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1. 发明申请

WO2005030992A3 METHOD FOR THE DIAGNOSIS/PROGNOSIS OF NEUROBLASTOMA 审中-公开
标题翻译：神经细胞瘤诊断/预防方法
公开(公告)号：WO2005030992A3
公开(公告)日：2006-04-06
申请号：PCT/FR2004050475
申请日：2004-10-01
申请人： BIOMERIEUX SA , CT LEON BERARD , COMBARET VALERIE , KRAUSE ALEXANDER , PUISIEUX ALAIN , LACROIX BRUNO
发明人： COMBARET VALERIE , KRAUSE ALEXANDER , PUISIEUX ALAIN , LACROIX BRUNO
IPC分类号： C12N15/12 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118
摘要： The invention relates to a method for the prognosis of neuroblastoma in a patient suffering from neuroblastoma, characterized in that said method comprises the following steps: a) biological material is extracted from a biological sample taken from the patient; b) the biological material is placed in contact with at least one specific reagent selected from specific reagents of target genes comprising a nucleic sequence having any one of SEQ ID Nos. 1 to 37, whereby if the target gene comprises a sequence having one of SEQ ID Nos. 11, 17 or 37, the biological material is placed in contact with at least two specific reagents selected from specific reagents of target genes comprising a nucleic sequence having one of SEQ ID Nos. 1 37; c) the expression of at least of one of said target genes is determined, whereby the expression of at least two of said target genes is determined if the target gene comprises a nuclear sequence having one of SEQ ID Nos. 11, 17 or 37.
摘要翻译：本发明涉及一种患有神经母细胞瘤患者神经母细胞瘤预后的方法，其特征在于所述方法包括以下步骤：a）从取自患者的生物样品中提取生物材料; b）使生物材料与至少一种特定试剂接触，所述试剂选自包含具有SEQ ID No.1至37中任一项所述的核酸序列的靶基因的特异性试剂，其中如果靶基因包含SEQ ID NO： ID号11,17或37，使生物材料与至少两种选自特定试剂的特异性试剂接触，所述特异性试剂包含具有SEQ ID No.17之一的核酸序列; c）确定至少一个所述靶基因的表达，由此如果靶基因包含具有SEQ ID No.11,17或37之一的核序列，则确定至少两个所述靶基因的表达。

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