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1. 发明申请

WO2008034047A3 ENDOPROSTHESIS WITH ADJUSTABLE SURFACE FEATURES 审中-公开
标题翻译：具有可调节表面特征的内窥镜
公开(公告)号：WO2008034047A3
公开(公告)日：2009-04-02
申请号：PCT/US2007078475
申请日：2007-09-14
申请人： BOSTON SCIENT LTD , FLANAGAN AIDEN , MCMORROW DAVE , MALONE ANTHONY , O'CONNOR TIM , HEANEY BARRY
发明人： FLANAGAN AIDEN , MCMORROW DAVE , MALONE ANTHONY , O'CONNOR TIM , HEANEY BARRY
IPC分类号： A61L31/14 , A61F2/82
CPC分类号： A61L31/146 , A61F2/82 , A61F2/91 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/626
摘要： A stent having a surface or portion thereof comprising a polymer having a morphology of surface features having a substantially uniform periodicity of about 1 to 50 microns.
摘要翻译：一种具有表面或其部分的支架，其包含聚合物，所述聚合物具有约1-50微米的基本上均匀的周期性的表面特征的形态。

2. 发明申请

WO2008066656A3 STENTS WITH DRUG ELUTING COATINGS 审中-公开
标题翻译：带药液涂层的手套
公开(公告)号：WO2008066656A3
公开(公告)日：2009-07-02
申请号：PCT/US2007023221
申请日：2007-11-01
申请人： BOSTON SCIENT LTD , MALONE ANTHONY , O'CONNOR TIM , MCMORROW DAVE , FLANAGAN AIDEN
发明人： MALONE ANTHONY , O'CONNOR TIM , MCMORROW DAVE , FLANAGAN AIDEN
IPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/14 , A61L31/16
CPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/622
摘要： Provided is a coated medical device (e.g., a stent) comprising one or more surfaces having dispersed thereon a plurality of microparticles comprising an active pharmaceutical ingredient (API) and a polymer. Specifically, the microparticles are disposed on a device surface in a microparticulate phase coating, i.e., as discrete microparticles in the absence of a continuous phase coating. The medical device effectively adheres one or more APIs to its surface, and allows controlled release of the APIs from the device surface to a desired treatment area by using a minimal amount of polymer. The medical device is suitable for insertion or implantation into a subject, preferably a human. Also provided are methods for preparing and using the coated medical device.
摘要翻译：提供了包含一个或多个在其上分散有多个包含活性药物成分（API）和聚合物的微粒的表面的涂覆医疗装置（例如支架）。具体地，微粒在微粒相涂层中的器件表面上，即在不存在连续相涂覆的情况下作为离散微粒布置。医疗设备有效地将一个或多个API粘附到其表面，并且允许通过使用最少量的聚合物将API从设备表面控制释放到所需的治疗区域。医疗装置适于插入或植入受试者，优选人。还提供了制备和使用涂覆的医疗装置的方法。

3. 发明申请

WO2008054655A3 SYSTEM AND METHOD FOR COATING A MEDICAL DEVICE 审中-公开
标题翻译：用于涂敷医疗装置的系统和方法
公开(公告)号：WO2008054655A3
公开(公告)日：2009-04-30
申请号：PCT/US2007022405
申请日：2007-10-22
申请人： BOSTON SCIENT LTD , O'CONNOR TIM , HE LIJUAN , FLANAGAN AIDEN , MALONE ANTHONY , HEANEY BARRY , MCMORROW DAVE
发明人： O'CONNOR TIM , HE LIJUAN , FLANAGAN AIDEN , MALONE ANTHONY , HEANEY BARRY , MCMORROW DAVE
IPC分类号： B05D1/28
CPC分类号： B05D1/28 , B05D1/002 , B05D1/32 , Y10T29/49927
摘要： A method and device for coating a medical device, such as a stent, including rolling the stent against a ribbon or gravure roll impregnated with coating material. The ribbon and gravure roll may include a recessed pattern matching a strut pattern of the stent. The stent may also be rolled against a plate or cylinder while coating material is forced onto the stent through a pattern of holes or openings in the plate or cylinder matching a strut pattern of the stent.
摘要翻译：一种用于涂覆诸如支架的医疗装置的方法和装置，包括将支架滚压到浸渍有涂层材料的带或凹版辊上。带和凹版辊可以包括与支架的支柱图案相匹配的凹陷图案。支架也可以滚动抵靠板或圆柱体，同时通过与支架的支柱图案匹配的板或圆筒中的孔或开口的图案将涂层材料强制施加到支架上。

4. 发明申请

WO2009079389A3 DRUG-ELUTING ENDOPROSTHESIS 审中-公开
标题翻译：药物治疗内吞
公开(公告)号：WO2009079389A3
公开(公告)日：2010-04-08
申请号：PCT/US2008086639
申请日：2008-12-12
申请人： BOSTON SCIENT LTD , CLARKE JOHN T , O'CONNOR TIM , XU YIXIN , O'BRIEN BARRY , ARCAND BEN , SHIPPY JAMES LEE III , ATANASOSKA LILIANA , FLANAGAN AIDEN , MCMORROW DAVE , WEBER JAN , KREMER JOHN , KUEHLING MICHAEL , SEIDEL DOMINIQUE
发明人： CLARKE JOHN T , O'CONNOR TIM , XU YIXIN , O'BRIEN BARRY , ARCAND BEN , SHIPPY JAMES LEE III , ATANASOSKA LILIANA , FLANAGAN AIDEN , MCMORROW DAVE , WEBER JAN , KREMER JOHN , KUEHLING MICHAEL , SEIDEL DOMINIQUE
IPC分类号： A61L31/08 , A61L31/16
CPC分类号： A61L31/088 , A61L31/16 , A61L2300/45 , A61L2300/61
摘要： A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.
摘要翻译：包括生物腐蚀性金属部分和治疗剂的药物洗脱内用假体。在一些方面，内假体包括多个离散沉积物和多个覆盖层，每个覆盖层覆盖多个离散沉积物之一。每个离散的沉积物包括一种或多种治疗剂，并且每个上覆层包括一种或多种生物可腐蚀金属。在其他方面，生物腐蚀性金属部分包括具有不同电负性的至少两个生物可腐蚀金属区域。所述至少两个生物浸渍金属区域彼此电接触。生物腐蚀性金属在生理环境中侵蚀以释放治疗剂。

5. 发明申请

WO2008051342A3 REDUCTION OF BURST RELEASE FROM THERAPEUTICALLY TREATED MEDICAL DEVICES 审中-公开
标题翻译：从治疗过的医疗器械中减少爆发
公开(公告)号：WO2008051342A3
公开(公告)日：2008-07-17
申请号：PCT/US2007020346
申请日：2007-09-19
申请人： BOSTON SCIENT SCIMED INC , O'CONNOR TIM , FLANAGAN AIDEN , MCMORROW DAVE , MALONE ANTHONY
发明人： O'CONNOR TIM , FLANAGAN AIDEN , MCMORROW DAVE , MALONE ANTHONY
IPC分类号： A61L31/16 , A61F2/06 , A61L31/08
CPC分类号： A61L31/16 , A61F2250/0067 , A61L31/08 , A61L2300/602
摘要： The present invention generally relates to the conditioning of coated medical devices such as stents. More specifically, the present invention relates to methods for positioning a medical device within an elution media for a predetermined time period to eliminate a burst release from the coating. Under methods and processes of the invention, a medical device target surface may be identified and coated with therapeutic. The coated surface of the medical device may then be positioned within an elution media for a predetermined period of time to release a predetermined amount of coating.
摘要翻译：本发明总体上涉及涂覆的医疗装置例如支架的调理。更具体地说，本发明涉及用于将医疗装置定位在洗脱介质内预定时间段以消除来自涂层的突发释放的方法。在本发明的方法和过程下，可以识别医疗装置目标表面并涂敷治疗剂。然后可将医疗装置的涂覆表面定位在洗脱介质内预定时间段以释放预定量的涂层。

6. 发明申请

WO2008108987A3 MEDICAL DEVICE WITH A POROUS SURFACE FOR DELIVERY OF A THERAPEUTIC AGENT 审中-公开
标题翻译：具有用于递送治疗剂的多孔表面的医疗装置
公开(公告)号：WO2008108987A3
公开(公告)日：2009-09-03
申请号：PCT/US2008002711
申请日：2008-02-29
申请人： BOSTON SCIENT LTD , FLANAGAN AIDEN , MCMORROW DAVID , MALONE ANTHONY , O'CONNOR TIM
发明人： FLANAGAN AIDEN , MCMORROW DAVID , MALONE ANTHONY , O'CONNOR TIM
IPC分类号： A61L31/08 , A61L31/14 , A61L31/16
CPC分类号： A61F2/06 , A61L31/082 , A61L31/146 , A61L31/16 , A61L2300/416
摘要： The present invention is generally directed to implantable medical devices for delivering therapeutic agents to the body tissue of a patient and methods for making such medical devices. In particular, the present invention is directed to implantable medical devices, such as intravascular stents, having a surface that includes a plurality of cavities and a plurality of pores and a composition disposed in the pores and/or cavities, as well as, implantable medical devices, such as intravascular stents, having a surface that has a coating composition disposed on the surface, wherein the coating composition includes a plurality of cavities and a plurality of pores and another coating composition disposed in the pores and/or cavities.
摘要翻译：本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置和用于制造这种医疗装置的方法。特别地，本发明涉及可植入医疗装置，例如血管内支架，其具有包括多个空腔的表面和多个孔以及设置在孔和/或空腔中的组合物，以及植入式医疗装置，例如血管内支架，其具有设置在表面上的涂层组合物的表面，其中所述涂层组合物包括多个空腔和多个孔以及设置在孔和/或空腔中的另一涂层组合物。

7. 发明申请

WO2009131911A2 MEDICAL DEVICES HAVING A COATING OF INORGANIC MATERIAL 审中-公开
标题翻译：具有无机材料涂层的医疗装置
公开(公告)号：WO2009131911A2
公开(公告)日：2009-10-29
申请号：PCT/US2009040964
申请日：2009-04-17
申请人： BOSTON SCIENT SCIMED INC , FLANAGAN AIDEN , KILCOOLEY JOHN , O'CONNOR TIM , O'BRIEN BARRY , SEIDEL DOMINIQUE , KUEHLING MICHAEL , SCHEUERMANN TORSTEN , WEBER JAN
发明人： FLANAGAN AIDEN , KILCOOLEY JOHN , O'CONNOR TIM , O'BRIEN BARRY , SEIDEL DOMINIQUE , KUEHLING MICHAEL , SCHEUERMANN TORSTEN , WEBER JAN
IPC分类号： A61L31/08 , A61L31/16
CPC分类号： A61L29/10 , A61L29/16 , A61L31/082 , A61L31/16 , A61L2300/602 , A61L2300/61
摘要： In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating. In yet another aspect, a medical device has a polymer layer comprising a block co-polymer, wherein the polymer layer contains a therapeutic agent, and a barrier layer disposed over the polymer layer, wherein the barrier layer comprises an inorganic material, and wherein the barrier layer has a plurality of discontinuities. Methods of forming coatings on medical devices and methods of delivering therapeutic agents to body sites are also disclosed.
摘要翻译：在一个方面，医疗装置具有第一构造和第二构造，包含治疗剂的贮存器和设置在贮存器上方的阻挡层，其中阻挡层包括无机材料。在另一方面，医疗装置具有容纳治疗剂的储存器，设置在贮存器上方的阻挡层，其中所述阻挡层包括无机材料，以及设置在所述阻挡层和所述医疗装置的表面之间的可溶胀材料，其中可膨胀材料是暴露于含水环境时膨胀的材料。在另一方面，医疗装置具有多层涂层，其具有交替的储层和阻挡层，以及穿透多层涂层的至少部分厚度的多个挖掘区域。在另一方面，医疗装置具有包含嵌段共聚物的聚合物层，其中所述聚合物层含有治疗剂，以及设置在所述聚合物层上的阻挡层，其中所述阻挡层包含无机材料，并且其中阻挡层具有多个不连续性。还公开了在医疗装置上形成涂层的方法和将治疗剂递送到身体部位的方法。

8. 发明申请

WO2009158276A3 MEDICAL DEVICES CONTAINING THERAPEUTIC AGENTS 审中-公开
标题翻译：含有治疗药物的医疗器械
公开(公告)号：WO2009158276A3
公开(公告)日：2010-11-25
申请号：PCT/US2009047899
申请日：2009-06-19
申请人： BOSTON SCIENT SCIMED INC , CLARKE JOHN , O'CONNOR TIM , O'BRIEN BARRY J , MCMORROW DAVID , WEBER JAN , FLANAGAN AIDEN
发明人： CLARKE JOHN , O'CONNOR TIM , O'BRIEN BARRY J , MCMORROW DAVID , WEBER JAN , FLANAGAN AIDEN
IPC分类号： A61L31/02 , A61L31/08 , A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0014 , A61F2250/0025 , A61F2250/0026 , A61F2250/0037 , A61F2250/0067 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/082 , A61L31/146 , A61L2300/416 , A61L2300/63
摘要： The present invention pertains to implantable or insertable medical devices which comprise a substrate and one or more therapeutic-agent-containing regions contain one or more therapeutic agents. In various aspects of the invention, one or more characteristics of such therapeutic-agent-containing regions are controlled. Further aspects of the invention relate to methods of forming such devices and to methods of using such devices.
摘要翻译：本发明涉及可植入或可插入的医疗装置，其包括底物和含有一种或多种治疗剂的一种或多种含治疗剂的区域。在本发明的各个方面，控制这种含治疗剂的区域的一个或多个特征。本发明的其它方面涉及形成这种装置的方法以及使用这种装置的方法。

9. 发明申请

WO2009042667A2 MEDICAL DEVICES HAVING A METAL PARTICULATE COMPOSITION FOR CONTROLLED DIFFUSION 审中-公开
标题翻译：具有用于控制扩散的金属颗粒组合物的医疗装置
公开(公告)号：WO2009042667A2
公开(公告)日：2009-04-02
申请号：PCT/US2008077496
申请日：2008-09-24
申请人： BOSTON SCIENT SCIMED INC , CLARKE JOHN , MCMORROW DAVID , FLANAGAN AIDEN , O'CONNOR TIM , WEBER JAN , O'BRIEN BARRY J
发明人： CLARKE JOHN , MCMORROW DAVID , FLANAGAN AIDEN , O'CONNOR TIM , WEBER JAN , O'BRIEN BARRY J
IPC分类号： A61L27/04 , A61L27/50 , A61L27/54
CPC分类号： A61L31/022 , A61L31/14 , A61L31/16 , A61L2300/00
摘要： An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a particulate composition disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device into a subject.
摘要翻译：提供了一种植入式或可插入的医疗装置，其包括作为部件：（a）底物组分，其包含至少部分地填充有包含第一治疗剂的含治疗剂的材料的凹陷，和（b）处理的颗粒组合物在凹陷中，使得在将装置植入或插入到受试者中时，其调节化学物质在装置的凹陷和外部之间的运输。

10. 发明申请

WO2008140482A3 MEDICAL DEVICES HAVING COATINGS FOR CONTROLLED THERAPEUTIC AGENT DELIVERY 审中-公开
标题翻译：具有用于受控治疗药物递送的涂层的医疗装置
公开(公告)号：WO2008140482A3
公开(公告)日：2009-03-19
申请号：PCT/US2007023601
申请日：2007-11-09
申请人： BOSTON SCIENT SCIMED INC , WEBER JAN , FLANAGAN AIDEN , O'CONNOR TIM , O'BRIEN BARRY J , CLARKE JOHN , MCMORROW DAVID
发明人： WEBER JAN , FLANAGAN AIDEN , O'CONNOR TIM , O'BRIEN BARRY J , CLARKE JOHN , MCMORROW DAVID
IPC分类号： A61F2/82 , A61L31/08
CPC分类号： A61F2/06 , A61F2250/0068 , A61L27/30 , A61L27/54 , A61L31/082 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61N1/05
摘要： According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.
摘要翻译：根据本发明的一个方面，提供了医疗装置，其包括设置在包括基底的结构的至少一部分上的纳米颗粒衍生的无机层，以及任选地，设置在至少一部分上的治疗剂含有层的基底。在一些实施方案中，无机层是纳米多孔无机层。本发明的其它方面包括用于形成这种医疗装置的方法。

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