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1. 发明申请

WO2008156331A2 NOVEL USE OF LIGNAN COMPOUNDS 审中-公开
标题翻译：使用LIGNAN化合物的新用途
公开(公告)号：WO2008156331A2
公开(公告)日：2008-12-24
申请号：PCT/KR2008/003525
申请日：2008-06-20
申请人： BIOCARE CO., LTD. , HWANG, Jae-Kwan , LEE, Jae Young , KIM, Jeong Hwan , SHIM, Jae-Seok , LEE, Hae Ji
发明人： HWANG, Jae-Kwan , LEE, Jae Young , KIM, Jeong Hwan , SHIM, Jae-Seok , LEE, Hae Ji
IPC分类号： A61K31/075
CPC分类号： A61K31/075 , A61K36/185
摘要： The present invention relates to novel use of lignan compounds, and more particularly, the present invention relates to novel use of an extract of the aril of nutmeg, 2- (4-allyl-2, 6-dimethoxyphenoxy) -1- (4-hydroxy- 3 -methoxyphenyl) -propane, austrobailignan 7 or licarin E, for preventing or treating diabetes or PPARγ-mediated diseases. The said compound and extract of the aril of nutmeg act as ligands for PPARy, and they may be used for preventing or treating PPARγ-mediated diseases, not limited thereto, such as diabetes and diabetic complication. Accordingly, 2- (4-allyl-2, 6- dimethoxyphenoxy) -1- (4 -hydroxy-3 -methoxyphenyl) -propane, austrobailignan 7 or licarin E and extract of the aril of nutmeg may be useful as preventing or treating agent for PPARγ-mediated diseases, not limited thereto, such as diabetes and diabetic complication.
摘要翻译：本发明涉及木脂素化合物的新用途，更具体地说，本发明涉及肉豆蔻酸的提取物2-（4-烯丙基-2,6-二甲氧基苯氧基）-1-（4- 羟基-3-甲氧基苯基） - 丙烷，奥司他林7或赖氨酸E，用于预防或治疗糖尿病或PPARα介导的疾病。所述的肉豆蔻的化合物和提取物作为PPARγ的配体，它们可以用于预防或治疗PPARα介导的疾病，不限于糖尿病和糖尿病并发症。因此，可以使用2-（4-烯丙基-2,6-二甲氧基苯氧基）-1-（4-羟基-3-甲氧基苯基） - 丙烷，奥罗韦利奈恩7或赖氨酸E和肉豆蔻的提取物作为预防或处理剂对于PPARβ介导的疾病，不限于糖尿病和糖尿病并发症。

2. 发明申请

WO2008156345A2 USE OF LIGNAN COMPOUND FOR ANTI-WRINKLE TREATMENT 审中-公开
标题翻译： LIGNAN化合物用于抗皱治疗的用途
公开(公告)号：WO2008156345A2
公开(公告)日：2008-12-24
申请号：PCT/KR2008/003547
申请日：2008-06-20
申请人： BIOCARE CO., LTD. , HWANG, Jae-Kwan , LEE, Hae Ji , LEE, Jae Young , SHIM, Jae-Seok , KIM, Jeong Hwan
发明人： HWANG, Jae-Kwan , LEE, Hae Ji , LEE, Jae Young , SHIM, Jae-Seok , KIM, Jeong Hwan
IPC分类号： A61K8/34
CPC分类号： A61K8/97 , A61K8/347 , A61K8/498 , A61Q19/08
摘要： The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme- 1(MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.
摘要翻译：本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠道中分离和纯化用于抗皱，更具体地，本发明涉及用于抗皱的提取物的抗皱纹的新用途肉豆蔻或肉豆蔻，fragrin A，奥维菌素7，licarin E和肉豆蔻衣木脂的提取物。本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的作用，从而具有抑制由光老化。因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。

3. 发明申请

WO2008156330A1 USE OF XANTHORRHIZOL FOR ANTI-WRINKLE TREATMENT 审中-公开
标题翻译：使用XANTHORRHIZOL进行抗皱治疗
公开(公告)号：WO2008156330A1
公开(公告)日：2008-12-24
申请号：PCT/KR2008/003522
申请日：2008-06-20
申请人： BIOCARE CO., LTD. , HWANG, Jae-Kwan , SHIM, Jae-Seok , LEE, Hae Ji , CHO, Yu-Mi , GWON, Song Hui
发明人： HWANG, Jae-Kwan , SHIM, Jae-Seok , LEE, Hae Ji , CHO, Yu-Mi , GWON, Song Hui
IPC分类号： A61K8/34
CPC分类号： A61Q19/08 , A61K8/347 , A61K8/97
摘要： The present invention relates to novel use of an extract of Curcuma xanthorrhiza or xanthorrhizol isolated from the extract and represented by Formula 1. The extract of Curcuma xanthorrhiza and xanthorrhizol of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-I, matrix metalloproteinase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibiting wrinkle. Accordingly, an extract of Curcuma xanthorrhiza or xanthorrhizol of the present -invention may be useful for preventing or treating wrinkle caused by photoaging.
摘要翻译：本发明涉及从提取物中分离出的由式1表示的姜黄黄嘌呤或黄嘌呤提取物的新用途。本发明的姜黄黄嘌呤和黄嘌呤的提取物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新胶原（1型前胶原）的形成，从而具有抑制皱纹的作用。因此，本发明的姜黄黄嘌呤或黄嘌呤的提取物可用于预防或治疗由光老化引起的皱纹。

4. 发明申请

WO2009051437A2 NOVEL USE OF LIGNAN-TYPE COMPOUNDS OR EXTRACT OF NUTMEG OR ARIL OF NUTMEG COMPRISING THE SAME 审中-公开
标题翻译：木脂素类化合物的新用途或包含该化合物的肉豆蔻或肉豆蔻的提取物的新用途
公开(公告)号：WO2009051437A2
公开(公告)日：2009-04-23
申请号：PCT/KR2008/006143
申请日：2008-10-17
申请人： BIOCARE CO., LTD. , HWANG, Jae-Kwan , CHO, Yu-Mi , KIM, Gyu Hoi , KIM, Jeong Hwan , LEE, Hae Ji , OH, Hyun In
发明人： HWANG, Jae-Kwan , CHO, Yu-Mi , KIM, Gyu Hoi , KIM, Jeong Hwan , LEE, Hae Ji , OH, Hyun In
IPC分类号： A61K8/49
CPC分类号： A61Q19/02 , A61K8/4973 , A61K8/97 , A61K31/357 , A61K36/185
摘要： The present invention relates to a new use of lignan-type compounds or an extract of nutmeg or aril of nutmeg comprising the same. More particularly, the present invention relates to a composition for skin whitening comprising a lignan-type compound or an extract of nutmeg or aril of nutmeg comprising the same. Because the lignan compound represented by Chemical Formulas 1 to 3 or the extract of nutmeg or aril of nutmeg has superior skin whitening activity by inhibiting melanin production and tyrosinase activity, it can be used for the preparation of a cosmetic composition, food composition or pharmaceutical composition for skin whitening.
摘要翻译：本发明涉及木脂素类化合物或包含其的肉豆蔻或肉豆蔻提取物的新用途。更具体地说，本发明涉及用于皮肤增白的组合物，其包含木脂素类化合物或包含其的肉豆蔻或肉豆蔻提取物。由于化学式1至3所示的木脂素化合物或肉豆蔻或肉豆蔻提取物通过抑制黑色素生成和酪氨酸酶活性而具有优异的皮肤增白活性，因此其可用于制备化妆品组合物，食品组合物或药物组合物皮肤美白。

5. 发明公开

EP2170255A2 USE OF LIGNAN COMPOUND FOR ANTI-WRINKLE TREATMENT 有权转让
标题翻译：使用木脂素连接对于治疗皱纹
公开(公告)号：EP2170255A2
公开(公告)日：2010-04-07
申请号：EP08766506.3
申请日：2008-06-20
申请人： Biocare CO., LTD. , Hwang, Jae-Kwan
发明人： HWANG, Jae-Kwan , LEE, Hae Ji , LEE, Jae Young , SHIM, Jae-Seok , KIM, Jeong Hwan
IPC分类号： A61K8/34
摘要： The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.

6. 发明授权

EP2200576B1 NOVEL USE OF LIGNAN-TYPE COMPOUNDS ISOLATED FROM EXTRACT OF NUTMEG OR ARIL OF NUTMEG 有权转让
标题翻译：新鲜的肉豆蔻或肉豆蔻提取物中分离的木脂素类化合物的新用途
公开(公告)号：EP2200576B1
公开(公告)日：2017-12-20
申请号：EP08839723.7
申请日：2008-10-17
申请人： Biocare Co., Ltd. , NEWTREE CO., LTD.
发明人： HWANG, Jae-Kwan , CHO, Yu-Mi , KIM, Gyu Hoi , KIM, Jeong Hwan , LEE, Hae Ji , OH, Hyun In , CHUNG, Hee Chul , CHUNG, Jae Youn , KIM, Do Un
IPC分类号： A61K8/49 , A61K8/97 , A61Q19/02 , A61K31/36 , A61K36/185
CPC分类号： A61Q19/02 , A61K8/4973 , A61K8/97 , A61K31/357 , A61K36/185
摘要： The present invention relates to a new use of lignan-type compounds or an extract of nutmeg or aril of nutmeg comprising the same. More particularly, the present invention relates to a composition for skin whitening comprising a lignan-type compound or an extract of nutmeg or aril of nutmeg comprising the same. Because the lignan compound represented by Chemical Formulas 1 to 3 or the extract of nutmeg or aril of nutmeg has superior skin whitening activity by inhibiting melanin production and tyrosinase activity, it can be used for the preparation of a cosmetic composition, food composition or pharmaceutical composition for skin whitening.

7. 发明公开

EP2200576A2 NOVEL USE OF LIGNAN-TYPE COMPOUNDS OR EXTRACT OF NUTMEG OR ARIL OF NUTMEG COMPRISING THE SAME 有权转让
标题翻译： NEUE VERWENDUNG VON AUS MUSKATEXTRAKT ODER MUSKATARILLUS EXTRAKT ISOLIERTEN LIGNANVERBINDUNGEN
公开(公告)号：EP2200576A2
公开(公告)日：2010-06-30
申请号：EP08839723.7
申请日：2008-10-17
申请人： Biocare Co., Ltd. , NEWTREE CO., LTD.
发明人： HWANG, Jae-Kwan , CHO, Yu-Mi , KIM, Gyu Hoi , KIM, Jeong Hwan , LEE, Hae Ji , OH, Hyun In , CHUNG, Hee Chul , CHUNG, Jae Youn , KIM, Do Un
IPC分类号： A61K8/49
CPC分类号： A61Q19/02 , A61K8/4973 , A61K8/97 , A61K31/357 , A61K36/185
摘要： The present invention relates to a new use of lignan-type compounds or an extract of nutmeg or aril of nutmeg comprising the same. More particularly, the present invention relates to a composition for skin whitening comprising a lignan-type compound or an extract of nutmeg or aril of nutmeg comprising the same. Because the lignan compound represented by Chemical Formulas 1 to 3 or the extract of nutmeg or aril of nutmeg has superior skin whitening activity by inhibiting melanin production and tyrosinase activity, it can be used for the preparation of a cosmetic composition, food composition or pharmaceutical composition for skin whitening.
摘要翻译：本发明涉及木质素型化合物或含有该木素素类化合物的肉豆蔻或肉豆蔻酸的提取物的新用途。更具体地，本发明涉及一种皮肤美白组合物，其包含木素素型化合物或包含该组合物的肉豆蔻或肉豆蔻的提取物。由于化学式1〜3所示的木酚素化合物或肉豆蔻肉豆蔻酸的提取物通过抑制黑色素生成和酪氨酸酶活性而具有优异的皮肤美白活性，因此可用于制备化妆品组合物，食品组合物或药物组合物用于皮肤美白。

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