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1. 发明专利

PL2796150T3 NOWE KONIUGATY OLIGONUKLEOTYDOWE I ICH ZASTOSOWANIE 未知
公开(公告)号：PL2796150T3
公开(公告)日：2021-08-30
申请号：PL12857568
申请日：2012-12-14
申请人： BIONEER CORP
发明人： CHAE JEIWOOK , HAN BORAM , KIM HAN-NA , PARK HAN OH , YOON PYOUNG OH , KIM SUN GI , JUNG KWANG-JU , KWON TAEWOO , CHOI JONG DEOK , LEE SAM YOUNG , JUNG EUN-JUNG
IPC分类号： C12N15/113 , A61K9/16 , A61K31/713 , A61K47/54 , A61K47/55 , A61K47/60 , C12N15/11

2. 发明公开

EP3019612A4 LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME 审中-公开
标题翻译： LEBERKREBS-VERWANDTE GENSPEZIFISCHE SIRNA，DOPPELSTRÄNGIGEOLIGO-RNA-MOLEKÜLEMIT DER SIRNA UND ZUSAMMENSETZUNG ZURPRÄVENTIONODER BEHANDLUNG VON KREBS DAMIT
公开(公告)号：EP3019612A4
公开(公告)日：2017-06-28
申请号：EP14823194
申请日：2014-07-09
申请人： BIONEER CORP , SANOFI-AVENTIS KOREA CO LTD
发明人： CHAE JEIWOOK , YOON PYOUNG OH , KIM HAN-NA , PARK HAN OH , HAN BORAM , KO YOUNGHO , CHOI GI-EUN , KIM JAE EUN
IPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , A61P35/00
CPC分类号： C12N15/1137 , A61K9/1075 , A61K31/713 , A61K47/6907 , C12N15/113 , C12N15/1135 , C12N2310/14 , C12N2310/31 , C12N2310/351 , C12N2320/30

3. 发明公开

EP3019611A4 LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME 审中-公开
标题翻译：肝癌相关基因特异性的siRNA，双OLIGO RNA分子的siRNA及组成预防和治疗癌症的任何保证，
公开(公告)号：EP3019611A4
公开(公告)日：2017-06-14
申请号：EP14822311
申请日：2014-07-09
申请人： BIONEER CORP , SANOFI-AVENTIS KOREA CO LTD
发明人： CHAE JEIWOOK , PARK HAN OH , YOON PYOUNG OH , HAN BORAM , KIM HAN-NA , YUN SUNG-IL , PARK JUN HONG , KO YOUNGHO , CHOI GI-EUN , JUNG JUNSOO , KIM JAE EUN
IPC分类号： C12N15/113 , A61K9/51 , A61K31/713
CPC分类号： C12N15/1135 , A61K9/0019 , A61K9/51 , A61K31/713 , A61K47/60 , C12N2310/14

4. 发明专利

CA2860527C HIGH-EFFICIENCY NANOPARTICLE-TYPE DOUBLE-HELICAL OLIGO-RNA STRUCTURE AND METHOD FOR PREPARING SAME 未知
公开(公告)号：CA2860527C
公开(公告)日：2019-04-09
申请号：CA2860527
申请日：2013-01-04
申请人： BIONEER CORP
发明人： CHAE JEIWOOK , HAN BORAM , KIM HAN-NA , PARK HAN OH
IPC分类号： C12N15/113 , A61K9/14 , A61K31/713 , C07H21/02
摘要： The present invention relates to a double-helical oligo-RNA structure and a method for manufacturing same, and more specifically, to a double-helical oligo-RNA structure in which a polymeric compound is connected to the double-helical oligo-RNA by means of a covalent bond to improve the biosatbility of the double-helical oligo-RNA and enhance cell delivery efficency, and to a method for manufacturing the structure. In the double-helical oligo-RNA structure having the optimum structure, as described above, a function of the double-helical oligo-RNA is not compromised, and the double-helical oligo-RNA can be delivered to cells even with a small dose of relatively low concentration due to the stability of the double-helical oligo-RNA and efficient enhancement of a cell membrane penetration function, can be efficiently enhanced, and thus can be useful as a tool for treating double-helical oligo-RNA in cancer and infectious diseases and as a novel form of a double-helical oligo-RNA delivery system.

5. 发明专利

AU2013206989B2 High-efficiency nanoparticle-type double-helical oligo-RNA structure and method for preparing same 未知
公开(公告)号：AU2013206989B2
公开(公告)日：2015-05-28
申请号：AU2013206989
申请日：2013-01-04
申请人： BIONEER CORP
发明人： CHAE JEIWOOK , HAN BORAM , KIM HAN-NA , PARK HAN OH
IPC分类号： C12N15/11 , A61K31/7105 , C07H21/02 , C12Q1/68
摘要： The present invention relates to a double-helical oligo-RNA structure and a method for manufacturing same, and more specifically, to a double-helical oligo-RNA structure in which a polymeric compound is connected to the double-helical oligo-RNA by means of a covalent bond to improve the biosatbility of the double-helical oligo-RNA and enhance cell delivery efficency, and to a method for manufacturing the structure. In the double-helical oligo-RNA structure having the optimum structure, as described above, a function of the double-helical oligo-RNA is not compromised, and the double-helical oligo-RNA can be delivered to cells even with a small dose of relatively low concentration due to the stability of the double-helical oligo-RNA and efficient enhancement of a cell membrane penetration function, can be efficiently enhanced, and thus can be useful as a tool for treating double-helical oligo-RNA in cancer and infectious diseases and as a novel form of a double-helical oligo-RNA delivery system.

6. 发明专利

AU2012353058B2 Novel oligonucleotide conjugates and use thereof 未知
公开(公告)号：AU2012353058B2
公开(公告)日：2015-05-21
申请号：AU2012353058
申请日：2012-12-14
申请人： BIONEER CORP
发明人： CHAE JEIWOOK , HAN BORAM , KIM HAN-NA , PARK HAN OH , YOON PYOUNG OH , KIM SUN GI , JUNG KWANG-JU , KWON TAEWOO , CHOI JONG DEOK , LEE SAM YOUNG , JUNG EUN-JUNG
IPC分类号： A61K47/48 , A61K9/16 , A61K48/00 , C12N15/11
摘要： The present invention provides a double helix oligo-RNA structure in which target-specific ligands are bonded to the double helix oligo-RNA structure in which high molecular compounds for improving the delivery of double helix oligo-RNA that can be valuably used in treating diseases, specifically, cancer, are covalently bonded. The present invention also provides a method for preparing the RNA structure and a target-specific double helix oligo-RNA delivery technology through said structure. Nanoparticles constituted by the double helix oligo-RNA structure to which ligands are bonded may efficiently deliver double helix oligo-RNA to a target, and thus may exhibit an activity of double helix oligo-RNA structure in a target cell even with an administration of double helix oligo-RNA of relatively lower concentration. The nanoparticles may prevent the delivery of non-specific double helix oligo-RNA to other organs and cells, and therefore, can be valuably used not only as a tool for double helix oligo-RNA for treating various diseases, specifically, cancer, but also as a new type of double helix oligo-RNA delivery system. The present invention also relates to hybrid conjugates in which a hydrophilic material and a hydrophobic material are connected to both ends of antisense oligonucleotide(ASO) through covalent bond so as to achieve in vivo stability of the ASO, and to a method for preparing the hybrid conjugates and to nanoparticles constituted by the conjugates. The conjugates between ASO and macromolecules according to the present invention may improve in vivo stability of ASO, and therefore, can efficiently deliver ASO for treatment into cells and may exhibit an activity of ASO even with an administration of a relatively lower concentration.

7. 发明专利

AU2013206989A1 High-efficiency nanoparticle-type double-helical oligo-RNA structure and method for preparing same 未知
公开(公告)号：AU2013206989A1
公开(公告)日：2014-07-24
申请号：AU2013206989
申请日：2013-01-04
申请人： BIONEER CORP
发明人： CHAE JEIWOOK , HAN BORAM , KIM HAN-NA , PARK HAN OH
IPC分类号： C12N15/11 , A61K31/7105 , C07H21/02 , C12Q1/68
摘要： The present invention relates to a double-helical oligo-RNA structure and a method for manufacturing same, and more specifically, to a double-helical oligo-RNA structure in which a polymeric compound is connected to the double-helical oligo-RNA by means of a covalent bond to improve the biosatbility of the double-helical oligo-RNA and enhance cell delivery efficency, and to a method for manufacturing the structure. In the double-helical oligo-RNA structure having the optimum structure, as described above, a function of the double-helical oligo-RNA is not compromised, and the double-helical oligo-RNA can be delivered to cells even with a small dose of relatively low concentration due to the stability of the double-helical oligo-RNA and efficient enhancement of a cell membrane penetration function, can be efficiently enhanced, and thus can be useful as a tool for treating double-helical oligo-RNA in cancer and infectious diseases and as a novel form of a double-helical oligo-RNA delivery system.

8. 发明专利

CA2860527A1 HIGH-EFFICIENCY NANOPARTICLE-TYPE DOUBLE-HELICAL OLIGO-RNA STRUCTURE AND METHOD FOR PREPARING SAME 未知
公开(公告)号：CA2860527A1
公开(公告)日：2013-07-11
申请号：CA2860527
申请日：2013-01-04
申请人： BIONEER CORP
发明人： CHAE JEIWOOK , HAN BORAM , KIM HAN-NA , PARK HAN OH
IPC分类号： C12N15/113 , A61K9/14 , A61K31/713 , A61K47/48 , C07H21/02
摘要： The present invention relates to a double-helical oligo-RNA structure and a method for manufacturing same, and more specifically, to a double-helical oligo-RNA structure in which a polymeric compound is connected to the double-helical oligo-RNA by means of a covalent bond to improve the biosatbility of the double-helical oligo-RNA and enhance cell delivery efficency, and to a method for manufacturing the structure. In the double-helical oligo-RNA structure having the optimum structure, as described above, a function of the double-helical oligo-RNA is not compromised, and the double-helical oligo-RNA can be delivered to cells even with a small dose of relatively low concentration due to the stability of the double-helical oligo-RNA and efficient enhancement of a cell membrane penetration function, can be efficiently enhanced, and thus can be useful as a tool for treating double-helical oligo-RNA in cancer and infectious diseases and as a novel form of a double-helical oligo-RNA delivery system.

9. 发明专利

CA2859127A1 NOVEL OLIGONUCLEOTIDE CONJUGATES AND USE THEREOF 未知
公开(公告)号：CA2859127A1
公开(公告)日：2013-06-20
申请号：CA2859127
申请日：2012-12-14
申请人： BIONEER CORP
发明人： CHAE JEIWOOK , HAN BORAM , KIM HAN-NA , PARK HAN OH , YOON PYOUNG OH , KIM SUN GI , JUNG KWANG-JU , KWON TAEWOO , CHOI JONG DEOK , LEE SAM YOUNG , JUNG EUN-JUNG
IPC分类号： A61K47/48 , A61K9/16 , A61K48/00 , C12N15/11
摘要： The present invention provides a double helix oligo-RNA structure in which target-specific ligands are bonded to the double helix oligo-RNA structure in which high molecular compounds for improving the delivery of double helix oligo-RNA that can be valuably used in treating diseases, specifically, cancer, are covalently bonded. The present invention also provides a method for preparing the RNA structure and a target-specific double helix oligo-RNA delivery technology through said structure. Nanoparticles constituted by the double helix oligo-RNA structure to which ligands are bonded may efficiently deliver double helix oligo-RNA to a target, and thus may exhibit an activity of double helix oligo-RNA structure in a target cell even with an administration of double helix oligo-RNA of relatively lower concentration. The nanoparticles may prevent the delivery of non-specific double helix oligo-RNA to other organs and cells, and therefore, can be valuably used not only as a tool for double helix oligo-RNA for treating various diseases, specifically, cancer, but also as a new type of double helix oligo-RNA delivery system. The present invention also relates to hybrid conjugates in which a hydrophilic material and a hydrophobic material are connected to both ends of antisense oligonucleotide(ASO) through covalent bond so as to achieve in vivo stability of the ASO, and to a method for preparing the hybrid conjugates and to nanoparticles constituted by the conjugates. The conjugates between ASO and macromolecules according to the present invention may improve in vivo stability of ASO, and therefore, can efficiently deliver ASO for treatment into cells and may exhibit an activity of ASO even with an administration of a relatively lower concentration.

10. 发明公开

EP2801615A4 HIGH-EFFICIENCY NANOPARTICLE-TYPE DOUBLE-HELICAL OLIGO-RNA STRUCTURE AND METHOD FOR PREPARING SAME 审中-公开
标题翻译：霍夫菲尔德纳米比亚多普勒血红蛋白 - RNA-STRUKTUR UND VERFAHREN ZU IHRER HERSTELLUNG
公开(公告)号：EP2801615A4
公开(公告)日：2015-08-19
申请号：EP13733748
申请日：2013-01-04
申请人： BIONEER CORP
发明人： CHAE JEIWOOK , HAN BORAM , KIM HAN-NA , PARK HAN OH
IPC分类号： C12N15/11 , A61K31/7105 , C07H21/02 , C12Q1/68
CPC分类号： A61K9/14 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/3515 , C12N2320/30 , C12N2320/32 , C12N2330/30
摘要： Provided are a double-stranded oligo RNA structure and a method of preparing the same, and more specifically, a double-stranded oligo RNA structure in which a polymer compound is covalently bound to a double-stranded oligo RNA in order to improve stability in vivo and a cell delivery efficiency of the double-stranded oligo RNA, and a method of preparing the same. The double-stranded oligo RNA structure having the optimized structure according to the present invention may not inhibit functions of the double-stranded oligo RNA, but effectively improve stability and cell membrane permeability of the double-stranded oligo RNA, such that the double-stranded oligo RNA may be delivered into the cell even at a low concentration dosage thereof to be significantly used as a tool for treatment of cancer, infectious diseases, and the like, as well as a new delivery system of the double-stranded oligo RNA.
摘要翻译：提供双链寡聚RNA结构及其制备方法，更具体地，其中高分子化合物与双链寡聚RNA共价结合以提高体内稳定性的双链寡RNA结构和双链寡聚RNA的细胞递送效率及其制备方法。具有本发明优化结构的双链寡聚RNA结构可能不抑制双链寡聚RNA的功能，而且有效地提高了双链寡聚RNA的稳定性和细胞膜通透性，使得双链寡聚RNA 寡核苷酸即使以低浓度剂量也可以递送到细胞中，以显着地用作治疗癌症，感染性疾病等的工具，以及双链寡聚RNA的新的递送系统。

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