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    • 4. 发明申请
    • CHELATING AND BINDING CHEMICALS TO A MEDICAL IMPLANT
    • 化学和化学化学品到医疗植物
    • WO2006056984A3
    • 2006-10-05
    • PCT/IL2005001247
    • 2005-11-23
    • NOVIK SHAIGENGRINOVITCH STELA
    • GENGRINOVITCH STELA
    • A61L31/02A61L27/54A61L29/16A61L31/08A61L31/16
    • A61L27/54A61L29/16A61L31/022A61L31/08A61L31/16A61L2300/416A61L2300/42A61L2300/80A61L2300/802A61N1/375
    • Chelating and binding chemicals to a medical implant, and therapeutic applications. Implantable 'metal chelated surface and chemical coated' medical implant device - drug (or biological moiety) coated or drug eluting stent, prosthesis, or other, includes a medical implant component having metal surface (M) with chemical entity (X) bound via chelator (C) chelated to the metal surface in an (M) - (C) - (X) configuration. Chelator or/and chemical entity - drug (or biological moiety), linker bonded to a drug (or biological moiety), other, are bound at surface concentration greater than 100 picograms per cm2. Manufacturing the implantable medical device. Medical implant system including medical implant component and delivery device for delivering and implanting medical implant component in a subject. Implanting the medical device. Preventing or/and treating medical conditions, such as restenosis or/and thrombosis, by implanting the medical device, wherein activity of bound chemical entity exhibits efficacy towards the medical condition.
    • 螯合和结合化学物质到医疗植入物,以及治疗应用。 可植入的金属螯合表面和化学涂覆的医用植入装置 - 药物(或生物部分)涂覆或药物洗脱支架,假体或其他包括具有金属表面(M)的医用植入物组分,化学实体(X)通过螯合剂结合 (C)以(M) - (C) - (X)构型螯合到金属表面。 螯合剂或/和化学实体 - 药物(或生物学部分),与药物(或生物部分)结合的连接体,其他的结合物,其表面浓度大于100皮克/ cm 2。 制造可植入医疗器械。 医疗植入系统,包括用于在受试者中递送和植入医学植入物部件的医疗植入部件和递送装置。 植入医疗器械。 通过植入医疗装置来预防或/和治疗诸如再狭窄或/和血栓形成的医学状况,其中结合的化学实体的活性对医疗状况表现出有效性。