invention provides a method comprising administering cells by infusion through a blood vessel and administering a vasodilator, a vascular enhancer, or both. In accordance with one embodiment, the delivery of stem cells to the myocardium by intracoronary infusion is improved by administration of one or more vasodilators and/or vascular permeability enhancers prior to or at the time of cell therapy.
摘要翻译：本发明提供了一种方法，其包括通过血管输注给予细胞并施用血管舒张剂，血管增强剂或两者。根据一个实施方案，通过在细胞治疗之前或之时施用一种或多种血管扩张剂和/或血管通透性增强剂来改善通过冠脉内输注将干细胞递送至心肌。

6. 发明申请

WO2007030534A2 STENT WITH POCKETS FOR CONTAINING A THERAPEUTIC AGENT 审中-公开
标题翻译：含有包含治疗药物的口袋的手套
公开(公告)号：WO2007030534A2
公开(公告)日：2007-03-15
申请号：PCT/US2006034707
申请日：2006-09-06
申请人： BOSTON SCIENT SCIMED INC , NAIMARK WENDY , SHANK PETER , PALASIS MARIA , FREYMAN TOBY , PANOS ANASTASIA , EPSTEIN SAMUEL J , ROUSSEAU ALEXANDRA
发明人： NAIMARK WENDY , SHANK PETER , PALASIS MARIA , FREYMAN TOBY , PANOS ANASTASIA , EPSTEIN SAMUEL J , ROUSSEAU ALEXANDRA
IPC分类号： A61L31/16
CPC分类号： A61L31/16 , A61F2/91 , A61F2/915 , A61F2002/075 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2220/0008 , A61F2230/0013 , A61F2250/0068 , A61L2300/606
摘要： A medical device for delivering a therapeutic agent to a body lumen is described. The device may generally be a stent with an inner sidewall surface and an outer sidewall surface, with a plurality of struts having a plurality of openings therein. An inner and outer layer may be applied to the stent, forming pockets within at least a portion of the openings. The pockets may be filled with at least one therapeutic agent. The pockets may take a variety of shapes and sizes, and may be designed for release or rupture in variety of ways.
摘要翻译：描述了用于将治疗剂递送到体腔的医疗装置。该装置通常可以是具有内侧壁表面和外侧壁表面的支架，多个支柱在其中具有多个开口。内层和外层可以施加到支架上，在开口的至少一部分内形成袋。口袋可以填充有至少一种治疗剂。口袋可以采取各种形状和尺寸，并且可以设计为以各种方式释放或破裂。

7. 发明申请

WO2006081026A2 MULTIPLE NEEDLE INJECTION CATHETER AND METHOD OF USE OF SAME 审中-公开
标题翻译：多针注射导管及其使用方法
公开(公告)号：WO2006081026A2
公开(公告)日：2006-08-03
申请号：PCT/US2005046775
申请日：2005-12-22
申请人： BOSTON SCIENT SCIMED INC , KHAYAL INAS , NAIMARK WENDY , PALASIS MARIA
发明人： KHAYAL INAS , NAIMARK WENDY , PALASIS MARIA
IPC分类号： A61M25/00 , A61B17/34
CPC分类号： A61M25/0084
摘要： Embodiments of the present invention relate to multiple needle catheter-based injection systems to deliver a plug of a therapeutic or other agent. A medical device may include a catheter with a distal end, a proximal end and a catheter lumen extending there between and an outer needle disposed in the catheter lumen with a distal end and a proximal end and an outer needle, lumen extending there between. The medical device may include an inner needle with a distal end and a proximal end, the inner needle being disposed in the outer needle lumen and the distal end of the inner needle to receive and hold a therapeutic plug, and a needle control mechanism coupled to the proximal ends of the outer needle and the inner needle, the needle control mechanism to independently and jointly control ejection and retraction of the outer and inner needles to deliver the therapeutic plug into a target tissue site.
摘要翻译：本发明的实施例涉及用于递送治疗剂或其他药剂的栓塞的基于多个基于导管的多注射系统。医疗装置可以包括具有远端，近端以及在其间延伸的导管内腔的导管以及布置在导管内腔中的具有远端和近端的外针以及在其间延伸的内针和外针。医疗装置可以包括具有远端和近端的内针，内针设置在外针内腔和内针的远端中以接收和保持治疗塞，以及针控制机构，其联接到外针和内针的近端，针控制机构独立且共同地控制外针和内针的弹出和缩回以将治疗塞递送到目标组织部位。

8. 发明公开

EP3043721A4 DRUG DELIVERY SYSTEMS AND RELATED METHODS 审中-公开
标题翻译：药物递送系统和相关方法
公开(公告)号：EP3043721A4
公开(公告)日：2016-09-21
申请号：EP14841961
申请日：2014-09-09
申请人： ARSENAL MEDICAL INC , PALASIS MARIA , CONCAGH DANNY , CORE LEE , WEBBER STEPHANIE , KUANG YINA , NAIMARK WENDY , KNOX RAYMOND
发明人： PALASIS MARIA , CONCAGH DANNY , CORE LEE , WEBBER STEPHANIE , KUANG YINA , NAIMARK WENDY , KNOX RAYMOND
IPC分类号： A61B17/12 , A61F2/90 , A61F2/95 , A61M25/10
CPC分类号： A61M25/10 , A61F2/90 , A61F2250/0067 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , A61M2025/105 , A61M2025/1075 , C08L67/04

9. 发明申请

WO2006015386A3 A METHOD OF MAKING A COATED MEDICAL DEVICE 审中-公开
标题翻译：制造涂层医疗装置的方法
公开(公告)号：WO2006015386A3
公开(公告)日：2006-11-09
申请号：PCT/US2005027890
申请日：2005-08-04
申请人： BOSTON SCIENT SCIMED INC , WEBER JAN , KOCUR GORDON J , HELMUS MICHAEL , PALASIS MARIA
发明人： WEBER JAN , KOCUR GORDON J , HELMUS MICHAEL , PALASIS MARIA
IPC分类号： A61L33/00 , A61F2/06 , B05D1/36
CPC分类号： A61L31/16 , A61F2250/0068 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/606
摘要： Medical devices, such as stents, having a surface, a coating layer comprising a polymer disposed on at least a portion of the surface, and a composition comprising a biologically active material injected into or under the coating layer at one or more locations in the coating layer to form at least one pocket containing a biologically active material are disclosed. The composition may be injected using a nanometer- or micrometer-sized needle. Methods for making such medical devices are also disclosed. Using this method, a precise amount of the biologically active material may be disposed accurately and efficiently on the medical device at predefined locations.
摘要翻译：医疗装置，例如具有表面的支架，包括设置在表面的至少一部分上的聚合物的涂层，以及包含在涂层中的一个或多个位置处注入到涂层内或之下的生物活性物质的组合物层以形成至少一个包含生物活性材料的口袋。可以使用纳米或微米尺寸的针注射组合物。还公开了制造这种医疗装置的方法。使用该方法，精确量的生物活性材料可以在预定义的位置处精确而有效地设置在医疗装置上。

10. 发明申请

WO2005094933A2 CATHETER WITH SENSOR TIPS, TOOL AND DEVICE AND METHODS OF USE OF SAME 审中-公开
标题翻译：带传感器提示的导管，工具和装置及其使用方法
公开(公告)号：WO2005094933A2
公开(公告)日：2005-10-13
申请号：PCT/US2005009788
申请日：2005-03-23
申请人： BOSTON SCIENT SCIMED INC , HARRIS CHAD G , HAWK MATTHEW L , MICKLEY TIMOTHY J , PANESCU DORIN , PALASIS MARIA , ROONEY JACOB
发明人： HARRIS CHAD G , HAWK MATTHEW L , MICKLEY TIMOTHY J , PANESCU DORIN , PALASIS MARIA , ROONEY JACOB
IPC分类号： A61B5/0408 , A61B5/042 , A61M25/00
CPC分类号： A61B5/4839 , A61B5/0422 , A61B5/0538 , A61B5/6885 , A61M25/0084
摘要： An apparatus and method for catheter-based sensing and injection at a target site within a patient's body. An injection catheter is equipped with a electrodes at its distal end which contact the surface of a target site, such as an AV node of the heart. Electrical signals detected at the target site by the electrodes are fed via leads to the proximal end of the catheter, where they are received by a monitor, such as an EKG monitor. If the electrical signals satisfy predetermined criteria, a needle within the catheter is extended into the target site, and a therapeutic agent is injected into the target site.
摘要翻译：一种用于基于导管的感测和注射在患者体内的靶位置的装置和方法。注射导管在其远端配备有电极，其接触目标部位的表面，例如心脏的AV节点。通过电极在目标部位检测到的电信号通过引线馈送到导管的近端，在那里它们被诸如EKG监视器的监视器接收。如果电信号满足预定标准，则导管内的针头延伸到目标部位，并将治疗剂注射到目标部位。

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