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1. 发明专利

DE19718843A1 New eliamide obtained by cultivating Sorangium cellulosum 未知
公开(公告)号：DE19718843A1
公开(公告)日：1998-11-12
申请号：DE19718843
申请日：1997-05-06
申请人： BIOTECHNOLOG FORSCHUNG GMBH
发明人： REICHENBACH HANS PROF DR , HOEFLE GERHARD PROF DR , GERTH KLAUS DR
IPC分类号： C07D207/38 , C12P17/10 , C07D207/36 , A61K31/40
摘要： Eliamide of formula (I) is new. Also claimed are: (i) a heterocyclic compound with the formula C23H35NO4, an IR spectrum (CHCl3) psi = 1719 cm , 1680 cm and 1632 cm and UV spectrum (CH3OH), lambda max ( iota ) = 223 (19200) and 234 (19300) nm; and (ii) a heterocyclic compound (I') which is prepared by cultivating Sorangium cellulosum DSM 11529 aerobically in a medium which contains carbon and nitrogen sources and mineral salts in the presence of an adsorbing resin, separating cells and the adsorber resin from the culture medium, stirring with a mixture of methanol and acetone, separating supernatant and solids, eluting the solids with methanol and concentrating until an aqueous phase appears, concentrating the supernatant until an aqueous phase appears, combining the aqueous phases, extracting with ethyl acetate and concentrating the extract to give a crude extract, creating a solution of the crude extract using petroleum ether in the presence of a small amount of methanol, then chromatographing this gradient on silica gel using a stepwise gradient of petroleum ether to petroleum ether/tert.-butyl methyl ether, subjecting the resulting fractions to thin layer chromatography on silica gel using a petroleum ether/diethyl ether mixture, detecting fractions which contain (I') using fluorescence quenching at 254 nm and separating these fractions, combining the separated fractions, evaporating them to give a crude product and chromatographing them on silica gel using a petroleum ether/tert.-butyl ether/methanol mixture as eluent, detecting fractions which contain (I') using UV light at 227 nm and separating these fractions, combining them, evaporating the combined fractions and isolating (I').

2. 发明专利

DE4319274A1 Gephyronic acids, their preparation and compositions comprising gephyronic acids 未知
公开(公告)号：DE4319274A1
公开(公告)日：1994-12-15
申请号：DE4319274
申请日：1993-06-09
申请人： BIOTECHNOLOG FORSCHUNG GMBH
发明人： REICHENBACH HANS PROF DR , HOEFLE GERHARD PROF DR , SASSE FLORENZ DR , STEINMETZ HEINRICH
IPC分类号： C07C59/90 , C07D309/10 , C12P7/64 , C12P17/06 , A01N37/42 , A01N43/16 , A61K31/19 , C07C51/42 , C12P7/42
摘要： The invention relates to gephyronic acids of the formula to salts of these acids, to their preparation, and to compositions comprising the acids.

3. 发明专利

DE4305486A1 Icumazoles and preparation processes 未知
公开(公告)号：DE4305486A1
公开(公告)日：1994-08-25
申请号：DE4305486
申请日：1993-02-23
申请人： BIOTECHNOLOG FORSCHUNG GMBH
发明人： REICHENBACH HANS PROF DR , HOEFLE GERHARD PROF DR , BOEHLENDORF BETTINA DR , IRSCHIK HERBERT DR
IPC分类号： C07D311/76 , C07D413/06 , C07D413/14
摘要： The invention relates to icumazoles of the following general formula in which R can have the following meanings: or or and processes for their preparation.l

4. 发明专利

DE4142950A1 未知
公开(公告)号：DE4142950A1
公开(公告)日：1993-07-01
申请号：DE4142950
申请日：1991-12-24
申请人： BIOTECHNOLOG FORSCHUNG GMBH
发明人： HOEFLE GERHARD PROF DR , REICHENBACH HANS PROF DR , SASSE FLORENZ DR , STEINMETZ HEINRICH
IPC分类号： C07D498/08 , C12P17/18
摘要： The invention relates to rhizopodines of general formula (1) and to the production thereof and compositions containing them.

5. 发明专利

DE19636721A1 未知
公开(公告)号：DE19636721A1
公开(公告)日：1998-03-12
申请号：DE19636721
申请日：1996-09-10
申请人： BIOTECHNOLOG FORSCHUNG GMBH
发明人： REICHENBACH HANS PROF DR , HOEFLE GERHARD PROF DR , GERTH KLAUS DR , WASHAUSEN PETER DR
IPC分类号： C07D309/30 , C12P17/06 , C12N1/20 , A61K31/365 , A61K31/35
摘要： The invention relates to a compound with antibiotic and antitumoral activity, having formula (I). Also disclosed is a process to produce an antibiotic and an antitumoral agent containing the compound. Finally, the invention concerns the Sorangium cellulosum strain DSM 11 071.

6. 发明专利

DE19607702A1 未知
公开(公告)号：DE19607702A1
公开(公告)日：1997-09-04
申请号：DE19607702
申请日：1996-02-29
申请人： BIOTECHNOLOG FORSCHUNG GMBH
发明人： REICHENBACH HANS PROF DR , HOEFLE GERHARD PROF DR , GERTH KLAUS DR , WASHAUSEN PETER DR
IPC分类号： C07D309/32 , C12P17/06 , A61K31/365
摘要： The invention relates to novel heterocyclic compounds which may also be designated as jerangolides. It also relates to a process for obtaining said compounds, and agents with a content thereof.

7. 发明专利

DE4324672A1 Compound with antibiotic activity, preparation process and composition containing the compound 未知
公开(公告)号：DE4324672A1
公开(公告)日：1995-01-26
申请号：DE4324672
申请日：1993-07-22
申请人： BIOTECHNOLOG FORSCHUNG GMBH
发明人： REICHENBACH HANS PROF DR , HOEFLE GERHARD PROF DR , JANSEN ROLF DR , KUNZE BRIGITTE DR
IPC分类号： C07C237/22 , C12P13/04 , C07K5/02 , A61K38/00 , C07C237/16 , C12P13/02 , C12P21/02 , C12P39/00
摘要： The invention relates to a compound of the formula to a process for the preparation thereof and to a composition containing the compound.

8. 发明专利

DE4138042C2 未知
公开(公告)号：DE4138042C2
公开(公告)日：1993-10-14
申请号：DE4138042
申请日：1991-11-19
申请人： BIOTECHNOLOG FORSCHUNG GMBH
发明人： HOEFLE GERHARD PROF DR , BEDORF NORBERT DR , GERTH KLAUS DR , REICHENBACH HANS PROF DR
IPC分类号： A01N43/90 , C07D493/04 , C12P17/18 , A01N63/02 , A61K31/425 , C07G11/00

9. 发明专利

DE58902503D1 未知
公开(公告)号：DE58902503D1
公开(公告)日：1992-11-26
申请号：DE58902503
申请日：1989-08-31
申请人： BIOTECHNOLOG FORSCHUNG GMBH , CIBA GEIGY AG
发明人： SUTTER MARIUS DR , BOEHLENDORF BETTINA , BEDORF NORBERT DR , HOEFLE GERHARD PROF DR
IPC分类号： A01N43/90 , C07D493/00 , C07D493/08 , C07D493/18 , C07H19/01
摘要： A macrocyclic compound of the formula I, (I) in which the substituents have the following meaning: X is hydrogen or methyl, Y is hydrogen, -CHO, -COCH3, -COCH2OCH3, -COCH2OCH3, -COCH2NH2, benzyl, methyl or a silyl group, and A-B-C is the following C3-chain members: in which R1, R2 and R3, independently of one another, are hydrogen, methyl, -CHO, -COCH2OCH3, -COCH2OCH3, -COCH2NH2 or a silyl group, and R4 and R5 are hydrogen, halogen or -COO(C1-C3) alkyl, is suitable for controlling and preventing plant diseases. A compound of this type can be employed in a customary manner in the form of plant-protecting agents formulated with carrier substances and extenders.

10. 发明专利

DE3930950A1 New derivatives of sorangicin A - are antibiotics active against resistant strains of myxo:bacterium 未知
公开(公告)号：DE3930950A1
公开(公告)日：1991-03-28
申请号：DE3930950
申请日：1989-09-15
申请人： BIOTECHNOLOG FORSCHUNG GMBH
发明人： HOEFLE GERHARD PROF DR , JANSEN ROLF DR , SCHUMMER DIETMAR DIPL CHEM
IPC分类号： C07D493/22 , C07F7/18
摘要： New derivatives of sorangicin A of formula (I) and their salts with acids and bases are claimed. R1 = 1-4C alkoxy, 2-5C alkenoxy, benzyloxy, substd. heterocyclyl-(1-4C)alkyleneoxy, -O-(CH2)n-CONR5R6 or NR7R8; R2 and R3 = H, formyl or trialkylsilyl, or together form a -CO-, -CS-, -C(CH3)2- or -Si(alkyl)2- gp. R4 = H, CHO, 1-3C alkyl, SO2R13, C(S)-phenyl, (1-3C alkyl)-carbonyl or -CONHR11. R5 and R6 = H, 1-3C alkyl or substd. phenyl; n = 1-3. R7 = H, 1-4C alkyl or cyclohexyl. R8 = H, 1-6C alkyl, 1-3C alkylenesulphonic acid, a substd. carbocycle or heterocycle, NR9R10 (where R9 and R10 = H, 1-3C alkyl or substd. piperazine), 1-3C alkoxy, benzyl, hydroxy-(1-4C)alkylene, -C(=NH)NH2, -C(=NH)-NH-NH2 or cyclohexylaminocarbonyl. R7 and R8 may also form - (CH2)n- gp. where n = 4 or 5. R11 = H or COCCl3. R13 = halogen-substd. 1-4C alkyl or tolyl. R1 cannot be CH3, C2H5 or NR7R8 when R7 = H and R8 = H, CH3 or isopropyl or R7 and R8 are both CH3 or form a -(CH2)5- gp. and when R2, R3 and R4 are H. USE/ADVANTAGE - Like sorangicin A, (I) is an antibiotic active against myxobacterium. It can be used to treat infections that are resistant to sorangicin A itself.

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