专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007127461A3 COMPOSITION AND METHODS FOR THE DETECTION OF CRIPTO-3 审中-公开
标题翻译：用于检测CRIPTO-3的组合物和方法
公开(公告)号：WO2007127461A3
公开(公告)日：2008-06-26
申请号：PCT/US2007010399
申请日：2007-04-30
申请人： BIOGEN IDEC INC , OROZCO OLIVIA , SANICOLA-NADEL MICHELE , CHOI EUGENE , CARULLI JOHN , TIZARD RICH , SZAK SUZANNE , SUN CHAO
发明人： OROZCO OLIVIA , SANICOLA-NADEL MICHELE , CHOI EUGENE , CARULLI JOHN , TIZARD RICH , SZAK SUZANNE , SUN CHAO
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： The present invention is based, at least in part, on the discovery that the pseudogene TDGF3 (Cripto-3) is expressed in cells and, in particular, that TDGF3 overexpression is associated with transformation of a cell, e.g., TDGF3 is overexpressed in cancer cell lines and cells from tumor tissue. Accordingly, the invention provides compositions, kits, and methods for detecting the presence of a TDGF3 polynucleotide or polypeptide in a sample. The invention further provides compositions, kits and methods for assessing whether a cell is transformed as well as for assessing whether a patient is a suitable candidate for an anti-Cripto antibody therapy.
摘要翻译：本发明至少部分地基于在细胞中表达假性TDGF3（Cripto-3）的发现，特别是TDGF3过表达与细胞的转化相关，例如TDGF3在癌症中过表达来自肿瘤组织的细胞系和细胞。因此，本发明提供用于检测样品中TDGF3多核苷酸或多肽的存在的组合物，试剂盒和方法。本发明还提供用于评估细胞是否转化以及评估患者是否是抗Cripto抗体治疗的合适候选者的组合物，试剂盒和方法。

2. 发明申请

WO0198360A3 GP354 NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
标题翻译： GP354核酸和多糖
公开(公告)号：WO0198360A3
公开(公告)日：2002-11-28
申请号：PCT/US0119904
申请日：2001-06-22
申请人： BIOGEN INC , CARULLI JOHN P , LUKASHIN ALEXANDER V , KILBURN DANIEL R , SUN CHAO
发明人： CARULLI JOHN P , LUKASHIN ALEXANDER V , KILBURN DANIEL R , SUN CHAO
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/18 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/28 , A61P35/00 , C07K14/705 , C07K16/18 , C07K16/42 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , A61K31/7088 , A61K38/17 , C07K16/28
CPC分类号： C07K14/70503 , A61K38/00
摘要： An isolated polynucleotide encoding a novel immunoglobulin superfamily member named GP354 is provided. GP354 has a predicted single membrane spanning domain and five immunoglobulin (Ig) domains in the extracellular portion of the protein. The protein structure and tissue distribution of GP354 indicate that it plays a role in cell-cell recognition, binding, signaling and adhesion events in the pancreas and central nervous system (CNS). Provided by the invention are isolated GP354 related polynucleotides and polypeptides, vectors, and host cells comprising any of the above, antibodies directed to GP354, cells which produce such antibodies, and related diagnostic and therapeutic methods.
摘要翻译：提供了编码名为GP354的新型免疫球蛋白超家族成员的分离的多核苷酸。 GP354在蛋白质的细胞外部分具有预测的单膜跨膜结构域和五个免疫球蛋白（Ig）结构域。 GP354的蛋白质结构和组织分布表明其在胰腺和中枢神经系统（CNS）中的细胞细胞识别，结合，信号传导和粘附事件中起作用。通过本发明提供了分离的GP354相关多核苷酸和多肽，载体和宿主细胞，其包含以上任何一种，针对GP354的抗体，产生此类抗体的细胞，以及相关的诊断和治疗方法。

3. 发明专利

AU2002322331B2 Pancam nucleic acids and polypeptides 未知
公开(公告)号：AU2002322331B2
公开(公告)日：2008-01-03
申请号：AU2002322331
申请日：2002-06-24
申请人： BIOGEN IDEC INC
发明人： CARULLI JOHN P , LUKASHIN ALEXANDER V , KILBURN DANIEL R , SUN CHAO
IPC分类号： G01N33/50 , A61K31/7088 , A61K35/39 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/18 , A61P3/10 , A61P5/00 , A61P5/06 , A61P5/10 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/28 , A61P35/00 , A61P37/00 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
摘要： An isolated polynucleotide encoding a novel immunoglobulin superfamily member named PanCAM (also named GP354) is provided. PanCAM has a predicted single membrane spanning domain and five immunoglobulin (Ig) domains in the extracellular portion of the protein. The protein structure and tissue distribution of PanCAM indicate that it plays a role in cell-cell recognition, binding, signaling and adhesion events in the pancreas (especially the beta islets), the pituitary gland, and the central nervous system (CNS). Provided by the invention are isolated PanCAM related polynucleotides and polypeptides, vectors, and host cells comprising any of the above, antibodies directed to PanCAM, cells which produce such antibodies, and related diagnostic and therapeutic methods.

4. 发明专利

AU2001270058B2 GP354 nucleic acids and polypeptides 未知
公开(公告)号：AU2001270058B2
公开(公告)日：2006-11-02
申请号：AU2001270058
申请日：2001-06-22
申请人： BIOGEN IDEC INC
发明人： KILBURN DANIEL R , SUN CHAO , LUKASHIN ALEXANDER V , CARULLI JOHN P
IPC分类号： C07K14/705 , G01N33/50 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/18 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/28 , A61P35/00 , C07K16/18 , C07K16/42 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
摘要： An isolated polynucleotide encoding a novel immunoglobulin superfamily member named PanCAM (also named GP354) is provided. PanCAM has a predicted single membrane spanning domain and five immunoglobulin (Ig) domains in the extracellular portion of the protein. The protein structure and tissue distribution of PanCAM indicate that it plays a role in cell-cell recognition, binding, signaling and adhesion events in the pancreas (especially the beta islets), the pituitary gland, and the central nervous system (CNS). Provided by the invention are isolated PanCAM related polynucleotides and polypeptides, vectors, and host cells comprising any of the above, antibodies directed to PanCAM, cells which produce such antibodies, and related diagnostic and therapeutic methods.

5. 发明专利

NZ535481A Polynucleotides encoding GP354 or biologically active portions thereof suitable for use as primers or hybridization probes for the detection of GP354-encoding polynucleotides 未知
公开(公告)号：NZ535481A
公开(公告)日：2008-04-30
申请号：NZ53548101
申请日：2001-06-22
申请人： BIOGEN IDEC INC
发明人： CARULLI JOHN P , LUKASHIN ALEXANDER V , KILBURN DANIEL R , SUN CHAO
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/18 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/28 , A61P35/00 , C07K14/705 , C07K16/18 , C07K16/42 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
摘要： Disclosed is an isolated polynucleotide encoding a immunoglobulin superfamily member named GP354. GP354 has a predicted single membrane spanning domain and five immunoglobulin (Ig) domains in the extracellular portion of the protein. The protein structure and tissue distribution of GP354 indicate that it plays a role in cell-cell recognition, binding, signaling and adhesion events in the pancreas and central nervous system (CNS). Disclosed are GP354 related polynucleotides and polypeptides, vectors, and host cells comprising any of the above, antibodies directed to GP354, cells which produce such antibodies, and related diagnostic and therapeutic methods. (62) Divided Out of 523478

6. 发明专利

AU2007243181A1 Composition and methods for the detection of Cripto-3 未知
公开(公告)号：AU2007243181A1
公开(公告)日：2007-11-08
申请号：AU2007243181
申请日：2007-04-30
申请人： BIOGEN IDEC INC
发明人： OROZCO OLIVIA , TIZARD RICH , CHOI EUGENE , SZAK SUZANNE , SUN CHAO , SANICOLA-NADEL MICHELE , CARULLI JOHN
IPC分类号： C12Q1/68
摘要： The present invention is based, at least in part, on the discovery that the pseudogene TDGF3 (Cripto-3) is expressed in cells and, in particular, that TDGF3 overexpression is associated with transformation of a cell, e.g., TDGF3 is overexpressed in cancer cell lines and cells from tumor tissue. Accordingly, the invention provides compositions, kits, and methods for detecting the presence of a TDGF3 polynucleotide or polypeptide in a sample. The invention further provides compositions, kits and methods for assessing whether a cell is transformed as well as for assessing whether a patient is a suitable candidate for an anti-Cripto antibody therapy.

7. 发明专利

NZ530696A Pancam nucleic acids and polypeptides 未知
公开(公告)号：NZ530696A
公开(公告)日：2008-04-30
申请号：NZ53069602
申请日：2002-06-24
申请人： BIOGEN IDEC INC
发明人： SUN CHAO , CARULLI JOHN P , LUKASHIN ALEXANDER V , KILBURN DANIEL R , GARDNER HUMPHREY ATHELSTAN ROY
IPC分类号： G01N33/50 , A61K31/7088 , A61K35/39 , A61K39/395 , A61K48/00 , A61P1/18 , A61P3/10 , A61P5/00 , A61P5/06 , A61P5/10 , A61P25/00 , C07H21/04 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/74 , C12P21/02 , C12P21/06 , C12Q1/68 , G01N33/53
摘要： Disclosed is an isolated polynucleotide encoding a novel immunoglobulin superfamily member named PanCAM (also named GP354). PanCAM has a predicted single membrane spanning domain and five immunoglobulin (Ig) domains in the extracellular portion of the protein. The protein structure and tissue distribution of PanCAM indicate that it plays a role in cell-cell recognition, binding, signaling and adhesion events in the pancreas (especially the beta islets), the pituitary gland, and the central nervous system (CNS). Also disclosed are isolated PanCAM related polynucleotides and polypeptides, vectors, and host cells comprising any of the above, antibodies directed to PanCAM, cells which produce such antibodies, and related diagnostic and therapeutic methods.

8. 发明专利

CA2650379A1 COMPOSITION AND METHODS FOR THE DETECTION OF CRIPTO-3 未知
公开(公告)号：CA2650379A1
公开(公告)日：2007-11-08
申请号：CA2650379
申请日：2007-04-30
申请人： BIOGEN IDEC INC
发明人： TIZARD RICHARD J , SZAK SUZANNE , CARULLI JOHN P , OROZCO OLIVIA E , CHOI EUGENE , SANICOLA-NADEL MICHELE , SUN CHAO
IPC分类号： C12Q1/68
摘要： The present invention is based, at least in part, on the discovery that the pseudogene TDGF3 (Cripto-3) is expressed in cells and, in particular, that TDGF3 overexpression is associated with transformation of a cell, e.g., TDGF3 is overexpressed in cancer cell lines and cells from tumor tissue. Accordingly, the invention provides compositions, kits, and methods for detecting the presence of a TDGF3 polynucleotide or polypeptide in a sample. The invention further provides compositions, kits and methods for assessing whether a cell is transformed as well as for assessing whether a patient is a suitable candidate for an anti-Cripto antibody therapy.

9. 发明申请

WO2016058485A3 METHODS AND DEVICES FOR CALCULATING RANKING SCORE AND CREATING MODEL, AND PRODUCT RECOMMENDATION SYSTEM 审中-公开
标题翻译：计算分级和创建模型的方法和设备，以及产品推荐系统
公开(公告)号：WO2016058485A3
公开(公告)日：2016-06-09
申请号：PCT/CN2015091216
申请日：2015-09-30
申请人： ALIBABA GROUP HOLDING LTD , LIU RUI , LV TAO , SUN CHAO , YANG ZHIXIONG
发明人： LIU RUI , LV TAO , SUN CHAO , YANG ZHIXIONG
IPC分类号： G06F17/30
CPC分类号： G06F17/30
摘要： A method and device for calculating a ranking score of an object to be evaluated, a method and device for creating a ranking score calculation model, and a product recommendation system. The method for calculating a ranking score of an object to be evaluated comprises: obtaining for an object to be evaluated initial evaluation score data and additional ranking factor values, as well as actual behavior data extracted from past behavior data in an actual interaction behavior system (101); minimizing to an optimal target the difference between the actual ranking distribution obtained on the basis of actual behavior data and the predicted ranking distribution obtained on the basis of a pre-set ranking score calculation model, and solving for the weight coefficients of additional ranking factors in the ranking score calculation model (102); using said ranking score calculation model to calculate the ranking score of the object (103). In the present invention, additional ranking factors may be quickly and conveniently factored into calculations, and ranking scores resulting from said calculations can objectively and accurately predict the ranking of an object.
摘要翻译：一种用于计算待评估对象的评分的方法和装置，用于创建排名得分计算模型的方法和装置以及产品推荐系统。用于计算要评估对象的排名得分的方法包括：获得待评估对象的初始评估分数数据和附加排名因子值，以及从实际交互行为系统中的过去行为数据中提取的实际行为数据（ 101）; 最小化到根据实际行为数据获得的实际排名分布与基于预先设定的排名分数计算模型获得的预测排名分布之间的差异的最优目标，并求解其中的附加排名因子的权重系数排名分数计算模型（102）; 使用所述排名分数计算模型来计算所述对象（103）的排名得分。在本发明中，附加排名因素可以快速方便地考虑到计算中，并且由所述计算得出的分数得分可以客观和准确地预测对象的排名。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式