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1. 发明申请

WO2005085871A1 A METHOD FOR PREDICTING THE STATE OF THE GASTRIC MUCOSA 审中-公开
标题翻译：一种预测胃粘膜状态的方法
公开(公告)号：WO2005085871A1
公开(公告)日：2005-09-15
申请号：PCT/FI2005/050061
申请日：2005-03-03
申请人： BIOHIT OYJ , SARNA, Seppo , TIUSANEN, Tapani , SUOVANIEMI, Osmo
发明人： SARNA, Seppo , TIUSANEN, Tapani , SUOVANIEMI, Osmo
IPC分类号： G01N33/74
CPC分类号： G01N33/6893 , G01N2333/595 , G01N2333/96477 , G01N2800/062
摘要： The present invention is directed to a method for assessing or predicting the state of the gastric mucosa in a subject by determining, in said subject, the probability for the gastric mucosa belonging to at least one gastric mucosa class, the method comprising: measuring, from a sample of said subject, the pepsinogen I (PGI) and gastrin-17 (G-17) analyte concentrations, as well as determining the presence or concentration of a marker for Helicobacter pylori ; entering the data so obtained in a data processing system comprising an operating system, a database and means for transceiving and processing data, the said data processing system being adapted to determine the probability for the gastric mucosa belonging to the at least one gastric mucosa class, based on the data entered as well as on predefined clinical data in the database, the information so generated being indicative of the state of the gastric mucosa in said subject.
摘要翻译：本发明涉及通过在所述受试者中确定属于至少一种胃粘膜类别的胃粘膜的概率来评估或预测受试者胃粘膜状态的方法，所述方法包括：从所述受试者的样品，胃蛋白酶原I（PGI）和胃泌素-17（G-17）分析物浓度，以及确定幽门螺杆菌标记物的存在或浓度; 输入在包括操作系统，数据库和用于收发和处理数据的装置的数据处理系统中获得的数据，所述数据处理系统适于确定属于至少一个胃粘膜类的胃粘膜的概率，基于输入的数据以及数据库中的预定临床数据，所生成的信息指示所述受试者中胃粘膜的状态。

2. 发明申请

WO2009034232A1 PREPARATION AND A COMPONENT INTENDED TO BE ADDED TO A TOBACCO PRODUCT 审中-公开
标题翻译：准备和组成部分预计将添加到烟草制品中
公开(公告)号：WO2009034232A1
公开(公告)日：2009-03-19
申请号：PCT/FI2008/050507
申请日：2008-09-12
申请人： BIOHIT OYJ , SUOVANIEMI, Osmo , SALASPURO, Mikko , SALASPURO, Ville , MARVOLA, Martti
发明人： SUOVANIEMI, Osmo , SALASPURO, Mikko , SALASPURO, Ville , MARVOLA, Martti
IPC分类号： A61K31/198 , A24B15/30 , A24D3/14 , A61P25/32 , A61P25/34
CPC分类号： A61K31/198 , A24D3/14 , A61K33/02 , A61K38/05
摘要： The present invention relates to the use of a preparation comprising a substance that is capable of binding acetaldehyde, and to the use of a filter that is attached to a tobacco product to reduce tobacco and/or alcohol dependence.
摘要翻译：本发明涉及包含能够结合乙醛的物质的制剂的用途，以及使用连接到烟草制品上的过滤器以减少烟草和/或酒精依赖性。

3. 发明申请

WO2008025877A1 METHOD AND SAMPLING KIT FOR ASSESSING THE CONDITION OF THE GASTRIC MUCOSA 审中-公开
标题翻译：用于评估胃肠道状况的方法和采样工具
公开(公告)号：WO2008025877A1
公开(公告)日：2008-03-06
申请号：PCT/FI2007/050458
申请日：2007-08-28
申请人： BIOHIT OYJ , SUOVANIEMI, Osmo
发明人： SUOVANIEMI, Osmo
IPC分类号： G01N33/68 , G01N33/573 , G01N33/574 , G01N33/74 , G01N33/569
CPC分类号： G01N33/6893 , G01N2333/96472 , G01N2469/20 , G01N2800/062
摘要： The invention concerns a method for assessing the condition of the gastric mucosa in an individual, which method comprises a) determining the concentration of the biomarkers pepsinogen I (PGI) and pepsinogen II (PGII) in a sample from the said individual, and forming the biomarker ratio PGI/PGII from the concentration values obtained for PGI and PGII, b) comparing the values obtained for PGI and PGI/PGII to the respective cut-off values or reference ranges for said biomarkers, whereby a value for at least one of the markers PGI an d PGI/PGII close to or below the lower limit of its reference range or its cut-off value is indicative of corpus atrophy in said individual. If necessary, the method can be combined with as further step of determining the Helicobacter pylori antibody and gastrin-17 (G-17) concentration in a sample from the said individual.
摘要翻译：本发明涉及一种用于评估个体胃粘膜状况的方法，该方法包括：a）测定来自所述个体的样品中生物标志物胃蛋白酶原I（PGI）和胃蛋白酶原II（PGII）的浓度，并形成从PGI和PGII获得的浓度值的生物标志物比例PGI / PGII，b）将对PGI和PGI / PGII获得的值与所述生物标志物的各个截止值或参考范围进行比较，其中至少一个标记PGI和PGI / PGII接近或低于其参考范围的下限，或其截止值表示所述个体中的语料库萎缩。如果需要，该方法可以与确定来自所述个体的样品中幽门螺杆菌抗体和胃泌素-17（G-17）浓度的进一步的步骤组合。

4. 发明申请

WO2007135241A3 COMPOSITION AND METHOD FOR BINDING ACETALDEHYDE IN STOMACH 审中-公开
公开(公告)号：WO2007135241A3
公开(公告)日：2007-11-29
申请号：PCT/FI2007/050287
申请日：2007-05-22
申请人： BIOHIT OYJ , SUOVANIEMI, Osmo , SALASPURO, Ville , MARVOLA, Martti , SALASPURO, Mikko
发明人： SUOVANIEMI, Osmo , SALASPURO, Ville , MARVOLA, Martti , SALASPURO, Mikko
IPC分类号： A61K31/198 , A61K31/131 , A23L1/305 , A23L1/00 , A23L1/30 , A23L1/29 , A61P39/02 , A61P25/32 , A61P25/34
摘要： This invention relates to a non-toxic composition which bind acetaldehyde present in the stomach, intestine and/or colon. The composition comprises one or more acetaldehyde-binding compound(s) comprising one or more free sulphhydryl and/or amino groups. The compound(s) are mixed with a non-toxic carrier that effects sustained release of said compound(s) in the gastrointestinal tract. These compositions are of benefit in particular to patients having atrophic gastritis or achlorhydric or low acid stomach.

5. 发明申请

WO2009053537A1 METHODS AND PRODUCTS FOR DIAGNOSING AUTOIMMUNE DISEASES AND GASTRIC CANCER LINKED WITH ATROPHIC GASTRITIS 审中-公开
标题翻译：用于诊断自身免疫性疾病的方法和产品和与ATROPHIC GASTRITI连接的胃癌
公开(公告)号：WO2009053537A1
公开(公告)日：2009-04-30
申请号：PCT/FI2008/050602
申请日：2008-10-27
申请人： BIOHIT OYJ , SUOVANIEMI, Osmo
发明人： SUOVANIEMI, Osmo
IPC分类号： G01N33/573 , G01N33/569 , G01N33/68 , G01N33/74
CPC分类号： G01N33/6893 , G01N33/564 , G01N2800/062 , G01N2800/24
摘要： The present invention relates to a method for examining a person having the symptoms and/or biomarker indicating an autoimmune disease for the presence of atrophic gastritis. The biomarker combination, which diagnoses atrophic gastritis, acts also as a part of a biomarker panel that helps diagnosis and assessment of autoimmune disease as well. The invention relates also to products used in these methods.
摘要翻译：本发明涉及一种检查具有症状和/或生物标志物的人的方法，所述症状和/或生物标志物表示存在萎缩性胃炎的自身免疫性疾病。诊断萎缩性胃炎的生物标志物组合也可作为有助于诊断和评估自身免疫疾病的生物标志物组的一部分。本发明还涉及这些方法中使用的产品。

6. 发明申请

WO2007135242A1 COMPOSITION FOR FOODSTUFF FOR BINDING ACETALDEHYDE 审中-公开
标题翻译：用于结合乙酰胆碱的食品组合物
公开(公告)号：WO2007135242A1
公开(公告)日：2007-11-29
申请号：PCT/FI2007/050288
申请日：2007-05-22
申请人： BIOHIT OYJ , SUOVANIEMI, Osmo , SALASPURO, Ville , MARVOLA, Martti , SALASPURO, Mikko
发明人： SUOVANIEMI, Osmo , SALASPURO, Ville , MARVOLA, Martti , SALASPURO, Mikko
IPC分类号： A61K31/198 , A61K31/131 , A23L1/305 , A23L1/00 , A23L1/30 , A23L1/29 , A61P39/02 , A61P25/32 , A61P25/34
CPC分类号： A61K31/198 , A61K31/131
摘要： This invention relates to a non-toxic composition which bind acetaldehyde present in the stomach, intestine and/or colon. The composition comprises one or more acetaldehyde-binding compound(s) comprising one or more free sulphhydryl and/or amino groups. The compound(s) are mixed with a non-toxic carrier that effects sustained release of said compound(s) in the gastrointestinal tract. This invention relates also to food additives and food compositions and packages comprising the composition.
摘要翻译：本发明涉及结合存在于胃，肠和/或结肠中的乙醛的无毒组合物。组合物包含一种或多种包含一个或多个游离巯基和/或氨基的乙醛结合化合物。化合物与在胃肠道中持续释放所述化合物的无毒载体混合。本发明还涉及包含该组合物的食品添加剂和食品组合物和包装。

7. 发明申请

WO2004041433A1 MULTICHANNEL PIPETTE 审中-公开
标题翻译：多通道管
公开(公告)号：WO2004041433A1
公开(公告)日：2004-05-21
申请号：PCT/FI2003/000846
申请日：2003-11-07
申请人： BIOHIT OYJ , SUOVANIEMI, Osmo , EKHOLM, Pertti
发明人： SUOVANIEMI, Osmo , EKHOLM, Pertti
IPC分类号： B01L3/02
CPC分类号： B01L3/0279 , B01L3/0217 , B01L2200/0689
摘要： A multichannel pipette, the suction tube arrangement of which is arranged to be resilient, so that a disposable tip is attached similarly to each suction tube regardless of the shape and elastic characteristics of a tip rack. The pipette comprises a body and a plunger-cylinder system with suction tubes for each channel. Each suction tube is thus adapted to the body, that the suction tube is movable between two extreme positions in its vertical direction with respect to the body.
摘要翻译：多通道移液器，其吸管配置被设置为具有弹性的，使得一次性尖端与每个吸管相似地附接，而与尖端齿条的形状和弹性特性无关。移液管包括一个主体和一个柱塞缸系统，每个通道都有吸气管。因此，每个抽吸管适合于身体，吸管可以在相对于身体的垂直方向上的两个极限位置之间移动。

8. 发明申请

WO2004023148A1 METHOD FOR DETECTING A RISK OF ACID RELATED DISEASE IN AN INDIVIDUAL 审中-公开
标题翻译：检测个体酸性相关疾病风险的方法
公开(公告)号：WO2004023148A1
公开(公告)日：2004-03-18
申请号：PCT/FI2003/000653
申请日：2003-09-05
申请人： BIOHIT OYJ , SUOVANIEMI, Osmo , HÄRKÖNEN, Matti , SIPPONEN, Pentti
发明人： SUOVANIEMI, Osmo , HÄRKÖNEN, Matti , SIPPONEN, Pentti
IPC分类号： G01N33/74
CPC分类号： G01N33/56922 , G01N33/573 , G01N2333/205 , G01N2333/595
摘要： The present invention is directed to a method for detecting a risk of gastric acid related disease in an individual based on assaying the analytes pepsinogen I, fasting gastrin-17 and a marker for Helicobacter pylori infection (Hp-marker), the method comprising selecting a cut-off value for pepsinogen I, fasting gastrin-17 and the Hp-marker, determining the concentration of pepsinogen I, fasting gastrin-17 and the concentration or presence of a Hp-marker in a sample from said individual, andcomparing the concentrations so determined with the selected cut-off values, whereby a pepsinogen I value at or above its respective cut-off value in combination with a Hp-marker value below its respective cut-off value and a fasting gastrin-17 value at or below its cut-off is indicative of an increased risk of gastric acid-related disease in said individual.
摘要翻译：本发明涉及一种基于测定分析物胃蛋白酶原I，空腹胃泌素-17和幽门螺杆菌感染（Hp-标记）的标记物来检测个体胃酸相关疾病风险的方法，所述方法包括选择胃蛋白酶原I，空腹胃泌素-17和Hp标记的临界值，确定胃蛋白酶原I，空腹胃泌素17的浓度，以及来自所述个体的样品中Hp标记的浓度或存在，并比较浓度用所选择的截止值确定，其中胃蛋白酶原I值等于或高于其各自的临界值，结合Hp-标记值低于其各自的临界值，以及在其切口处或其下方的空腹胃泌素-17值 -off表明在所述个体中胃酸相关疾病的风险增加。

9. 发明申请

WO2002099127A1 METHOD FOR DETERMINING THE PRESENCE OF EXTENSION PRODUCTS 审中-公开
标题翻译：确定延伸产品存在的方法
公开(公告)号：WO2002099127A1
公开(公告)日：2002-12-12
申请号：PCT/FI2002/000489
申请日：2002-06-06
申请人： BIOHIT OYJ , ORPANA, Arto , SUOVANIEMI, Osmo
发明人： ORPANA, Arto , SUOVANIEMI, Osmo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q1/6869 , C12Q2565/101 , C12Q2533/101
摘要： The present invention relates to a method and reagents for determining extension products in reactions involving nucleic acid chain extension, e.g., in cyclic minisequencing, and to the use of this method when identifying specific point mutations and genetic variations. Three standard unmodified primers are needed and a non-specific fluorescent reagent (e.g. a ssDNA-binding dye) can be used as one of the fluorophores in the FRET assay used. The invention is also related to vertical light beam fluorometry.
摘要翻译：本发明涉及用于确定在涉及核酸链延伸的反应中的延伸产物的方法和试剂，例如在循环分选中，以及在鉴定特定点突变和遗传变异时使用该方法。需要三种标准的未修饰的引物，并且可以使用非特异性荧光试剂（例如ssDNA结合染料）作为所用FRET测定中的荧光团之一。本发明还涉及垂直光束荧光测定法。

10. 发明申请

WO2013001167A1 NON-TOXIC COMPOSITIONS FOR DECREASING THE RISK OF CANCER CAUSED BY ORAL MICROBES 审中-公开
标题翻译：用于减轻口服微生物引起的癌症风险的非毒性组合物
公开(公告)号：WO2013001167A1
公开(公告)日：2013-01-03
申请号：PCT/FI2012/050680
申请日：2012-06-28
申请人： BIOHIT OYJ , SALASPURO, Mikko , SUOVANIEMI, Osmo
发明人： SALASPURO, Mikko , SUOVANIEMI, Osmo
IPC分类号： A61K31/198 , A61K9/00 , A61K9/20 , A61K47/00 , A61P35/00 , A61P31/00
CPC分类号： A61K31/198 , A61K9/0007 , A61K9/006 , A61K33/00 , A61K45/06 , A61K2300/00
摘要： The present invention concerns a product in the form of a non-toxic liquid composition, such as a mouthwash, or in the form of an effervescent tablet,for decreasing the risk of cancer caused by oral microbes,which composition comprises cysteine or a derivative thereof. Alternatively, the product may be in the form of a non-toxic combination product including an effervescent tablet, a powder or granules comprising cysteine or a derivative thereof and a mouthwash, the combination product being intended for decreasing the risk of cancer caused by oral microbes. The components of the combination product may be administered either at the same time or separately.
摘要翻译：本发明涉及一种无毒液体组合物形式的产品，例如漱口水或以泡腾片形式，用于降低由口腔微生物引起的癌症风险，该组合物包含半胱氨酸或其衍生物。或者，产品可以是无毒组合产品的形式，包括泡腾片剂，包含半胱氨酸的粉末或颗粒或其衍生物和漱口剂，所述组合产品旨在降低口腔微生物引起的癌症风险。组合产品的组分可以同时或分开施用。

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