专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007008547A3 SP35 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译： SP35抗体及其用途
公开(公告)号：WO2007008547A3
公开(公告)日：2009-03-26
申请号：PCT/US2006026271
申请日：2006-07-07
申请人： BIOGEN IDEC INC , MI SHA , PEPINSKY R BLAKE , SHAO ZHAOHUI , GRAFF CHRISTILYN P
发明人： MI SHA , PEPINSKY R BLAKE , SHAO ZHAOHUI , GRAFF CHRISTILYN P
IPC分类号： C07K16/00 , C07K14/00 , C12N15/113
CPC分类号： A61K47/48538 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2319/30 , C12N15/1138 , C12N2310/111 , C12N2310/14
摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination (Negative Regulator). Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.
摘要翻译：内源性Sp35是神经元存活，轴突再生，少突胶质细胞分化和髓鞘形成（负调节因子）的负调节因子。阻断内源性Sp35功能的分子，这种抗Sp35抗体可以用作治疗神经元和少突胶质细胞功能障碍的治疗剂。本发明提供对Sp35特异性的抗体，以及使用抗体作为内源性Sp35功能拮抗剂的方法。本发明还提供特异性杂交瘤和源自噬菌体文库的单克隆抗体，编码这些抗体的核酸，以及包含这些抗体的载体和宿主细胞。本发明还提供了在脊椎动物中促进少突胶质细胞存活和髓鞘形成的方法，其包括对需要这种治疗的脊椎动物施用有效量的抗Sp35抗体。

2. 发明公开

EP1904104A4 SP35 ANTIBODIES AND USES THEREOF 有权
标题翻译： SP35抗体和用途
公开(公告)号：EP1904104A4
公开(公告)日：2009-12-09
申请号：EP06786428
申请日：2006-07-07
申请人： BIOGEN IDEC INC
发明人： MI SHA , PEPINSKY R BLAKE , SHAO ZHAOHUI , GRAFF CHRISTILYN P
IPC分类号： A61K39/395 , A61P25/00 , C07K16/18 , C07K16/28 , C12N15/113
CPC分类号： A61K47/48538 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2319/30 , C12N15/1138 , C12N2310/111 , C12N2310/14

3. 发明专利

CY1114634T1 SP35 ΑΝΤΙΣΩΜΑΤΑ ΚΑΙ ΧΡΗΣΕΙΣ ΑΥΤΩΝ 未知
公开(公告)号：CY1114634T1
公开(公告)日：2016-10-05
申请号：CY131101031
申请日：2013-11-21
申请人： BIOGEN IDEC INC
发明人： MI SHA , PEPINSKY R BLAKE , SHAO ZHAOHUI , GRAFF CHRISTILYN P
IPC分类号： A61K39/395 , A61P25/00 , C07K16/18 , C07K16/28 , C12N15/113
摘要： Ενδογενής SΡ35 είναιέναςαρνητικόςρυθμιστήςγιανευρωνικήεπιβίωση, επαναδημιουργίαάξονα, διαφοροποίησηκαιμυελίνωσηολιγοδενδροκυττάρου (αρνητικόςρυθμιστής). Μόριαπουαναστέλλουνλειτουργίαενδογενούς SΡ35 όπωςαντι-SΡ35 αντισώματαμπορείναχρησιμοποιηθούνωςθεραπευτικέςουσίεςγιατηθεραπείαδυσλειτουργίαςνευρώνακαιολιγοδενδροκυττάρου. Ηπαρούσαεφεύρεσηπαρέχειαντισώματαειδικάγια SΡ35 καιμεθόδουςχρήσηςτέτοιωναντισωμάτωνωςανταγωνιστώνλειτουργίαςενδογενούς SΡ35. Ηεφεύρεσηπεραιτέρωπαρέχειειδικά, λαμβανόμενααπόυβρίδωμακαισυλλογήφάγου, μονοκλωνικάαντισώματα, νουκλεϊνικάοξέαπουκωδικοποιούναυτάτααντισώματακαιφορείςκαικύτταραξενιστέςπουπεριλαμβάνουναυτάτααντισώματα. Ηεφεύρεσηπεραιτέρωπαρέχειμεθόδουςπροαγωγής, επιβίωσηςκαιμυελίνωσηςολιγοδενδροκυττάρουσεένασπονδυλωτό, πουπεριλαμβάνουνχορήγησησεένασπονδυλωτόπουέχειανάγκημιαςτέτοιαςθεραπείαςμιαςαποτελεσματικήςποσότηταςενόςαντι-SΡ35 αντισώματος.

4. 发明专利

SI1904104T1 Protitelesa SP35 in njihova uporaba 未知
公开(公告)号：SI1904104T1
公开(公告)日：2013-12-31
申请号：SI200631699
申请日：2006-07-07
申请人： BIOGEN IDEC INC
发明人： MI SHA , PEPINSKY R BLAKE , SHAO ZHAOHUI , GRAFF CHRISTILYN P
IPC分类号： A61K39/00 , A61P25/00 , C07K16/00 , C12N15/00 , C12N15/113

5. 发明专利

CA2902070A1 SP35 ANTIBODIES AND USES THEREOF 未知
公开(公告)号：CA2902070A1
公开(公告)日：2007-01-18
申请号：CA2902070
申请日：2006-07-07
申请人： BIOGEN IDEC INC
发明人： MI SHA , PEPINSKY R BLAKE , SHAO ZHAOHUI , GRAFF CHRISTILYN P
IPC分类号： C12N15/13 , A61K39/395 , A61P9/10 , A61P27/02 , C07K16/18 , C07K16/22 , C07K16/46 , C07K19/00 , C12N15/113
摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination (Negative Regulator). Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.

6. 发明专利

CA2614421A1 SP35 ANTIBODIES AND USES THEREOF 未知
公开(公告)号：CA2614421A1
公开(公告)日：2007-01-18
申请号：CA2614421
申请日：2006-07-07
申请人： BIOGEN IDEC INC
发明人： MI SHA , SHAO ZHAOHUI , PEPINSKY R BLAKE , GRAFF CHRISTILYN P
IPC分类号： A61K39/395 , C12N15/113
摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination (Negative Regulator). Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.

7. 发明专利

DK1904104T3 SP35-antistoffer og anvendelser heraf 未知
公开(公告)号：DK1904104T3
公开(公告)日：2013-11-11
申请号：DK06786428
申请日：2006-07-07
申请人： BIOGEN IDEC INC
发明人： MI SHA , PEPINSKY BLAKE R , SHAO ZHAOHUI , GRAFF CHRISTILYN P
IPC分类号： A61K39/395 , A61P25/00 , C07K16/18 , C07K16/28 , C12N15/113

8. 发明专利

PH12014500347A1 SP35 ANTIBODIES AND USES THEREOF 未知
公开(公告)号：PH12014500347A1
公开(公告)日：2015-09-28
申请号：PH12014500347
申请日：2014-02-12
申请人： BIOGEN IDEC INC
发明人： SHA MI , BLAKE PEPINSKY R , ZHAOHUI SHAO , GRAFF CHRISTILYN P
IPC分类号： C07K14/00 , C07K16/00 , C12N15/113
摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination (Negative Regulator). Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.

9. 发明专利

BRPI0613387A2 未知
公开(公告)号：BRPI0613387A2
公开(公告)日：2011-01-11
申请号：BRPI0613387
申请日：2006-07-07
申请人： BIOGEN IDEC INC
发明人： MI SHA , PEPINSKY R BLAKE , SHAO ZHAOHUI , GRAFF CHRISTILYN P
IPC分类号： A61K39/395 , C12N15/113
摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination (Negative Regulator). Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.

10. 发明专利

SG163591A1 SP35 ANTIBODIES AND USES THEREOF 未知
公开(公告)号：SG163591A1
公开(公告)日：2010-08-30
申请号：SG2010049534
申请日：2006-07-07
申请人： BIOGEN IDEC INC
发明人： MI SHA , PEPINSKY R BLAKE , SHAO ZHAOHUI , GRAFF CHRISTILYN P
IPC分类号： C12N15/113
摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination (Negative Regulator). Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式