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1. 发明申请

WO2012130103A1 METHOD AND KIT FOR DETERMINING IN VITRO THE PROBABILITY FOR AN INDIVIDUAL TO SUFFER FROM COLORECTAL CANCER 审中-公开
标题翻译：用于确定个体对彩色癌症的可能性的方法和工具
公开(公告)号：WO2012130103A1
公开(公告)日：2012-10-04
申请号：PCT/CN2012/072931
申请日：2012-03-23
申请人： BIOMERIEUX , YE, Xun , WU, Fei , XU, Qinghua , LIU, Fang , MENG, Xia , MOUGIN, Bruno
发明人： YE, Xun , WU, Fei , XU, Qinghua , LIU, Fang , MENG, Xia , MOUGIN, Bruno
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The present invention provides a method for determining in vitro, in a peripheral blood sample, the probability for an individual to suffer from a colorectal cancer, using the comparison of the amount of expression products of nucleic acids of genes of the individual to be tested with the amount of expression products of nucleic acids of the same genes obtained from a CRC group of patients constituting the positive control and with the amount of expression products of nucleic acids of the same genes obtained from a CNC group of individuals constituting the negative control; and a kit comprising specific binding partners for said expression products.
摘要翻译：本发明提供了一种用于在外周血样品中测定个体遭受结肠直肠癌的可能性的方法，该方法使用待测个体的基因的核酸的表达产物的量与从构成阳性对照的CRC组获得的相同基因的核酸的表达产物的量以及从构成阴性对照的个体的CNC组获得的相同基因的核酸的表达产物的量; 以及包含所述表达产物的特异性结合伴侣的试剂盒。

2. 发明申请

WO2012129758A1 METHOD AND KIT FOR DETERMINING IN VITRO PROBABILITY FOR INDIVIDUAL TO SUFFER FROM COLORECTAL CANCER 审中-公开
标题翻译：用于确定个体对染色体癌患者体内可靠性的方法和工具包
公开(公告)号：WO2012129758A1
公开(公告)日：2012-10-04
申请号：PCT/CN2011/072155
申请日：2011-03-25
申请人： BIOMERIEUX , YE, Xun , WU, Fei , XU, Qinghua , LIU, Fang , MENG, Xia , MOUGIN, Bruno
发明人： YE, Xun , WU, Fei , XU, Qinghua , LIU, Fang , MENG, Xia , MOUGIN, Bruno
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The present invention discloses a method for determining in vitro, in a peripheral blood sample, the probability for an individual to suffer from a colorectal cancer, using the comparison of the amount of expression products of nucleic acids of genes of the individual to be tested with the amount of expression products of nucleic acids of the same genes obtained from a CRC group of patients constituting the positive control and with the same genes obtained from a CNC group of individuals constituting the negative control; and a kit comprising specific binding partners for the expression products.
摘要翻译：本发明公开了一种用于在外周血样品中测定个体遭受结肠直肠癌的可能性的方法，该方法使用待测个体的基因核酸的表达产物的量与从构成阳性对照的CRC组的患者获得的相同基因的核酸的表达产物的量和从构成阴性对照的个体的CNC组获得的相同基因的表达产物的量; 以及包含用于表达产物的特异性结合伴侣的试剂盒。

3. 发明申请

WO2011153684A1 METHOD AND KIT FOR THE PROGNOSIS OF COLORECTAL CANCER 审中-公开
标题翻译：用于预防癌症的方法和工具包
公开(公告)号：WO2011153684A1
公开(公告)日：2011-12-15
申请号：PCT/CN2010/073659
申请日：2010-06-08
申请人： BIOMERIEUX , YE, Xun , WU, Fei , XU, Qinghua , LIU, Fang , MENG, Xia , MOUGIN, Bruno
发明人： YE, Xun , WU, Fei , XU, Qinghua , LIU, Fang , MENG, Xia , MOUGIN, Bruno
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： The present invention discloses a method and kit for the prognosis of colorectal cancer, especially a method comprising: a) obtaining the peripheral blood sample and extracting total RNA from the blood sample, b) contacting the total RNA with at least one reagent that is specific for at least one NK cell gene and no more than 25 specific reagents for 25 NK cell genes, c) determining the expression level of the at least one NK cell gene and of the most 25 NK cell genes to obtain an expression profile for the patient, and d) performing analysis of the expression profile of the patient.
摘要翻译：本发明公开了一种用于预后结直肠癌的方法和试剂盒，特别是一种方法，包括：a）获得外周血样品并从血液样品中提取总RNA，b）使总RNA与至少一种特异性试剂对于至少一种NK细胞基因，对于25个NK细胞基因不超过25种特异性试剂，c）确定至少一种NK细胞基因和最多25个NK细胞基因的表达水平以获得患者的表达谱，以及d）对患者的表达谱进行分析。

4. 发明申请

WO2011150976A1 METHOD AND KIT FOR THE PROGNOSIS OF COLORECTAL CANCER 审中-公开
标题翻译：用于预防癌症的方法和工具包
公开(公告)号：WO2011150976A1
公开(公告)日：2011-12-08
申请号：PCT/EP2010/057843
申请日：2010-06-04
申请人： BIOMÉRIEUX , YE, Xun , WU, Fei , XU, Qinghua , MENG, Xia , MOUGIN, Bruno , LIU, Fang
发明人： YE, Xun , WU, Fei , XU, Qinghua , MENG, Xia , MOUGIN, Bruno , LIU, Fang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C40B40/06
摘要： The present invention relates to method and kit for the prognosis of colorectal cancer. Especially a method comprising: a) obtaining the peripheral blood sample and extracting total RNA from the blood sample, b) contacting the total RNA with at least one reagent that is specific for at least one NK cell gene and no more than 25 specific reagents for 25 NK cell genes, c) determining the expression level of the at least one NK cell gene and of the most 25 NK cell genes to obtain an expression profile for the patient, d) performing analysis of the expression profile of the patient with expression profiles of NK cell genes from patients previously clinically classified as a good prognosis and expression profiles of NK cell genes from patients previously classified as a poor prognosis, wherein - if the expression profile for the patient is clustered with the expression profiles from patients previously clinically classified as a poor prognosis, then the patient is determined to have a poor prognosis, and - if the expression profile for the patient is clustered with the expression profiles from patients previously clinically classified as a good prognosis, then the patient is determined to have a good prognosis.
摘要翻译：本发明涉及结直肠癌预后的方法和试剂盒。特别是一种方法，包括：a）获得外周血液样品并从血液样品中提取总RNA，b）使总RNA与至少一种对至少一种NK细胞基因特异性的试剂和不超过25种特异性试剂接触 25个NK细胞基因，c）确定至少一个NK细胞基因和最多25个NK细胞基因的表达水平以获得患者的表达谱，d）用表达谱分析患者的表达谱来自先前临床分类为良好预后的患者的NK细胞基因的NK细胞基因和先前归类为不良预后的患者的NK细胞基因的表达谱，其中 - 如果患者的表达谱与来自先前临床分类为预后不良，那么患者的预后判定不佳，如果患者的表达谱与快速聚集离子谱从先前临床分类为良好的预后，然后确定患者有良好的预后。

5. 发明申请

WO2011147096A1 METHOD AND KIT FOR DISCRIMINATING BETWEEN BREAST CANCER AND BENIGN BREAST DISEASE 审中-公开
标题翻译：用于鉴别乳腺癌和勃起乳腺疾病之间的方法和工具包
公开(公告)号：WO2011147096A1
公开(公告)日：2011-12-01
申请号：PCT/CN2010/073342
申请日：2010-05-28
申请人： BIOMERIEUX , YE, Xun , WU, Fei , XU, Qinghua , MENG, Xia , MOUGIN, Bruno
发明人： YE, Xun , WU, Fei , XU, Qinghua , MENG, Xia , MOUGIN, Bruno
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： The present invention relates to a method and kit for discriminating between breast cancer and benign breast disease by the determination of the expression level of at least one target gene comprising a nucleic acid sequence selected from the nucleic acid sequences set forth in SEQ ID NOs: 1, 2 or 3, 4 and 5 or 6 to obtain an expression profile for the patient, and the comparison of the expression profile of the patient with expression profiles of target genes from patients previously clinically classified as breast cancer and expression profiles of target genes from patients previously clinically classified as benign breast disease.
摘要翻译：本发明涉及通过测定包含选自SEQ ID NO：1所示的核酸序列的核酸序列的至少一种靶基因的表达水平来区分乳腺癌和良性乳腺疾病的方法和试剂盒，2或3,4和5或6以获得患者的表达谱，并且将患者的表达谱与先前临床分类为乳腺癌的患者的靶基因的表达谱进行比较和靶基因的表达谱以前临床分类为良性乳腺疾病的患者。

6. 发明公开

EP2689035A1 METHOD AND KIT FOR DETERMINING IN VITRO THE PROBABILITY FOR AN INDIVIDUAL TO SUFFER FROM COLORECTAL CANCER 有权
标题翻译：方法和试剂盒用于患结直肠癌患者的可能性的体外测定
公开(公告)号：EP2689035A1
公开(公告)日：2014-01-29
申请号：EP12765725.2
申请日：2012-03-23
申请人： Biomerieux
发明人： YE, Xun , WU, Fei , XU, Qinghua , LIU, Fang , MENG, Xia , MOUGIN, Bruno
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The present invention provides a method for determining in vitro, in a peripheral blood sample, the probability for an individual to suffer from a colorectal cancer, using the comparison of the amount of expression products of nucleic acids of genes of the individual to be tested with the amount of expression products of nucleic acids of the same genes obtained from a CRC group of patients constituting the positive control and with the amount of expression products of nucleic acids of the same genes obtained from a CNC group of individuals constituting the negative control; and a kit comprising specific binding partners for said expression products.
摘要翻译：本发明提供了用于在体外确定采矿的方法，外周血样品中，对于在个体从一个大肠癌患的概率，使用的单独的基因的核酸的表达产物的量的比较，以与待测试的从构成阳性对照的一组CRC患者的并用从一组构成阴性对照CNC值得个体获得的相同基因的核酸表达产物的量而得到的相同的基因的核酸的表达产物的量; 和试剂盒，包括用于所述表达产物特异性结合伴侣。

7. 发明授权

EP2689035B1 METHOD AND KIT FOR DETERMINING IN VITRO THE PROBABILITY FOR AN INDIVIDUAL TO SUFFER FROM COLORECTAL CANCER 有权
标题翻译：用于确定个体患大肠癌的概率的方法和试剂盒
公开(公告)号：EP2689035B1
公开(公告)日：2018-05-09
申请号：EP12765725.2
申请日：2012-03-23
申请人： Biomerieux
发明人： YE, Xun , WU, Fei , XU, Qinghua , LIU, Fang , MENG, Xia , MOUGIN, Bruno
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The present invention provides a method for determining in vitro, in a peripheral blood sample, the probability for an individual to suffer from a colorectal cancer, using the comparison of the amount of expression products of nucleic acids of genes of the individual to be tested with the amount of expression products of nucleic acids of the same genes obtained from a CRC group of patients constituting the positive control and with the amount of expression products of nucleic acids of the same genes obtained from a CNC group of individuals constituting the negative control; and a kit comprising specific binding partners for said expression products.

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