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1. 发明申请

WO2009018035A2 DRUG ELUTING MEDICAL DEVICES HAVING POROUS LAYERS 审中-公开
标题翻译：药物洗脱具有多孔层的医疗器械
公开(公告)号：WO2009018035A2
公开(公告)日：2009-02-05
申请号：PCT/US2008070842
申请日：2008-07-23
申请人： BOSTON SCIENT SCIMED INC , ATANASOSKA LILIANA , WARNER ROBERT W , ARNEY MICHAEL S , WEBER JAN
发明人： ATANASOSKA LILIANA , WARNER ROBERT W , ARNEY MICHAEL S , WEBER JAN
IPC分类号： A61L31/16 , A61L31/02 , A61L31/08 , A61L31/10 , A61L31/14
CPC分类号： A61L31/16 , A61L31/022 , A61L31/082 , A61L31/10 , A61L31/146 , A61L31/148 , A61L2300/608 , Y10T428/13 , Y10T428/249994
摘要： In accordance with an aspect of the invention, implantable or insertable medical devices are provided that comprise (a) a substrate and (b) a porous layer comprising close packed spherical pores disposed over the substrate. The porous layer may also comprise a therapeutic agent. In another aspect, the present invention provides methods of forming implantable or insertable medical devices. These methods comprise forming a predecessor structure that comprises (i) a substrate over which is disposed (ii) an assembly of microspheres. This assembly of microspheres is then used as a template for the formation of a porous layer, which may be subsequently loaded with a therapeutic agent.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包括（a）基底和（b）多孔层，其包括设置在基底上的密堆积的球形孔。多孔层还可以包含治疗剂。另一方面，本发明提供了形成可植入或可插入的医疗装置的方法。这些方法包括形成前体结构，该前体结构包括（i）其上设置有（ii）微球体组件的基体。然后将该微球体组件用作形成多孔层的模板，其随后可装载治疗剂。

2. 发明申请

WO2010101901A3 SELF-BUFFERING MEDICAL IMPLANTS 审中-公开
标题翻译：自助医疗植入物
公开(公告)号：WO2010101901A3
公开(公告)日：2011-01-06
申请号：PCT/US2010025896
申请日：2010-03-02
申请人： BOSTON SCIENT SCIMED INC , ATANASOSKA LILIANA , SHIPPY JAMES LEE III , HOLMAN TOM , ARNEY MICHAEL S , SCHOENLE VICTOR , GENOVESE FRANK , FENG JAMES Q , FLANAGAN AIDEN , WEBER JAN
发明人： ATANASOSKA LILIANA , SHIPPY JAMES LEE III , HOLMAN TOM , ARNEY MICHAEL S , SCHOENLE VICTOR , GENOVESE FRANK , FENG JAMES Q , FLANAGAN AIDEN , WEBER JAN
IPC分类号： A61L27/04 , A61L27/18 , A61L27/42 , A61L27/54 , A61L31/02 , A61L31/06 , A61L31/12 , A61L31/16
CPC分类号： A61L31/148 , A61L27/34 , A61L27/446 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2400/12 , A61L2420/04 , C08L67/04
摘要： A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.
摘要翻译：医疗植入物包括生物腐蚀性部分，其包括生物可蚀解聚合物和生物腐蚀性金属。生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。生物腐蚀金属在生理条件下降解形成碱性降解产物。酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。在一个方面，生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。在另一方面，医疗植入物可以包括主体，身体上的生物可蚀解聚合物的多个离散沉积物，以及身体上的生物可腐蚀金属的多个离散沉积物。

3. 发明申请

WO2008088507A3 BLOOD-CONTACTING MEDICAL DEVICES FOR THE RELEASE OF NITRIC OXIDE AND ANTI-RESTENOTIC AGENTS 审中-公开
标题翻译：用于释放氮氧化物和抗病毒剂的血液接触医疗装置
公开(公告)号：WO2008088507A3
公开(公告)日：2009-06-18
申请号：PCT/US2007025076
申请日：2007-12-07
申请人： BOSTON SCIENT SCIMED INC , IPPOLITI THOMAS J , SCHEWE SCOTT , ZOROMSKI MICHELE , WARNER ROBERT W , ATANASOSKA LILIANA , WEBER JAN
发明人： IPPOLITI THOMAS J , SCHEWE SCOTT , ZOROMSKI MICHELE , WARNER ROBERT W , ATANASOSKA LILIANA , WEBER JAN
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/416 , A61L2300/45
摘要： According to an aspect of the present invention, implantable or insertable blood- contacting devices are provided, which contain one or more release regions that release nitric oxide and one or more anti-restenotic agents. The release region contains one or more polymeric components. The release region also optionally contains one or more inorganic components. Nitric oxide producing groups may be attached to the polymeric component(s), to the optional inorganic component(s), or both. The one or more anti-restenotic agents may be admixed with the polymeric and optional inorganic components, attached to the polymeric component(s), attached to the optional inorganic component(s), or a combination thereof.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的血液接触装置，其包含一个或多个释放一氧化氮的释放区和一种或多种抗再狭窄剂。释放区域包含一种或多种聚合物组分。释放区域还任选地含有一种或多种无机组分。一氧化碳生成基团可以连接到聚合物组分，任选的无机组分或两者。一种或多种抗再狭窄剂可以与附着于任选的无机组分的一种或多种聚合物组分的聚合物和任选的无机组分或其组合物混合。

4. 发明申请

WO2008036549A2 MEDICAL DEVICES 审中-公开
标题翻译：医疗设备
公开(公告)号：WO2008036549A2
公开(公告)日：2008-03-27
申请号：PCT/US2007078412
申请日：2007-09-13
申请人： BOSTON SCIENT SCIMED INC , ATANASOSKA LILIANA , WEBER JAN , LARSEN STEVEN R , WARNER ROBERT W
发明人： ATANASOSKA LILIANA , WEBER JAN , LARSEN STEVEN R , WARNER ROBERT W
IPC分类号： A61F2/90 , A61L31/02 , A61L31/10 , A61L31/14
CPC分类号： A61L31/148 , A61F2/91 , A61F2/915 , A61F2002/9155 , A61F2002/91575 , A61F2210/0004 , A61F2250/003 , A61F2250/0054 , A61F2250/0068
摘要： Medical devices are described that include a device body that carries a first bioerodible member and a second bioerodible member. One of the first or second members includes a bioerodible metallic material or ceramic, and the other includes a bioerodible polymeric material. The first and/or second member can include a therapeutic agent such as paclitaxel.
摘要翻译：描述了医疗装置，其包括携带第一生物可侵蚀构件和第二生物可侵蚀构件的装置主体。第一或第二构件中的一个包括生物腐蚀性金属材料或陶瓷，另一个包括生物可腐蚀的聚合材料。第一和/或第二成员可以包括治疗剂如紫杉醇。

5. 发明申请

WO2009026086A3 MEDICAL DEVICES HAVING SOL-GEL DERIVED CERAMIC REGIONS WITH MOLDED SUBMICRON SURFACE FEATURES 审中-公开
标题翻译：具有模具底层表面特征的溶胶凝胶陶瓷区域的医疗设备
公开(公告)号：WO2009026086A3
公开(公告)日：2010-03-11
申请号：PCT/US2008073109
申请日：2008-08-14
申请人： BOSTON SCIENT SCIMED INC , WEBER JAN , ATANASOSKA LILIANA , ZOROMSKI MICHELE , WARNER ROBERT W
发明人： WEBER JAN , ATANASOSKA LILIANA , ZOROMSKI MICHELE , WARNER ROBERT W
IPC分类号： A61L27/10 , A61L27/56 , A61L31/08 , A61L31/14
CPC分类号： A61L31/16 , A61L27/306 , A61L27/54 , A61L27/56 , A61L29/106 , A61L29/146 , A61L29/16 , A61L31/088 , A61L31/146 , A61L2300/00 , A61L2400/12
摘要： According to one aspect of the present invention, implantable or insertable medical devices are provided, which contain sol-gel derived ceramic regions which have molded submicron surface features.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含具有模制的亚微米表面特征的溶胶 - 凝胶衍生的陶瓷区域。

6. 发明申请

WO2008083190A9 BIOERODIBLE ENDOPROSTHESES AND METHODS OF MAKING SAME 审中-公开
标题翻译：生物可分解内窥镜及其制备方法
公开(公告)号：WO2008083190A9
公开(公告)日：2008-09-04
申请号：PCT/US2007088888
申请日：2007-12-27
申请人： BOSTON SCIENT SCIMED INC , ATANASOSKA LILIANA , WEBER JAN , WARNER ROBERT W
发明人： ATANASOSKA LILIANA , WEBER JAN , WARNER ROBERT W
IPC分类号： A61L31/02 , A61L31/14
CPC分类号： A61L31/14 , A61L31/022 , A61L31/148
摘要： A bioerodible endoprosthesis erodes by galvanic erosion that can provide, e.g., improved endothelialization and therapeutic effects.
摘要翻译：生物蚀解的内置假体由于电流侵蚀而腐蚀，这可以提供例如改善的内皮化和治疗效果。

7. 发明申请

WO2008094897A2 CATHETERS AND MEDICAL BALLOONS 审中-公开
标题翻译：导管和医用气囊
公开(公告)号：WO2008094897A2
公开(公告)日：2008-08-07
申请号：PCT/US2008052294
申请日：2008-01-29
申请人： BOSTON SCIENT SCIMED INC , ATANASOSKA LILIANA , WEBER JAN , SCHEWE SCOTT R , WARNER ROBERT W
发明人： ATANASOSKA LILIANA , WEBER JAN , SCHEWE SCOTT R , WARNER ROBERT W
IPC分类号： A61F2/958
CPC分类号： A61L29/126
摘要： Medical balloons and/or catheters are disclosed that include a wall that includes a composite material. The composite material includes a polymeric material and particles that include an allotrope of carbon. In some instances, at least some of the particles are covalently bonded to the polymeric material. Methods for making such medical balloons and/or catheters are also disclosed.
摘要翻译：公开了包括包括复合材料的壁的医疗气囊和/或导管。复合材料包括聚合物材料和包含碳同素异形体的颗粒。在一些情况下，至少一些颗粒共价键合到聚合物材料上。还公开了制造这种医用气囊和/或导管的方法。

8. 发明申请

WO2008033546A3 IMPLANTABLE ELECTRODES WITH POLYOXOMETALATES 审中-公开
标题翻译：可植入电极与POLYOXOMETALATES
公开(公告)号：WO2008033546A3
公开(公告)日：2008-07-17
申请号：PCT/US2007020081
申请日：2007-09-14
申请人： BOSTON SCIENT SCIMED INC , ATANASOSKA LILIANA L , WEBER JAN , HASTINGS ROGER N , WARNER ROBERT W , POLKINGHORNE JEANNETTE C
发明人： ATANASOSKA LILIANA L , WEBER JAN , HASTINGS ROGER N , WARNER ROBERT W , POLKINGHORNE JEANNETTE C
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/056
摘要： An electrode with an electrode surface having a polyoxometalate (POM). The use of POM with an electrode surface increases the active electrochemical surface area, with a resulting increase in capacitance and impedance, and a decrease of polarization losses at the electrode/tissue interface. In addition, electrodes having POM can include pseudo-capacitive properties from their redox properties and charge storage properties.
摘要翻译：具有多金属氧酸盐（POM）的电极表面的电极。具有电极表面的POM的使用增加了活性电化学表面积，导致电容和阻抗的增加以及电极/组织界面处的极化损失的降低。另外，具有POM的电极可以包括其氧化还原性质和电荷存储性质的赝电容性质。

9. 发明申请

WO2009158333A3 MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH GALVANIC CORROSION 审中-公开
标题翻译：用于与治疗性腐蚀相关的用于输送治疗药物的医疗装置
公开(公告)号：WO2009158333A3
公开(公告)日：2010-08-19
申请号：PCT/US2009048242
申请日：2009-06-23
申请人： BOSTON SCIENT SCIMED INC , ATANASOSKA LILIANA , WEBER JAN , GROSSO PAUL , WARNER ROBERT W , SEETHAMRAJU KASYAP V
发明人： ATANASOSKA LILIANA , WEBER JAN , GROSSO PAUL , WARNER ROBERT W , SEETHAMRAJU KASYAP V
IPC分类号： A61L31/02 , A61L31/16
CPC分类号： A61L31/022 , A61L31/10 , A61L31/14 , A61L31/148 , A61L31/16 , A61L2300/00
摘要： According to an aspect of the present invention, at least one ionic therapeutic agent is delivered from an implantable or insertable medical device that comprises an ion-conductive polymeric region that is disposed on a metallic region. The metallic region is in electrical contact with a dissimilar metallic region, such that a galvanic current is generated by the dissimilar metals when the device is implanted or inserted into a patient. Delivery of the ionic therapeutic agent from the ion-conductive polymeric region may be, for example, either accelerated or retarded by the galvanic current. According to another aspect of the present invention, implantable or insertable medical devices are provided which comprise: (a) a first metallic region having a first corrosion potential, (b) a second metallic region in electrical contact with the first metallic region and having a second corrosion potential that is greater than the first corrosion potential, and (c) a solid ion-conductive polymeric region, comprising an ion conducting polymer and an ionic therapeutic agent, disposed on the first metallic region, the second metallic region, or both.
摘要翻译：根据本发明的一个方面，至少一种离子治疗剂从可植入或可插入的医疗装置输送，其包括设置在金属区域上的离子导电聚合物区域。金属区域与异种金属区域电接触，使得当器件植入或插入患者体内时，异种金属产生电流。离子导电聚合物区域的离子治疗剂的递送可以例如由电流加速或延迟。根据本发明的另一方面，提供了可植入或可插入的医疗装置，其包括：（a）具有第一腐蚀电位的第一金属区域，（b）与第一金属区域电接触的第二金属区域，第二腐蚀电位大于第一腐蚀电位，和（c）固体离子传导聚合物区域，其包含离子导电聚合物和离子治疗剂，设置在第一金属区域，第二金属区域或两者上。

10. 发明申请

WO2010019645A3 MEDICAL DEVICES HAVING ELECTRODEPOSITED CONDUCTIVE POLYMER COATINGS 审中-公开
标题翻译：具有电沉积导电聚合物涂层的医疗设备
公开(公告)号：WO2010019645A3
公开(公告)日：2010-08-05
申请号：PCT/US2009053521
申请日：2009-08-12
申请人： BOSTON SCIENT SCIMED INC , ATANASOSKA LILIANA , CHANDRASEKARAN CHANDRU , WARNER ROBERT W , WEBER JAN
发明人： ATANASOSKA LILIANA , CHANDRASEKARAN CHANDRU , WARNER ROBERT W , WEBER JAN
IPC分类号： A61L31/10
CPC分类号： A61L31/10 , A61L31/14 , C08L101/12
摘要： According to one aspect, the present invention provides implantable or insertable medical devices that comprise a substrate and a coating over the substrate that comprises at least one type of conductive polymer and at least one type of additional polymer.
摘要翻译：根据一个方面，本发明提供了可植入或可插入的医疗装置，其包括基底和在基底上的包括至少一种类型的导电聚合物和至少一种附加聚合物的涂层。

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