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1. 发明专利

SK278500B6 AN AGENT FOR MOTION SICKNESS PREVENTION This paten 未知
公开(公告)号：SK278500B6
公开(公告)日：1997-05-14
申请号：SK949187
申请日：1987-12-18
申请人： BODO GYORGY , KNOLL JOZSEF , SOMFAI EVA , VIRAG SANDOR , ZAK FERENC
发明人： BODO GYORGY , KNOLL JOZSEF , SOMFAI EVA , VIRAG SANDOR , ZAK FERENC
IPC分类号： A61K31/137 , A23G3/34 , A23G4/00 , A23K1/00 , A23K1/16 , A23L1/00 , A23L2/52 , A61K9/00 , A61K9/20 , A61K31/135 , A61P1/08 , A61P25/00 , C07C211/48
摘要： t describes an agent used for motion sickness prevention, with an oral dosage application, mixed with additives, carriers, diluents, flavouring additives and/or colorants, flavouring agents and it contains the compound with a general formula (I) as the active compound, in the quantity of 0,01 up to 10 weight percent, while the symbol R in the formula (I) means hydrogen or halogen.

2. 发明申请

WO9502573A2 NEW METHOD FOR N-CYCLOPROPYLATION OF AROMATIC AMINES, AS WELL AS COMPOUNDS AND COMPOSITIONS OBTAINED 审中-公开
标题翻译：新方法用于芳族化合物的N-环丙烷化作为化合物和组合物获得
公开(公告)号：WO9502573A2
公开(公告)日：1995-01-26
申请号：PCT/HU9400025
申请日：1994-07-12
申请人： SOMFAI EVA
发明人： SOMFAI EVA
IPC分类号： C07C227/08 , C07D215/56 , A61K31/495 , C07D215/36
CPC分类号： C07D215/56 , C07C227/08
摘要： Process for the introduction of a cyclopropyl group into a primary or secondary aromatic amine or into heterocyclic compounds containing a secondary nitrogen atom reacting to the corresponding amines or their salts so as to form the corresponding N-cyclopropyl-(1'-carboxy)-derivatives either with the reagent of general formula (I), optionally in the presence of an acid binding agent or with 2,4-dihalogen-butyric acid ester or with chloroacetic acid ester, whereupon the resulting N-(alkoxy-carbonyl)-methyl-derivative is treated with alkali alkylate and dihalogen-ethane to convert the alkoxy-carbonyl-methyl group into a carbalkoxy-cyclopropyl group and subsequently optionally hydrolysing the ester groups if present and optionally eliminating the 1'-carboxyl group introduced in the course of the first step, whereby the last step is carried out optionally after introducing other substituents into the aromatic ring or after eliminating other substituents from the aromatic group. The method is suitable to synthesize 1-cyclopropyl-7-piperazine-1,4-dihydro-quinolone-3-carboxylic acid derivatives. New biologically active compounds are formed including compounds of formula (IV) and their salts which are used in pharmaceutical and veterinary compositions.
摘要翻译：将环丙基引入伯或仲芳族胺或含有与相应胺或其盐反应的仲氮原子的杂环化合物中以形成相应的N-环丙基 - （1'-羧基） - 衍生物的方法任选地在酸结合剂或2,4-二卤代丁酸酯或氯乙酸酯的存在下，与通式（I）的试剂反应，由此得到的N-（烷氧羰基） - 甲基 - 衍生物用碱性烷基化物和二卤代乙烷处理以将烷氧基羰基 - 甲基转化为烷氧基 - 环丙基，随后任选地水解酯基（如果存在的话），并且任选地除去在第一个过程中引入的1'-羧基其中最后一步可任选地在将其它取代基引入到芳环中之后或在从芳族基团中除去其它取代基之后进行。该方法适用于合成1-环丙基-7-哌嗪-1,4-二氢喹诺酮-3-羧酸衍生物。形成新的生物活性化合物，包括用于药物和兽药组合物的式（IV）化合物及其盐。

3. 发明专利

HU9302005D0 CHEMICAL PROCEDURE AND MATERIALS 未知
公开(公告)号：HU9302005D0
公开(公告)日：1993-10-28
申请号：HU9302005
申请日：1993-07-13
申请人： SOMFAI EVA
发明人： SOMFAI EVA
IPC分类号： C07C227/08 , C07D215/56
摘要： Process for the introduction of a cyclopropyl group into a primary or secondary aromatic amine or into heterocyclic compounds containing a secondary nitrogen atom reacting to the corresponding amines or their salts so as to form the corresponding N-cyclopropyl-(1'-carboxy)-derivatives either with the reagent of general formula (I), optionally in the presence of an acid binding agent or with 2,4-dihalogen-butyric acid ester or with chloroacetic acid ester, whereupon the resulting N-(alkoxy-carbonyl)-methyl-derivative is treated with alkali alkylate and dihalogen-ethane to convert the alkoxy-carbonyl-methyl group into a carbalkoxy-cyclopropyl group and subsequently optionally hydrolysing the ester groups if present and optionally eliminating the 1'-carboxyl group introduced in the course of the first step, whereby the last step is carried out optionally after introducing other substituents into the aromatic ring or after eliminating other substituents from the aromatic group. The method is suitable to synthesize 1-cyclopropyl-7-piperazine-1,4-dihydro-quinolone-3-carboxylic acid derivatives. New biologically active compounds are formed including compounds of formula (IV) and their salts which are used in pharmaceutical and veterinary compositions.

5. 发明专利

CS185841B1 AGENT FOR PROTECTION OF RAW LEATHERS AND WOOL AGAINST PESTS 未知
公开(公告)号：CS185841B1
公开(公告)日：1978-10-31
申请号：CS190275
申请日：1975-03-20
申请人： VERMES ERZSEBET , LUGOSI GYOERGY , LASZLOFFY ISTVAN , NIKOLETTI FERENC , SOMFAI EVA
发明人： VERMES ERZSEBET , LUGOSI GYOERGY , LASZLOFFY ISTVAN , NIKOLETTI FERENC , SOMFAI EVA
IPC分类号： D06M13/02 , A01N57/20 , C14C11/00 , D06M13/07 , D06M13/244 , D06M13/282 , D06M13/292 , D06M16/00 , D06M101/00 , D06M101/02 , D06M101/10 , D06M101/12 , A01N9/02 , A01N9/04 , A01N9/36

6. 发明专利

CS185355B1 DERIVATIVES OF PENICILLANIC AND CEPHALOSPHORIC ACID AND METHOD FOR PREPARING THEREOF 未知
公开(公告)号：CS185355B1
公开(公告)日：1978-09-15
申请号：CS529275
申请日：1975-07-28
申请人： HUHN MAGDA , SZABO GABOR , RESOFSZKI GABOR , SOMFAI EVA
发明人： HUHN MAGDA , SZABO GABOR , RESOFSZKI GABOR , SOMFAI EVA
IPC分类号： C07C69/353 , A61K31/43 , A61K31/545 , A61K31/546 , A61P31/04 , C07D333/24 , C07D499/00 , C07D499/12 , C07D499/72 , C07D501/06 , C07D501/20 , C07D501/22 , C07D501/26 , C07D501/28 , C07D501/32 , C07D501/34 , C07D501/60 , C07D499/44
摘要： This invention relates to a process for the preparation of acid amides having the formula (I) or their salts (I) wherein R1 is hydrogen or an easily removable ester-forming or salt-forming group, preferably a trialkylamine, trialkylsilyl, trichloroethyl, acetoxymethyl, phenacyl, substituted phenacyl, substituted phenyl or benzyl group, R2 is hydrogen, alkyl group, alkenyl group, alkyl group having an aryl or heterocyclic (preferably furyl or thienyl) - substituent, an aryl group having an alkyl substituent (preferably xylyl), or an aryl, aralkyl or heterocyclic group (preferably a phenyl, thienyl, or furyl group) which can have one or more substituents, R3 is hydrogen, or substituted or unsubstituted aryl, alkyl, cycloalkyl or aralkyl group, and X is a group of one of the formulae according to the invention an amine of the formula (II), (II) wherein R4 is an easily removable ester-forming group, preferably a trialkylamino, trialkylsilyl, trichloroethyl, acetoxymethyl, phenacyl, substituted phenacyl, substituted phenyl or benzyl group, or a salt formed preferably with an alkali metal or a trialkylamine, is acylated with an ester of the formula (III), (III) wherein R5 is a substituted or unsubstituted aryl, alkyl, cycloalkyl or aralkyl group, and, if desired, substituents R4 and/or R5 of the obtained product can be split off, and/or, if desired, the obtained product is converted into its salt or a salt is converted into the free acid.

7. 发明专利

YU145486A PROCESS FOR MAKING COLOURLESS PRODUCTS CONTAINING FORMED ELEMENTS OF BLOOD 未知
公开(公告)号：YU145486A
公开(公告)日：1988-08-31
申请号：YU145486
申请日：1986-08-19
申请人： HARMATH SANDOR , ALMASI LASZLO , FAZEKAS ARPAD , SOMFAI EVA , HUTAS ISTVAN
发明人： SANDOR HARMATH , HARMATH SANDOR , LASZLO ALMASI , ALMASI LASZLO , ARPAD FAZEKAS , FAZEKAS ARPAD , EVA SOMFAI , SOMFAI EVA , ISTVAN HUTAS , HUTAS ISTVAN
IPC分类号： A23J1/06

8. 发明专利

AU7236494A New method for n-cyclopropylation of aromatic amines, as well as compounds and compositions obtained 未知
公开(公告)号：AU7236494A
公开(公告)日：1995-02-13
申请号：AU7236494
申请日：1994-07-12
申请人： SOMFAI EVA
发明人： SOMFAI EVA
IPC分类号： C07C227/08 , C07D215/56 , C07D215/36 , A61K31/495
摘要： Process for the introduction of a cyclopropyl group into a primary or secondary aromatic amine or into heterocyclic compounds containing a secondary nitrogen atom reacting to the corresponding amines or their salts so as to form the corresponding N-cyclopropyl-(1'-carboxy)-derivatives either with the reagent of general formula (I), optionally in the presence of an acid binding agent or with 2,4-dihalogen-butyric acid ester or with chloroacetic acid ester, whereupon the resulting N-(alkoxy-carbonyl)-methyl-derivative is treated with alkali alkylate and dihalogen-ethane to convert the alkoxy-carbonyl-methyl group into a carbalkoxy-cyclopropyl group and subsequently optionally hydrolysing the ester groups if present and optionally eliminating the 1'-carboxyl group introduced in the course of the first step, whereby the last step is carried out optionally after introducing other substituents into the aromatic ring or after eliminating other substituents from the aromatic group. The method is suitable to synthesize 1-cyclopropyl-7-piperazine-1,4-dihydro-quinolone-3-carboxylic acid derivatives. New biologically active compounds are formed including compounds of formula (IV) and their salts which are used in pharmaceutical and veterinary compositions.

9. 发明专利

HU191320B OXIDATION PROCESS 未知
公开(公告)号：HU191320B
公开(公告)日：1987-02-27
申请号：HU102285
申请日：1985-03-20
申请人： HORVATH SANDOR , ALMASI LASZLO , FAZEKAS ARPAD , SOMFAI EVA , HUTAS ISTVAN
发明人： HORVATH SANDOR , ALMASI LASZLO , FAZEKAS ARPAD , SOMFAI EVA , HUTAS ISTVAN
IPC分类号： A23J1/06 , A23J3/12 , A23K10/24

10. 发明专利

DK550886A 未知
公开(公告)号：DK550886A
公开(公告)日：1986-11-18
申请号：DK550886
申请日：1986-11-18
申请人： HARMATH SANDOR , ALMASI LASZLO , FAZEKAS ARPAD , SOMFAI EVA , HUTAS ISTVAN
发明人： HARMATH SANDOR , ALMASI LASZLO , FAZEKAS ARPAD , SOMFAI EVA , HUTAS ISTVAN
IPC分类号： A23J20060101 , A23J1/00

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