专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004058264A1 COMPOUND LIBRARIES OF 2H-SPIRO (ISOQUINOLINE-1, -PIPERIDINE DERIVATIVES AND RELATED COMPOUNDS FOR TARGETTING COMPOUNDS CAPABLE OF BINDING TO THE G-PROTEIN RECEPTOR 审中-公开
标题翻译： 2H-SPIRO的化合物图（异喹啉-1，哌啶衍生物及相关化合物，可用于与G蛋白受体结合的靶向化合物
公开(公告)号：WO2004058264A1
公开(公告)日：2004-07-15
申请号：PCT/GB2003/005637
申请日：2003-12-24
申请人： BIOFOCUS PLC , WARD, Terence , CROSSLEY, Roger , SLATER, Martin, John
发明人： WARD, Terence , CROSSLEY, Roger , SLATER, Martin, John
IPC分类号： A61K31/475
CPC分类号： A61K31/4184 , A61K31/438 , A61K31/445 , A61K31/4747 , C07D241/20 , C07D241/24 , C07D403/04 , C07D403/10 , C07D405/10 , C07D413/12 , C07D471/04 , C07D471/10 , C40B40/04 , C40B50/08
摘要： The present invention provides a compound library, designed to pick up interactions with receptors for a subset of peptidic receptors, with recognition sites for amide and acidic ligands centred on transmembrane helices TM3 and TM6, although similar interactions are also found in lipid-type and ADP/ATP/UDP-types of receptors. The library comprises or consists of a set of structurally related compounds based on scaffolds of general formulae PS203, PS204, PS205 and PS144.
摘要翻译：本发明提供了一种化合物文库，其设计用于吸收与肽受体亚组的受体的相互作用，以及以跨膜螺旋TM3和TM6为中心的酰胺和酸性配体的识别位点，尽管在脂质型和ADP中也发现类似的相互作用 / ATP / UDP型受体。该文库包含一组基于通式PS203，PS204，PS205和PS144的支架的结构相关化合物或由其构成。

2. 发明申请

WO2004058259A1 COMPOUND LIBRARIES OF N-(AMINOCARBONYL)-PIPERIDINE-4-CARBOXAMIDE DERIVATIVES CAPABLE OF BINDING TO G-PROTEIN COUPLED RECEPTORS 审中-公开
标题翻译：可结合G蛋白偶联受体的N-（氨基羰基） - 哌啶-4-羧酰胺衍生物的化合物图
公开(公告)号：WO2004058259A1
公开(公告)日：2004-07-15
申请号：PCT/GB2003/005656
申请日：2003-12-24
申请人： BIOFOCUS PLC , WARD, Terence , CROSSLEY, Roger
发明人： WARD, Terence , CROSSLEY, Roger
IPC分类号： A61K31/445
CPC分类号： C07D241/24 , A61K31/4184 , A61K31/438 , A61K31/445 , A61K31/4747 , C07D241/20 , C07D403/04 , C07D403/10 , C07D405/10 , C07D413/12 , C07D471/04 , C07D471/10 , C40B40/04 , C40B50/08
摘要： The present invention provides a compound library targeted to receptors with a requirement for a positively charged amine in their structure activity relationships. It is designed to produce both agonists and antagonists and so is expected to be especially useful in producing ligands for orphan receptors. The library is designed around an acylurea coupled to a piperidine moiety. A combination of specific motifs R2 and R1 are appended from the central scaffold and are designed to pick up different interactions at a receptor site. The library comprises or consists of a set of structurally related compounds of general formula (I).
摘要翻译：本发明提供了靶向受体的化合物文库，其中需要带正电胺的结构活性关系。其设计用于产生激动剂和拮抗剂，因此预期在产生孤儿受体的配体中尤其有用。该文库设计在与哌啶部分偶联的酰基脲周围。特定基序R2和R1的组合从中心支架附加并被设计成在受体位点处吸收不同的相互作用。该文库由一组结构相关的通式（I）化合物组成或由其组成。

3. 发明申请

WO2004058263A1 COMPOUND LIBRARIES OF 2, 3, 4, 9-TETRAHYDROSPIRO (BETA-CARBOLINE-1, 4 -PIPERIDINE) DERIVATIVES AND RELATED COMPOUNDS FOR TARGETTING COMPOUNDS CAPABLE OF BINDING TO THE G-PROTEIN RECEPTOR 审中-公开
标题翻译： 2,3,4,9-四氢吡啶（BET-CARBOLINE-1,4-PIPERIDINE）衍生物的化合物和能够与G蛋白受体结合的靶向化合物的相关化合物
公开(公告)号：WO2004058263A1
公开(公告)日：2004-07-15
申请号：PCT/GB2003/005642
申请日：2003-12-24
申请人： BIOFOCUS PLC , WARD, Terence , CROSSLEY, Roger
发明人： WARD, Terence , CROSSLEY, Roger
IPC分类号： A61K31/4747
CPC分类号： A61K31/4184 , A61K31/438 , A61K31/445 , A61K31/4747 , C07D241/20 , C07D241/24 , C07D403/04 , C07D403/10 , C07D405/10 , C07D413/12 , C07D471/04 , C07D471/10 , C40B40/04 , C40B50/08
摘要： The present invention provides a compound library designed to target the interplay of electron-rich rings and basic amines. The spatial arrangements between these functions can be captured in two ways, one is captured in series of spiro-fused piperidines which show a propensity to interact with all-helical environments, and the other is present in a more folded back isoquinoline type arrangement. In GPCRs the basic function is commonly found to interact with TM3 aspartates and the electron-rich ring often is stabilised by Phe or Tyr and Ser or Thr on TM4 and TM5. The library is also designed to extend this recognition site for a subset of compounds to recruit antagonist recognition sites around TM7. The library comprises or consists of a set of structurally related compounds of general formulae A, B and C.
摘要翻译：本发明提供了设计用于靶向富电子环和碱性胺的相互作用的化合物文库。这些功能之间的空间布置可以通过两种方式来捕获，一种是以一系列螺旋稠合的哌啶捕获，其表现出与全螺旋环境相互作用的倾向，另一种以更折叠的异喹啉型布置存在。在GPCR中，通常发现基本功能与TM3天冬氨酸相互作用，富含电子的环通常在TM4和TM5上被Phe或Tyr和Ser或Thr稳定。该图书馆还旨在将该识别位点扩展到一组化合物，以招募TM7周围的拮抗剂识别位点。该文库由一组结构相关的通式A，B和C化合物组成或由其组成。

4. 发明申请

WO2004058755A3 COMPOUND LIBRARIES OF IMIDAZO[1,5-A]PYRIDIN-3-YL DERIVATIVES AND RELATED HETEROBICYCLES FOR TARGETTING COMPOUNDS CAPABLE OF BINDING TO G-PROTEIN COUPLED RECEPTORS 审中-公开
公开(公告)号：WO2004058755A3
公开(公告)日：2004-07-15
申请号：PCT/GB2003/005652
申请日：2003-12-24
申请人： BIOFOCUS PLC , WARD, Terence , CROSSLEY, Roger , MACRITCHIE, Jacqueline, Anne
发明人： WARD, Terence , CROSSLEY, Roger , MACRITCHIE, Jacqueline, Anne
IPC分类号： C07D471/00
摘要： The present invention provides a library designed to take advantage of a common recognition feature of G-protein coupled receptors, namely the ‘benzhydryl’ or ‘rabbit ears’ arrangement of aromatic rings. In addition the library utilises several themes common in GPCRs selecting for subsets which recognise basic and ‘acidic’ ligands. The library comprises or consists of a set of structurally related compounds of general formulae (A)or (B). The present invention also provides intermediates (formula (3)).

5. 发明申请

WO2008031081A2 VEHICULAR WHEEL ASSEMBLY WITH IMPROVED LOAD DISTRIBUTION 审中-公开
标题翻译：具有改进装载分配的车辆轮组件
公开(公告)号：WO2008031081A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/077949
申请日：2007-09-07
申请人： GM GLOBAL TECHNOLOGY OPERATIONS INC. , WARD, Terence , CRESCIBINI, Fabio , CARICCHI, Federico
发明人： WARD, Terence , CRESCIBINI, Fabio , CARICCHI, Federico
IPC分类号： B62D7/16
CPC分类号： B60K7/0007 , B60K2007/0038 , B60K2007/0092
摘要： A vehicular wheel assembly (24) includes a first bearing component (42) including at least one frame connector (52) configured to be coupled to a frame of a vehicle (10), a second bearing component (44) rotatably coupled to the first bearing component (42), a motor (36) including a stator (62) and a rotor (64), the stator (62) being coupled to the first bearing component (42) and the rotor (64) being coupled to the second bearing component (44) such that rotation of the rotor (64) relative to the stator (62) causes the second bearing component (44) to rotate relative to the first bearing component (42), the first bearing component (42) and the motor (36) being shaped such that a gap (55) is formed between the at least one frame connector (52) and the motor (36), and a brake mechanism (40) coupled to the second bearing component (44) to slow the rotation of the second bearing component (44) and the rotor (64).
摘要翻译：车轮组件（24）包括第一轴承部件（42），第一轴承部件（42）包括构造成联接到车辆（10）的框架的至少一个框架连接器（52），第二轴承部件（44），其可旋转地联接到第一轴承部件（42），包括定子（62）和转子（64）的马达（36），定子（62）联接到第一轴承部件（42），转子（64）轴承部件（44），使得转子（64）相对于定子（62）的旋转导致第二轴承部件（44）相对于第一轴承部件（42），第一轴承部件（42）和电动机（36）成形为使得在所述至少一个框架连接器（52）和所述电动机（36）之间形成间隙（55），以及联接到所述第二轴承部件（44）的制动机构（40）第二轴承部件（44）和转子（64）的旋转。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式