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1. 发明申请

WO2007059470A2 BLACK BEAR PARATHYROID HORMONE AND METHODS OF USING BLACK BEAR PARATHYROID HORMONE 审中-公开
标题翻译：黑熊鹦鹉火鸡和黑熊使用方法PARATHYROID HORMONE
公开(公告)号：WO2007059470A2
公开(公告)日：2007-05-24
申请号：PCT/US2006/060844
申请日：2006-11-13
申请人： BOARD OF CONTROL OF MICHIGAN TECHNOLOGICAL UNIVERSITY , DONAHUE, Seth, W.
发明人： DONAHUE, Seth, W.
IPC分类号： C12N5/077
CPC分类号： C07K14/635 , A61K38/00 , C12N5/0654 , C12N2501/37
摘要： Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Also provided are methods of using black bear PTH and functional fragments for increasing cAMP in a bone-forming cell; reducing apoptosis in a bone-forming cell; decreasing the ratio of expression levels of Bax protein to Bcl-2 protein in a bone-forming cell; increasing the expression level of one or more of a bone matrix protein, a transcriptional activator, or a transcriptional regulator in a bone-forming cell; enhancing bone mineral density, increasing bone mass, decreasing bone loss, or reducing the incidence of bone fractures, or any combination thereof, in a subject; also provided are antibodies directed against black bear parathyroid hormone (PTH) and functional fragments thereof.
摘要翻译：提供黑熊甲状旁腺激素（PTH）及其功能片段。还提供了使用黑熊PTH和功能片段在骨形成细胞中增加cAMP的方法; 减少骨形成细胞凋亡; 降低骨形成细胞中Bax蛋白与Bcl-2蛋白的表达水平之比; 增加骨形成细胞中骨基质蛋白，转录激活子或转录调节子中的一种或多种的表达水平; 在受试者中增强骨矿物质密度，增加骨质量，减少骨丢失或减少骨折的发生率或其任何组合; 还提供针对黑熊甲状旁腺激素（PTH）的抗体及其功能片段。

2. 发明公开

EP1945245A2 BLACK BEAR PARATHYROID HORMONE AND METHODS OF USING BLACK BEAR PARATHYROID HORMONE 审中-公开
标题翻译：黑熊甲状旁腺激素及其使用方法黑熊甲状旁腺激素
公开(公告)号：EP1945245A2
公开(公告)日：2008-07-23
申请号：EP06846290.2
申请日：2006-11-13
申请人： The Board of Control of Michigan Technological University
发明人： DONAHUE, Seth, W.
IPC分类号： A61K38/48
CPC分类号： C07K14/635 , A61K38/00 , C12N5/0654 , C12N2501/37
摘要： Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Also provided are methods of using black bear PTH and functional fragments for increasing cAMP in a bone-forming cell; reducing apoptosis in a bone-forming cell; decreasing the ratio of expression levels of Bax protein to Bcl-2 protein in a bone-forming cell; increasing the expression level of one or more of a bone matrix protein, a transcriptional activator, or a transcriptional regulator in a bone-forming cell; enhancing bone mineral density, increasing bone mass, decreasing bone loss, or reducing the incidence of bone fractures, or any combination thereof, in a subject; also provided are antibodies directed against black bear parathyroid hormone (PTH) and functional fragments thereof.

3. 发明申请

WO2011071480A1 BLACK BEAR PARATHYROID HORMONE AND METHODS OF USING BLACK BEAR PARATHYROID HORMONE 审中-公开
标题翻译：黑熊鹦鹉火鸡和黑熊使用方法PARATHYROID HORMONE
公开(公告)号：WO2011071480A1
公开(公告)日：2011-06-16
申请号：PCT/US2009/066974
申请日：2009-12-07
申请人： MICHIGAN TECHNOLOGICAL UNIVERSITY , DONAHUE, Seth, W.
发明人： DONAHUE, Seth, W.
IPC分类号： C07K14/635
CPC分类号： C07K14/635 , A61K38/00
摘要： Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Also provided are methods of using black bear PTH and functional fragments for increasing cAMP in a bone-forming cell; reducing apoptosis in a bone-forming cell; decreasing the ratio of expression levels of Bax protein to Bcl-2 protein in a bone-forming cell; increasing the expression level of one or more of a bone matrix protein, a transcriptional activator, or a transcriptional regulator in a bone-forming cell; enhancing bone mineral density, increasing bone mass, decreasing bone loss, or reducing the incidence of bone fractures, or any combination thereof, in a subject; also provided are antibodies directed against black bear parathyroid hormone (PTH) and functional fragments thereof.
摘要翻译：提供黑熊甲状旁腺激素（PTH）及其功能片段。还提供了使用黑熊PTH和功能片段在骨形成细胞中增加cAMP的方法; 减少骨形成细胞凋亡; 降低骨形成细胞中Bax蛋白与Bcl-2蛋白的表达水平之比; 增加骨形成细胞中骨基质蛋白，转录激活子或转录调节子中的一种或多种的表达水平; 在受试者中增强骨矿物质密度，增加骨质量，减少骨丢失或减少骨折的发生率或其任何组合; 还提供针对黑熊甲状旁腺激素（PTH）的抗体及其功能片段。

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