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1. 发明申请

WO2008156331A3 NOVEL USE OF LIGNAN COMPOUNDS 审中-公开
标题翻译：使用LIGNAN化合物的新用途
公开(公告)号：WO2008156331A3
公开(公告)日：2009-02-26
申请号：PCT/KR2008003525
申请日：2008-06-20
申请人： BIOCARE CO LTD , HWANG JAE-KWAN , LEE JAE YOUNG , KIM JEONG HWAN , SHIM JAE-SEOK , LEE HAE JI
发明人： HWANG JAE-KWAN , LEE JAE YOUNG , KIM JEONG HWAN , SHIM JAE-SEOK , LEE HAE JI
IPC分类号： A61K31/075 , A61K36/18 , A61K36/53 , A61P3/04
CPC分类号： A61K31/075 , A61K36/185
摘要： The present invention relates to novel use of lignan compounds, and more particularly, the present invention relates to novel use of an extract of the aril of nutmeg, 2- (4-allyl-2, 6-dimethoxyphenoxy) -1- (4-hydroxy- 3 -methoxyphenyl) -propane, austrobailignan 7 or licarin E, for preventing or treating diabetes or PPAR?-mediated diseases. The said compound and extract of the aril of nutmeg act as ligands for PPARy, and they may be used for preventing or treating PPAR?-mediated diseases, not limited thereto, such as diabetes and diabetic complication. Accordingly, 2- (4-allyl-2, 6- dimethoxyphenoxy) -1- (4 -hydroxy-3 -methoxyphenyl) -propane, austrobailignan 7 or licarin E and extract of the aril of nutmeg may be useful as preventing or treating agent for PPAR?-mediated diseases, not limited thereto, such as diabetes and diabetic complication.
摘要翻译：本发明涉及木脂素化合物的新用途，更具体地说，本发明涉及肉豆蔻酸的提取物2-（4-烯丙基-2,6-二甲氧基苯氧基）-1-（4- 羟基-3-甲氧基苯基） - 丙烷，奥司他林7或赖氨酸E，用于预防或治疗糖尿病或PPARα介导的疾病。所述的肉豆蔻的化合物和提取物作为PPARγ的配体，它们可以用于预防或治疗PPARα介导的疾病，不限于糖尿病和糖尿病并发症。因此，可以使用2-（4-烯丙基-2,6-二甲氧基苯氧基）-1-（4-羟基-3-甲氧基苯基） - 丙烷，奥罗韦利奈恩7或赖氨酸E和肉豆蔻的提取物作为预防或处理剂对于PPARβ介导的疾病，不限于糖尿病和糖尿病并发症。

2. 发明申请

WO2008156345A3 USE OF LIGNAN COMPOUND FOR ANTI-WRINKLE TREATMENT 审中-公开
标题翻译： LIGNAN化合物用于抗皱治疗的用途
公开(公告)号：WO2008156345A3
公开(公告)日：2009-03-12
申请号：PCT/KR2008003547
申请日：2008-06-20
申请人： BIOCARE CO LTD , HWANG JAE-KWAN , LEE HAE JI , LEE JAE YOUNG , SHIM JAE-SEOK , KIM JEONG HWAN
发明人： HWANG JAE-KWAN , LEE HAE JI , LEE JAE YOUNG , SHIM JAE-SEOK , KIM JEONG HWAN
IPC分类号： A61K8/34
CPC分类号： A61K8/97 , A61K8/347 , A61K8/498 , A61Q19/08
摘要： The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme- 1(MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.
摘要翻译：本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠道中分离和纯化用于抗皱，更具体地，本发明涉及用于抗皱的提取物的抗皱纹的新用途肉豆蔻或肉豆蔻，fragrin A，奥维菌素7，licarin E和肉豆蔻衣木脂的提取物。本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的作用，从而具有抑制由光老化。因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。

3. 发明申请

WO2009051437A3 NOVEL USE OF LIGNAN-TYPE COMPOUNDS OR EXTRACT OF NUTMEG OR ARIL OF NUTMEG COMPRISING THE SAME 审中-公开
标题翻译：新型使用LIGNAN型化合物或提取NUTMEG或包含其的NUTMEG
公开(公告)号：WO2009051437A3
公开(公告)日：2009-07-16
申请号：PCT/KR2008006143
申请日：2008-10-17
申请人： BIOCARE CO LTD , HWANG JAE-KWAN , CHO YU-MI , KIM GYU HOI , KIM JEONG HWAN , LEE HAE JI , OH HYUN IN
发明人： HWANG JAE-KWAN , CHO YU-MI , KIM GYU HOI , KIM JEONG HWAN , LEE HAE JI , OH HYUN IN
IPC分类号： A61K8/49
CPC分类号： A61Q19/02 , A61K8/4973 , A61K8/97 , A61K31/357 , A61K36/185
摘要： The present invention relates to a new use of lignan-type compounds or an extract of nutmeg or aril of nutmeg comprising the same. More particularly, the present invention relates to a composition for skin whitening comprising a lignan-type compound or an extract of nutmeg or aril of nutmeg comprising the same. Because the lignan compound represented by Chemical Formulas 1 to 3 or the extract of nutmeg or aril of nutmeg has superior skin whitening activity by inhibiting melanin production and tyrosinase activity, it can be used for the preparation of a cosmetic composition, food composition or pharmaceutical composition for skin whitening.
摘要翻译：本发明涉及木素素型化合物或含有该木素素类化合物的肉豆蔻或肉豆蔻酸提取物的新用途。更具体地，本发明涉及一种皮肤美白组合物，其包含木素素型化合物或包含该组合物的肉豆蔻或肉豆蔻酸的提取物。由于化学式1〜3所示的木酚素化合物或肉豆蔻肉豆蔻酸提取物通过抑制黑色素生成和酪氨酸酶活性而具有优异的皮肤美白活性，因此可用于制备化妆品组合物，食品组合物或药物组合物用于皮肤美白。

4. 发明申请

WO2011145909A3 NOVEL USE OF PANDURATIN DERIVATIVES OR AN EXTRACT OF BOESENBERGIA PANDURATA FOR PROMOTING MUSCLE MASS GROWTH, FIGHTING FATIGUE, AND ENHANCING EXERCISE PERFORMANCE CAPABILITY 审中-公开
标题翻译：潘多拉汀衍生物的新用途或提取物，用于促进肌肉大量生长，消除疲劳和增强锻炼性能能力
公开(公告)号：WO2011145909A3
公开(公告)日：2012-03-29
申请号：PCT/KR2011003735
申请日：2011-05-20
申请人： BIOCARE CO LTD , NEWTREE CO LTD , HWANG JAE-KWAN , KIM DO UN
发明人： HWANG JAE-KWAN , KIM DO UN
IPC分类号： A61K31/05 , A61K36/906 , A61P21/00 , A61P43/00
CPC分类号： A61K36/906 , A23L33/105 , A61K31/12 , A61K36/00
摘要： The present invention relates to the novel use of panduratin derivatives or an extract of Boesenbergia pandurata for promoting muscle mass growth, fighting fatigue, and enhancing exercise performance capability. More particularly, the present invention relates to a composition for enhancing exercise performance capability, promoting muscle mass growth, and fighting fatigue, which comprises panduratin derivatives or salts thereof, or an extract of Boesenbergia pandurata, as active ingredients, and which promotes muscle mass growth and recovery from fatigue to improve mobility. The present invention also relates to a method for improving exercise performance capability, promoting muscle mass growth, and fighting fatigue, which involves injecting panduratin derivatives or salts thereof, or an extract of Boesenbergia pandurata, into an individual requiring same. The panduratin derivatives or the extract of Boesenbergia pandurata of the present invention can be used safely with no adverse effects, and increases the expression of PPAR d in the muscles, thus exhibiting excellent effects in promoting muscle mass growth, recovery from fatigue, and an enhancement in exercise performance capability such as an enhancement in mobility.
摘要翻译：本发明涉及潘多蛋白衍生物或泛黄柏提取物的新用途，用于促进肌肉生长，抗疲劳，提高运动能力。更具体地，本发明涉及一种用于增强运动性能能力，促进肌肉量增长和抗疲劳的组合物，其包含潘多汀衍生物或其盐，或作为活性成分的Boesenbergia pandurata的提取物，并且其促进肌肉质量生长并从疲劳中恢复，提高流动性。本发明还涉及一种用于提高运动能力，促进肌肉量增长和抗疲劳的方法，其包括将潘多蛋白衍生物或其盐，或Boesenbergia pandurata的提取物注射到需要相同的个体中。可以安全地使用本发明的潘氏白藜芦素衍生物或提取物，没有副作用，并且增加肌肉中PPAR d的表达，因此在促进肌肉量生长，疲劳恢复和增强方面表现出优异的效果在运动表现能力，如增加流动性。

5. 发明专利

AU9605001A Dietary fibers and oligosaccharides from ginseng and process for preparation thereof 未知
公开(公告)号：AU9605001A
公开(公告)日：2002-04-22
申请号：AU9605001
申请日：2001-10-09
申请人： HWANG JAE-KWAN
发明人： HWANG JAE-KWAN
IPC分类号： A23L1/30 , A23L1/308 , A23L19/00 , A23L1/212 , C07H3/06

6. 发明公开

EP2351559A4 NOVEL USE OF PANDURATIN DERIVATIVE OR BOESENBERGIA PANDURATA EXTRACT 有权转让
标题翻译：潘多汀衍生物或提琴形凹唇蓬莪萃取物的新用途
公开(公告)号：EP2351559A4
公开(公告)日：2012-03-28
申请号：EP09819415
申请日：2009-10-09
申请人： NEWTREE CO LTD , HWANG JAE KWAN
发明人： HWANG JAE-KWAN , KIM DO UN
IPC分类号： A61K31/05 , A23L1/29 , A61K31/121 , A61K36/906 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： A23C9/152 , A23L2/02 , A23L2/52 , A23L13/67 , A23L23/00 , A23L33/105 , A23L33/30 , A61K31/121 , A61K36/906
摘要： The present invention relates to a novel use of a panduratin derivative or a Boesenbergia pandurata extract. More specifically, the invention relates to a composition for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, containing a panduratin derivative represented by Chemical Formula 1, 2 or 3 or a Boesenbergia pandurata extract as an active ingredient, a method for treating a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, by administering an effective amount of the panduratin derivative or the Boesenbergia pandurata extract to a subject in need thereof, and a use of the panduratin derivative or the Boesenbergia pandurata extract to prepare a reagent for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes. As can be seen foregoing, the present invention provides a novel use of a panduratin derivative or a Boesenbergia pandurata extract. A panduratin derivative or a Boesenbergia pandurata extract of the present invention shows excellent effects on a metabolic disease such as obesity, hyperlipidemia, hypercholesterolemia and diabetes by decreasing highly related causes of metabolic diseases such as on weight, body fat and lipid-content. Since a composition of the present invention is originated from natural materials, it can be used without side effect and provides novel method for preventing and treating/relieving a metabolic disease through body weight loss and body fat loss and the like.

7. 发明申请

WO2012099449A3 NOVEL USE OF FLAVONE-BASED COMPOUND 审中-公开
标题翻译：使用基于FLAVONE的化合物的新用途
公开(公告)号：WO2012099449A3
公开(公告)日：2012-12-06
申请号：PCT/KR2012000601
申请日：2012-01-25
申请人： INDUSTRY ACADEMIC COOPERATION , HWANG JAE-KWAN , KIM JAEKYUNG
发明人： HWANG JAE-KWAN , KIM JAEKYUNG
IPC分类号： A61K8/49 , A61K8/97 , A61K31/352 , A61Q19/00
CPC分类号： A61K8/498 , A23G3/48 , A23G4/068 , A23L2/52 , A23L33/105 , A61K8/97 , A61K31/352 , A61Q19/007 , A61Q19/08
摘要： The present invention relates to a novel use of a flavone-based compound or Kaempferia parviflora extract, and more particularly, to a composition for anti-wrinkle, anti-aging and improvement of skin elasticity, comprising a flavone-based compound or Kaempferia parviflora extract, as an active ingredient. The composition of the present invention has superior effects of inhibiting collagenases and promoting collagen production, and therefore, may be effective in preventing skin wrinkles and aging and improving skin elasticity, and has superior effects of inhibiting loss of skin moisture and thus is effective in skin moisturizing.
摘要翻译：本发明涉及一种黄酮类化合物或小叶草提取物的新用途，更具体地说，涉及一种抗皱，抗衰老，改善皮肤弹性的组合物，其含有黄酮类化合物或小叶草（Kaempferia parviflora extract），作为活性成分。本发明的组合物具有抑制胶原酶和促进胶原蛋白生成的优异效果，因此可以有效地防止皮肤皱纹和老化并改善皮肤弹性，并且具有抑制皮肤水分损失的优异效果，因此在皮肤中有效保湿。

8. 发明申请

WO2012165888A2 COMPOSITION FOR TREATING OBESITY AND DIABETES AND FOR INCREASING MUSCLE MASS AND IMPROVING CAPACITY FOR EXERCISE, COMPRISING EXTRACTS OF PIPER RETROFRACTUM VAHL. FRUITS AS ACTIVE INGREDIENTS 审中-公开
标题翻译：用于治疗肥胖和糖尿病并用于增加肌肉质量并改善运动能力的组合物，包括管状回流VAHL的提取物。水果作为主要成分
公开(公告)号：WO2012165888A2
公开(公告)日：2012-12-06
申请号：PCT/KR2012004325
申请日：2012-05-31
申请人： CJ CHEILJEDANG CORP , UNIV YONSEI IACF , KIM KYUNG-JIN , KIM MIN-SUN , HWANG JAE-KWAN
发明人： KIM KYUNG-JIN , KIM MIN-SUN , HWANG JAE-KWAN
IPC分类号： A61K36/67 , A61P3/00 , A61P3/10
CPC分类号： A61K36/67 , A23L33/105 , A23V2002/00 , A61K2236/37 , A61K2236/51
摘要： The present invention relates to a food composition, and to a pharmaceutical composition, which exhibit anti-obesity effects by means of a thermogenesis produced by an activity of a UCP of fat cells, which exhibit anti-diabetes effects by means of an improved insulin resistance, increase muscle mass, and improve capacity for exercise. More particularly, the present invention relates to a novel use of a composition containing extracts of piper retrofractum, and to the food composition or pharmaceutical composition which exhibit anti-obesity effects by means of decreased body weight and body fat, exhibit anti-diabetes effects by means of ameliorated insulin resistance through the reduction of blood glucose and blood insulin, increase muscle mass by increasing an energy source being supplied to the muscles, and improve the capacity for exercise including increased endurance.
摘要翻译：本发明涉及一种食品组合物和药物组合物，其通过由脂肪细胞的UCP的活性产生的产生嗜酸性的表现出抗肥胖作用，其通过改善的胰岛素抵抗显示抗糖尿病作用增加肌肉量，提高运动能力。更具体地说，本发明涉及一种含有枸杞子提取物的组合物的新用途，以及通过降低体重和体脂肪显示出抗肥胖作用的食品组合物或药物组合物，具有抗糖尿病作用通过减少血糖和血液胰岛素来改善胰岛素抵抗的手段，通过增加供应给肌肉的能量来增加肌肉量，并且提高运动能力，包括增加耐力。

9. 发明申请

WO2012165888A3 COMPOSITION FOR TREATING OBESITY AND DIABETES AND FOR INCREASING MUSCLE MASS AND IMPROVING CAPACITY FOR EXERCISE, COMPRISING EXTRACTS OF PIPER RETROFRACTUM VAHL. FRUITS AS ACTIVE INGREDIENTS 审中-公开
标题翻译：用于治疗肥胖和糖尿病并用于增加肌肉质量并改善运动能力的组合物，包括管状回流VAHL的提取物。水果作为主要成分
公开(公告)号：WO2012165888A3
公开(公告)日：2013-05-16
申请号：PCT/KR2012004325
申请日：2012-05-31
申请人： CJ CHEILJEDANG CORP , UNIV YONSEI IACF , KIM KYUNG-JIN , KIM MIN-SUN , HWANG JAE-KWAN
发明人： KIM KYUNG-JIN , KIM MIN-SUN , HWANG JAE-KWAN
IPC分类号： A61K36/67 , A61P3/00 , A61P3/10
CPC分类号： A61K36/67 , A23L33/105 , A23V2002/00 , A61K2236/37 , A61K2236/51
摘要： The present invention relates to a food composition, and to a pharmaceutical composition, which exhibit anti-obesity effects by means of a thermogenesis produced by an activity of a UCP of fat cells, which exhibit anti-diabetes effects by means of an improved insulin resistance, increase muscle mass, and improve capacity for exercise. More particularly, the present invention relates to a novel use of a composition containing extracts of piper retrofractum, and to the food composition or pharmaceutical composition which exhibit anti-obesity effects by means of decreased body weight and body fat, exhibit anti-diabetes effects by means of ameliorated insulin resistance through the reduction of blood glucose and blood insulin, increase muscle mass by increasing an energy source being supplied to the muscles, and improve the capacity for exercise including increased endurance.
摘要翻译：本发明涉及一种食品组合物和药物组合物，其通过由脂肪细胞的UCP的活性产生的产生嗜酸性的表现出抗肥胖作用，其通过改善的胰岛素抵抗显示抗糖尿病作用增加肌肉量，提高运动能力。更具体地说，本发明涉及一种含有枸杞子提取物的组合物的新用途，以及通过降低体重和体脂肪显示出抗肥胖作用的食品组合物或药物组合物，具有抗糖尿病作用通过减少血糖和血液胰岛素来改善胰岛素抵抗的手段，通过增加供应给肌肉的能量来增加肌肉量，并且提高运动能力，包括增加耐力。

10. 发明申请

WO2010041908A2 NOVEL USE OF PANDURATIN DERIVATIVE OR BOESENBERGIA PANDURATA EXTRACT 审中-公开
标题翻译：使用潘多林衍生物或槟榔酚提取物
公开(公告)号：WO2010041908A2
公开(公告)日：2010-04-15
申请号：PCT/KR2009005804
申请日：2009-10-09
申请人： NEWTREE CO LTD , HWANG JAE-KWAN , KIM DO UN
发明人： HWANG JAE-KWAN
IPC分类号： A61K31/05
CPC分类号： A23C9/152 , A23L2/02 , A23L2/52 , A23L13/67 , A23L23/00 , A23L33/105 , A23L33/30 , A61K31/121 , A61K36/906
摘要： The present invention relates to a novel use of panduratin derivative or Boesenbergia pandurata extract. More specifically, the present invention relates to: a composition containing panduratin derivative or Boesenbergia pandurata extract denoted by chemical formulas 1 to 3 as an active ingredient for preventing and treating/relieving metabolic disease; a method for treating metabolic disease characterized by administering effective amount of panduratin derivative or Boesenbergia pandurata extract to a needed individual; a use of the panduratin derivative or Boesenbergia pandurata extract to manufacture a formulation for preventing and treating/relieving metabolic diseases. The metabolic disease is selected from the group consisting of obesity, hyperlipidemia, hypercholesterolemia, and diabetes. The present invention provides a novel use of the panduratin derivative or Boesenbergia pandurata extract. The panduratin derivative or Boesenbergia pandurata extract of the present invention has an effect on metabolic disease such as obesity, hyperlipidemia, hypercholesterolemia, and diabetes by reducing a factor relating to the metabolic disease such as weight, body fat, or lipid content. Thus, the present invention provides a novel means which is safely used as a natural substance without side effects and is effective in preventing and treating/relieving metabolic diseases through weight loss and body fat reduction.
摘要翻译：本发明涉及一种潘多汀衍生物或潘氏白僵菌提取物的新用途。更具体地说，本发明涉及以化学式1〜3表示的作为预防和治疗/缓解代谢性疾病的活性成分的潘多汀衍生物或潘氏石斛提取物的组合物，一种治疗代谢性疾病的方法，其特征在于向需要的个体施用有效量的潘多汀衍生物或Boesenbergia pandurata提取物; 使用潘多汀衍生物或Boesenbergia pandurata提取物制备用于预防和治疗/缓解代谢性疾病的制剂。代谢疾病选自肥胖症，高脂血症，高胆固醇血症和糖尿病。本发明提供了潘多汀衍生物或潘氏白僵菌提取物的新用途。本发明的潘多汀衍生物或潘氏白僵菌提取物通过减少与代谢疾病如体重，体脂肪或脂质含量有关的因素，对代谢疾病如肥胖症，高脂血症，高胆固醇血症和糖尿病具有影响。因此，本发明提供了一种新颖的方法，其被安全地用作天然物质而没有副作用，并且通过减肥和减少体重有助于预防和治疗/减轻代谢疾病。

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