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1. 发明申请

WO2011139629A2 LIGHT TARGETING MOLECULES AND USES THEREOF 审中-公开
标题翻译：光靶向分子及其用途
公开(公告)号：WO2011139629A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/033752
申请日：2011-04-25
申请人： BIOGEN IDEC MA INC. , WANG, Xinzhong , BAILLY, Veronique , FARRINGTON, Graham, K. , LUGOVSKOY, Alexey
发明人： WANG, Xinzhong , BAILLY, Veronique , FARRINGTON, Graham, K. , LUGOVSKOY, Alexey
IPC分类号： G01N33/68 , G01N33/53 , G01N33/52 , C07K14/00 , C12N15/09
CPC分类号： C07K16/30 , C07K14/525 , C07K14/7151 , C07K2319/01 , G01N33/57415
摘要： LIGHT-targeting molecules (e.g., LIGHT fusion molecules), compositions, e.g., pharmaceutical compositions thereof, are disclosed. Methods of using these molecules to treat, prevent and/or diagnose hyperproliferative, e.g., neoplastic, diseases or conditions, including, but not limited to, cancer and metastasis are also provided.
摘要翻译：公开了光靶向分子（例如，LIGHT融合分子），组合物，例如其药物组合物。还提供了使用这些分子来治疗，预防和/或诊断过度增殖，例如肿瘤性疾病或病症（包括但不限于癌症和转移）的方法。

2. 发明申请

WO2010051502A3 LIGHT TARGETING MOLECULES AND USES THEREOF 审中-公开
公开(公告)号：WO2010051502A3
公开(公告)日：2010-05-06
申请号：PCT/US2009/062870
申请日：2009-10-30
申请人： BIOGEN IDEC MA INC. , WANG, Xinzhong , BAILLY, Veronique , GLASER, Scott , LUGOVSKOY, Alexey , FARRINGTON, Graham, K. , GRAFF, Christilyn
发明人： WANG, Xinzhong , BAILLY, Veronique , GLASER, Scott , LUGOVSKOY, Alexey , FARRINGTON, Graham, K. , GRAFF, Christilyn
IPC分类号： A61K39/395 , C12N15/62 , C07K19/00 , C07K16/30 , A61P35/00
摘要： LIGHT-targeting molecules ( e.g ., LIGHT fusion molecules), anti-HER2 antibody molecules, compositions, e.g ., pharmaceutical compositions thereof, are disclosed. Methods of using these molecules to treat, prevent and/or diagnose hyperproliferative, e.g. , neoplastic, diseases or conditions, including, but not limited to, cancer and metastasis are also provided.

3. 发明申请

WO2007089601A3 NOGO RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2007089601A3
公开(公告)日：2007-08-09
申请号：PCT/US2007/002199
申请日：2007-01-26
申请人： BIOGEN IDEC MA INC. , LEE, Daniel, H.S. , WEN, Dingyi , PEPINSKY, R., Blake , RELTON, Jane, K. , WANG, Xinzhong , LUGOVSKOY, Alexey , MEIER, Werner , GARBER, Ellen, A. , SILVIAN, Laura , WEINREB, Paul, H.
发明人： LEE, Daniel, H.S. , WEN, Dingyi , PEPINSKY, R., Blake , RELTON, Jane, K. , WANG, Xinzhong , LUGOVSKOY, Alexey , MEIER, Werner , GARBER, Ellen, A. , SILVIAN, Laura , WEINREB, Paul, H.
IPC分类号： A61K39/395 , A61K38/17 , C07K16/28 , C07K14/705
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.

4. 发明申请

WO2012044684A2 INTERFERON-BETA FOR USE AS MONOTHERAPY OR IN COMBINATION WITH OTHER CANCER THERAPIES 审中-公开
标题翻译：干扰素作为单独使用或与其他癌症治疗组合使用
公开(公告)号：WO2012044684A2
公开(公告)日：2012-04-05
申请号：PCT/US2011/053681
申请日：2011-09-28
申请人： BIOGEN IDEC MA INC. , BAKER, Darren, P. , JOSEPH, Ingrid, B.J.K. , WANG, Xinzhong
发明人： BAKER, Darren, P. , JOSEPH, Ingrid, B.J.K. , WANG, Xinzhong
IPC分类号： A61K38/21 , A61P35/00
CPC分类号： A61K38/215 , A61K31/166 , A61K31/337 , A61K31/4188 , A61K31/436 , A61K31/44 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , A61K2300/00 , C07K16/22 , C07K2317/24 , C07K2317/76
摘要： This description relates to the use of a polymer-conjugated interferon-beta as monotherapy or in combination with other cancer therapies.
摘要翻译：该描述涉及聚合物缀合的干扰素-β作为单一疗法或与其它癌症治疗组合的用途。

5. 发明申请

WO2008069942A2 NOVEL METHODS OF ENHANCING DELIVERY OF A GENE THERAPY VECTOR USING STEROIDS 审中-公开
标题翻译：用STEROIDS增强基因治疗载体的递送的新方法
公开(公告)号：WO2008069942A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/024526
申请日：2007-11-29
申请人： BIOGEN IDEC MA INC. , WANG, Xinzhong , PARR, Michael
发明人： WANG, Xinzhong , PARR, Michael
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K48/0083 , C12N2710/10343
摘要： The invention provides methods for enhancing the delivery of a therapeutic gene product into a subject by administering a viral vector comprising a nucleic acid encoding the therapeutic gene product along with a steroid or a fragment, variant, derivative, or analog thereof that reduces the level of an inflammatory response and/or that modulates Kupffer cell function.
摘要翻译：本发明提供了通过施用包含编码治疗性基因产物的核酸的病毒载体以及类固醇或其片段，变体，衍生物或衍生物来增强治疗性基因产物向受试者的递送的方法，或降低炎症反应水平和/或调节Kupffer细胞功能的其类似物。

6. 发明申请

WO2006060089A2 NOVEL METHODS FOR PRODUCING ADENOVIRAL VECTOR PREPARATIONS WITH REDUCED REPLICATION-COMPETENT ADENOVIRUS CONTAMINATION AND NOVEL ADENOVIRAL VECTORS AND PREPARATIONS 审中-公开
标题翻译：用于生产具有降低的复制性腺病毒污染和新型腺病毒载体和制剂的腺病毒载体制备的新方法
公开(公告)号：WO2006060089A2
公开(公告)日：2006-06-08
申请号：PCT/US2005/038714
申请日：2005-10-25
申请人： BIOGEN IDEC MA INC. , WANG, Xinzhong , KAYNOR, George, C. , BARSOUM, James
发明人： WANG, Xinzhong , KAYNOR, George, C. , BARSOUM, James
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/53 , C12N2710/10343 , C12N2830/42 , C12N2840/203
摘要： This invention provides novel replication-defective adenoviral vectors comprising an adenoviral genome in which the protein IX gene, preferably under the control of its own promoter, is in an inverted orientation relative to the direction of transcription of the native protein IX gene at a location where the protein IX gene normally resides, for production of replication-competent adenovirus (RCA) free, or substantially RCA-free, adenovirus preparations. Said vector preferably encodes a gene of interest. The invention relates to viral particles, host cells and compositions comprising said adenoviral vector. This invention further relates a method for propagating adenovirus preparations, free, or substantially free, of replication-competent adenovirus (RCA) particles, from host cells comprising vectors of this invention, for use to treat a subject suffering from a disease or disorder or to prevent a subject from getting a disease or disorder, such as cancer. The invention also provides methods of treating such subjects and methods of prophylactically treating unaffected subjects. This invention further provides for vaccine compositions comprising the novel replication-defective adenoviral vectors of the present invention.
摘要翻译：本发明提供了包含腺病毒基因组的新型复制缺陷型腺病毒载体，其中优选在其自身启动子控制下的蛋白质IX基因相对于天然蛋白IX基因的转录方向处于倒置方向，蛋白IX基因通常存在，用于产生无复制的腺病毒（RCA）或基本上不含RCA的腺病毒制剂。所述载体优选编码感兴趣的基因。本发明涉及包含所述腺病毒载体的病毒颗粒，宿主细胞和组合物。本发明还涉及从包含本发明载体的宿主细胞中扩增游离或基本上游离的具有复制能力的腺病毒（RCA）颗粒的腺病毒制剂的方法，用于治疗患有疾病或病症的受试者或防止受试者患有疾病或病症，如癌症。本发明还提供了治疗这些受试者的方法和预防性治疗未受影响的受试者的方法。本发明进一步提供包含本发明的新型复制缺陷型腺病毒载体的疫苗组合物。

7. 发明公开

EP2621516A2 INTERFERON-BETA FOR USE AS MONOTHERAPY OR IN COMBINATION WITH OTHER CANCER THERAPIES 有权
标题翻译：干扰素-βFOR USE单药或联合其它癌症疗法
公开(公告)号：EP2621516A2
公开(公告)日：2013-08-07
申请号：EP11829825.6
申请日：2011-09-28
申请人： Biogen Idec MA Inc.
发明人： BAKER, Darren, P. , JOSEPH, Ingrid, B.J.K. , WANG, Xinzhong
IPC分类号： A61K38/21 , A61P35/00
CPC分类号： A61K38/215 , A61K31/166 , A61K31/337 , A61K31/4188 , A61K31/436 , A61K31/44 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , A61K2300/00 , C07K16/22 , C07K2317/24 , C07K2317/76
摘要： This description relates to the use of a polymer-conjugated interferon-beta as monotherapy or in combination with other cancer therapies.

8. 发明公开

EP2362783A2 LIGHT TARGETING MOLECULES AND USES THEREOF 审中-公开
标题翻译： LIGHT靶向分子及其应用
公开(公告)号：EP2362783A2
公开(公告)日：2011-09-07
申请号：EP09749277.1
申请日：2009-10-30
申请人： Biogen Idec MA Inc.
发明人： WANG, Xinzhong , BAILLY, Veronique , GLASER, Scott , LUGOVSKOY, Alexey , FARRINGTON, Graham, K. , GRAFF, Christilyn
IPC分类号： A61K39/395 , C12N15/62 , C07K19/00 , C07K16/30 , A61P35/00
CPC分类号： C07K16/32 , A61K38/00 , A61K2039/505 , C07K14/525 , C07K16/2851 , C07K16/2869 , C07K2317/21 , C07K2317/55 , C07K2317/74 , C07K2317/77 , C07K2319/00 , C07K2319/32
摘要： LIGHT-targeting molecules (
e.g ., LIGHT fusion molecules), anti-HER2 antibody molecules, compositions,
e.g ., pharmaceutical compositions thereof, are disclosed. Methods of using these molecules to treat, prevent and/or diagnose hyperproliferative,
e.g. , neoplastic, diseases or conditions, including, but not limited to, cancer and metastasis are also provided.

9. 发明公开

EP1981902A2 NOGO RECEPTOR ANTAGONISTS 有权转让
标题翻译： Nogo受体拮抗剂
公开(公告)号：EP1981902A2
公开(公告)日：2008-10-22
申请号：EP07762730.5
申请日：2007-01-26
申请人： Biogen Idec MA Inc.
发明人： LEE, Daniel, H.S. , WEN, Dingyi , PEPINSKY, R. Blake , RELTON, Jane, K. , WANG, Xinzhong , LUGOVSKOY, Alexey , MEIER, Werner , GARBER, Ellen, A. , SILVIAN, Laura , WEINREB, Paul, H.
IPC分类号： C07K7/64
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.

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