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1. 发明申请

WO2007012947A2 METHOD OF TREATING ISCHEMIA-REPERFUSION INJURY 审中-公开
标题翻译：治疗异位再灌注损伤的方法
公开(公告)号：WO2007012947A2
公开(公告)日：2007-02-01
申请号：PCT/IB2006/002028
申请日：2006-07-25
申请人： BIOREST LTD. , RICHTER, Yoram , EDELMAN, Elazer, R. , GOLOMB, Gershon , DANENBERG, Haim, D.
发明人： RICHTER, Yoram , EDELMAN, Elazer, R. , GOLOMB, Gershon , DANENBERG, Haim, D.
IPC分类号： A61K31/47
CPC分类号： A61K31/337 , A61K9/127 , A61K31/282 , A61K31/365 , A61K31/436 , A61K31/47 , A61K31/4745 , A61K31/513 , A61K31/56 , A61K31/60 , A61K31/616 , A61K31/663 , A61K31/7072 , A61K33/00 , A61K33/04 , A61K33/24
摘要： The present invention relates to methods and compositions designed for the prevention, reduction, treatment or management of ischemia-reperfusion injury. The methods of the invention comprise the administration of an effective amount of a therapeutic formulation containing one or more active compounds in a formulation which specifically decreases or inhibits the activity of and/or eliminates or diminishes the amount of phagocytic cells including, but not limited to, macrophages and/or monocytes. In preferred embodiments, the active compound is a bisphosphonate. The invention also provides pharmaceutical compositions of therapeutic formulations for administration to subjects currently suffering from, having recently suffered, or at risk of suffering from an ischemia-reperfusion injury.
摘要翻译：本发明涉及设计用于预防，减少，治疗或治疗缺血再灌注损伤的方法和组合物。本发明的方法包括在制剂中施用有效量的含有一种或多种活性化合物的治疗制剂，所述制剂特异性降低或抑制吞噬细胞的活性和/或消除或减少吞噬细胞的量，包括但不限于，巨噬细胞和/或单核细胞。在优选的实施方案中，活性化合物是双膦酸盐。本发明还提供了用于给予目前患有，最近遭受或有遭受缺血再灌注损伤风险的受试者的治疗制剂的药物组合物。

2. 发明申请

WO2014140670A1 LIPOSOME FORMULATION AND MANUFACTURE 审中-公开
标题翻译：药物制剂和制造
公开(公告)号：WO2014140670A1
公开(公告)日：2014-09-18
申请号：PCT/IB2013/000951
申请日：2013-03-14
申请人： BIOREST LTD. , RICHTER, Yoram , ZELIG, Yehuda , ELMALAK, Omar , EYAL, Dror
发明人： RICHTER, Yoram , ZELIG, Yehuda , ELMALAK, Omar , EYAL, Dror
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/1277 , A61K31/663
摘要： The present invention relates to a liposomal formulation containing a therapeutic agent and a process for producing the formulation. The liposomal formulation comprises particular characteristics that enhance uniformity and stability of the formulation. The manufacturing process is a novel process that produces a liposomal formulation of a uniform size with many desirable properties that may be independently controlled. Further, the invention relates to a liposome formulation made in accordance with the manufacturing process.
摘要翻译：本发明涉及含有治疗剂的脂质体制剂及其制备方法。脂质体制剂包含增强制剂的均匀性和稳定性的特定特征。制造过程是产生具有许多可以独立控制的所需性质的具有均匀尺寸的脂质体制剂的新方法。此外，本发明涉及根据制造方法制备的脂质体制剂。

3. 发明申请

WO2011086401A1 SELF-ASSEMBLING MODULAR PERCUTANEOUS VALVE AND METHODS OF FOLDING, ASSEMBLY AND DELIVERY 审中-公开
标题翻译：自组装模块式阀门及折叠，组装和运输方法
公开(公告)号：WO2011086401A1
公开(公告)日：2011-07-21
申请号：PCT/IB2010/000049
申请日：2010-01-13
申请人： VALVE MEDICAL LTD , RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
发明人： RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
IPC分类号： A61F2/24
CPC分类号： A61F2/2415 , A61F2/24 , A61F2/2406 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/844 , A61F2210/0014 , A61F2230/0091 , A61F2250/006
摘要： The present invention provides a modular prosthetic valve device designed as two or more device modules that may be delivered to a body lumen unassembled and then assembled into the assembled valve device in the body at least in part using a self-assembly member at or near the site of valve implantation. The device modules may include a support structure and a valve module. The valve module may be delivered in an unassembled, folded delivery configuration, and unfolded and assembled into a working configuration via the self-assembly member. In its unassembled form, the valve module may be a single-piece leaflets substructure or a plurality of valve sections. The self-assembly member has a delivery configuration and a preset configuration, and may be triggered to revert to the preset configuration to assemble the valve module. The modular valve device may be folded in a manner not possible with current valve devices, for example, by rolling the unassembled valve module along its circumferential axis in the direction of its height, so that the diameter of the folded valve module may be equivalent to that of one rolled leaflet. This feature of the invention provides a percutaneous valve device having a smaller delivery diameter than pre-assembled valve devices. This in turn permits use of a delivery device of reduced diameter and increases the flexibility of the loaded delivery device compared to percutaneous valve devices in the art. The invention further provides a system for and method of folding and delivering such a modular valve device and assembling it using the self-assembly member, preferably in the body.
摘要翻译：本发明提供了一种设计为两个或更多个装置模块的模块化假体瓣膜装置，其可以被输送到未被组装的身体腔体，然后至少部分地使用位于或靠近该组件的自组装构件瓣膜植入部位。装置模块可以包括支撑结构和阀模块。阀模块可以以未组装的折叠输送构造递送，并且经由自组装构件展开并组装成工作构型。在其组装形式中，阀模块可以是单件式叶片子结构或多个阀部分。自组装构件具有输送配置和预设配置，并且可以被触发以恢复到预设配置以组装阀模块。模块化阀装置可以以当前阀装置不可能的方式进行折叠，例如通过沿着其周向轴线在其高度方向上滚动未组装的阀模块，使得折叠的阀模块的直径可以等于一个滚动的小叶。本发明的该特征提供了一种具有比预组装阀装置更小的输送直径的经皮瓣膜装置。这又允许使用减小直径的输送装置，并且与本领域中的经皮瓣膜装置相比增加了装载的输送装置的灵活性。本发明还提供了一种用于折叠和传送这种模块化阀装置的系统和方法，并且使用自组装构件优选地在身体中组装它。

4. 发明申请

WO2010079426A1 METHOD AND APPARATUS FOR FINE ADJUSTMENT OF A PERCUTANEOUS VALVE STRUCTURE 审中-公开
标题翻译：精密调节阀门结构的方法和装置
公开(公告)号：WO2010079426A1
公开(公告)日：2010-07-15
申请号：PCT/IB2010/000051
申请日：2010-01-13
申请人： VALVE MEDICAL LTD , RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
发明人： RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2427 , A61F2230/0013 , A61F2250/0006 , A61F2250/0008 , A61F2250/006
摘要： The invention provides a device for fine adjustment of a prosthetic valve device and a method of adjusting the position of a prosthetic valve after implantation. The adjustment mechanism includes complementary structures on a valve member and device frame that cooperate to provide relative axial and/or angular motion between the valve member and device frame (and thus the native vessel). The adjustment mechanism of the invention may also include a means for selectively maintaining the relative position of the valve member and device frame. The device and method are particularly applicable for use with a modular prosthetic valve device that is assembled in the body lumen.
摘要翻译：本发明提供了一种用于精细调节假体瓣膜装置的装置和调节植入后假体瓣膜位置的方法。调节机构包括在阀构件和装置框架上的互补结构，其协作以在阀构件和装置框架之间提供相对的轴向和/或角运动（因此也是本机容器）。本发明的调节机构还可以包括用于选择性地保持阀构件和装置框架的相对位置的装置。该装置和方法特别适用于组装在体腔中的模块化的人造瓣膜装置。

5. 发明申请

WO2010079427A1 MODULAR PERCUTANEOUS VALVE STRUCTURE AND DELIVERY METHOD 审中-公开
标题翻译：模块化的经皮瓣膜结构与输送方法
公开(公告)号：WO2010079427A1
公开(公告)日：2010-07-15
申请号：PCT/IB2010/000052
申请日：2010-01-13
申请人： VALVE MEDICAL LTD , RICHTER, Yoram , RICHTER, Jacob
发明人： RICHTER, Yoram , RICHTER, Jacob
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2439 , A61F2220/0033 , A61F2230/0091 , A61F2250/0004 , A61F2250/0008 , A61F2250/006 , Y10T29/49826
摘要： A modular prosthetic valve device for implantation in a patient is disclosed. The valve device is designed as two or more modules to be delivered unassembled and combined into an assembled valve device in the body - e.g., in the body at or near the site where implantation occurs. The two or more modules may be a support structure and a valve assembly. The valve assembly may be formed from two or more valve sections. Because the valve device of the invention is deliverable as modules, it may have a smaller delivery diameter than pre-assembled percutaneous valves and permits use of a delivery device of reduced diameter. Delivering the valve device as modules increases the flexibility of the valve device during delivery, compared to percutaneous valve devices in the art. The invention further provides a system for and method of delivering such a modular valve device and assembling it in vivo. The modules of the valve device may be connected by pull wires for delivery sequentially to or near the implantation site in the body lumen, and then assembled by remote manipulation using the pull wires. The system may further include a temporary valve that may be deployed to maintain valvular function while the device modules are assembled. The temporary valve may be attached to the delivery device and deployed either before or after the support structure is expanded, or the temporary valve may be attached to the support structure and deployed when the support structure is expanded. Various locking mechanisms are provided for attaching the device modules together.
摘要翻译：公开了一种用于植入患者体内的模块化假体瓣膜装置。该阀装置被设计为两个或更多个未组装的组件并且被组合成体内组装的阀装置 - 例如在发生植入的部位处或附近的体内。两个或更多个模块可以是支撑结构和阀组件。阀组件可以由两个或更多个阀部分形成。因为本发明的阀装置可作为模块输送，所以其可具有比预组装的经皮瓣膜更小的输送直径，并且允许使用直径减小的输送装置。与本领域中的经皮瓣膜装置相比，作为模块递送瓣膜装置增加了瓣膜装置在输送期间的灵活性。本发明还提供了一种用于输送这种模块化阀装置并在体内进行装配的系统和方法。阀装置的模块可以通过拉线连接，以顺序地输送到体腔内的植入部位或其附近，然后通过使用拉线的远程操作来组装。该系统可以进一步包括临时阀，该临时阀可以被部署以在装置模块被组装时保持瓣膜功能。临时阀可以连接到输送装置并且在支撑结构扩张之前或之后展开，或者临时阀可以连接到支撑结构并且在支撑结构扩张时展开。提供各种锁定机构用于将设备模块连接在一起。

6. 发明申请

WO2013171590A2 SYSTEM AND METHOD FOR ASSEMBLING A FOLDED PERCUTANEOUS VALVE 审中-公开
标题翻译：用于组装经折叠的周期阀的系统和方法
公开(公告)号：WO2013171590A2
公开(公告)日：2013-11-21
申请号：PCT/IB2013/001819
申请日：2013-05-14
申请人： VALVE MEDICAL LTD. , RICHTER, Yoram , WEISZ, Ety , SCHWARZ, Boaz , REUVEN, Eran , JASSBY, Eran , DAVID, Yaron , HAREL, Amir
发明人： RICHTER, Yoram , WEISZ, Ety , SCHWARZ, Boaz , REUVEN, Eran , JASSBY, Eran , DAVID, Yaron , HAREL, Amir
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2427 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0033 , A61F2220/0041 , A61F2220/005 , A61F2220/0075 , A61F2230/0013 , A61F2250/006
摘要： The invention provides a multi-component (modular) percutaneous valve device that includes a valve module having valve leaflets and a valve frame. The valve frame includes one or more, for example two, ring members and a plurality of masts. Also provided is a valve frame having specially designed pivot points at the connection between masts and first and second ring members to assist folding the valve module and minimizing delivery diameter. The valve frame may also include wire guides to facilitate combining the valve module with a support module. The masts or a ring of the valve frame may also include locking members, such as shafts for closing the valve module and securing the valve module to the support module. The support module includes corresponding locking members, such as spears that align with the shafts on the valve module for assembly and locking the valve module to the support module.
摘要翻译：本发明提供了一种多组分（模块化）经皮瓣膜装置，其包括具有瓣叶和阀框的阀模块。阀框架包括一个或多个，例如两个环构件和多个桅杆。还提供了一种阀架，其在桅杆与第一和第二环构件之间的连接处具有特别设计的枢转点，以帮助折叠阀模块并最小化输送直径。阀框架还可以包括线引导件，以便于将阀模块与支撑模块组合。桅杆或阀框的环也可以包括锁定构件，例如用于关闭阀模块的轴和将阀模块固定到支撑模块上的锁定构件。支撑模块包括相应的锁定构件，例如与阀模块上的轴对准的矛，用于组装并将阀模块锁定到支撑模块。

7. 发明申请

WO2013033506A1 METHOD OF DETECTING PORTAL AND/OR HEPATIC PRESSURE AND A PORTAL HYPERTENSION MONITORING SYSTEM 审中-公开
标题翻译：检测门静脉压力和门静脉监测系统的方法
公开(公告)号：WO2013033506A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/053298
申请日：2012-08-31
申请人： MICROTECH MEDICAL TECHNOLOGIES LTD. , RICHTER, Yoram , TAMMAM, Eric, S. , MANDEL, Shahar, Even-dar
发明人： RICHTER, Yoram , TAMMAM, Eric, S. , MANDEL, Shahar, Even-dar
IPC分类号： A61B5/0215 , A61B5/00
CPC分类号： A61B5/02152 , A61B5/6862 , A61B5/6876 , A61B5/6882 , A61B2562/0247 , A61B2562/12
摘要： The devices and methods generally relate to vibratable sensors for measuring ambient fluid pressure, in particular implantable sensors. The devices and methods are particularly well-suited to implantation within the body of a living animal or human to monitor physiological conditions, such as portal and/or hepatic venous blood pressure, and allow frequent, remote interrogation of venous pressure using the resonance frequency of an implanted sensor. The sensor devices are relatively small compared to conventional devices for measuring fluid pressure and can be implanted in the porto- hepatic venous system, whereas conventional devices are too large. The small size of the device is accomplished by using a thick sensor membrane, compared to conventional devices, and by limiting the size of additional elements of the device relative to the size of the sensor membrane. The thicker sensor member also obviates the need for multiple sensor arrays and maintains the accuracy and robustness of the sensor device. A data capture, processing, and display system provides a pressure measurement reading, and is particularly well-suited for detecting portal hypertension in patients with liver disorders.
摘要翻译：装置和方法通常涉及用于测量环境流体压力的可振动传感器，特别是可植入传感器。这些装置和方法特别适合于植入活的动物或人的体内以监测生理状态，例如门静脉和/或肝静脉血压，并且允许频繁，远程询问静脉压，使用谐振频率植入传感器。与用于测量流体压力的常规装置相比，传感器装置相对较小，并且可以植入到肝静脉系统中，而常规装置太大。与常规装置相比，通过使用厚的传感器膜，并且通过相对于传感器膜的尺寸限制装置的附加元件的尺寸来实现该装置的小尺寸。较厚的传感器构件也避免了对多个传感器阵列的需要并且保持传感器装置的精度和鲁棒性。数据采集，处理和显示系统提供压力测量读数，特别适用于检测肝功能障碍患者门静脉高压。

8. 发明申请

WO2010079425A1 SYSTEM AND METHOD FOR PLACING A PERCUTANEOUS VALVE DEVICE 审中-公开
标题翻译：用于配置胰腺瓣装置的系统和方法
公开(公告)号：WO2010079425A1
公开(公告)日：2010-07-15
申请号：PCT/IB2010/000048
申请日：2010-01-13
申请人： VALVE MEDICAL LTD , RICHTER, Yoram , RICHTER, Jacob
发明人： RICHTER, Yoram , RICHTER, Jacob
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2439 , A61F2250/006
摘要： A system and process for placing a percutaneous valve device in a body lumen at the location of implantation is provided. The placement system and method are simple and enhance the accuracy of the placement of the valve device. Anchors and placement wires or sutures are used to fix the implantation target and guide the device to the implantation site. The system and method are applicable to pre-assembled percutaneous valve devices as well as a modular prosthetic valve device, which modular device is also provided. The modular valve device comprises two or more device modules and is designed to be delivered unassembled and then assembled in the body lumen at or near the site where implantation occurs. The device modules may be assembled before or after the implantation target is fixed with the anchor, and then placed using the placement system in a manner similar to how a pre-assembled percutaneous valve device may be placed in accordance with the invention.
摘要翻译：提供了一种用于将经皮瓣膜装置置于植入位置的体腔内的系统和方法。放置系统和方法简单，提高了阀门装置的放置精度。使用锚和放置线或缝线来固定植入物并将装置引导到植入部位。该系统和方法适用于预先组装的经皮瓣膜装置以及还提供了模块化装置的组合式假体瓣膜装置。模块化阀装置包括两个或更多个装置模块，并被设计成未被组装地输送，然后在植入发生的位置处或附近组装在体腔中。装置模块可以在植入对象与锚固件固定之前或之后组装，然后以类似于根据本发明放置预组装的经皮瓣膜装置的方式放置在放置系统中。

9. 发明申请

WO2002071975A3 METHOD AND APPARATUS FOR STENTING 审中-公开
公开(公告)号：WO2002071975A3
公开(公告)日：2002-09-19
申请号：PCT/US2002/007529
申请日：2002-03-13
申请人： RICHTER, Yoram , EDELMAN, Elazer
发明人： RICHTER, Yoram , EDELMAN, Elazer
IPC分类号： A61F2/06
摘要： A method and an apparatus to create a more favorable flow regime in a lumen. An artificial shape in the lumen is created to at least one of eliminate flow disturbances and enhance aspects of fluid flow through a treatment site. First stent segment (12), second stent segment (14) and thrid stent segement (16) show a schematic view of the stent envelope or profile.

10. 发明申请

WO2002071975A2 METHOD AND APPARATUS FOR STENTING 审中-公开
标题翻译：方法和装置
公开(公告)号：WO2002071975A2
公开(公告)日：2002-09-19
申请号：PCT/US2002/007529
申请日：2002-03-13
申请人： RICHTER, Yoram , EDELMAN, Elazer
发明人： RICHTER, Yoram , EDELMAN, Elazer
IPC分类号： A61F
CPC分类号： A61F2/90 , A61F2/06 , A61F2/86 , A61F2/958 , A61F2002/068 , A61F2230/0006 , A61F2250/0039 , A61M25/1002
摘要： A method and an apparatus to create a more favorable flow regime in a lumen. An artificial shape in the lumen is created to at least one of eliminate flow disturbances and enhance aspects of fluid flow through a treatment site.
摘要翻译：一种在管腔中产生更有利的流动状态的方法和装置。产生管腔中的人造形状用于消除流动干扰中的至少一种并增强通过治疗部位的流体流动的方面。

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