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1. 发明申请

WO2008101311A1 PROCESS FOR PURIFICATION OF WATER SOLUBLE POLYMERS 审中-公开
标题翻译：水溶性聚合物的纯化方法
公开(公告)号：WO2008101311A1
公开(公告)日：2008-08-28
申请号：PCT/CA2007/000272
申请日：2007-02-22
申请人： BIOVECTRA INC. , MONTHONY, James, F. , YANG, Li , KERSHAW, Kurt, E. , WINSLOW, Christopher, D. , RILEY, John, G.
发明人： MONTHONY, James, F. , YANG, Li , KERSHAW, Kurt, E. , WINSLOW, Christopher, D. , RILEY, John, G.
IPC分类号： C08L29/02 , B01D59/30 , C08F6/12 , C08G65/30 , G01N33/44
CPC分类号： C08F8/44 , B01D15/361 , B01J47/12 , C08F6/003 , C08G65/30 , C08G65/3326 , C08G65/3346 , G01N30/02 , Y10T436/255
摘要： A process for purification of water soluble polymers is provided. A polymer of interest can be separated from a mixture of polymers, provided the polymer of interest differs from other polymers in the mixture in the number of reactive terminal groups. The process involves derivatizing polymers at the reactive terminal groups with a derivatizing molecule, bearing either (i) two or three cationic or anionic ionizable groups, and a group capable of covalent bonding to the reactive terminal groups or (ii) three or four ionizable groups, at least one of which is capable of covalent bonding to the reactive terminal groups; followed by ion exchange. The process allows removal of PEG from MPEG, and can be used for polymers having an average size greater than 9,000 Da Derivatization may be reversible in order to allow re-use of recovered contaminant polymers.
摘要翻译：提供了一种用于纯化水溶性聚合物的方法。感兴趣的聚合物可以从聚合物的混合物中分离出来，只要所关心的聚合物与反应性末端基团数目的混合物中的其它聚合物不同。该方法包括用衍生化分子衍生化反应性末端基团的聚合物，该衍生化分子带有（i）两个或三个阳离子或阴离子可离子基团，以及能够与反应性末端基团共价结合的基团，或（ii）三个或四个可离子化基团，其中至少一个能够与反应性末端基团共价结合; 然后进行离子交换。该方法允许从MPEG去除PEG，并且可以用于平均尺寸大于9,000Da的聚合物。衍生化可以是可逆的，以便允许再利用回收的污染物聚合物。

2. 发明申请

WO2009073977A1 POLYPEPTIDES MODIFIED BY PROTEIN TRANS-SPLICING TECHNOLOGY 审中-公开
标题翻译：蛋白质分离技术改性多肽
公开(公告)号：WO2009073977A1
公开(公告)日：2009-06-18
申请号：PCT/CA2008/002171
申请日：2008-12-12
申请人： BIOVECTRA INC. , MONTHONY, James, F. , LIU, Paul, Xiang-Qin , YANG, Li , ZHOU, Kaisong
发明人： MONTHONY, James, F. , LIU, Paul, Xiang-Qin , YANG, Li , ZHOU, Kaisong
IPC分类号： C07K14/195 , C07K17/00 , C07K19/00 , C08G65/329 , C12N15/52 , C12N15/62 , C12N9/00 , C12P21/02
CPC分类号： C12N15/1027 , C07K1/1075 , C07K1/1077 , C07K14/00 , C12N15/63
摘要： The present invention relates to a method of preparing modified polypeptides, by linking a target polypeptide to a carrier molecule that is designed to bear one or more water-soluble polymer molecules, via protein trans-splicing. The polymer molecules can be attached to the carrier molecule either before or after ligation to the target polypeptide. Novel protein trans-splicing elements (known as "split inteins") and trans-splicing partners are also provided.
摘要翻译：本发明涉及通过蛋白质转接将目标多肽与被设计为承载一种或多种水溶性聚合物分子的载体分子连接来制备修饰的多肽的方法。聚合物分子可以在与靶多肽连接之前或之后连接至载体分子。还提供了新的蛋白质转接元件（称为“分裂内含肽”）和转拼合子。

3. 发明公开

EP2113009A1 PROCESS FOR PURIFICATION OF WATER SOLUBLE POLYMERS 有权
标题翻译： VERFAHREN ZUR AUFREINIGUNGWASSERLÖSLICHERPOLYMERE
公开(公告)号：EP2113009A1
公开(公告)日：2009-11-04
申请号：EP07701815.8
申请日：2007-02-22
申请人： Biovectra Inc.
发明人： MONTHONY, James, F. , YANG, Li , KERSHAW, Kurt, E. , WINSLOW, Christopher, D. , RILEY, John, G.
IPC分类号： C08L29/02 , B01D59/30 , C08F6/12 , C08G65/30 , G01N33/44
CPC分类号： C08F8/44 , B01D15/361 , B01J47/12 , C08F6/003 , C08G65/30 , C08G65/3326 , C08G65/3346 , G01N30/02 , Y10T436/255
摘要： A process for purification of water soluble polymers is provided. A polymer of interest can be separated from a mixture of polymers, provided the polymer of interest differs from other polymers in the mixture in the number of reactive terminal groups. The process involves derivatizing polymers at the reactive terminal groups with a derivatizing molecule, bearing either (i) two or three cationic or anionic ionizable groups, and a group capable of covalent bonding to the reactive terminal groups or (ii) three or four ionizable groups, at least one of which is capable of covalent bonding to the reactive terminal groups; followed by ion exchange. The process allows removal of PEG from MPEG, and can be used for polymers having an average size greater than 9,000 Da Derivatization may be reversible in order to allow re-use of recovered contaminant polymers.
摘要翻译：提供了一种用于纯化水溶性聚合物的方法。感兴趣的聚合物可以从聚合物的混合物中分离出来，只要所关心的聚合物与反应性末端基团数目的混合物中的其它聚合物不同。该方法包括用衍生化分子衍生化反应性末端基团的聚合物，该衍生化分子带有（i）两个或三个阳离子或阴离子可离子基团，以及能够与反应性末端基团共价结合的基团，或（ii）三个或四个可离子化基团，其中至少一个能够与反应性末端基团共价结合; 然后进行离子交换。该方法允许从MPEG去除PEG，并且可以用于平均尺寸大于9,000Da的聚合物。衍生化可以是可逆的，以便允许再利用回收的污染物聚合物。

4. 发明授权

EP2113009B1 PROCESS FOR PURIFICATION OF WATER SOLUBLE POLYMERS 有权
公开(公告)号：EP2113009B1
公开(公告)日：2018-11-21
申请号：EP07701815.8
申请日：2007-02-22
申请人： Biovectra Inc.
发明人： MONTHONY, James, F. , YANG, Li , KERSHAW, Kurt, E. , WINSLOW, Christopher, D. , RILEY, John, G.
IPC分类号： C08L29/02 , B01D59/30 , C08F6/12 , C08G65/30 , G01N33/44 , B01D15/36 , B01J47/12 , C08F6/00 , C08F8/44 , C08G65/332 , C08G65/334 , G01N30/02
CPC分类号： C08F8/44 , B01D15/361 , B01J47/12 , C08F6/003 , C08G65/30 , C08G65/3326 , C08G65/3346 , G01N30/02 , Y10T436/255
摘要： A process for purification of water soluble polymers is provided. A polymer of interest can be separated from a mixture of polymers, provided the polymer of interest differs from other polymers in the mixture in the number of reactive terminal groups. The process involves derivatizing polymers at the reactive terminal groups with a derivatizing molecule, bearing either (i) two or three cationic or anionic ionizable groups, and a group capable of covalent bonding to the reactive terminal groups or (ii) three or four ionizable groups, at least one of which is capable of covalent bonding to the reactive terminal groups; followed by ion exchange. The process allows removal of PEG from MPEG, and can be used for polymers having an average size greater than 9,000 Da Derivatization may be reversible in order to allow re-use of recovered contaminant polymers.

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