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1. 发明申请

WO2023006920A1 COMPOSITIONS AND METHODS FOR TREATMENT OF MELANOMA 审中-公开
公开(公告)号：WO2023006920A1
公开(公告)日：2023-02-02
申请号：PCT/EP2022/071276
申请日：2022-07-28
申请人： BIONTECH SE
发明人： SAHIN, Ugur , JABULOWSKY, Robert A. , SCHWARCK-KOKARAKIS, Doreen , TÜRECI, Özlem
IPC分类号： A61K39/00 , A61K39/395 , A61P35/00 , C07K16/28
摘要： The present disclosure provides compositions and methods for treatment of melanoma.

2. 发明申请

WO2021214204A1 RNA CONSTRUCTS AND USES THEREOF 审中-公开
公开(公告)号：WO2021214204A1
公开(公告)日：2021-10-28
申请号：PCT/EP2021/060508
申请日：2021-04-22
申请人： BIONTECH SE
发明人： SAHIN, Ugur , GÜLER, Alptekin , KUHN, Andreas , MUIK, Alexander , VOGEL, Annette , WALZER, Kerstin , WITZEL, Sonja , HEIN, Stephanie , TÜRECI, Özlem , BOROS, Gábor , MAHINY, Azita Josefine , REINHOLZ, Jonas , KARIKO, Katalin
IPC分类号： C12N15/11 , A61K39/215 , A61K45/06 , C12N15/00 , C12N15/10 , C07H21/00 , C07H21/02
摘要： Disclosed herein are RNA polynucleotides comprising a 5' Cap, a 5' UTR comprising a cap proximal sequence disclosed herein, and a sequence encoding a payload. Also disclosed herein are compositions and medical preparations comprising the same, and methods of making and using the same.

3. 发明申请

WO2021213924A1 CORONAVIRUS VACCINE 审中-公开
公开(公告)号：WO2021213924A1
公开(公告)日：2021-10-28
申请号：PCT/EP2021/059947
申请日：2021-04-16
申请人： BIONTECH SE
发明人： SAHIN, Ugur , GÜLER, Alptekin , KUHN, Andreas , MUIK, Alexander , VOGEL, Annette , WALZER, Kerstin , WITZEL, Sonja , HEIN, Stephanie , TÜRECI, Özlem
IPC分类号： A61K39/12 , A61K39/00
摘要： This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. These methods and agents are, in particular, useful for the prevention or treatment of coronavirus infection. Administration of RNA disclosed herein to a subject can protect the subject against coronavirus infection. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen. Administering to the subject RNA encoding vaccine antigen may provide (following expression of the RNA by appropriate target cells) vaccine antigen for inducing an immune response against vaccine antigen (and disease-associated antigen) in the subject. In December 2019, a pneumonia outbreak of unknown cause occurred in Wuhan, China and it became clear that a novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) was the underlying cause. The genetic sequence of SARS-CoV-2 became available to the WHO and public (MN908947.3) and the virus was categorized into the betacoronavirus subfamily. By sequence analysis, the phylogenetic tree revealed a closer relationship to severe acute respiratory syndrome (SARS) virus isolates than to another coronavirus infecting humans, namely the Middle East respiratory syndrome (MERS) virus. On February 2nd, a total of 14'557 cases were globally confirmed in 24 countries including Germany and a subsequent self-sustaining, human-to-human virus spread resulted in that SARS-CoV-2 became a global epidemic.

4. 发明申请

WO2021198157A1 RNA COMPOSITIONS TARGETING CLAUDIN-18.2 审中-公开
公开(公告)号：WO2021198157A1
公开(公告)日：2021-10-07
申请号：PCT/EP2021/058112
申请日：2021-03-29
申请人： BIONTECH SE
发明人： SAHIN, Ugur , LINDEMANN, Claudia , DIEKMANN, Jan , BRETTSCHNEIDER, Kerstin , BÄHR-MAHMUD, Hayat , ELLINGHAUS, Ursula , FISCHER, Leyla , STADLER, Christiane , TÜRECI, Özlem
IPC分类号： C07K16/28 , A61K9/10 , A61K2039/505 , A61K2039/53 , A61K9/0019 , A61K9/5123 , A61K9/5146 , C07K2317/33 , C07K2317/732 , C07K2317/734 , C07K2317/94
摘要： The present disclosure provides RNA technologies for targeting Claudin-18.2 polypeptides. In some embodiments, such RNA technologies can be useful for treatment of diseases associated with positive expression of Claudin-18.2. For example, in some embodiments, such RNA technologies can be useful for treatment of Claudin-18.2 positive cancer, including, e.g, but not limited to biliary cancers, ovarian cancers, gastric cancers, gastro-esophageal cancers, pancreatic cancers. In some embodiments, such RNA technologies can be used in combination therapy (e.g, in combination with a chemotherapeutic agent).

5. 发明申请

WO2021213945A1 CORONAVIRUS VACCINE 审中-公开
公开(公告)号：WO2021213945A1
公开(公告)日：2021-10-28
申请号：PCT/EP2021/060004
申请日：2021-04-16
申请人： PFIZER INC. , BIONTECH SE
发明人： NAUTA, Marjoh , PEETERS, Dirk Jozef , VAN DOORSLAER, Tom Frank Steven , BADKAR, Advait Vijay , DARVARI, Ramin , WARNE, Nicholas William , JEAN, James , HENDRIKSE, Danny Pierre G. , SAHIN, Ugur , GÜLER, Alptekin , KUHN, Andreas , MUIK, Alexander , VOGEL, Annette , WALZER, Kerstin , WITZEL, Sonja , HEIN, Stephanie , TÜRECI, Özlem
IPC分类号： F25D3/12 , A61K39/215 , A61K45/06 , B65D81/18 , C12N15/00
摘要： The present disclosure relates to the fields of packaging, transportation, and storage of temperature-sensitive materials, such as biological and/or pharmaceutical products. Various aspects of such packaging, transportation, and storage are provided herein for ultra-low temperature materials useful for the treatment and/or prevention of disease. The present disclosure also provides packaging materials, methods of transportation, and methods of storage for maintaining biological and/or pharmaceutical materials at ultra-low temperatures in order to maintain the integrity of the materials. The present disclosure further relates to the field of RNA to prevent or treat coronavirus infection.

7. 发明公开

EP4138897A1 CORONAVIRUS VACCINE 审中-实审
公开(公告)号：EP4138897A1
公开(公告)日：2023-03-01
申请号：EP21720413.0
申请日：2021-04-16
申请人： BioNTech SE
发明人： SAHIN, Ugur , GÜLER, Alptekin , KUHN, Andreas , MUIK, Alexander , VOGEL, Annette , WALZER, Kerstin , WITZEL, Sonja , HEIN, Stephanie , TÜRECI, Özlem
IPC分类号： A61K39/12 , A61K39/00

8. 发明公开

EP4126947A1 RNA COMPOSITIONS TARGETING CLAUDIN-18.2 审中-实审
公开(公告)号：EP4126947A1
公开(公告)日：2023-02-08
申请号：EP21715591.0
申请日：2021-03-29
申请人： BioNTech SE
发明人： SAHIN, Ugur , LINDEMANN, Claudia , DIEKMANN, Jan , BRETTSCHNEIDER, Kerstin , BÄHR-MAHMUD, Hayat , ELLINGHAUS, Ursula , FISCHER, Leyla , STADLER, Christiane , TÜRECI, Özlem
IPC分类号： C07K16/28 , A61K9/10

10. 发明公开

EP4043494A1 BISPECIFIC TRIVALENT ANTIBODIES BINDING TO CLAUDIN 6 OR CLAUDIN 18.2 AND CD3 FOR TREATMENT OF CLAUDIN EXPRESSING CANCER DISEASES 审中-公开
公开(公告)号：EP4043494A1
公开(公告)日：2022-08-17
申请号：EP22160052.1
申请日：2017-09-20
申请人： BioNTech SE , Astellas Pharma Inc.
发明人： SAHIN, Ugur , STADLER, Christiane , FISCHER, Leyla , JENDRETZKI, Arne , TÜRECI, Özlem , LE GALL, Fabrice , KREUZBERG, Maria
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
摘要： The present disclosure provides binding agents comprising at least three binding domains, wherein a first binding domain binds to a T cell-specific antigen and a second binding domain and a third binding domain bind to a claudin, and methods of using these binding agents or nucleic acids encoding therefor for treating cancer.

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