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1. 发明专利

SG10201912558YA 3' UTR SEQUENCES FOR STABILIZATION OF RNA 未知
公开(公告)号：SG10201912558YA
公开(公告)日：2020-02-27
申请号：SG10201912558Y
申请日：2016-10-05
申请人： BIONTECH RNA PHARMACEUTICALS GMBH , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GGMBH
发明人： ORLANDINI VON NIESSEN ALEXANDRA , FESSER STEPHANIE , VALLAZZA BRITTA , BEISSERT TIM , KUHN ANDREAS , SAHIN UGUR , POLEGANOV MARCO ALEXANDER
摘要： The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3'-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.

2. 发明专利

AU2016335029A1 3' UTR sequences for stabilization of RNA 未知
公开(公告)号：AU2016335029A1
公开(公告)日：2018-04-19
申请号：AU2016335029
申请日：2016-10-05
申请人： BIONTECH RNA PHARMACEUTICALS GMBH , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GGMBH
发明人： ORLANDINI VON NIESSEN ALEXANDRA , FESSER STEPHANIE , VALLAZZA BRITTA , BEISSERT TIM , KUHN ANDREAS , SAHIN UGUR , POLEGANOV MARCO ALEXANDER
IPC分类号： C12N15/67
摘要： The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular

3. 发明专利

CA2998554A1 3' UTR SEQUENCES FOR STABILIZATION OF RNA 未知
公开(公告)号：CA2998554A1
公开(公告)日：2017-04-13
申请号：CA2998554
申请日：2016-10-05
申请人： BIONTECH RNA PHARMACEUTICALS GMBH , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GGMBH
发明人： ORLANDINI VON NIESSEN ALEXANDRA , FESSER STEPHANIE , VALLAZZA BRITTA , BEISSERT TIM , KUHN ANDREAS , SAHIN UGUR , POLEGANOV MARCO ALEXANDER
IPC分类号： C12N15/67
摘要： The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3'- untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.

4. 发明专利

HK1258262A1 用於使RNA穩定的3'UTR序列未知
公开(公告)号：HK1258262A1
公开(公告)日：2019-11-08
申请号：HK19100626
申请日：2019-01-15
申请人： BIONTECH RNA PHARMACEUTICALS GMBH , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GGMBH
发明人： ORLANDINI VON NIESSEN ALEXANDRA , FESSER STEPHANIE , VALLAZZA BRITTA , BEISSERT TIM , KUHN ANDREAS , SAHIN UGUR , POLEGANOV MARCO ALEXANDER
IPC分类号： C12N20060101

5. 发明专利

NZ740946A 3’ utr sequences for stabilization of rna 未知
公开(公告)号：NZ740946A
公开(公告)日：2022-08-26
申请号：NZ74094616
申请日：2016-10-05
申请人： TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GGMBH , BIONTECH SE
发明人： SAHIN UGUR , BEISSERT TIM , ORLANDINI VON NIESSEN ALEXANDRA , FESSER STEPHANIE , VALLAZZA BRITTA , KUHN ANDREAS , POLEGANOV MARCO ALEXANDER
IPC分类号： C12N15/67
摘要： The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3’-untranslated region (UTR) of Amino-Terminal Enhancer Of Split (AES) improves stability and translation efficiency.

6. 发明专利

AU2016335029B2 3' UTR sequences for stabilization of RNA 未知
公开(公告)号：AU2016335029B2
公开(公告)日：2021-04-29
申请号：AU2016335029
申请日：2016-10-05
申请人： BIONTECH SE , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GGMBH
发明人： ORLANDINI VON NIESSEN ALEXANDRA , FESSER STEPHANIE , VALLAZZA BRITTA , BEISSERT TIM , KUHN ANDREAS , SAHIN UGUR , POLEGANOV MARCO ALEXANDER
IPC分类号： C12N15/67
摘要： The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular

7. 发明公开

KR20180057647A RNA의 안정화를 위한 3' UTR 서열 审中-公开
公开(公告)号：KR20180057647A
公开(公告)日：2018-05-30
申请号：KR20187010043
申请日：2016-10-05
申请人： BIONTECH RNA PHARMACEUTICALS GMBH , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUETZIGE GMBH
发明人： ORLANDINI VON NIESSEN ALEXANDRA , FESSER STEPHANIE , VALLAZZA BRITTA , BEISSERT TIM , KUHN ANDREAS , SAHIN UGUR , POLEGANOV MARCO ALEXANDER
IPC分类号： C12N15/67
CPC分类号： C12N15/67
摘要： 본발명은 RNA, 특히 mRNA의안정화및 mRNA 번역의증가에관한것이다. 본발명은특히증가된전사안정성및/또는번역효율을결과시키는변형된 RNA, 특히전사된 RNA에관한것이다. 본발명에따라, RNA 분자의 3'-미번역영역 (UTR) 내의특정서열들이안정성및 번역효율을개선시킨다는것이입증되었다.

8. 发明申请

WO2017060314A3 3' UTR SEQUENCES FOR STABILIZATION OF RNA 审中-公开
标题翻译： 3'UTR序列稳定RNA
公开(公告)号：WO2017060314A3
公开(公告)日：2017-05-18
申请号：PCT/EP2016073814
申请日：2016-10-05
申请人： BIONTECH RNA PHARMACEUTICALS GMBH , TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ
发明人： ORLANDINI VON NIESSEN ALEXANDRA , FESSER STEPHANIE , VALLAZZA BRITTA , BEISSERT TIM , KUHN ANDREAS , SAHIN UGUR , POLEGANOV MARCO ALEXANDER
IPC分类号： C12N15/67
CPC分类号： C12N15/67
摘要： The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3'- untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.
摘要翻译：本发明涉及RNA（特别是mRNA）的稳定性以及mRNA翻译的增加。本发明特别涉及RNA的修饰，特别是体外转录的RNA，导致转录本稳定性和/或翻译效率提高。根据本发明，证明了RNA分子的3'非翻译区（UTR）中的某些序列提高了稳定性和翻译效率。

10. 发明专利

RU2752580C2 ТРАНС-РЕПЛИЦИРУЮЩАЯ РНК 未知
公开(公告)号：RU2752580C2
公开(公告)日：2021-07-29
申请号：RU2018131783
申请日：2017-03-13
申请人： BIONTECH RNA PHARMACEUTICALS GMBH
发明人： BEISSERT TIM , SAHIN UGUR , PERKOVIC MARIO
IPC分类号： C12N15/86 , A61K48/00 , C12N5/10 , C12N15/40
摘要： Изобретениеотноситсяк областибиотехнологии. Описанагруппаизобретений, включающаясистемудляполучениябелка, фармацевтическуюкомпозициюдляэкспрессииальфавируснойрепликазыи/илирепликона, способполучениябелкав клетке, эукариотическуюклетку-хозяиндляполучениябелкаи способполучениябелкау субъекта. ВодномизвариантовреализациисистемасодержитконструкциюРНКдляэкспрессииальфавируснойрепликазыи РНК-репликон, которыйможетбытьреплицированрепликазойin trans, причемконструкцияРНКсодержит 5' UTR, открытуюрамкусчитывания, кодирующуюрепликазу, и 3' UTR, гдеконструкцияРНКсодержит 5’-кэпдлятрансляциирепликазы, иРНК-репликонсодержит 5' репликационнуюпоследовательностьраспознаванияальфавируса, открытуюрамкусчитывания, кодирующуюпредставляющийинтересбелок, и 3' репликационнуюпоследовательностьраспознаванияальфавируса. 5 н. и 10 з.п. ф-лы, 8 ил., 7 пр.

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