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    • 2. 发明申请
    • DERIVATIVES OF 14.15-DIHYDRO 20.21-DINOREBURNAMENIN-14-OL, AND APPLICATIONS THEREOF
    • 14.15-二氢O O O O O IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF
    • WO2005103047A8
    • 2006-11-16
    • PCT/FR2005000902
    • 2005-04-14
    • BIOCORTECHCIAPETTI PAOLADEYON LAURENCEWERMUTH CAMILLE-GEORGESPUJOL JEAN-FRANCOISWEISSMANN DINAH
    • CIAPETTI PAOLADEYON LAURENCEWERMUTH CAMILLE-GEORGESPUJOL JEAN-FRANCOISWEISSMANN DINAH
    • C07D461/00A61K31/437A61P25/18A61P25/24
    • C07D461/00
    • The invention relates to novel derivatives of 14,15-dihydro 20,21 dinoreburnamenin-14-ol, having formula (I), in which R represents a radical -AR', wherein A represents a heteroatom and R' represents a group selected from the group comprising alkyl radicals at C 1 -C 6 , alkenyls at C 1 -C 6 , alkynyls at C 1 -C 6 , aralkyls; esters having formula -R 1 -CO-O-R 2 ; amides having formula -R 3 -CO-NZY, wherein Y and Z together can form a cycloalkyl radical or a heterocyclic radical, optionally substituted by one or more alkyl radicals; a radical selected from the group comprising alkyl radicals, alkenyls or alkynyls, substituted by at least one amine having formula -NZY; or one of the pharmaceutically-acceptable salts thereof, including the isomers, enantiomers and diastereoisomers thereof and mixtures of same. The invention also relates to the use of said novel derivatives for the preparation of a pharmaceutical composition which is intended, in particular, for the treatment and/or prevention of depression, sleep/wake cycle disorders and symptomatic frontal disorders in cognitive components among humans.
    • 本发明涉及具有式(I)的14,15-二氢20,21二辛烷亚胺-14-醇的新衍生物,其中R表示一个自由基-AR',其中A表示杂原子,R'表示选自 C 1 -C 6烷基,C 1 -C 6亚烷基,C 1 -C 6亚烷基,C 1 -C 6亚烷基,C 1 -C 6亚烷基, C 1 -C 6 - 芳烷基; 具有式-R 1 -CO-O-R 2的酯; 具有式-R 3 -CO-NZY的酰胺,其中Y和Z一起可以形成任选被一个或多个烷基取代的环烷基或杂环基; 选自由至少一个具有式-NZY的胺取代的烷基,烯基或炔基的基团; 或其药学上可接受的盐之一,包括其异构体,对映体和非对映异构体及其混合物。 本发明还涉及所述新型衍生物用于制备药物组合物的用途,该药物组合物特别用于治疗和/或预防人类中认知成分中的抑郁症,睡眠/觉醒周期障碍和症状性正面疾病。
    • 3. 发明专利
    • AT488516T
    • 2010-12-15
    • AT05757149
    • 2005-04-14
    • BIOCORTECH
    • CIAPETTI PAOLADEYON LAURENCEWERMUTH CAMILLE-GEORGESPUJOL JEAN-FRANCOISWEISSMANN DINAH
    • C07D461/00A61K31/437A61P25/18A61P25/24
    • The invention relates to novel derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol, having formula (I) in which R represents a radical -AR' wherein A represents a heteroatom and R' represents a group selected from the group comprising linear or branched C 1 -C 6 alkyl radicals, C 2 -C 6 alkenyls, C 2 -C 6 alkynyls, arylalkyls; esters comprising the formula -R 1 - CO-O-R 2 ; amides comprising the formula -R 3 -CO-NZY, wherein Y and Z together can form a cycloalkyl radical or a heterocyclic radical, optionally substituted by one or more alkyl radicals; a radical selected from the group comprising alkyl radicals, alkenyls or alkynyls, substituted by at least one amine with formula -NZY; or one of the pharmaceutically-acceptable salts thereof, including the isomers, enantiomers and diastereoisomers thereof and mixtures thereof. The invention also relates to the use of the novel derivatives for the preparation of a pharmaceutical composition which is intended, in particular, for the treatment and/or prevention of depression, sleep-wake cycle disorders and symptomatic frontal disorders in cognitive components among humans.
    • 7. 发明专利
    • HK1106502A1
    • 2008-03-14
    • HK07111220
    • 2007-10-17
    • BIOCORTECH
    • CIAPETTI PAOLADEYON LAURENCEWERMUTH CAMILLE-GEORGESPUJOL JEAN-FRANCOISWEISSMANN DINAH
    • A61K20060101A61P20060101C07D20060101C07D461/00
    • The invention relates to novel derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol, having formula (I) in which R represents a radical -AR' wherein A represents a heteroatom and R' represents a group selected from the group comprising linear or branched C 1 -C 6 alkyl radicals, C 2 -C 6 alkenyls, C 2 -C 6 alkynyls, arylalkyls; esters comprising the formula -R 1 - CO-O-R 2 ; amides comprising the formula -R 3 -CO-NZY, wherein Y and Z together can form a cycloalkyl radical or a heterocyclic radical, optionally substituted by one or more alkyl radicals; a radical selected from the group comprising alkyl radicals, alkenyls or alkynyls, substituted by at least one amine with formula -NZY; or one of the pharmaceutically-acceptable salts thereof, including the isomers, enantiomers and diastereoisomers thereof and mixtures thereof. The invention also relates to the use of the novel derivatives for the preparation of a pharmaceutical composition which is intended, in particular, for the treatment and/or prevention of depression, sleep-wake cycle disorders and symptomatic frontal disorders in cognitive components among humans.