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1. 发明专利

JPH1067785A 2-AMINO-2, 4, 4-TRIMETHYLPENTANE SALT OF CLAVULANIC ACID 失效
公开(公告)号：JPH1067785A
公开(公告)日：1998-03-10
申请号：JP21873297
申请日：1997-08-13
申请人： BIOCHEMIE GMBH
发明人： KRENMUELLER FRANZ DR , SUMMER HARALD DR
IPC分类号： A61K31/42 , A61P31/04 , C07C311/03 , C07D503/00 , C07D503/18
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound comprising 2-amino-2,4,4 trimethylpentane salt of clavulanic acid useful as an intermediate capable of providing a pharmaceutically permissible alkali (earth) metal salt of clavulanic acid in a high yield and purity. SOLUTION: This 2-amino-2,4,4-trimethylpentane salt of clavulanic acid is the new one used as an intermediate for production of a pharmaceutically permissible alkali earth metal salt of the clavulanic acid and useful as the intermediate for a pharmaceutically permissible salt of the clavulanic acid important as an additive, etc., for β-lactam antibiotic medicine because of inhibiting activities against β-lactamase. The compound salt is obtained by mixing a dried methylisobutylketone solution containing clavulanic acid with 2-amino-2,4,4-trimethypentane while stirring, filtering the mixture after stirring the mixed solution for 30min at room temperature and further for 2hr at 5 deg.C to separate the precipitated sediment and washing and drying the precipitated sediment.

2. 发明专利

ATA106391A 未知
公开(公告)号：ATA106391A
公开(公告)日：1992-08-15
申请号：AT106391
申请日：1991-05-24
申请人： BIOCHEMIE GMBH
发明人： ASCHER GERD DR , EGERBACHER JOSEF DR , KRENMUELLER FRANZ DR
IPC分类号： C07D501/00 , C07D501/04 , C07D501/08 , C07D501/18 , C07D501/38 , C07D501/24
摘要： The invention relates to a new process for the production of 7-amino-3-azidomethyl-3-cephem-4-carboxylic acid.

3. 发明专利

ATA79187A 未知
公开(公告)号：ATA79187A
公开(公告)日：1988-08-15
申请号：AT79187
申请日：1987-04-01
申请人： BIOCHEMIE GMBH
发明人： ASCHER GERD DR , KRENMUELLER FRANZ DR , STURM HUBERT DR
IPC分类号： C07D277/74 , C07D277/70

4. 发明专利

ATA47292A 未知
公开(公告)号：ATA47292A
公开(公告)日：1995-01-15
申请号：AT47292
申请日：1992-03-10
申请人： BIOCHEMIE GMBH
发明人： KRENMUELLER FRANZ DR , SUMMER HARALD DR
IPC分类号： A61K31/42 , A61P31/04 , C07C311/03 , C07D503/00 , C07D503/18
摘要： Use of the 2-amino-2,4,4-trimethylpentane salt of clavulanic acid as an intermediate in the production of pharmaceutically acceptable salts of clavulanic acid.

5. 发明专利

DE4307422A1 未知
公开(公告)号：DE4307422A1
公开(公告)日：1993-09-30
申请号：DE4307422
申请日：1993-03-09
申请人： BIOCHEMIE GMBH
发明人： KRENMUELLER FRANZ DR , SUMMER HARALD DR
IPC分类号： A61K31/42 , A61P31/04 , C07C311/03 , C07D503/00 , C07D503/18 , C07D498/047 , C07C211/03
摘要： Use of the 2-amino-2,4,4-trimethylpentane salt of clavulanic acid as an intermediate in the production of pharmaceutically acceptable salts of clavulanic acid.

6. 发明专利

AT400033B 未知
公开(公告)号：AT400033B
公开(公告)日：1995-09-25
申请号：AT47292
申请日：1992-03-10
申请人： BIOCHEMIE GMBH
发明人： KRENMUELLER FRANZ DR , SUMMER HARALD DR
IPC分类号： A61K31/42 , A61P31/04 , C07C311/03 , C07D503/00 , C07D503/18
摘要： Use of the 2-amino-2,4,4-trimethylpentane salt of clavulanic acid as an intermediate in the production of pharmaceutically acceptable salts of clavulanic acid.

7. 发明专利

AT387772B Processes for the preparation of novel organic compounds 未知
公开(公告)号：AT387772B
公开(公告)日：1989-03-10
申请号：AT79187
申请日：1987-04-01
申请人： BIOCHEMIE GMBH
发明人： ASCHER GERD DR , KRENMUELLER FRANZ DR , STURM HUBERT DR
IPC分类号： C07D277/74 , C07D277/70
摘要： The invention relates to processes for the preparation of novel compounds with the Z configuration of the formula Ia and Ib in which R1 to R5 are identical or different and each is hydrogen or a lower alkyl group, R6 is thiazole or thiadiazole, each of which may be substituted by the amino group or a protected amino group, and the indicated Het is a 5- or 6-membered heterocycle which may, in addition to the N atom, contain an S atom, and is fused to an optionally substituted benzene ring.

8. 发明专利

CH685054A5 Verfahren zur Herstellung von Clavulansäuresalzen. 未知
公开(公告)号：CH685054A5
公开(公告)日：1995-03-15
申请号：CH67093
申请日：1993-03-05
申请人： BIOCHEMIE GMBH
发明人： KRENMUELLER FRANZ DR , SUMMER HARALD DR
IPC分类号： A61K31/42 , A61P31/04 , C07C311/03 , C07D503/00 , C07D503/18

9. 发明专利

AT395854B 未知
公开(公告)号：AT395854B
公开(公告)日：1993-03-25
申请号：AT106391
申请日：1991-05-24
申请人： BIOCHEMIE GMBH
发明人： ASCHER GERD DR , EGERBACHER JOSEF DR , KRENMUELLER FRANZ DR
IPC分类号： C07D501/00 , C07D501/04 , C07D501/08 , C07D501/18 , C07D501/38
摘要： The invention relates to a new process for the production of 7-amino-3-azidomethyl-3-cephem-4-carboxylic acid.

10. 发明专利

AT388919B Process for the preparation of cephalosporin derivatives 未知
公开(公告)号：AT388919B
公开(公告)日：1989-09-25
申请号：AT10388
申请日：1988-01-20
申请人： BIOCHEMIE GMBH
发明人： ASCHER GERD DR , KRENMUELLER FRANZ DR , STURM HUBERT DR
IPC分类号： C07D501/20 , C07D501/46
摘要： The invention relates to a novel process for the preparation of cephalosporin derivatives with the Z configuration of the formula I in which R1 to R5 are identical or different and each is hydrogen or a lower alkyl group, R6 is thiazole or thiadiazole, each of which may be substituted by the amino group or a protected amino group, R8 is hydrogen, the pivaloyloxymethyl or a carboxyl protective group, R9 is hydrogen, the acetoxy or the carbamoyloxy group, is an optionally substituted heterocycle which is bonded via a quaternary N, such as pyridine, tetrazole or imidazole, or is an S-Y group where Y is an unsubstituted or substituted heterocycle, characterized in that a compound with the Z configuration of the formula IIa or IIb in which R1 to R6 have the above meaning, and the radicals VII and VIII are a 5- membered heterocycle which may contain an S atom in addition to the N atom, and is fused to an optionally substituted benzene ring, is reacted with a compound of the formula III in which R8 and R9 have the above meaning, and R10 is hydrogen or an amino protective group, and, if desired, a resulting final product is deprotected and, where appropriate, a resulting final product in which R8 is hydrogen is converted into a salt or vice versa.

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