专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

DE60006649T2 未知
公开(公告)号：DE60006649T2
公开(公告)日：2004-09-30
申请号：DE60006649
申请日：2000-02-17
申请人： BIOTECHNOLOG FORSCHUNG GMBH , BRISTOL MYERS SQUIBB CO
发明人： HOEFLE GERHARD , GLASER NICOLE , LEIBOLD THOMAS , VITE GREGORY , KIM SOONG-HOON
IPC分类号： A01N43/78 , A01N43/90 , A61K31/425 , A61P35/00 , C07D417/06 , C07D493/04
摘要： The invention is concerned with epothilones in which the thiazole substituent has been modified, with methods for their preparation and with antifungal or therapeutic agents which contain these epothilones.

2. 发明专利

AU771089B2 C-21 modified epothilones 未知
公开(公告)号：AU771089B2
公开(公告)日：2004-03-11
申请号：AU3234800
申请日：2000-02-17
申请人： BIOTECHNOLOG FORSCHUNG GMBH , BRISTOL MYERS SQUIBB CO
发明人： HOEFLE GERHARD , GLASER NICOLE , LEIBOLD THOMAS , VITE GREGORY , KIM SOONG-HOON
IPC分类号： A01N43/78 , A01N43/90 , A61K31/425 , A61P35/00 , C07D417/06 , C07D493/04
摘要： The invention is concerned with epothilones in which the thiazole substituent has been modified, with methods for their preparation and with antifungal or therapeutic agents which contain these epothilones.

3. 发明专利

SK10782001A3 C-21 MODIFIED EPOTHILONES 未知
公开(公告)号：SK10782001A3
公开(公告)日：2002-03-05
申请号：SK10782001
申请日：2000-02-17
申请人： BIOTECHNOLOG FORSCHUNG GMBH , BRISTOL MYERS SQUIBB CO
发明人： HOEFLE GERHARD , GLASER NICOLE , LEIBOLD THOMAS , VITE GREGORY , KIM SOONG-HOON
IPC分类号： A01N43/78 , A01N43/90 , A61K31/425 , A61P35/00 , C07D417/06 , C07D493/04
摘要： The invention is concerned with epothilones in which the thiazole substituent has been modified, with methods for their preparation and with antifungal or therapeutic agents which contain these epothilones.

4. 发明专利

NO320806B1 未知
公开(公告)号：NO320806B1
公开(公告)日：2006-01-30
申请号：NO20014017
申请日：2001-08-17
申请人： BRISTOL MYERS SQUIBB CO , BIOTECHNOLOG FORSCHUNG GMBH
发明人： HOFLE GERHARD , KIM SOONG-HOON , VITE GREGORY , GLASER NICOLE , LEIBOLD THOMAS
IPC分类号： C07D417/06 , A01N43/78 , A01N43/90 , A61K31/425 , A61P35/00 , C07D493/04
摘要： The invention is concerned with epothilones in which the thiazole substituent has been modified, with methods for their preparation and with antifungal or therapeutic agents which contain these epothilones.

5. 发明专利

DE60006649D1 未知
公开(公告)号：DE60006649D1
公开(公告)日：2003-12-24
申请号：DE60006649
申请日：2000-02-17
申请人： BIOTECHNOLOG FORSCHUNG GMBH , BRISTOL MYERS SQUIBB CO
发明人： HOEFLE GERHARD , GLASER NICOLE , LEIBOLD THOMAS , VITE GREGORY , KIM SOONG-HOON
IPC分类号： A01N43/78 , A01N43/90 , A61K31/425 , A61P35/00 , C07D417/06 , C07D493/04
摘要： The invention is concerned with epothilones in which the thiazole substituent has been modified, with methods for their preparation and with antifungal or therapeutic agents which contain these epothilones.

6. 发明专利

BR0008379A 未知
公开(公告)号：BR0008379A
公开(公告)日：2002-09-24
申请号：BR0008379
申请日：2000-02-17
申请人： BIOTECHNOLOG FORSCHUNG GMBH , BRISTOL MYERS SQUIBB CO
发明人： HOEFLE GERHARD , GLASER NICOLE , LEIBOLD THOMAS , VITE GREGORY , KIM SOONG-HOON
IPC分类号： A01N43/78 , A01N43/90 , A61K31/425 , A61P35/00 , C07D417/06 , C07D493/04
摘要： The invention is concerned with epothilones in which the thiazole substituent has been modified, with methods for their preparation and with antifungal or therapeutic agents which contain these epothilones.

7. 发明专利

TR200102401T2 未知
公开(公告)号：TR200102401T2
公开(公告)日：2001-12-21
申请号：TR200102401
申请日：2000-02-17
申请人： BIOTECHNOLOG FORSCHUNG GMBH , BRISTOL MYERS SQUIBB CO
发明人： HOEFLE GERHARD , LEIBOLD THOMAS , VITE GREGORY , KIM SOONG-HOON
IPC分类号： A01N43/78 , A01N43/90 , A61K31/425 , A61P35/00 , C07D417/06 , C07D493/04
摘要： The invention is concerned with epothilones in which the thiazole substituent has been modified, with methods for their preparation and with antifungal or therapeutic agents which contain these epothilones.

8. 发明专利

AU3234800A C-21 modified epothilones 未知
公开(公告)号：AU3234800A
公开(公告)日：2000-09-14
申请号：AU3234800
申请日：2000-02-17
申请人： BIOTECHNOLOG FORSCHUNG GMBH , BRISTOL MYERS SQUIBB CO
发明人： HOEFLE GERHARD , GLASER NICOLE , LEIBOLD THOMAS , VITE GREGORY , KIM SOONG-HOON
IPC分类号： A01N43/78 , A01N43/90 , A61K31/425 , A61P35/00 , C07D417/06 , C07D493/04
摘要： The invention is concerned with epothilones in which the thiazole substituent has been modified, with methods for their preparation and with antifungal or therapeutic agents which contain these epothilones.

9. 发明专利

CZ301498B6 C-21 modifikované epothilony 未知
公开(公告)号：CZ301498B6
公开(公告)日：2010-03-24
申请号：CZ20012991
申请日：2000-02-17
申请人： BIOTECHNOLOG FORSCHUNG GMBH , BRISTOL MYERS SQUIBB CO
发明人： HOEFLE GERHARD , GLASER NICOLE , LEIBOLD THOMAS , VITE GREGORY , KIM SOONG-HOON
IPC分类号： C07D417/06 , A01N43/78 , A01N43/90 , A61K31/335 , A61K31/425 , A61K31/427 , A61P35/00 , A61P35/02 , A61P35/04 , C07D277/22 , C07D493/04 , C07D521/00
摘要： Epothilonový derivát obecného vzorce Ia nebo Ib, zpusob jeho prípravy a farmaceutický prostredek s jeho obsahem. Tyto slouceniny mají antifungální a cytotoxické vlastnosti, a používají se pro lécení nádorových onemocnení a poruch rustu.

10. 发明专利

NO20000076D0 未知
公开(公告)号：NO20000076D0
公开(公告)日：2000-01-07
申请号：NO20000076
申请日：2000-01-07
申请人： BRISTOL MYERS SQUIBB CO
发明人： VITE GREGORY , BORZILLERI ROBERT M , KIM SOONG-HOON , JOHNSON JAMES A
IPC分类号： C07D491/044 , A61K31/335 , A61K31/395 , A61K31/427 , A61P19/00 , A61P35/00 , A61P43/00 , C07D225/00 , C07D273/00 , C07D277/26 , C07D313/00 , C07D417/06 , C07D417/08 , C07D491/04 , C07D493/04 , C07D498/04 , C07D
摘要： The present invention relates to compounds of the formulaQ is selected from the group consisting ofG is selected from the group consisting of alkyl, substituted alkyl, substituted or unsubstituted aryl, heterocyclo,W is O or NR 15 ;X is O or H,H;Y is selected from the group consisting of O; H,OR 16 ; OR 17 ,OR 17 ; NOR 18 ; H,NOR 19 ; H,NR 20 R 21 ; H,H; or CHR 22 ; OR 17 OR 17 can be a cyclic ketal;Z 1 , and Z 2 are selected from the group consisting of CH 2 , O, NR 23 , S, or SO 2 , wherein only one of Z and Z 2 is a heteroatom;B 1 and B 2 are selected from the group consisting of OR 24 , or OCOR 25 , or O 2 CNR 26 R 27 ; when B 1 is H and Y is OH, H they can form a six-membered ring ketal or acetal;D is selected from the group consisting of NR 28 R 29 , NR 30 COR 31 or saturated heterocycleR 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 13 , R 14 , R 18 , R 19 , R 20 , R 21 , R 22 , R 26 , and R 27 are selected from the group H, alkyl, substituted alkyl, or aryl and when R 1 and R 2 are alkyl can be joined to form a cycloalkyl; R 3 and R 4 are alkyl can be joined to form a cycloalkyl;R 9 , R 10 , R 16 , R 17 , R 24 , R 25 , and R 31 are selected from the group H, alkyl, or substituted alkyl;R 8 , R 11 , R 12 , R 28 , R 30 , R 32 , R 33 , and R 30 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, or heterocyclo;R 15 , R 23 and R 29 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, heterocyclo, R 32 C=O, R 33 SO 2 , hydroxy, O-alkyl or O-substituted alkyl, the pharmaceutically acceptable salts thereof and any hydrates, solvates or geometric, optical and stereoisomers thereof, with the proviso that compounds whereinW and X are both O; andR 1 , R 2 , R 7 , are H; andR 3 , R 4 , R 6 , are methyl; andR 8 , is H or methyl; andZ 1 , and Z 2 , are CH 2 ; andG is 1-methyl-2-(substituted-4-thiazolyl)ethenyl; andQ is as defined above are excluded.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式