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1. 发明申请

WO2010028084A2 MULTIPLE TUNABLE CENTRAL CATHODES ON A PADDLE FOR INCREASED MEDIAL-LATERAL AND ROSTRAL-CAUDAL FLEXIBILITY VIA CURRENT STEERING 审中-公开
标题翻译：通过电流转向增加内侧和鼻侧 - 腰空间弹性的鞍座上的多中央可调电极
公开(公告)号：WO2010028084A2
公开(公告)日：2010-03-11
申请号：PCT/US2009055781
申请日：2009-09-02
申请人： BOSTON SCIENT NEUROMODULATION , MOFFITT MICHAEL , LEE DONGCHUL , BRADLEY KERRY , PETERSON DAVID K L
发明人： MOFFITT MICHAEL , LEE DONGCHUL , BRADLEY KERRY , PETERSON DAVID K L
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/36071 , A61N1/36185
摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.
摘要翻译：提供神经刺激桨导程，神经刺激方法和神经刺激系统。神经刺激桨叶引线承载多个电极，所述多个电极包括至少四列电极，两列内电极列之间的间距小于内电极列和相邻外电极列之间的间距。内电极列也可以从外电极列纵向偏移。这些方法和神经刺激系统引导电极之间的电流以修改邻近脊髓组织产生的内侧 - 外侧电场。

2. 发明申请

WO2010065761A3 IMPLANTABLE NEUROSTIMULATORS HAVING REDUCED POCKET STIMULATION 审中-公开
标题翻译：可植入的神经刺激器具有减少的口袋刺激
公开(公告)号：WO2010065761A3
公开(公告)日：2010-08-12
申请号：PCT/US2009066621
申请日：2009-12-03
申请人： BOSTON SCIENT NEUROMODULATION , MOFFITT MICHAEL A , LEE DONGCHUL , BRADLEY KERRY
发明人： MOFFITT MICHAEL A , LEE DONGCHUL , BRADLEY KERRY
IPC分类号： A61N1/08 , A61N1/36 , A61N1/372 , A61N1/375
CPC分类号： A61N1/36175 , A61N1/08 , A61N1/36185 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： Neurostimulators and methods of using neurostimulators are provided. The neurostimulator is implanted within a tissue pocket of a patient, and electrical energy is conveyed from the neurostimulator to stimulate a target tissue site remote from the tissue pocket. The neurostimulator has a case with which one or more electrodes are associated. The electrical energy is returned to the electrode(s) in a manner that prevents, or at least reduces, pocket stimulation that may otherwise occur due to the return of electrical energy to the case of the neurostimulator.
摘要翻译：提供了神经刺激器和使用神经刺激器的方法。将神经刺激器植入患者的组织袋内，并且从神经刺激器输送电能以刺激远离组织袋的目标组织位点。神经刺激器具有与一个或多个电极相关联的情况。电能以防止或至少减少由于电能返回到神经刺激器的壳体而可能发生的口袋刺激的方式返回到电极。

3. 发明申请

WO2012170854A3 SYSTEMS AND METHODS FOR CUSTOMIZING STIMULATION USING IMPLANTABLE ELECTRICAL STIMULATION SYSTEMS 审中-公开
标题翻译：使用可植入电刺激系统定制刺激的系统和方法
公开(公告)号：WO2012170854A3
公开(公告)日：2013-04-11
申请号：PCT/US2012041611
申请日：2012-06-08
申请人： BOSTON SCIENT NEUROMODULATION , PIANCA ANNE MARGARET , LEE DONGCHUL
发明人： PIANCA ANNE MARGARET , LEE DONGCHUL
IPC分类号： A61N1/05
CPC分类号： A61N1/0553
摘要： An implantable paddle lead includes at least one lead body with a proximal end and a distal end. Terminals are disposed at the proximal end of the lead body. A paddle body is coupled to the distal end of the lead body. The paddle body has a length, a width, a first surface, and an opposing second surface. Electrodes are disposed on the first surface of the paddle body. At least one region of the paddle body has a higher pliability than remaining portions of the paddle body. The at least one region of higher pliability extends along the second surface of the paddle body. The paddle body is configured and arranged to preferentially bend along the at least one region of higher pliability. Conductors are disposed along the paddle lead. Each conductor electrically couples at least one of the electrodes to at least one of the terminals.
摘要翻译：可植入桨叶包括具有近端和远端的至少一个引线体。端子设置在引线主体的近端。桨体连接到引线主体的远端。桨体具有长度，宽度，第一表面和相对的第二表面。电极设置在桨体的第一表面上。桨体的至少一个区域具有比桨体的剩余部分更高的柔韧性。具有较高柔韧性的至少一个区域沿着桨体的第二表面延伸。桨体被构造和布置成沿着较高柔韧性的至少一个区域优先弯曲。导线沿着桨引线排列。每个导体将至少一个电极电耦合到至少一个端子。

4. 发明申请

WO2012125863A3 NEUROSTIMULATION SYSTEM FOR DEFINING A GENERALIZED IDEAL MULTIPOLE CONFIGURATION 审中-公开
标题翻译：用于定义一般化理想多重配置的神经网络系统
公开(公告)号：WO2012125863A3
公开(公告)日：2013-11-07
申请号：PCT/US2012029290
申请日：2012-03-15
申请人： BOSTON SCIENT NEUROMODULATION , LEE DONGCHUL , ZHU CHANGFANG
发明人： LEE DONGCHUL , ZHU CHANGFANG
IPC分类号： A61N1/372 , A61N1/36 , G06F19/00
CPC分类号： A61N1/36185 , A61N1/37247
摘要： A system for a neurostimulator coupled to electrodes. The system comprises an input device configured for generating control signals. The system further comprising memory storing a first set of variable values defining a first spatial relationship between a central ideal pole of a first polarity and the plurality of electrodes, a second set of variable values defining a second spatial relationship respectively between four ideal poles of a second polarity and the first ideal pole, and a third set of variable values defining relative intensities between the four ideal poles. The system further comprises control circuitry configured for modifying the first variable values, the second variable values, and/or the third variable values, and generating stimulation parameter values defining relative amplitude values for the electrodes that emulate the ideal poles, and instructing the neurostimulator to convey energy to the electrodes in accordance with the stimulation parameter values.
摘要翻译：耦合到电极的神经刺激器的系统。该系统包括被配置为产生控制信号的输入装置。该系统还包括存储器，其存储限定第一极性的中心理想极点和多个电极之间的第一空间关系的第一组可变值，第二组可变值分别定义在第一极性的四个理想极之间的第二空间关系第二极性和第一理想极点，以及限定四个理想极点之间的相对强度的第三组可变值。该系统还包括配置用于修改第一可变值，第二可变值和/或第三可变值的控制电路，以及产生限定模拟理想极点的电极的相对幅度值的刺激参数值，并且指示神经刺激器根据刺激参数值将能量传递到电极。

5. 发明申请

WO2014145222A2 SYSTEMS AND METHODS FOR DELIVERING SUB-THRESHOLD THERAPY TO A PATIENT 审中-公开
标题翻译：将患者进行次级治疗的系统和方法
公开(公告)号：WO2014145222A2
公开(公告)日：2014-09-18
申请号：PCT/US2014029945
申请日：2014-03-15
申请人： BOSTON SCIENT NEUROMODULATION
发明人： VANSICKLE DENNIS ALLEN , LEE DONGCHUL , KOTHANDARAMAN SRIDHAR , DOAN QUE T , ZHU CHANGFANG , PARRAMON JORDI , HOLLEY JUSTIN , HERSHEY BRADLEY L , GILLESPIE CHRISTOPHER E , CARBUNARU RAFAEL , WAHAB NAZIM
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/36185 , A61N1/37247
摘要： An external control device, neuromodulation system, and method of providing therapy to a patient. Electrical modulation energy is delivered to a target tissue site of the patient at a programmed amplitude value, thereby providing therapy to the patient without the perception of paresthesia
摘要翻译：外部控制装置，神经调节系统和向患者提供治疗的方法。电调制能量以编程的振幅值输送到患者的目标组织部位，由此向患者提供治疗，而不感觉到感觉异常

6. 发明申请

WO2013142837A2 HEURISTIC SAFETY NET FOR TRANSITIONING CONFIGURATIONS IN A NEURAL STIMULATION SYSTEM 审中-公开
标题翻译：用于在神经刺激系统中过渡配置的透明安全网
公开(公告)号：WO2013142837A2
公开(公告)日：2013-09-26
申请号：PCT/US2013033593
申请日：2013-03-22
申请人： BOSTON SCIENT NEUROMODULATION
发明人： LEE DONGCHUL , ZHU CHANGFANG
IPC分类号： A61N1/05
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/36142 , A61N1/37211 , A61N1/37247 , A61N1/37264
摘要： A system and method using a plurality of electrodes. An immediate virtual multipole is defined, an immediate electrode configuration emulating the immediate virtual multipole is defined, electrical energy is conveyed to the electrodes in accordance with the immediate electrode configuration, a new virtual multipole is defined by changing a parameter of the immediate virtual multipole by a step size, a new electrode configuration that emulates the new virtual multipole is defined, a difference value as a function of the immediate virtual multipole and the new virtual multipole is computed, the different value is compared to a limit value, electrical energy is conveyed to the electrodes in accordance with the new electrode configuration if the difference value does not exceed the limit value, and the absolute value of the step size is decreased to create a new step size if the difference value does exceed the limit value.
摘要翻译：一种使用多个电极的系统和方法。定义立即虚拟多极，定义仿真立即虚拟多极的立即电极配置，根据直接电极配置将电能传送到电极，新的虚拟多极通过将立即虚拟多极的参数改变定义步长，模拟新的虚拟多极的新电极配置，计算作为立即虚拟多极和新虚拟多极的函数的差值，将不同值与极限值进行比较，传送电能如果差值不超过极限值，则根据新电极配置到电极，并且如果差值超过极限值，则步长的绝对值减小以产生新的步长。

7. 发明专利

ES2927647T3 Sistema para determinar una distribución de la amplitud de la neuroestimulación basada en las distancias de los electrodos a un polo virtual 未知
公开(公告)号：ES2927647T3
公开(公告)日：2022-11-08
申请号：ES12809966
申请日：2012-12-17
申请人： BOSTON SCIENT NEUROMODULATION CORP
发明人： LEE DONGCHUL
IPC分类号： A61N1/36 , A61N1/372
摘要： Un sistema (10) y método para proporcionar terapia a un paciente usando una pluralidad de electrodos (26) implantados dentro del paciente. Se define una configuración multipolar virtual relativa a la pluralidad de electrodos. Se determina la distancia entre cada uno de un grupo de electrodos y un polo virtual de la configuración multipolar virtual. Se determina una distribución de amplitud de estimulación para el grupo de electrodos en función de las distancias determinadas, emulando así la configuración multipolar virtual. La energía eléctrica se transporta desde el grupo de electrodos de acuerdo con la distribución de amplitud de estimulación calculada. (Traducción automática con Google Translate, sin valor legal)

8. 发明专利

AU2017204544B2 Systems for delivering subthreshold therapy to a patient 未知
公开(公告)号：AU2017204544B2
公开(公告)日：2018-10-04
申请号：AU2017204544
申请日：2017-07-03
申请人： BOSTON SCIENT NEUROMODULATION CORP
发明人： VANSICKLE DENNIS ALLEN , LEE DONGCHUL , KOTHANDARAMAN SRIDHAR , DOAN QUE T , ZHU CHANGFANG , PARRAMON JORDI , HOLLEY JUSTIN , HERSHEY BRADLEY L , GILLESPIE CHRISTOPHER E , CARBUNARU RAFAEL , WAHAB NAZIM
IPC分类号： A61N1/36 , A61B5/055 , A61N1/372
摘要： Abstract An external control device for programming an implantable neuromodulator coupled to an electrode array is provided. The external control device comprises a user interface including a programming selection control element configured for allowing a user to select one of a first programming mode (e.g., a semi- automated programming mode) having a first limit on a modulation parameter and a second programming mode (e.g., a semi-automated programming mode) having a second limit on the modulation parameter different from the first limit. The modulation parameter may be a pulse rate, with the first limit being less than 1500 Hz, and the second limit being greater than 1500 Hz. Or the modulation parameter may be a pulse width, with the first limit being greater than 100 ps, and the second limit being less than 100 ps. In another embodiment, the modulation parameter is an electrode combination, with the first limit being a range of electrode combinations having only anodic electrodes as primary modulating electrodes, and the second limit being a range of electrode combinations having only cathodic electrodes as primary modulating electrodes, or the first limit being a range of monopolar electrode combinations, and the second limit being a range of multipolar electrode combinations.

9. 发明专利

AU2015214522B2 System and method for delivering modulated sub-threshold therapy to a patient 未知
公开(公告)号：AU2015214522B2
公开(公告)日：2017-08-31
申请号：AU2015214522
申请日：2015-01-21
申请人： BOSTON SCIENT NEUROMODULATION CORP
发明人： PARRAMON JORDI , HERSHEY BRADLEY L , LEE DONGCHUL
IPC分类号： A61N1/36 , A61N1/372
摘要： A neuromodulation system configured for providing sub-threshold neuromodulation therapy to a patient. The neuromodulation system comprises a neuromodulation lead having at least one electrode configured for being implanted along a spinal cord of a patient, a plurality of electrical terminals configured for being respectively coupled to the at least one electrode, modulation output circuitry configured for delivering sub-threshold modulation energy to active ones of the at least one electrode, and control/processing circuitry configured for selecting a percentage from a plurality of percentages based on a known longitudinal location of the neuromodulation lead relative to the spinal cord, computing an amplitude value as a function of the selected percentage, and controlling the modulation output circuitry to deliver sub-threshold modulation energy to the patient at the computed amplitude value.

10. 发明专利

CA2736011C MULTIPLE TUNABLE CENTRAL CATHODES ON A PADDLE FOR INCREASED MEDIAL-LATERAL AND ROSTRAL-CAUDAL FLEXIBILITY VIA CURRENT STEERING 未知
公开(公告)号：CA2736011C
公开(公告)日：2017-01-03
申请号：CA2736011
申请日：2009-09-02
申请人： BOSTON SCIENT NEUROMODULATION CORP
发明人： MOFFITT MICHAEL ADAM , LEE DONGCHUL , BRADLEY KERRY , PETERSON DAVID K L
IPC分类号： A61N1/05 , A61N1/34
摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.

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