专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012122532A3 COMPOSITIONS AND METHODS FOR TREATMENT OF HYPERURICEMIA 审中-公开
标题翻译：用于治疗高血压的组合物和方法
公开(公告)号：WO2012122532A3
公开(公告)日：2014-04-24
申请号：PCT/US2012028616
申请日：2012-03-09
申请人： BIOCRYST PHARM INC , HOLLISTER ALAN , SHERIDAN WILLIAM P , BANTIA SHANTA , FLYNT AMY , ELDER JENNA , WAUGH ANITA , LYMAN SCOTT
发明人： HOLLISTER ALAN , SHERIDAN WILLIAM P , BANTIA SHANTA , FLYNT AMY , ELDER JENNA , WAUGH ANITA , LYMAN SCOTT
IPC分类号： A61P19/06
CPC分类号： A61K31/495 , A61K31/519 , A61K31/52 , A61K2300/00
摘要： The present invention is directed to methods and compositions for reduction of uric acid levels in subjects, and methods and compositions that are useful for treating, suppressing and/or preventing afflictions related to elevated uric acid levels in subjects. The methods comprise administering to the subject an effective amount of compound I, or a pharmaceutically acceptable salt or hydrate thereof, or a composition comprising compound I, or a pharmaceutically acceptable salt or hydrate thereof, and a pharmaceutically acceptable carrier. The compositions and/or methods may further comprise administering to the subject an effective amount of xanthine oxidase inhibitor such as allopurinol, or a pharmaceutically acceptable salt or hydrate thereof.
摘要翻译：本发明涉及用于降低受试者的尿酸水平的方法和组合物，以及可用于治疗，抑制和/或预防与受试者中升高的尿酸水平相关的疾病的方法和组合物。所述方法包括向受试者施用有效量的化合物I或其药学上可接受的盐或水合物，或包含化合物I或其药学上可接受的盐或水合物和药学上可接受的载体的组合物。组合物和/或方法还可以包括向受试者施用有效量的黄嘌呤氧化酶抑制剂，例如别嘌呤醇，或其药学上可接受的盐或水合物。

2. 发明申请

WO2009076455A2 METHODS OF TREATING HEMATOLOGIC CANCERS 审中-公开
标题翻译：治疗肝癌的方法
公开(公告)号：WO2009076455A2
公开(公告)日：2009-06-18
申请号：PCT/US2008086256
申请日：2008-12-10
申请人： BIOCRYST PHARM INC , BANTIA SHANTA , BREITFELD PHILIP , BABU YARLAGADDA S
发明人： BANTIA SHANTA , BREITFELD PHILIP , BABU YARLAGADDA S
IPC分类号： A61K31/4184 , A61K31/4745 , A61K35/00 , A61K39/395 , A61K45/06 , A61P35/02
CPC分类号： A61K31/519 , A61K31/4184 , A61K31/7076 , A61K39/39541 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/545 , C07K16/2887 , A61K2300/00
摘要： The present application relates to treatment of hematologic cancers, which treatments can include, e.g., administration of a purine nucleoside phosphorylase (PNP) inhibitor, an alkylating agent and/or an anti-CD20 agent, and related compositions and kits.
摘要翻译：本申请涉及血液癌的治疗，该治疗可以包括例如给予嘌呤核苷磷酸化酶（PNP）抑制剂，烷化剂和/或抗CD20剂，以及相关组合物和试剂盒。

3. 发明申请

WO2014205199A2 COMPOSITIONS AND METHODS FOR POTENTIATING IMMUNE RESPONSE, ENHANCING IMMUNOTHERAPY, AND INCREASING VACCINE POTENCY 审中-公开
标题翻译：潜在的免疫应答组合物和方法，增强免疫力和增加疫苗吸收
公开(公告)号：WO2014205199A2
公开(公告)日：2014-12-24
申请号：PCT/US2014043155
申请日：2014-06-19
申请人： NITOR THERAPEUTICS , BANTIA SHANTA
发明人： BANTIA SHANTA
IPC分类号： A61K47/22 , A61K39/00
CPC分类号： A61K47/22 , A61K31/519 , A61K31/7064 , A61K39/00 , A61K39/08 , A61K39/39 , A61K45/06 , A61K2039/55511 , A61K2300/00
摘要： Compositions including at least one PNP inhibitor or at least one PNP inhibitor in combination with one or more agents identified as endogenous adjuvants useful for enhancing the potency of vaccine and cancer immunotherapies being administered for the prevention or treatment of infectious diseases or cancer. The compositions may be formulated as pharmaceutical dosage forms and components may be assembled as kits. Methods for increasing the levels of endogenous adjuvants to enhance the immunogenicity of an antigen as well as to augment the potency of vaccine and cancer immunotherapies are also disclosed.
摘要翻译：组合物包括至少一种PNP抑制剂或至少一种PNP抑制剂与一种或多种被鉴定为用于增强疫苗和癌症免疫疗法效力的内源性佐剂联合用于预防或治疗感染性疾病或癌症。组合物可以配制成药物剂型，组分可以作为试剂盒组装。还公开了增加内源性佐剂水平以提高抗原免疫原性以及提高疫苗和癌症免疫治疗效力的方法。

4. 发明公开

KR20200143519A 정맥내 항바이러스 치료 审中-公开
公开(公告)号：KR20200143519A
公开(公告)日：2020-12-23
申请号：KR20207036259
申请日：2007-02-12
申请人： BIOCRYST PHARM INC
发明人： BABU YARLAGADDA SUDHAKARA , CHAND POORAN , BANTIA SHANTA , ARNOLD SHANE , KILPATRICK JOHN MICHAEL
IPC分类号： A61K31/196 , A61K9/00 , A61K9/08
摘要： 본발명은바이러스감염치료에유용한단위투여형태, 키트및 방법을제공한다.

5. 发明公开

EP3010507A4 COMPOSITIONS AND METHODS FOR POTENTIATING IMMUNE RESPONSE FOR THE TREATMENT OF INFECTIOUS DISEASES AND CANCER 审中-公开
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZURVERSTÄRKUNGDER IMMUNREAKTION ZUR BEHANDLUNG VON INFEKTIONSKRANKHEITEN UND KREBS
公开(公告)号：EP3010507A4
公开(公告)日：2017-06-07
申请号：EP14814310
申请日：2014-06-19
申请人： NITOR THERAPEUTICS , BANTIA SHANTA
发明人： BANTIA SHANTA
IPC分类号： A61K31/519
CPC分类号： A61K47/22 , A61K31/519 , A61K31/7064 , A61K39/00 , A61K39/08 , A61K39/39 , A61K45/06 , A61K2039/55511 , A61K2300/00
摘要： Compositions and methods including at least one PNP inhibitor or at least one PNP inhibitor in combination with one or more agents identified as endogenous adjuvants useful in the treatment of pathogen infection and cancer are disclosed. The compositions may be formulated as pharmaceutical dosage forms and components may be assembled as kits. Methods for increasing levels of endogenous adjuvants to enhance an immune response and to potentiate/augment antiviral, antibacterial or anticancer effects of therapeutic agents are also disclosed.
摘要翻译：公开了包含至少一种PNP抑制剂或至少一种PNP抑制剂与一种或多种鉴定为可用于治疗病原体感染和癌症的内源性佐剂的试剂组合和方法。组合物可以配制成药物剂型，并且组分可以组装成试剂盒。还公开了增加内源性佐剂的水平以增强免疫应答并增强/增强治疗剂的抗病毒，抗细菌或抗癌作用的方法。

6. 发明公开

EP3010340A4 COMPOSITIONS AND METHODS FOR POTENTIATING IMMUNE RESPONSE, ENHANCING IMMUNOTHERAPY, AND INCREASING VACCINE POTENCY 审中-公开
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZURVERSTÄRKUNGEINER IMMUNANTWORT，ZUR IMMUNTHERAPIEVERBESSERUNG UND ZURERHÖHUNGDER POTENZ VON IMPFSTOFFEN
公开(公告)号：EP3010340A4
公开(公告)日：2017-08-02
申请号：EP14814431
申请日：2014-06-19
申请人： NITOR THERAPEUTICS , BANTIA SHANTA
发明人： BANTIA SHANTA
IPC分类号： A61K31/519
CPC分类号： A61K47/22 , A61K31/519 , A61K31/7064 , A61K39/00 , A61K39/08 , A61K39/39 , A61K45/06 , A61K2039/55511 , A61K2300/00
摘要： Compositions and methods including at least one PNP inhibitor or at least one PNP inhibitor in combination with one or more agents identified as endogenous adjuvants useful in the treatment of pathogen infection and cancer are disclosed. The compositions may be formulated as pharmaceutical dosage forms and components may be assembled as kits. Methods for increasing levels of endogenous adjuvants to enhance an immune response and to potentiate/augment antiviral, antibacterial or anticancer effects of therapeutic agents are also disclosed.
摘要翻译：公开了包含至少一种PNP抑制剂或至少一种PNP抑制剂与一种或多种鉴定为可用于治疗病原体感染和癌症的内源性佐剂的试剂组合和方法。组合物可以配制成药物剂型，并且组分可以组装成试剂盒。还公开了增加内源性佐剂的水平以增强免疫应答并增强/增强治疗剂的抗病毒，抗细菌或抗癌作用的方法。

7. 发明申请

WO2014078778A3 ANTIVIRAL AZASUGAR-CONTAINING NUCLEOSIDES 审中-公开
标题翻译：抗病毒含AZUGUGAR的核苷
公开(公告)号：WO2014078778A3
公开(公告)日：2014-10-09
申请号：PCT/US2013070537
申请日：2013-11-18
申请人： BIOCRYST PHARM INC
发明人： BABU YARLAGADDA S , KOTIAN PRAVIN L , BANTIA SHANTA , WU MINWAN , KUMAR V SATISH
IPC分类号： A61K31/505
CPC分类号： C07D487/04 , A61K31/519 , C07D401/04 , C07D403/04
摘要： Disclosed are compounds comprising an azasugar attached to a heterocyclic base, including pharmaceutically acceptable salts thereof, suitable for use in inhibiting viral RNA polymerase activity or viral replication, and treating viral infections. The compounds are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with enteral administration, including, in particular, oral administration. Also disclosed are pharmaceutical compositions comprising one or more compounds mentioned above, or pharmaceutically acceptable salts thereof, as well as methods for preparing same. Also provided are methods for inhibiting viral RNA polymerase activity, viral replication, and treating viral infections.
摘要翻译：公开了包含与杂环碱基连接的氮杂糖的化合物，包括其药学上可接受的盐，其适用于抑制病毒RNA聚合酶活性或病毒复制，以及治疗病毒感染。这些化合物的部分特征在于对活性药物成分有利的药代动力学，特别是与肠内给药相结合，特别是包括口服给药。还公开了包含一种或多种上述化合物或其药学上可接受的盐的药物组合物，以及其制备方法。还提供了抑制病毒RNA聚合酶活性，病毒复制和治疗病毒感染的方法。

8. 发明公开

EP2996685A4 ANTI-INFLUENZA COMPOSITIONS AND METHODS 有权
标题翻译： GRIPPESCHUTZZUSAMMENSETZUNGEN UND VERFAHREN
公开(公告)号：EP2996685A4
公开(公告)日：2016-12-07
申请号：EP14798158
申请日：2014-05-14
申请人： BIOCRYST PHARM INC
发明人： SHERIDAN WILLIAM P , BANTIA SHANTA , KOTIAN PRAVIN L , BABU YARLAGADDA S
IPC分类号： A61K31/155 , A61K31/519 , A61K45/06 , A61P31/16 , C07D207/02 , C07D471/04 , C07D487/04
CPC分类号： C07D487/04 , A61K31/13 , A61K31/519 , A61K45/06 , C07D471/04 , C07D519/00 , A61K2300/00
摘要： Disclosed are novel compounds comprising an imino-ribose derivative covalently linked to a carbocycle or heterocycle. Pharmaceutical compositions comprising the compounds of the invention are also described. Methods of inhibition, treatment and/or suppression of viral infections with the compounds of the invention are also described. The compositions or methods may optionally comprise one or more additional anti-viral agents.
摘要翻译：公开了包含与碳环或杂环共价连接的亚氨基 - 核糖衍生物的新化合物。还描述了包含本发明化合物的药物组合物。还描述了用本发明化合物进行病毒感染的抑制，治疗和/或抑制的方法。组合物或方法可任选地包含一种或多种另外的抗病毒剂。

9. 发明公开

EP2919785A4 ANTIVIRAL AZASUGAR-CONTAINING NUCLEOSIDES 审中-公开
标题翻译：抗病毒核苷AZAZUCKERHALTIGE
公开(公告)号：EP2919785A4
公开(公告)日：2016-10-05
申请号：EP13855441
申请日：2013-11-18
申请人： BIOCRYST PHARM INC
发明人： BABU YARLAGADDA S , KOTIAN PRAVIN L , BANTIA SHANTA , WU MINWAN , KUMAR V SATISH
IPC分类号： A61K31/505 , C07D401/04 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519 , C07D401/04 , C07D403/04
摘要： Disclosed are compounds comprising an azasugar attached to a heterocyclic base, including pharmaceutically acceptable salts thereof, suitable for use in inhibiting viral RNA polymerase activity or viral replication, and treating viral infections. The compounds are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with enteral administration, including, in particular, oral administration. Also disclosed are pharmaceutical compositions comprising one or more compounds mentioned above, or pharmaceutically acceptable salts thereof, as well as methods for preparing same. Also provided are methods for inhibiting viral RNA polymerase activity, viral replication, and treating viral infections.

10. 发明公开

EP2627334A4 METHODS AND COMPOSITIONS FOR INHIBITION OF POLYMERASE 有权
标题翻译： VERFAHREN UND ZUSAMMENSETZUNGEN ZUR POLYMERASEHEMMUNG
公开(公告)号：EP2627334A4
公开(公告)日：2014-04-16
申请号：EP11833515
申请日：2011-10-14
申请人： BIOCRYST PHARM INC
发明人： BANTIA SHANTA , KOTIAN PRAVIN L , BABU YARLAGADDA S
IPC分类号： A61K31/519 , A61K31/215 , A61K45/06 , A61P31/14
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0053 , A61K31/196 , A61K31/215 , A61K31/351 , A61K31/7064 , A61K45/06 , C07D487/04 , C07H7/06 , A61K2300/00
摘要： The present invention is directed to methods and compositions for inhibition of viral nucleic acid polymerases, such as RNA and DNA polymerases, and methods and compositions that are useful for treating viral infections in subjects. The methods comprise administering to the subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or hydrate thereof, or a composition comprising a compound of formula I, or a pharmaceutically acceptable salt or hydrate thereof, and a pharmaceutically acceptable carrier. The composition or method may optionally comprise one or more additional anti-viral agents.
摘要翻译：本发明涉及用于抑制病毒核酸聚合酶（例如RNA和DNA聚合酶）的方法和组合物，以及可用于治疗受试者的病毒感染的方法和组合物。所述方法包括向受试者施用治疗有效量的式I化合物或其药学上可接受的盐或水合物，或包含式I化合物或其药学上可接受的盐或水合物的组合物和药学上可接受的载体。组合物或方法可任选地包含一种或多种另外的抗病毒剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式