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1. 发明专利

ZA8800263B TRICYCLIC BENZIMIDAZOLES,PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：ZA8800263B
公开(公告)日：1988-06-29
申请号：ZA8800263
申请日：1988-01-15
申请人： BOEHRINGER MANNHEIM GMBH.
发明人： ALFRED MERTENS , WOLFGANG VON DER SAAL , ERWIN BOEHM , KLAUS STREIN
IPC分类号： A61K31/47 , A61K31/495 , A61P7/02 , C07D471/04 , C07D471/10 , C07D487/04 , C07D498/04 , C07D513/04 , C07D , A61K
CPC分类号： C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04

3. 发明专利

ZA888880B THE USE OF ANELLATED COMPOUNDS AS INHIBITORS OF ERTYHROCYTE AGGREGATION 未知
公开(公告)号：ZA888880B
公开(公告)日：1989-08-30
申请号：ZA888880
申请日：1988-11-29
申请人： BOEHRINGER MANNHEIM GMBH
发明人： SAAL WOLFGANG VON DER , MERTENS ALFRED , ALFRED MERTENS , WOLFGANG VON DER SAAL , BOEHM ERWIN , ERWIN BOEHM , MARTIN ULRICH , ULRICH MARTIN , HOELCK JENS-PETER , JENS-PETER HOELCK
IPC分类号： A61K31/40 , A61K31/41 , C07D487/04 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/50 , A61P1/04 , A61P3/08 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P17/00 , A61P25/02 , A61P29/00 , A61P35/00 , C07D498/04 , C07D513/04 , A61K
摘要： The tricyclics of the formula I in which R1 is an optionally substituted phenyl ring or an optionally substituted heterocyclic five-membered ring with 1 - 4 hetero atoms or a heterocyclic six-membered ring with 1 - 5 hetero atoms, where the hetero atoms can be identical or different and are oxygen, sulphur or nitrogen, and, if required, can carry an oxygen atom on one or more nitrogen atoms, or in the case where X is a bond, R1 is, besides the abovementioned groups, also a hydrogen atom, an alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, halogenoalkyl, alkoxyalkyl, carboxyalkyl, alkoxyl-carbonylalkyl, a hydroxyl, mercapto, amino, alkylmercapto, formylaminoalkyl or a pyridylcarbonylamino group, X is a bond, an alkylene or the vinylene group, A can be a nitrogen atom or the group CR5 where R5 is a hydrogen atom, an alkyl, alkenyl, cycloalkyl, cycloalkenyl, cyano, alkylcarbonyl, alkoxycarbonyl, carboxyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl or aryl group, B is an oxygen atom, a sulphur atom or the group NR6 where R6 is a hydrogen atom or an alkyl group, or B can be the group CR7R8 where R7 is a hydrogen atom, an alkyl, alkenyl or a cycloalkyl group, and R8 is a hydrogen atom, an alkyl, alkenyl or cyano group, a carbonyl group which is substituted by hydroxyl, alkyl, alkoxy, amino, alkylamino, dialkylamino or hydrazino, or R7 and R8 together form an alkylidene or cycloalkylidene group, or R7 and R8 form together with the C atom to which they are bonded a spirocycle, and their pharmacologically tolerated salts are used for the treatment of diseases in whose pathogenesis erythrocyte aggregation plays an important part.

5. 发明专利

ZA88263B TRICYCLIC BENZIMIDAZOLES,PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：ZA88263B
公开(公告)日：1988-06-29
申请号：ZA88263
申请日：1988-01-15
申请人： BOEHRINGER MANNHEIM GMBH.
发明人： ALFRED MERTENS , WOLFGANG VON DER SAAL , ERWIN BOEHM , KLAUS STREIN
IPC分类号： A61K31/435 , A61K31/47 , A61K31/495 , A61P7/02 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D498/04 , C07D513/04 , C07D , A61K
摘要： Novel tricyclic benzimidazoles of the formula I … … in which… R1 represents an optionally substituted phenyl ring, a naphthyl radical or a saturated or unsaturated heterocyclic 5-membered ring having 1-4 heteroatoms or a heterocyclic 6-membered ring having 1-5 heteroatoms, where the heteroatoms can be identical or different and denote oxygen, sulphur or nitrogen and, if desired, can carry an oxygen atom on one or more nitrogen atoms, and the 5- or 6-membered rings can optionally be substituted by one or more alkyl, alkoxy, alkylmercapto, hydroxyl, nitro, amino, halo or cyano groups or can be condensed with a phenyl ring to give a bicycle,… or in the case in which X represents a bond, R1 in addition to the abovementioned groups also denotes a hydrogen atom, an alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, haloalkyl, alkoxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, aminoalkyl, hydroxyalkyl, hydroxyl, mercapto, amino, alkylmercapto, alkylcarbonylamino, formylamino, alkylsulphonylamino, formylaminoalkyl, alkoxycarbonylaminoalkyl, alkylsulphonylaminoalkyl, alkoxycarbonylamino, trifluoromethyl or alkylcarbonylaminoalkyl group, X denotes a bond, an alkylene group, the vinylene group, the imino group -NH- or the amide group -CONH-, and… A, B, C and D independently of one another denote carbon and nitrogen atoms which can be substituted by hydrogen, alkyl groups or cycloalkyl groups, where the carbon atoms can also carry hydroxyl or oxo groups or can be constituents of a 3-7-membered spirocycle, where the 6-membered ring containing A, B, C and D can be saturated, partially unsaturated or unsaturated,… their tautomers and their physiologically tolerable salts of inorganic or organic acids, for the treatment of circulatory disorders, where they inhibit platelet and erythrocyte aggregation.

6. 发明专利

ZA89958B PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAMS,NEW SUBSTITUTED LACTAMS AND PROCESSES FOR THE PREPARATION THEREOF 未知
公开(公告)号：ZA89958B
公开(公告)日：1989-10-25
申请号：ZA89958
申请日：1989-02-08
申请人： BOEHRINGER MANNHEIM GMBH
发明人： ZILCH HARALD , HARALD ZILCH , MERTENS ALFRED , ALFRED MERTENS , SAAL WOLFGANG VON DER , WOLFGANG VON DER SAAL , BOEHM ERWIN , ERWIN BOEHM , STREIN KLAUS , KLAUS STREIN
IPC分类号： A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/47 , A61P7/02 , C07D209/34 , C07D209/54 , C07D215/38 , C07D215/54 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D , A61K
摘要： Novel medicaments containing lactams of the formula I … … in which… R represents a hydrogen atom, an alkyl or cycloalkyl group,… R denotes a hydrogen atom, an alkyl, alkenyl or a cycloalkyl group,… R denotes an alkyl, alkenyl or cyano group, or a carbonyl group substituted by a hydroxyl, alkyl, alkoxy, amino, alkylamino, dialkylamino or hydrazino group,… or R and R together represent an alkylidene or cycloalkylidene group,… or R and R , together with the carbon atom to which they are bonded, form a spirocycle,… n can be equal to 0 or 1,… A in the substituents R -X-A- represents the groups R -X-CO-NH-, R -X-NH-CO-NH- or R -X-O-CO-NH- in which… X represents a valence line, an alkylene chain or the vinyl group,… R denotes a mono- or polysubstituted phenyl ring, or a heterocyclic 5-membered ring having 1-4 hetero atoms, or a pyrazine, pyridazine, oxazine, thiazine, triazine or tetrazine ring or quinoline radical,… or in the case in which X represents a bond, R , besides the radicals mentioned, also denotes a C2-C12-alkyl or formylaminoalkyl group, their tautomers and their physiologically tolerable salts, and also novel lactams of the general formula I, process for their preparation and medicaments containing them for the treatment of diseases in which erythrocyte and platelet aggregation play an important role.

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