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1. 发明申请

WO2007076064A3 AEROSOL PROCESSING AND INHALATION METHOD AND SYSTEM FOR HIGH DOSE RATE AEROSOL DRUG DELIVERY 审中-公开
标题翻译：高剂量率气溶胶药物递送的气雾剂处理和吸入方法和系统
公开(公告)号：WO2007076064A3
公开(公告)日：2007-12-13
申请号：PCT/US2006049134
申请日：2006-12-22
申请人： BIOTECHPLEX CORP , YEATES DONOVAN , YI JINGHAI , LI GUANGLIN
发明人： YEATES DONOVAN , YI JINGHAI , LI GUANGLIN
IPC分类号： A61M15/00
CPC分类号： A61M15/0086 , A61M11/042 , A61M11/06 , A61M15/008 , A61M2016/0036 , A61M2205/362 , A61M2205/368 , B01D45/08
摘要： A method and system is disclosed which is capable of delivering at a high dose rate, respirable solid aerosols derived from aqueous- or nonaqueous-based solutions containing the desired therapeutic agent(s). The method and system comprises the integration of an aerosol generator, an aerosol evaporator, an aerosol concentrator, and an aerosol flow regulator. The aerosol generator generates 10-30 µm droplets, with a narrow size distribution. The aerosol jet is arrested by a coaxial counter-flow heated air jet, and evaporated rapidly by annular swirling heated air. Most of the air, together with the unwanted solvent vapor, is removed from the aerosol stream during the process of aerosol concentration. The output aerosol carries the dry particles to be inhaled by the patient. The respiratory-governed control of aerosol fluid generation system delivers fluid containing the test agent of interest (drug or toxin) to the aerosol generator throughout inhalation.
摘要翻译：公开了一种方法和系统，其能够以高剂量率输送源自含有所需治疗剂的水基或非水基溶液的可呼吸固体气溶胶。该方法和系统包括气溶胶发生器，气溶胶蒸发器，气溶胶浓缩器和气溶胶流量调节器的集成。气溶胶发生器产生10-30微米的液滴，具有狭窄的尺寸分布。气溶胶射流被同轴逆流加热的空气射流阻止，并且通过环形旋转热空气迅速蒸发。在气溶胶浓缩过程中，大部分空气连同不需要的溶剂蒸汽一起从气溶胶流中除去。输出气雾携带干燥的颗粒以被患者吸入。气雾剂流体产生系统的呼吸控制控制在整个吸入过程中将含有感兴趣测试剂（药物或毒素）的流体递送到气雾剂发生器。

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