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1. 发明专利

MD3433368T2 Trans-replicarea ARN 未知
公开(公告)号：MD3433368T2
公开(公告)日：2021-12-31
申请号：MDE20190126
申请日：2017-03-13
申请人： BIONTECH SE , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUTZIGE GMBH
发明人： BEISSERT TIM , SAHIN UGUR , PERKOVIC MARIO
IPC分类号： C12N15/86 , A61K48/00 , C12N5/10 , C12N15/40
摘要： Prezenta invenţie se referă în general la sisteme şi metode adecvate pentru producerea de proteine de nivel înalt. În timp ce unul sau mai multe elemente ale prezentei invenţii sunt derivate dintr-un alfavirus, prezenta invenţie nu necesită propagarea particulelor de virus. În special, este prevăzut un sistem care cuprinde două molecule de ARN separate, fiecare cuprinzând o secvenţă de nucleotide derivată dintr-un alfavirus: o moleculă de ARN cuprinde un construct de ARN pentru exprimarea replicazei alfavirusului şi o moleculă de ARN cuprinde o pictogramă ARN re pi care poate fi replicată prin replicaza în trans. Construcţia ARN pentru exprimarea replicazei alfavirusului cuprinde un capac 5'. S-a descoperit în mod surprinzător că capacul 5' este adecvat pentru a conduce eficient expresia unei transgene din replicon în trans. Sistemul prezentei invenţii permite exprimarea unei proteine de interes într-o celulă sau organism, dar nu este asociat cu formarea nedorită de particule de virus. Prin urmare, prezenta invenţie este adecvată pentru producerea eficientăşi sigură a unei proteine de interes, de ex. o proteină terapeutică sau o proteină antigenică, cum ar fi un vaccin, într-un organism ţintă. Metodele respective de producere a proteinelor in vitro şi in vivo, precum şi utilizări medicale sunt furnizate aici. Prezenta invenţie furnizează de asemenea ADN care codifică moleculele de ARN ale invenţiei şi celule care cuprind molecule de ARN ale invenţiei.

2. 发明专利

CA3017272A1 RNA REPLICON FOR VERSATILE AND EFFICIENT GENE EXPRESSION 未知
公开(公告)号：CA3017272A1
公开(公告)日：2017-09-28
申请号：CA3017272
申请日：2017-03-13
申请人： BIONTECH RNA PHARMACEUTICALS GMBH , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUTZIGE GMBH
发明人： BEISSERT TIM , SAHIN UGUR , PERKOVIC MARIO
IPC分类号： C12N15/86 , C12N5/10 , C12N15/85
摘要： The present invention embraces a RNA replicon that can be replicated by a replicase of alphavirus origin. The RNA replicon comprises sequence elements required for replication by the replicase, but these sequence elements do not encode any protein or fragment thereof, such as an alphavirus non-structural protein or fragment thereof. Thus, in the RNA replicon according to the invention, sequence elements required for replication by the replicase and protein-coding region(s) are uncoupled. According to the present invention the uncoupling is achieved by the removal of at least one initiation codon compared to a native alphavirus genomic RNA. In particular, the RNA replicon comprises a 5' replication recognition sequence, wherein the 5' replication recognition sequence is characterized in that it comprises the removal of at least one initiation codon compared to a native alphavirus 5' replication recognition sequence. The replicase of alphavirus origin may be encoded by an open reading frame on the RNA replicon or on a separate RNA molecule. The present invention enables efficient and safe expression of a protein of interest in a cell or organism, but is not associated with undesired production of fragments of alphavirus non-structural protein. Methods of protein production in vitro and in vivo, as well as medical uses, are provided herein.

3. 发明专利

AU2013347184B2 Agents for treatment of claudin expressing cancer diseases 未知
公开(公告)号：AU2013347184B2
公开(公告)日：2018-06-14
申请号：AU2013347184
申请日：2013-11-12
申请人： ASTELLAS PHARMA INC , BIONTECH AG , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUTZIGE GMBH
发明人： SAHIN UGUR , TURECI OZLEM , STADLER CHRISTIANE , HOLLAND JULIA , BAHR-MAHMUD HAYAT , BEISSERT TIM , PLUM LAURA , LE GALL FABRICE , JENDRETZKI ARNE , FIEDLER MARKUS
IPC分类号： C07K16/28
摘要： The present invention provides binding agents that contain a binding domain that is specific for CD3 allowing binding to T cells and a binding domain that is specific for a tumor- associated claudin molecule and methods of using these binding agents or nucleic acids encoding therefor for treating cancer.

4. 发明专利

CA3017285A1 TRANS-REPLICATING RNA 未知
公开(公告)号：CA3017285A1
公开(公告)日：2017-09-28
申请号：CA3017285
申请日：2017-03-13
申请人： BIONTECH RNA PHARMACEUTICALS GMBH , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUTZIGE GMBH
发明人： BEISSERT TIM , SAHIN UGUR , PERKOVIC MARIO
IPC分类号： C12N15/86 , A61K48/00 , C12N5/10 , C12N15/40
摘要： The present invention generally relates to systems and methods suitable for high-level protein production. While one or more elements of the present invention are derived from an alphavirus, the present invention does not require propagation of virus particles. In particular, a system comprising two separate RNA molecules is foreseen, each comprising a nucleotide sequence derived from an alphavirus: one RNA molecule comprises a RNA construct for expressing alphavirus replicase, and one RNA molecule comprises a RNA re pi icon that can be replicated by the replicase in trans. The RNA construct for expressing alphavirus replicase comprises a 5'-cap. It was surprisingly found that the 5'-cap is suitable for efficiently driving expression of a transgene from the replicon in trans. The system of the present invention enables expression of a protein of interest in a cell or organism, but is not associated with undesired virus-particle formation. Therefore, the present invention is suitable for efficiently and safely producing a protein of interest, e.g. a therapeutic protein or an antigenic protein, such as a vaccine, in a target organism. Respective methods of protein production in vitro and in vivo as well as medical uses are provided herein. The present invention also provides DNA encoding the RNA molecules of the invention, and cells comprising the RNA molecules of the invention.

5. 发明专利

CA2890438C AGENTS FOR TREATMENT OF CLAUDIN EXPRESSING CANCER DISEASES 未知
公开(公告)号：CA2890438C
公开(公告)日：2022-10-18
申请号：CA2890438
申请日：2013-11-12
申请人： BIONTECH AG , GANYMED PHARMACEUTICALS AG , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUTZIGE GMBH
发明人： SAHIN UGUR , TURECI OZLEM , STADLER CHRISTIANE , HOLLAND JULIA , BAHR-MAHMUD HAYAT , BEISSERT TIM , PLUM LAURA , LE GALL FABRICE , JENDRETZKI ARNE , FIEDLER MARKUS
IPC分类号： C07K16/18 , C07K16/46 , C07K16/28 , C12N15/13
摘要： The present invention provides binding agents that contain a binding domain that is specific for CD3 allowing binding to T cells and a binding domain that is specific for a tumor- associated claudin molecule and methods of using these binding agents or nucleic acids encoding therefor for treating cancer.

6. 发明专利

UA117741C2 З'ЄДНУВАЛЬНИЙ АГЕНТ ДЛЯ ЛІКУВАННЯ ЕКСПРЕСУЮЧИХ КЛАУДИН РАКОВИХ ЗАХВОРЮВАНЬ 未知
公开(公告)号：UA117741C2
公开(公告)日：2018-09-25
申请号：UAA201505768
申请日：2013-11-12
申请人： BIONTECH AG , GANYMED PHARMACEUTICALS AG , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUTZIGE GMBH
发明人： SAHIN UGUR , TURECI OZLEM , STADLER CHRISTIANE , HOLLAND JULIA , BAHR-MAHMUD HAYAT , BEISSERT TIM , PLUM LAURA , LE GALL FABRICE , JENDRETZKI ARNE , FIEDLER MARKUS
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C07K14/00 , C12N15/13
摘要： Винахідстосуєтьсяз'єднувальногоагента, якийміститьз'єднувальнийдомен, якийє специфічнимвідносно CD3, щозабезпечуєможливістьзв'язуванняз Т-клітинами, ізв'язуючийдомен, якийє специфічнимвідноснопухлиноасоційованоїмолекуликлаудину CLDN18.2; рекомбінантноїнуклеїновоїкислоти; клітини-хазяїна; фармацевтичноїкомпозиції, щоміститьтакийагент; йогозастосуваннядлялікуванняабопопередженняраковогозахворювання; таспособулікуванняабопопередженняраковогозахворювання.

7. 发明专利

HUE059139T2 RNS-replikon a sokoldalú és hatékony génexpresszióhoz 未知
公开(公告)号：HUE059139T2
公开(公告)日：2022-10-28
申请号：HUE20156693
申请日：2017-03-13
申请人： BIONTECH SE , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUETZIGE GMBH
发明人： BEISSERT TIM , SAHIN UGUR , PERKOVIC MARIO
IPC分类号： A61K35/76 , C12N5/10 , C12N15/85 , C12N15/86

8. 发明专利

ES2896927T3 ARN transreplicante 未知
公开(公告)号：ES2896927T3
公开(公告)日：2022-02-28
申请号：ES17710268
申请日：2017-03-13
申请人： BIONTECH SE , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUETZIGE GMBH
发明人： BEISSERT TIM , SAHIN UGUR , PERKOVIC MARIO
IPC分类号： C12N15/86 , A61K48/00 , C12N5/10 , C12N15/40
摘要： Una composición farmacéutica que comprende: (a) un constructo de ARNm para expresar la replicasa del alfavirus que no es capaz de autorreplicarse, y (b) un replicón de ARN que puede ser replicado por la replicasa en trans, en donde el constructo de ARNm de (a) para expresar la replicasa del alfavirus comprende una cubierta 5' para impulsar la traducción de la replicasa; y en donde el replicón de ARN de (b) comprende (1) una secuencia de reconocimiento de replicación de alfavirus 5', (2) un marco de lectura abierto que codifica una proteína o péptido farmacéuticamente activo y (3) una secuencia de reconocimiento de replicación de alfavirus 3' y en donde la secuencia de reconocimiento de la replicación del alfavirus 5' y la secuencia de reconocimiento de la replicación del alfavirus 3' dirigen la replicación del replicón de ARN en presencia de la replicasa.

9. 发明专利

NZ740946A 3’ utr sequences for stabilization of rna 未知
公开(公告)号：NZ740946A
公开(公告)日：2022-08-26
申请号：NZ74094616
申请日：2016-10-05
申请人： TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GGMBH , BIONTECH SE
发明人： SAHIN UGUR , BEISSERT TIM , ORLANDINI VON NIESSEN ALEXANDRA , FESSER STEPHANIE , VALLAZZA BRITTA , KUHN ANDREAS , POLEGANOV MARCO ALEXANDER
IPC分类号： C12N15/67
摘要： The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3’-untranslated region (UTR) of Amino-Terminal Enhancer Of Split (AES) improves stability and translation efficiency.

10. 发明专利

RS62864B1 RNK REPLIKON ZA UNIVERZALNU I EFIKASNU EKSPRESIJU GENA 未知
公开(公告)号：RS62864B1
公开(公告)日：2022-02-28
申请号：RSP20220067
申请日：2017-03-13
申请人： BIONTECH SE , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUETZIGE GMBH
发明人： BEISSERT TIM , SAHIN UGUR , PERKOVIC MARIO
IPC分类号： A61K35/76 , C12N5/10 , C12N15/85 , C12N15/86

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