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1. 发明申请

WO2007002580A3 DIAGNOSTIC AS SAY SYSTEM WITH MULTI -WELL REAGENT CONTAINER 审中-公开
标题翻译：诊断为具有多个试剂容器的SAY系统
公开(公告)号：WO2007002580A3
公开(公告)日：2007-05-31
申请号：PCT/US2006024791
申请日：2006-06-23
申请人： BIOVERIS CORP , KOCHAR MANISH SWARNARAJ , DAVIS CHARLES QUENTIN , LELAND JONATHAN K , MANTEUFFEL RICHARD , COOK RICHARD A
发明人： KOCHAR MANISH SWARNARAJ , DAVIS CHARLES QUENTIN , LELAND JONATHAN K , MANTEUFFEL RICHARD , COOK RICHARD A
IPC分类号： G01N35/00 , G01N21/76
CPC分类号： G01N21/76 , B01L3/5082 , B01L2200/025 , B01L2300/0858 , G01N33/54326 , G01N33/5438 , G01N35/00 , G01N2035/0436 , G01N2035/0493 , G01N2035/1025
摘要： A biological detection system used to measure one or more analytes in a sample through the use of binding reactions comprises a detector (192) configured to detect a label used in the binding reactions; a holder (115,1501) to hold at least one multi-well reagent container (373,375,550) containing the label and binding reagents for a plurality of binding reactions; a probe (150) to distribute a portion of a sample into the multi-well reagent containers; a pump (870) fluidically connected to the probe; and a liquid-level detector (LLD) for determining the presence and/or amount of liquid in at least one of a sample container and the multi-well reagent container. The system may also comprise magnetic capture zones for magnetisable beads and filter means for filtering the sample. The labelled binding partner may be a compound useful for an electrochemiluminescent (ECL) assay, and the system may include an electrode for initiating ECL.
摘要翻译：用于通过使用结合反应测量样品中的一种或多种分析物的生物检测系统包括被配置为检测在结合反应中使用的标记的检测器（192）保持器（115,1501），用于容纳至少一个容纳标签的多孔试剂容器（373,375,550）和用于多个结合反应的结合试剂; 将一部分样品分配到多孔试剂容器中的探针（150）; 与所述探针流体连接的泵（870）以及用于确定样品容器和多孔试剂容器中的至少一个中的液体的存在和/或量的液位检测器（LLD）。该系统还可以包括用于可磁化珠的磁捕获区和用于过滤样品的过滤装置。标记的结合配偶体可以是可用于电化学发光（ECL）测定的化合物，并且该系统可以包括用于启动ECL的电极。

2. 发明申请

WO2004061418A3 ASSAY CARTRIDGES AND METHODS OF USING THE SAME 审中-公开
标题翻译：测定盒及其使用方法
公开(公告)号：WO2004061418A3
公开(公告)日：2007-09-07
申请号：PCT/US0341241
申请日：2003-12-23
申请人： MESO SCALE TECHNOLOGIES LLC , GLAZER ELI N , LELAND JONATHAN K , BILLADEAU MARK A , LEGINUS JOSEPH M , JEFFREY-COKER BANDELE , DEBAD JEFF D , PHALNIKAR KOUSTUBH A , JAMBUNATHAN SRIRAM
发明人： GLAZER ELI N , LELAND JONATHAN K , BILLADEAU MARK A , LEGINUS JOSEPH M , JEFFREY-COKER BANDELE , DEBAD JEFF D , PHALNIKAR KOUSTUBH A , JAMBUNATHAN SRIRAM
IPC分类号： C12M1/34 , B01L3/00 , B01L9/00 , B01L99/00 , C12M3/00 , C12Q1/00 , C12Q1/68 , C40B40/10 , G01N15/06 , G01N21/00 , G01N25/18 , G01N27/02 , G01N31/22 , G01N33/00 , G01N33/48 , G01N33/53 , G01N33/543 , G01N33/553
CPC分类号： G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
摘要翻译：测定模块，优选测定盒，被描述为可用于控制模块操作的方面的读取器设备。模块优选地包括具有集成电极的检测室，其可用于执行电极诱导的发光测量。描述了以这种控制方式将测定试剂固定在这些电极和其它表面上的方法。还描述了具有检测室，优选地具有集成电极的测定模块和盒，以及可以包括样品室，废物室，导管，通风口，气泡阱，试剂室，干试剂丸区等的其它流体组分。在某些优选实施例中，这些模块适于接收和分析在施用器棒上收集的样品。

3. 发明专利

DK0871891T3 未知
公开(公告)号：DK0871891T3
公开(公告)日：2006-07-17
申请号：DK95944075
申请日：1995-12-04
申请人： BIOVERIS CORP
发明人： NACAMULLI LAURETTE , LELAND JONATHAN K , JAMEISON STEPHANIE A
IPC分类号： G01N33/532 , G01N33/557 , C09K11/06 , C12Q1/00 , G01N33/58
摘要： The rate of a biomolecular reaction, such as an enzymatic reaction or an affinity binding reaction, is measured using electrochemiluminescence ("ECL"). The reaction is conducted in an electrochemical cell with a mixture of reagents including a luminophore which will relate the concentration of a reactant, a reaction partner or the reaction product of a reaction partner to the ECL intensity. The reaction partner is a reagent which reacts with the reactant and which participates with the luminophore (or its reaction product participates with the luminophore) to cause the emission of ECL. The ECL intensity is modulated with a series of electrical pulses which are applied to the mixture of reagents at a preselected potential and for preselected intervals of time and duration. The ECL intensity is measured at the same intervals to provide a timed series of values (P). The same experiment is repeated except that the modulation is conducted after the reaction has gone to completion to obtain a timed series of values (C). The same experiment is repeated a third time in the absence of the reaction partner to obtain a times series of values (B). The results are normalized (N) using the following formula: N = P - B C - B ( I ) to obtain a series of values N which can be used to plot the time course (concentration vs. time) of the reaction.

4. 发明专利

AU7562694A Apparatus and methods for carrying out electrochemiluminescence test measurements 未知
公开(公告)号：AU7562694A
公开(公告)日：1996-03-07
申请号：AU7562694
申请日：1994-08-15
申请人： BIOVERIS CORP
发明人： GHAED ALI , LELAND JONATHAN K , ZOSKI GLENN D , GOODMAN JACK E , GROSSER JOHN T
IPC分类号： G01N21/76 , B01F15/00 , G01N21/69 , G01N21/75 , G01N35/00 , G01N35/02 , G01N35/04
摘要： An apparatus for detecting the presence of analytes of interest by inducing and detecting electrocheluminescence in a test sample includes an agitated carousel (140) to releasably support a plurality of sample tubes (142).

5. 发明专利

CA2583643A1 APPARATUS AND METHODS FOR CARRYING OUT ELECTROCHEMILUMINESCENCE TEST MEASUREMENTS 未知
公开(公告)号：CA2583643A1
公开(公告)日：1996-02-22
申请号：CA2583643
申请日：1994-08-15
申请人： BIOVERIS CORP
发明人： GHAED ALI , LELAND JONATHAN K , GROSSER JOHN T , ZOSKI GLENN D , GOODMAN JACK E
IPC分类号： G01N21/69 , B01F15/00 , G01N21/76

6. 发明专利

ES2260767T3 MEDICIONES DE LA VELOCIDAD DE LAS REACCIONES BIOMOLECULARES UTILIZANDO ELECTROLUMINISCENCIA. 未知
公开(公告)号：ES2260767T3
公开(公告)日：2006-11-01
申请号：ES95944075
申请日：1995-12-04
申请人： BIOVERIS CORP
发明人： NACAMULLI LAURETTE , LELAND JONATHAN K , JAMEISON STEPHANIE A
IPC分类号： G01N33/532 , C09K11/06 , C12Q1/00 , G01N33/557 , G01N33/58
摘要： UNA REACCION BIOMOLECULAR, COMO POR EJEMPLO UNA REACCION DE UNION ENZIMATICA O DE AFINIDAD, SE EFECTUA EN UNA CELULA ELECTROQUIMICA CON UNA MEZCLA DE REACTIVOS QUE INCLUYE UN LUMINOFORO QUE RELACIONARA LA CONCENTRACION DE UN REACTIVO, UN PARTICIPE DE LA REACCION O PRODUCTO DE LA REACCION DE UN PARTICIPE DE REACCION DE LA INTENSIDAD DE ELECTROQUIMIOLUMINISCENCIA, CON OBJETO DE DETERMINAR LA VELOCIDAD DE LA REACCION BIOMOLECULAR. EL PARTICIPE DE LA REACCION ES UN REACTIVO QUE REACCIONA CON EL REACTANTE, Y QUE EL MISMO O EL PRODUCTO DE LA REACCION PARTICIPAN CON EL LUMINOFORO PARA ORIGINAR EMISIONES DE ECL. LA INTENSIDAD ECL SE MODULA CON UNA SERIE DE PULSOS ELECTRICOS QUE SE SUMINISTRAN A LA MEZCLA DE REACTIVOS SEGUN UN POTENCIAL PRESELECCIONADO PARA INTERVALOS PRESELECCIONADOS DE TIEMPO Y DURACION. LA INTENSIDAD SE MIDE DURANTE DICHOS INTERVALOS PARA SUMINISTRAR UNA SERIE TEMPORIZADA DE VALORES (P). EL MISMO EXPERIMENTO SE REPITE DOS VECES MAS, UNO EN EL QUE LA MODULACION SE REALIZA UNA VEZQUE LA REACCION HA FINALIZADO PARA OBTENER LA SERIE TEMPORIZADA DE VALORES (C), Y LA ULTIMA VEZ QUE SE REALIZO LA REACCION EN AUSENCIA DEL PARTICIPE DE LA REACCION PARA OBTENER LAS SERIES TEMPORIZADAS DE VALORES (B). LOS RESULTADOS SE NORMALIZAN (N) USANDO LA FORMULA I PARA OBTENER UNA SERIE DE VALORES (N) QUE SON REPRESENTADOS EN UN GRAFICO PARA OBTENER EL TIEMPO TRANSCURRIDO DE LA REACCION.

7. 发明专利

ES2273339T3 APARATO Y METODO DE DETECCION ELECTROQUIMIOLUMINISCENTE BASADA EN PARTICULAS MAGNETICAS. 未知
公开(公告)号：ES2273339T3
公开(公告)日：2007-05-01
申请号：ES95943578
申请日：1995-11-13
申请人： BIOVERIS CORP
发明人： TALLEY DAVID B , LELAND JONATHAN K
IPC分类号： G01N21/76 , G01N21/66 , G01N21/69 , G01N21/78 , G01N33/543 , G01N33/553 , G01N33/58 , G01N35/00
摘要： UN METODO Y APARATO PARA MEDIR LA ELECTROQUIMIOLUMINISCENCIA DE UNA COMPOSICION MUESTRA SE DESCRIBEN, EN DONDE ESPECIES ELECTROQUIMIOLUMINISCENTES ACTIVAS SENSIBLES SE CAPTURAN POR EL ELECTRODO (5) CON LA AYUDA DE UN IMAN (15) DE CAPTURA QUE TIENE UNA CONFIGURACION TAL QUE LAS LINEAS DE FLUJO MAGNETICO (O EL GRADIENTE DEL CAMPO MAGNETICO) DE AL MENOS UNA FUENTE DE CAMPO MAGNETICO EN SU INTERIOR SE COMPRIMEN Y/O DISPERSAN. DICHO IMAN (15) DE CAPTURA MEJORA LA DISTRIBUCION DE LAS ESPECIES ELECTROQUIMIOLUMINISCENTEMENTE ACTIVAS SENSIBLES MAGNETICAMENTE SOBRE LA SUPERFICIE (5) DEL ELECTRODO Y REDUCE LA INTERFERENCIA CON EL TUBO (20) FOTOMULTIPLICADOR, POTENCIANDO DE DICHA FORMA LA SEÑAL (ECL) Y MEJORANDO LA SENSIBILIDAD. LA DISTRIBUCION Y CAPTURA MEJORADAS TAMBIEN PERMITEN TIEMPOS DE ANALISIS MENORES.

8. 发明专利

PT871891E MEDICOES DA VELOCIDADE DE REACCAO DE REACCOES BIOMOLECULARES UTILIZANDO ELECTROQUIMIOLUMINESCENCIA 未知
公开(公告)号：PT871891E
公开(公告)日：2006-07-31
申请号：PT95944075
申请日：1995-12-04
申请人： BIOVERIS CORP
发明人： LELAND JONATHAN K , JAMEISON STEPHANIE A , LAURETTE NACAMULLI
IPC分类号： G01N33/532 , C09K11/06 , C12Q1/00 , G01N33/557 , G01N33/58

9. 发明专利

ES2227580T3 MARCADORES DE QUIMIOLUMINISCENCIA ELECTROGENERADA PARA LABORES DE ANALISIS Y/O REFERENCIA. 未知
公开(公告)号：ES2227580T3
公开(公告)日：2005-04-01
申请号：ES96903716
申请日：1996-02-09
申请人： BIOVERIS CORP
发明人： BARD ALLEN J , RICHARDS THOMAS C , LELAND JONATHAN K
IPC分类号： G01N33/532 , C07D279/24 , C07H19/04 , C09K11/07 , C12N15/09 , C12Q1/00 , C12Q1/68 , C12Q1/70 , G01N21/76 , G01N21/78 , G01N27/00 , G01N33/483 , G01N33/53 , G01N33/543 , G01N33/58 , G01N37/00
摘要： ANALISIS DE BIOMOLECULAS QUE EMPLEA OXIDACION ANODICA DE 9, 10-DIFENILANTRACEN-2-SULFONATO DE SODIO ACUOSO (DPAS) Y ACIDO 1- Y 2-TIANTRENOCARBOXILICO (1-THCOOH Y 2-THCOOH) EN PRESENCIA DE TRIN-PROPILAMINA (TPRA) COMO CORREACTIVO EN SOLUCION ACUOSA QUE PRODUCE QUIMILUMINISCENCIA ELECTROGENERADA (ECL). ADEMAS, LA REDUCCION CATODICA DE DPAS EN PRESENCIA DE PEROXIDISULFATO (S2O8-2) COMO CORREACTIVO PRODUCE TAMBIEN ECL EN UNA SOLUCION ACUOSA DE ACETONITRILO (MECN) (1:1 EN VOLUMEN). LA OXIDACION DE CLOROPROMAZINA (CPZ) PRODUCE UNA EMISION ECL EN AUSENCIA DE UN CORREACTIVO AÑADIDO SIGUIENDO UN MECANISMO "AUTOANIQUILACION" SIN PRECEDENTES.

10. 发明专利

PT755458E 未知
公开(公告)号：PT755458E
公开(公告)日：2005-01-31
申请号：PT96903716
申请日：1996-02-09
申请人： BIOVERIS CORP
发明人： BARD ALLEN J , LELAND JONATHAN K , RICHARDS THOMAS C
IPC分类号： G01N33/532 , C07D279/24 , C07H19/04 , C09K11/07 , C12N15/09 , C12Q1/00 , C12Q1/68 , C12Q1/70 , G01N21/76 , G01N21/78 , G01N27/00 , G01N33/483 , G01N33/53 , G01N33/543 , G01N33/58 , G01N37/00

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