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1. 发明专利

EE200100184A 未知
公开(公告)号：EE200100184A
公开(公告)日：2002-08-15
申请号：EEP200100184
申请日：1999-09-22
申请人： BOEHRINGER INGELHEIM PHARMA
发明人： WALTER RAINER , GRELL WOLFGANG , HECKEL ARMIN , HIMMELSBACH FRANK , EBERLEIN WOLFGANG , ROTH GERALD , MEEL JACOBUS C A VAN , REDEMANN NORBERT , SPEVAK WALTER , TONTSCH-GRUNT ULRIKE , RUEDEN THOMAS VON
IPC分类号： C07D401/12 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/34 , C07D209/36 , C07D209/48 , C07D401/14 , C07D403/12
摘要： The present invention relates to new substituted indolinones of general formulawhereinX and R1 to R5 are defined as in claim 1, the isomers and the salts thereof which have valuable properties.The above compounds of general formula I wherein R1 denotes a hydrogen atom, a C1-3-alkyl group or a prodrug group have valuable pharmacological properties, particularly an inhibiting effect on various kinases, on viral cyclin and on receptor tyrosine kinases, and the other compounds of the above general formula I wherein R1 does not represent a hydrogen atom, a C1-3-alkyl group or a prodrug group are valuable intermediate products for the preparation of the abovementioned compounds.

2. 发明专利

NO20011477D0 未知
公开(公告)号：NO20011477D0
公开(公告)日：2001-03-22
申请号：NO20011477
申请日：2001-03-22
申请人： BOEHRINGER INGELHEIM PHARMA
发明人： WALTER RAINER , GRELL WOLFGANG , HECKEL ARMIN , HIMMELSBACH FRANK , EBERLEIN WOLFGANG , ROTH GERALD , MEEL JACOBUS C A VAN , REDEMANN NORBERT , SPEVAK WALTER , TONTSCH-GRUNT ULRIKE , RUEDEN THOMAS VON
IPC分类号： C07D401/12 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/34 , C07D209/36 , C07D209/48 , C07D401/14 , C07D403/12 , C07D
摘要： The present invention relates to new substituted indolinones of general formulawhereinX and R1 to R5 are defined as in claim 1, the isomers and the salts thereof which have valuable properties.The above compounds of general formula I wherein R1 denotes a hydrogen atom, a C1-3-alkyl group or a prodrug group have valuable pharmacological properties, particularly an inhibiting effect on various kinases, on viral cyclin and on receptor tyrosine kinases, and the other compounds of the above general formula I wherein R1 does not represent a hydrogen atom, a C1-3-alkyl group or a prodrug group are valuable intermediate products for the preparation of the abovementioned compounds.

5. 发明专利

HRP20010216A2 NEW SUBSTITUTED INDOLINONES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS 未知
公开(公告)号：HRP20010216A2
公开(公告)日：2002-04-30
申请号：HRP20010216
申请日：2001-03-21
申请人： BOEHRINGER INGELHEIM PHARMA
发明人： WALTER RAINER , GRELL WOLFGANG , HECKEL ARMIN , HIMMELSBACH FRANK , EBERLEIN WOLFGANG , ROTH GERALD , MEEL JACOBUS C A VAN , REDEMANN NORBERT , SPEVAK WALTER , TONTSCH-GRUNT ULRIKE , RUEDEN THOMAS VON
IPC分类号： C07D401/12 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/34 , C07D209/36 , C07D209/48 , C07D401/14 , C07D403/12
摘要： The present invention relates to new substituted indolinones of general formulawhereinX and R1 to R5 are defined as in claim 1, the isomers and the salts thereof which have valuable properties.The above compounds of general formula I wherein R1 denotes a hydrogen atom, a C1-3-alkyl group or a prodrug group have valuable pharmacological properties, particularly an inhibiting effect on various kinases, on viral cyclin and on receptor tyrosine kinases, and the other compounds of the above general formula I wherein R1 does not represent a hydrogen atom, a C1-3-alkyl group or a prodrug group are valuable intermediate products for the preparation of the abovementioned compounds.

6. 发明专利

TR200100854T2 未知
公开(公告)号：TR200100854T2
公开(公告)日：2001-12-21
申请号：TR200100854
申请日：1999-09-22
申请人： BOEHRINGER INGELHEIM PHARMA
发明人： WALTER RAINER , GRELL WOLFGANG , HECKEL ARMIN , HIMMELSBACH FRANK , EBERLEIN WOLFGANG , ROTH GERALD , MEEL JACOBUS C A VAN , REDEMANN NORBERT , SPEVAK WALTER , TONTSCH-GRUNT ULRIKE , RUEDEN THOMAS VON
IPC分类号： C07D401/12 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/34 , C07D209/36 , C07D209/48 , C07D401/14 , C07D403/12
摘要： The present invention relates to new substituted indolinones of general formulawhereinX and R1 to R5 are defined as in claim 1, the isomers and the salts thereof which have valuable properties.The above compounds of general formula I wherein R1 denotes a hydrogen atom, a C1-3-alkyl group or a prodrug group have valuable pharmacological properties, particularly an inhibiting effect on various kinases, on viral cyclin and on receptor tyrosine kinases, and the other compounds of the above general formula I wherein R1 does not represent a hydrogen atom, a C1-3-alkyl group or a prodrug group are valuable intermediate products for the preparation of the abovementioned compounds.

7. 发明专利

BR9914065A 未知
公开(公告)号：BR9914065A
公开(公告)日：2001-06-19
申请号：BR9914065
申请日：1999-09-22
申请人： BOEHRINGER INGELHEIM PHARMA
发明人： WALTER RAINER , GRELL WOLFGANG , HECKEL ARMIN , HIMMELSBACH FRANK , EBERLEIN WOLFGANG , ROTH GERALD , MEEL JACOBUS C A VAN , REDEMANN NORBERT , SPEVAK WALTER , TONTSCH-GRUNT ULRIKE , RUEDEN THOMAS VON
IPC分类号： C07D401/12 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/34 , C07D209/36 , C07D209/48 , C07D401/14 , C07D403/12
摘要： The present invention relates to new substituted indolinones of general formulawhereinX and R1 to R5 are defined as in claim 1, the isomers and the salts thereof which have valuable properties.The above compounds of general formula I wherein R1 denotes a hydrogen atom, a C1-3-alkyl group or a prodrug group have valuable pharmacological properties, particularly an inhibiting effect on various kinases, on viral cyclin and on receptor tyrosine kinases, and the other compounds of the above general formula I wherein R1 does not represent a hydrogen atom, a C1-3-alkyl group or a prodrug group are valuable intermediate products for the preparation of the abovementioned compounds.

8. 发明专利

NO20011477L 未知
公开(公告)号：NO20011477L
公开(公告)日：2001-03-22
申请号：NO20011477
申请日：2001-03-22
申请人： BOEHRINGER INGELHEIM PHARMA
发明人： WALTER RAINER , GRELL WOLFGANG , HECKEL ARMIN , HIMMELSBACH FRANK , EBERLEIN WOLFGANG , ROTH GERALD , MEEL JACOBUS C A VAN , REDEMANN NORBERT , SPEVAK WALTER , TONTSCH-GRUNT ULRIKE , RUEDEN THOMAS VON
IPC分类号： C07D401/12 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P35/00 , A61P43/00 , C07D20060101 , C07D209/34 , C07D209/36 , C07D209/48 , C07D401/14 , C07D403/12
摘要： The present invention relates to new substituted indolinones of general formulawhereinX and R1 to R5 are defined as in claim 1, the isomers and the salts thereof which have valuable properties.The above compounds of general formula I wherein R1 denotes a hydrogen atom, a C1-3-alkyl group or a prodrug group have valuable pharmacological properties, particularly an inhibiting effect on various kinases, on viral cyclin and on receptor tyrosine kinases, and the other compounds of the above general formula I wherein R1 does not represent a hydrogen atom, a C1-3-alkyl group or a prodrug group are valuable intermediate products for the preparation of the abovementioned compounds.

9. 发明专利

DE19844003A1 New 3-aminomethylidene-2-indolinone derivatives useful as kinase inhibitors and antiproliferative agents e.g. for treating viral infections, tumors, inflammation or autoimmune disease 未知
公开(公告)号：DE19844003A1
公开(公告)日：2000-03-30
申请号：DE19844003
申请日：1998-09-25
申请人： BOEHRINGER INGELHEIM PHARMA
发明人： WALTER RAINER , GRELL WOLFGANG , HECKEL ARMIN , HIMMELSBACH FRANK , EBERLEIN WOLFGANG , MEEL JAKOBUS VAN , REDEMANN NORBERT , SPEVAK WALTER , TONTSCH-GRUNT ULRIKE , RUEDEN THOMAS VON
IPC分类号： A61K20060101 , A61K31/40 , C07D20060101 , C07D209/34 , C07D295/04
摘要： 3-(1-Amino-1-aryl-methylidene)-2-indolinone or thione derivatives (I) are new. 3-(1-Amino-1-aryl-methylidene)-2-indolinone or thione derivatives of formula (I) and their isomers and salts are new. X = O or S; R1, R4 = H or alkyl; R2 = H, halo, alkyl or NO2; R3 = phenyl or naphthyl (both optionally substituted by 1 or 2 of F, Cl, Br, alkyl, alkoxy, CN, CF3, NO2, NH2, mono- or dialkylamino, alkylsulfonylamino, aminoalkyl, mono- or dialkylaminoalkyl, alkanoylaminoalkyl and N-alkanoyl-N-alkylamino); R5 = phenyl or naphthyl both optionally substituted by one alkyl and further optionally substituted by (i) halo, alkyl, alkoxy, CN, NO2 or CF3, (ii) alkyl substituted by piperidino, hexamethyleneimino, morpholino or piperazino (where rings are all optionally substituted by alkyl, phenyl or phenylalkyl; and piperidino or hexamethyleneimino rings are further optionally substituted in the 3- or 4-position by OH, alkoxy or COOH), (iii) alkyl substituted by OH, alkoxy, COOH or CN, (iv) aminocarbonyl, amidino or guanidino (all optionally substituted by 1 or 2 alkyl), (v) piperidino, hexamethyleneimino, morpholino, piperazino or N-alkyl-piperazino, (vi) -CO-Q, (vii) NH2, 1-5C alkylamino, aminoalkyl, N-(alkylamino)-alkyl or di-(1-5C alkylamino)-alkyl (where all alkyl moieties are optionally substituted by CN, COOH, CONH2, mono- or di-alkylaminocarbonyl, 2-(dialkylamino)-ethylaminocarbonyl or 3-(dialkylamino)-propylcarbonyl or in the 2- or 3-position by OH, alkoxy, dialkylamino, piperidino, hexamethyleneimino, morpholino, piperazino or N-alkyl-piperazino; and N (where applicable) is optionally substituted by (1-5C) alkoxycarbonyl), (viii) 1-5C alkyl (optionally substituted (but not in the 1-position) by OH, alkoxy, NH2, or mono- or dialkylamino), (ix) alkylsulfonyl, amidosulfonyl or mono- or di-alkylaminoamidosulfonyl or (x) phenylalkylsulfonyl or phenylsulfonyl (both optionally substituted in the ring by F, Cl, Br, alkyl or alkoxy) and Q = H, OH, CF3, alkyl, alkoxyalkyl or dialkylamino; amino or alkylamino (both optionally substituted on N by carboxyalkyl, aminoalkyl or mono- or di-alkylaminoalkyl); piperidino, hexamethyleneimino, morpholino, piperazino, N-alkyl-piperazino, N-(phenylalkyl)-piperazino or 1-5C alkoxy; or alkyl (optionally substituted by COOH, OH, alkoxy, NH2, alkanoylamino, (1-5C) alkoxycarbonylamino, mono- or di-alkylamino, piperidino, hexamethyleneimino, morpholino, piperazino, N-alkyl-piperazino or N-(phenylalkyl)-piperazino). Any carboxy, amino or imino groups are optionally substituted by in vivo cleavable groups; Alkyl moieties have 1-3C and alkanoyl moieties 2-4C unless specified otherwise. An Independent claim is included for the preparation of (I).

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