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2. 发明专利

CH633887A5 VERFAHREN UND REAGENS ZUR BESTIMMUNG VON SUBSTRATEN ODER ENZYMAKTIVITAETEN. 未知
公开(公告)号：CH633887A5
公开(公告)日：1982-12-31
申请号：CH571277
申请日：1977-05-06
申请人： BOEHRINGER MANNHEIM GMBH
发明人： DANNINGER JOSEF , DENEKE ULFERT DR , LANG GUNTER , MICHAL GERHARD DR , ROESCHLAU PETER DR
IPC分类号： G01N33/50 , C12Q1/26 , C12Q1/54

3. 发明专利

DE3064242D1 METHOD AND REAGENT FOR THE DETERMINATION OF FRUCTOSE 未知
公开(公告)号：DE3064242D1
公开(公告)日：1983-08-25
申请号：DE3064242
申请日：1980-06-16
申请人： BOEHRINGER MANNHEIM GMBH
发明人： BEUTLER HANS-OTTO DR , MICHAL GERHARD DR , STAHLER FRITZ DR
IPC分类号： C12Q1/48 , C12Q1/54 , G01N33/02

4. 发明专利

CH603682A5 未知
公开(公告)号：CH603682A5
公开(公告)日：1978-08-31
申请号：CH761071
申请日：1971-05-25
申请人： BOEHRINGER MANNHEIM GMBH
发明人： BERGMEYER HANS ULRICH DR , MICHAL GERHARD DR , NELBOECK-HOCHSTETTER MICHAEL D , STORK HARALD DR , WEIMANN GUENTER DR
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7056 , A61P3/06 , C07H19/052 , C07H19/04
摘要： 1316034 Imidazole ribosyl cyclophosphates BOEHRINGER MANNHEIM GmbH 25 May 1971 [27 May 1970] 16951/71 Heading C2P The invention comprises compounds of the Formula I where R is hydrogen or -(CH 2 ) n -A, n is 2 or 3, A is -SO 3 H or -COR 1 and R 1 is OH, C 1-6 alkoxy, alkylamino or dialkylamino, and the salts thereof. Compounds of Formula I in which R is other than hydrogen may be prepared by reacting inosine-3 1 ,5 1 -monophosphate with a compound of the Formula II where X is -CO- or -SO 2 -, heating the product with an aqueous solution of an alkali metal hydroxide and optionally, when an acid is obtained, converting the acid into an ester or amide. Compounds of Formula I in which R is hydrogen may be prepared by (a) reacting 2 1 - O - acetyl - inosine - 3 1 ,5 1 - monophosphate in a polar organic solvent with a metal hydride and then with chlorodimethylether, and heating the N 1 - methoxymethyl - 2 1 - O - acetyl - inosine - 3 1 ,5 1 - monophosphate obtained with an alkali metal hydroxide solution, or (b) by dissolving the 51-phosphate of 5-amino-1#-D- ribosyl-4-imidazole carboxamide and morpholino - N,N - dicyclohexylcarboxamidinium salt in a pyridine-water mixture, removing the water and heating the solution obtained with dicyclohexylcarbodiimide. The compounds of Formula I may be used as the active ingredients in pharmaceutical compositions, together with a solid or liquid diluent or carrier. 2 1 - O - Acetyl - inosine - 3 1 ,5 1 - monophosphate triethylammonium salt may be prepared by reacting inosine-3 1 ,5 1 -monophosphate with acetic anhydride and triethylamine.

5. 发明专利

DE2960533D1 METHOD FOR THE QUANTITATIVE ENZYMATIC DETERMINATION OF ADP AND REAGENT FOR THIS METHOD 未知
公开(公告)号：DE2960533D1
公开(公告)日：1981-10-29
申请号：DE2960533
申请日：1979-07-03
申请人： BOEHRINGER MANNHEIM GMBH
发明人： DENEKE ULFERT DR , MICHAL GERHARD DR , BEUTLER HANS-OTTO DR
IPC分类号： C12Q1/32 , C12Q1/25 , C12Q1/48 , C12Q1/527

7. 发明专利

CH640271A5 VERFAHREN ZUR BESTIMMUNG VON FORMIAT ODER IN FORMIAT UEBERFUEHRBAREN VERBINDUNGEN UND HIERFUER GEEIGNETES REAGENS. 未知
公开(公告)号：CH640271A5
公开(公告)日：1983-12-30
申请号：CH283478
申请日：1978-03-15
申请人： BOEHRINGER MANNHEIM GMBH
发明人： MICHAL GERHARD DR , LAUBE ROLF , ROEDER ALBERT DR , SCHNEIDER WALTER
IPC分类号： G01N33/00 , C12N9/02 , C12N9/04 , C12Q1/32 , G01N33/53

8. 发明专利

CH638050A5 VERFAHREN UND REAGENS ZUR BESTIMMUNG VON ASCORBINSAEURE. 未知
公开(公告)号：CH638050A5
公开(公告)日：1983-08-31
申请号：CH485778
申请日：1978-05-03
申请人： BOEHRINGER MANNHEIM GMBH
发明人： DENEKE ULFERT DR , MICHAL GERHARD DR , BEAUCAMP KLAUS DR
IPC分类号： G01N33/82 , C12Q1/26 , G01N21/78 , G01N31/00 , G01N33/02 , G01N33/14 , G01N31/22

9. 发明专利

DE2962335D1 METHOD AND REAGENT FOR THE DETERMINATION OF AN OXIDIZED PYRIDINE COENZYME 未知
公开(公告)号：DE2962335D1
公开(公告)日：1982-04-29
申请号：DE2962335
申请日：1979-07-03
申请人： BOEHRINGER MANNHEIM GMBH
发明人： WULFF KARL DR , STAHLER FRITZ DR , MICHAL GERHARD DR
IPC分类号： C12Q1/60 , C12Q1/00 , C12Q1/66 , G01N21/76
摘要： A method for the quantitative determination of an oxidized pyridine co-enzyme which comprises reacting a sample containing oxidized pyridine co-enzyme in the presence of its specific alcohol dehydrogenase with an aliphatic alcohol of 8 to 16 carbon atoms, oxidizing the aldehyde formed with reduced flavine mononucleotide and oxygen in the presence of luciferase and of the particular FMN-reductase which is independent of the co-enzyme to be determined and of the reduced substrate co-enzyme of the latter, and measuring the resulting light emission as a measure of the initial oxidized pyridine co-enzyme content.

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