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1. 发明申请

WO2006073941A9 POLYPEPTIDES THAT BIND BR3 AND USES THEREOF 审中-公开
标题翻译：聚合BR3并使用它
公开(公告)号：WO2006073941A9
公开(公告)日：2007-07-05
申请号：PCT/US2005047072
申请日：2005-12-23
申请人： GENENTECH INC , BIOGEN IDEC INC , AMBROSE CHRISTINE M , BALAZS MERCEDESZ , DEFORGE LAURA , DENNIS MARK S , FUH GERMAINE , HURST STEPHEN D , LEE CHINGWEI V , LOWMAN HENRY B , MARTIN FLAVIUS , NAKAMURA GERALD R , SESHASAYEE DHAYA , STAROVASNIK MELISSA , THOMPSON JEFFREY S
发明人： AMBROSE CHRISTINE M , BALAZS MERCEDESZ , DEFORGE LAURA , DENNIS MARK S , FUH GERMAINE , HURST STEPHEN D , LEE CHINGWEI V , LOWMAN HENRY B , MARTIN FLAVIUS , NAKAMURA GERALD R , SESHASAYEE DHAYA , STAROVASNIK MELISSA , THOMPSON JEFFREY S
IPC分类号： C07K16/28
CPC分类号： C07K16/2878 , C07K2317/34 , C07K2317/732
摘要： The present invention relates to novel BR3 binding antibodies and polypeptides, including antagonist and agonist polypeptides. The present invention also relates to the use of the BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.
摘要翻译：本发明涉及新型BR3结合抗体和多肽，包括拮抗剂和激动剂多肽。本发明还涉及例如治疗方法，筛选方法，诊断方法，测定和蛋白质纯化方法中BR3结合抗体和多肽的用途。

2. 发明申请

WO2006073941A2 POLYPEPTIDES THAT BIND BR3 AND USES THEREOF 审中-公开
标题翻译：多边形BR3和其使用
公开(公告)号：WO2006073941A2
公开(公告)日：2006-07-13
申请号：PCT/US2005047072
申请日：2005-12-23
申请人： GENENTECH INC , BIOGEN IDEC INC , AMBROSE CHRISTINE M , BALAZS MERCEDESZ , DEFORGE LAURA , DENNIS MARK S , FUH GERMAINE , HURST STEPHEN D , LEE CHINGWEI V , LOWMAN HENRY B , MARTIN FLAVIUS , NAKAMURA GERALD R , SESHASAYEE DHAYA , STAROVASNIK MELISSA , THOMPSON JEFFREY S
发明人： AMBROSE CHRISTINE M , BALAZS MERCEDESZ , DEFORGE LAURA , DENNIS MARK S , FUH GERMAINE , HURST STEPHEN D , LEE CHINGWEI V , LOWMAN HENRY B , MARTIN FLAVIUS , NAKAMURA GERALD R , SESHASAYEE DHAYA , STAROVASNIK MELISSA , THOMPSON JEFFREY S
CPC分类号： C07K16/2878 , C07K2317/34 , C07K2317/732
摘要： The present invention relates to novel BR3 binding antibodies and polypeptides, including antagonist and agonist polypeptides. The present invention also relates to the use of the BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.
摘要翻译：本发明涉及新型BR3结合抗体和多肽，包括拮抗剂和激动剂多肽。本发明还涉及例如治疗方法，筛选方法，诊断方法，测定和蛋白质纯化方法中BR3结合抗体和多肽的用途。

3. 发明专利

AU2005323025A1 Polypeptides that bind BR3 and uses thereof 未知
公开(公告)号：AU2005323025A1
公开(公告)日：2006-07-13
申请号：AU2005323025
申请日：2005-12-23
申请人： BIOGEN IDEC INC , GENENTECH INC
发明人： MARTIN FLAVIUS , DENNIS MARK S , THOMPSON JEFFREY S , STAROVASNIK MELISSA , SESHASAYEE DHAYA , NAKAMURA GERALD R , DEFORGE LAURA , AMBROSE CHRISTINE M , BALAZS MERCEDESZ , HURST STEPHEN D , LEE CHINGWEI V , LOWMAN HENRY B , FUH GERMAINE
IPC分类号： C07K16/28
摘要： The present invention relates to novel BR3 binding antibodies and polypeptides, including antagonist and agonist polypeptides. The present invention also relates to the use of the BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.

4. 发明专利

CA2595112A1 POLYPEPTIDES THAT BIND BR3 AND USES THEREOF 未知
公开(公告)号：CA2595112A1
公开(公告)日：2006-07-13
申请号：CA2595112
申请日：2005-12-23
申请人： GENENTECH INC , BIOGEN IDEC INC
发明人： SESHASAYEE DHAYA , STAROVASNIK MELISSA , AMBROSE CHRISTINE M , BALAZS MERCEDESZ , DEFORGE LAURA , DENNIS MARK S , FUH GERMAINE , LEE CHINGWEI V , HURST STEPHEN D , LOWMAN HENRY B , MARTIN FLAVIUS , THOMPSON JEFFREY S , NAKAMURA GERALD R
IPC分类号： C07K16/28
摘要： The present invention relates to novel BR3 binding antibodies and polypeptides, including antagonist and agonist polypeptides. The present invention also relates to the use of the BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.

5. 发明专利

BRPI0518994A2 未知
公开(公告)号：BRPI0518994A2
公开(公告)日：2008-12-02
申请号：BRPI0518994
申请日：2005-12-23
申请人： BIOGEN IDEC INC , GENENTECH INC
发明人： HURST STEPHEN D , LEE CHINGWEI V , LOWMAN HENRY B , MARTIN FLAVIUS , NAKAMURA GERALD R , SESHASAYEE DHAYA , STAROVASNIK MELISSA , THOMPSON JEFFREY S , AMBROSE CHRISTINE M , BALAZS MERCEDESZ , DEFORGE LAURA , DENNIS MARK S , FUH GERMAINE
IPC分类号： C07K16/28
摘要： The present invention relates to novel BR3 binding antibodies and polypeptides, including antagonist and agonist polypeptides. The present invention also relates to the use of the BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.

6. 发明公开

KR20180053315A 항-VEGF 항체의 최적화된 변이체들 审中-公开
公开(公告)号：KR20180053315A
公开(公告)日：2018-05-21
申请号：KR20187008132
申请日：2016-09-23
申请人： GENENTECH INC
发明人： KOENIG PATRICK , LEE CHINGWEI VIVIAN , RAJAGOPAL KARTHIKAN , FAMILI AMIN , FUH GERMAINE
IPC分类号： C07K16/22 , C12N15/10 , C12N15/115
CPC分类号： C07K16/22 , A61K39/3955 , A61K47/34 , A61K47/60 , A61K47/61 , A61K2039/505 , A61K2039/54 , C07K14/475 , C07K16/44 , C07K16/468 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C12N15/1037 , C12N15/115 , C12N2310/16
摘要： 본발명은항-VEGF 항체및 항-VEGF 항체가함유된조성물 (예컨데, 항체콘쥬게이트, 융합단백질, 및중합체제제), 이의용도, 예를들면혈관신생과병리학적으로관련된장애치료에용도를제공한다. 본발명은또한개선된특성, 예를들면, 강화된결합친화력, 안정성, 약동학을갖고, 및/또는발현을하는항체변이체를동정하는방법에관한것이다.

7. 发明公开

KR20180069069A 항-HtrA1 항체 및 이의 사용 방법 审中-公开
公开(公告)号：KR20180069069A
公开(公告)日：2018-06-22
申请号：KR20187015311
申请日：2016-10-27
申请人： GENENTECH INC
发明人： KELLEY ROBERT F , KIRCHHOFER DANIEL K , LAI JOYCE , LEE CHINGWEI V , LIANG WEI CHING , LIPARI MICHAEL T , LOYET KELLY M , SAI TAO , VAN LOOKEREN CAMPAGNE MENNO , WU YAN , FUH GERMAINE
IPC分类号： C07K16/40 , A61K9/00 , A61K39/00 , A61P27/02
CPC分类号： C07K16/40 , A61K2039/507 , C07K2317/24 , C07K2317/34 , C07K2317/53 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： 본발명은항-HtrA1 항체 (이중특이적항-HtrA1 항-인자 D 항체포함) 및상기를제조하고사용하는방법, 예를들어, HtrA1-연관된장애, 안구장애, 및/또는보체-연관된장애를치료하는방법을제공한다.

8. 发明专利

JP2011026321A Composition and method relating to stop-1 审中-公开
标题翻译：与STOP-1相关的组成和方法
公开(公告)号：JP2011026321A
公开(公告)日：2011-02-10
申请号：JP2010177021
申请日：2010-08-06
申请人： Genentech Inc , ジェネンテック, インコーポレイテッド
发明人： ACKERLY HEIDI , ASHKENAZI AVI , EBERHARD DAVID , FRANTZ GRETCHEN , FRENCH DOROTHY , FUH GERMAINE , HONGO JO-ANNE , LEE CHINGWEI , MARSTERS SCOT , PITTI ROBERT , RAAB HELGA , SOROCEANU LILIANA , VARFOLOMEEV EVGENY , WOLF BENI
IPC分类号： C07K19/00 , G01N33/53 , A61K38/00 , A61P9/00 , A61P9/02 , A61P9/10 , A61P17/02 , A61P19/08 , A61P35/00 , A61P43/00 , C07K14/435 , C07K16/00 , C07K16/22 , C07K16/32 , C07K16/42 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/12 , C12Q1/02 , G01N33/15 , G01N33/50
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： PROBLEM TO BE SOLVED: To provide novel therapeutic agents, diagnostic agents and methods for the purpose of treating or preventing uncontrollable proliferation of cells of, for example, cancers and other diseases by targeting activity, development and control of STOP-1. SOLUTION: There are provided novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide, that are useful for treatment and prevention of diseases and for medical diagnosis and research. There are also provided consensus sequences and specific sequences for antibodies that specifically bind to STOP-1. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为了通过靶向STOP-1的活性，开发和控制来提供用于治疗或预防例如癌症和其他疾病的细胞的不可控增殖的新型治疗剂，诊断剂和方法。解决方案：提供了可用于治疗和预防疾病和用于医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽有关的组合物和方法。还提供了与STOP-1特异性结合的抗体的共有序列和特异性序列。版权所有（C）2011，JPO＆INPIT

9. 发明专利

JP2014088392A Anti-vegf antibodies 有权
标题翻译：抗VEGF抗体
公开(公告)号：JP2014088392A
公开(公告)日：2014-05-15
申请号：JP2013250791
申请日：2013-12-04
申请人： Genentech Inc , ジェネンテック, インコーポレイテッド
发明人： FUH GERMAINE , LEE CHINGWEI V
IPC分类号： A61K39/395 , A61P9/10 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , G01N33/6893 , G01N2333/475
摘要： PROBLEM TO BE SOLVED: To provide anti-VEGF (vascular endothelial growth factor) antibody for blocking or preventing relapse tumor growth or relapse cancer cell growth, and for treating non-neoplastic conditions comprising chronic inflammation or atherosclerosis, and to provide its composition.SOLUTION: A VEGF antibody comprises HVR antibodies selected from six HVRs as follows: (i) an HVR-L1 comprising the amino acid sequence of X1X2R X3SL [X1 is G or A, X2 is V or I, and/or X3 is T or R], wherein the HVR-L1 comprises 1, 2 or 3 substitutions in any combination of the following positions; (ii) an HVR-L2 comprising the amino acid sequence of DASSLA; (iii) an HVR-L3 comprising the amino acid sequence of SYKSPL; (iv) an HVR-H1 comprising the amino acid sequence of SISGSWIF; (v) an HVR-H2 comprising the amino acid sequence of GAIWPFGGYTH; and (vi) an HVR-H3 comprising the amino acid sequence of RWGHSTSPWAMDY.
摘要翻译：要解决的问题：提供用于阻断或预防复发肿瘤生长或复发癌细胞生长的抗VEGF（血管内皮生长因子）抗体，以及用于治疗包括慢性炎症或动脉粥样硬化的非肿瘤性病症并提供其组成。解决方案 VEGF抗体包含选自以下六种HVR的HVR抗体：（i）包含X1X2R X3SL的氨基酸序列的HVR-L1 [X1为G或A，X2为V或I，和/或X3为T或R ]，其中HVR-L1包含以下位置的任何组合中的1,2或3个取代; （ii）包含DASSLA的氨基酸序列的HVR-L2; （iii）包含SYKSPL的氨基酸序列的HVR-L3; （iv）包含SISGSWIF的氨基酸序列的HVR-H1; （v）包含GAIWPFGGYTH的氨基酸序列的HVR-H2; 和（vi）包含RWGHSTSPWAMDY的氨基酸序列的HVR-H3。

10. 发明专利

JP2014158481A Anti-her antibodies 审中-公开
标题翻译：抗体抗体
公开(公告)号：JP2014158481A
公开(公告)日：2014-09-04
申请号：JP2014072340
申请日：2014-03-31
申请人： Genentech Inc , ジェネンテック, インコーポレイテッド
发明人： FUH GERMAINE , GABRIELE SCHAEFER , LAURIC HABER , MARK X SLIWKOWSKI
IPC分类号： C12N15/09 , A61K39/395 , A61P35/00 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
CPC分类号： A61K47/48569 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要： PROBLEM TO BE SOLVED: To provide anti-HER antibodies, including multispecific anti-HER antibodies for use in treating various cancers; compositions including these antibodies; and methods of using these antibodies.SOLUTION: The invention provides multispecific antibodies comprising an antigen-binding domain that specifically binds to EGFR and HER3, the antibodies being less toxic than EGFR antagonists. The invention also provides EGFR/HER3 multispecific antibodies that have less dermatological toxicity than traditional EGFR antagonists. The antibodies inhibit biological activity of at least one of EGFR and HER3. The antibodies inhibit tumor cell growth.
摘要翻译：要解决的问题：提供抗HER抗体，包括用于治疗各种癌症的多特异性抗HER抗体; 包括这些抗体的组合物; 以及使用这些抗体的方法。解决方案：本发明提供了包含特异性结合EGFR和HER3的抗原结合结构域的多特异性抗体，该抗体的毒性低于EGFR拮抗剂。本发明还提供比传统EGFR拮抗剂具有更少皮肤病毒性的EGFR / HER3多特异性抗体。抗体抑制EGFR和HER3中的至少一种的生物活性。抗体抑制肿瘤细胞生长。

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